Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TUB Gene

protein-coding   GIFtS: 59
GCID: GC11P008040

Tubby Bipartite Transcription Factor

(Previous names: tubby (mouse) homolog, tubby homolog (mouse))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tubby Bipartite Transcription Factor1 2     Tubby Homolog2
Tubby (Mouse) Homolog1     Tubby Homologue2
Tubby Homolog (Mouse)1     Tubby Protein Homolog2
rd52     

External Ids:    HGNC: 124061   Entrez Gene: 72752   Ensembl: ENSG000001664027   OMIM: 6011975   UniProtKB: P506073   

Export aliases for TUB gene to outside databases

Previous GC identifers: GC11P008828 GC11P008520 GC11P007999 GC11P008024 GC11P008016 GC11P007727


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TUB Gene:
This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a
role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in
mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response
to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TUB Gene: 
TUB (tubby bipartite transcription factor) is a protein-coding gene. Diseases associated with TUB include ecthyma, and otitis externa, and among its related super-pathways are Transcription Transcription factor Tubby signaling pathways and G beta:gamma signalling through PLC beta. GO annotations related to this gene include G-protein coupled photoreceptor activity. An important paralog of this gene is TULP2.

UniProtKB/Swiss-Prot: TUB_HUMAN, P50607
Function: Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes
containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of
transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity).
Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages

Gene Wiki entry for TUB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TUB gene promoter:
         c-Fos   Spz1   AP-1   NCX/Ncx   CUTL1   HEN1   S8   Ik-2   Zic1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TUB promoter sequence
   Search SABiosciences Chromatin IP Primers for TUB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.5

TUB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUB gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P008040:  view genomic region     (about GC identifiers)

Start:
8,040,791 bp from pter      End:
8,127,659 bp from pter
Size:
86,869 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TUB_HUMAN, P50607 (See protein sequence)
Recommended Name: Tubby protein homolog  
Size: 506 amino acids; 55651 Da
Subunit: Interacts with GNAQ (By similarity). Interacts with TULP1 (By similarity)
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Secreted (By similarity). Cell membrane;
Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Binds phospholipid and is anchored to the
plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of
phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine
nucleotide-binding protein G(q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a
non-conventional pathway (By similarity)
1 PDB 3D structure from and Proteopedia for TUB:
1S31 (3D)    
Secondary accessions: D3DQU4 O00293 Q6B007
Alternative splicing: 2 isoforms:  P50607-1   P50607-2   

Explore the universe of human proteins at neXtProt for TUB: NX_P50607

Explore proteomics data for TUB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P50607

  • TUB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TUB Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_003311.2  NP_813977.1  

    ENSEMBL proteins: 
     ENSP00000434400   ENSP00000305426   ENSP00000299506  

    Human Recombinant Protein Products for TUB: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TUB
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TUB
    GenScript Custom Purified and Recombinant Proteins Services for TUB
    Novus Biologicals TUB Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TUB 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS11000483
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane IEA--

    TUB for ontologies           About GeneDecksing



    TUB Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TUB
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TUB
    OriGene Custom Antibody Services for TUB
    GenScript Superior Antibodies for TUB
    Novus Biologicals TUB Antibodies
    Abcam antibodies for TUB
    Cloud-Clone Corp. Antibodies for TUB 
    ThermoFisher Antibody for TUB
    LSBio Antibodies in human, mouse, rat for TUB 

    Assay Products for TUB: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TUB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TUB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TUB 
    Cloud-Clone Corp. CLIAs for TUB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR025659 Tubby_C-like
     IPR018066 Tubby_C_CS
     IPR005398 Tubby_N
     IPR000007 Tubby_C

    Graphical View of Domain Structure for InterPro Entry P50607

    ProtoNet protein and cluster: P50607

    2 Blocks protein domains:
    IPB000007 Tubby
    IPB005398 Tubby protein signature


    UniProtKB/Swiss-Prot: TUB_HUMAN, P50607
    Similarity: Belongs to the TUB family


    TUB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TUB_HUMAN, P50607
    Function: Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes
    containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of
    transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity).
    Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages

         Genatlas biochemistry entry for TUB:
    tubby gene homolog of mouse (Tub) of mild naturity onset obesity,progressive retinal and cochlear
    degeneration,expressed in cochlea,retina,brain,testis

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008020G-protein coupled photoreceptor activity IEA--
         
    TUB for ontologies           About GeneDecksing


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tub):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland 
     growth/size  hearing/vestibular/ear  homeostasis/metabolism  immune system  liver/biliary system 
     nervous system  pigmentation  vision/eye 

    TUB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tubtm1Rok for TUB

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TUB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TUB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TUB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TUB 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TUB
    8/69 QIAGEN miScript miRNA Assays for microRNAs that regulate TUB (see all 69):
    hsa-miR-520f hsa-miR-4272 hsa-miR-128 hsa-miR-938 hsa-miR-3613-3p hsa-miR-3116 hsa-miR-2113 hsa-miR-3690
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TUB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TUB
    Sirion Biotech Customized adenovirus for overexpression of TUB

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TUB (see all 14)
    OriGene ORF clones in mouse, rat for TUB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TUB (NM_003320)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUB
    Sirion Biotech Customized lentivirus for stable overexpression of TUB 
                         Customized lentivirus expression plasmids for stable overexpression of TUB 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TUB
    Search LifeMap BioReagents cell lines for TUB
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TUB About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transcription Transcription factor Tubby signaling pathways
    Transcription Transcription factor Tubby signaling pathways1.00
    2Prostacyclin signalling through prostacyclin receptor
    G-Protein Signaling through Tubby Protein0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TUB
        Transcription Transcription factor Tubby signaling pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TUB
        G-Protein Signaling through Tubby Protein

    1 GeneGo (Thomson Reuters) Pathway for TUB
        Transcription Transcription factor Tubby signaling pathways



    TUB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TUB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/14 Interacting proteins for TUB (P506073 ENSP000003054264) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005193, ENSP000003614234I2D: score=3 STRING: ENSP00000361423
    PLCG1P191743, ENSP000002440074I2D: score=3 STRING: ENSP00000244007
    GNAQP501483, ENSP000002865484I2D: score=2 STRING: ENSP00000286548
    LCKP062393, ENSP000003378254I2D: score=2 STRING: ENSP00000337825
    PIK3R1P279863, ENSP000002743354I2D: score=2 STRING: ENSP00000274335
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006909phagocytosis IEA--
    GO:0007602phototransduction IEA--
    GO:0007605sensory perception of sound IEA--
    GO:0009584detection of visible light ----
    GO:0009725response to hormone stimulus IEA--

    TUB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TUB

    1 DrugBank Compound for TUB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Alpha-Glycerophospho-D-Myo-Inositol-4,5-Bis-Phosphate-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about TUB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TUB gene (2 alternative transcripts): 
    NM_003320.4  NM_177972.2  

    Unigene Clusters for TUB:

    Tubby homolog (mouse)
    Hs.568986  [show with all ESTs], Hs.733193  [show with all ESTs]
    Unigene Representative Sequences: NM_003320, AB209618
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534099 ENST00000305253(uc010rbk.2 uc001mfy.3 uc001mga.3)
    ENST00000299506
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TUB
    8/69 QIAGEN miScript miRNA Assays for microRNAs that regulate TUB (see all 69):
    hsa-miR-520f hsa-miR-4272 hsa-miR-128 hsa-miR-938 hsa-miR-3613-3p hsa-miR-3116 hsa-miR-2113 hsa-miR-3690
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TUB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUB
    Clone
    Products:
         
    OriGene clones in human, mouse for TUB (see all 14)
    OriGene ORF clones in mouse, rat for TUB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TUB (NM_003320)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUB
    Sirion Biotech Customized lentivirus for stable overexpression of TUB 
                         Customized lentivirus expression plasmids for stable overexpression of TUB 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TUB
    OriGene qSTAR qPCR primer pairs in human, mouse for TUB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TUB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUB

    Additional mRNA sequence: 

    AB209618.1 AK128611.1 

    11 DOTS entries:

    DT.100649186  DT.40125226  DT.303992  DT.100773456  DT.95215754  DT.95254196  DT.92060927  DT.120705939 
    DT.120705945  DT.120705978  DT.99946648 

    24/72 AceView cDNA sequences (see all 72):

    BM679358 AA338677 BU150872 BC075031 NM_003320 BC075032 CR619255 NM_177972 
    BE505023 AA910482 AA338676 BM720656 CD674811 CR617957 BM975413 BE552316 
    BM721755 BE045456 BM992151 AL528916 U82467 AI692942 AW024146 BF312704 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TUB    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:              -     -     -     -     -                       -                                                         
    SP2:                                                                                                                        
    SP3:                          -                                                                                             
    SP4:                                                                                                                        


    ECgene alternative splicing isoforms for TUB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TUB expression in normal human tissues (normalized intensities)      TUB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACAGGCGG
    TUB Expression
    About this image


    TUB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             autonomic/sympathetic/ganglion   
     
     Blood Brain Barrier (Nervous System)
             Postnatal Endothelial Cells Blood Brain Barrier
     
     Gut Tube (Gastrointestinal Tract)
             Primitive gut tube-like cells ( A scalable, suspension protocol for derivation of...
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer
     
     Endothelium (Cardiovascular System)
             Postnatal Endothelial Cells Blood Brain Barrier

    See TUB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TUB

    SOURCE GeneReport for Unigene clusters: Hs.568986 Hs.733193
        SABiosciences Custom PCR Arrays for TUB
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TUB
    OriGene qSTAR qPCR primer pairs in human, mouse for TUB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TUB
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TUB gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tub1 , 5 tubby candidate gene1, 5 91.6(n)1
    95.93(a)1
      7 (57.21 cM)5
    221411  NM_021885.41  NP_068685.11 
     1090108255 
    chicken
    (Gallus gallus)
    Aves TUB1 tubby homolog (mouse) 72.14(n)
    79.06(a)
      423061  XM_420992.3  XP_420992.2 
    lizard
    (Anolis carolinensis)
    Reptilia TUB6
    tubby homolog (mouse)
    74(a)
    1 ↔ 1
    GL343294.1(613870-802467)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.121412 Transcribed sequence with moderate similarity to protein more 75.44(n)    BX708616.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tub1 tubby homolog (mouse) 73.54(n)
    78.96(a)
      568677  XM_692022.2  XP_697114.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tulp3
    king-tubby1
    king tubby1 63(a)3
    54.41(n)1
    48.88(a)1
      374001  NM_206189.11  NP_995911.11 
    worm
    (Caenorhabditis elegans)
    Secernentea tub-11 , 3 Tub family protein tub-13
    Protein TUB-11
    50(a)3
    49.55(n)1
    48.17(a)1
      II(8154693-8156859)3
    1743121  NM_063309.31  NP_495710.11 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.68352 Vitis vinifera transcribed sequence with weak similarity more 79.81(n)    CB916004.1 
    rice
    (Oryza sativa)
    Liliopsida AK070139.12   -- 77.24(n)    AK070139.1 


    ENSEMBL Gene Tree for TUB (if available)
    TreeFam Gene Tree for TUB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TUB gene
    TULP22  TULP42  TULP12  WDR352  TULP32  
    3 SIMAP similar genes for TUB using alignment to 4 protein entries:     TUB_HUMAN (see all proteins):
    TULP3    TULP2    TULP1

    TUB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1789 SNPs in TUB are shown (see all 1789)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1509362691,2
    Cuntested17985255(+) GAGATC/TGGTAA 2 R W mis11Minor allele frequency- T:0.00NA 4544
    rs1380113491,2
    C--7983007(+) TCCCCA/GGTTGT 1 -- us2k10--------
    rs1124050941,2
    F--7983022(+) CAGGGG/AGTCAT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs122718741,2
    F,H--7983047(+) TAGCAC/TGGGCC 1 -- us2k15Minor allele frequency- T:0.00NS EA WA 534
    rs1909693041,2
    C--7983096(+) AGGAAA/GCTGGC 1 -- us2k10--------
    rs1822238131,2
    --7983129(+) ACCTTC/TTTTCC 1 -- us2k10--------
    rs1494870151,2
    --7983132(+) TTTTTA/TCCTGG 1 -- us2k10--------
    rs1873722521,2
    --7983193(+) AAGGAA/GACCAG 1 -- us2k10--------
    rs1156920641,2
    C,F--7983409(+) TGTGCG/ATGTGC 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1917533851,2
    --7983572(+) AGATGC/TGCTTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TUB (8040791 - 8127659 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TUB:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1001231CNV Insertion20482838
    nsv428249CNV Loss18775914
    esv25122CNV Loss19812545
    nsv499766OTHER Inversion21111241
    nsv7215OTHER Inversion18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TUB
    DNA2.0 Custom Variant and Variant Library Synthesis for TUB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601197    OMIM disorders: --

    11 diseases for TUB:    About MalaCards
    ecthyma    otitis externa    pontiac fever    folliculitis
    obesity    autism spectrum disorder    retinal degeneration    retinitis
    prostate cancer    prostatitis    neuronitis


    TUB for disorders           About GeneDecksing

    Genetic Association Database (GAD): TUB
    Human Genome Epidemiology (HuGE) Navigator: TUB (10 documents)

    Export disorders for TUB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TUB gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with TUB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. (PubMed id 8612280)1, 2, 3 Kleyn P.W.... Moore K.J. (1996)
    2. Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases. (PubMed id 9096357)1, 2, 9 North M.A.... Nishina P.M. (1997)
    3. Identification of tubby and tubby-like protein 1 as eat-me signals by phage display. (PubMed id 19837063)1, 2 Caberoy N.B.... Li W. (2010)
    4. Inherited genetic variant predisposes to aggressive b ut not indolent prostate cancer. (PubMed id 20080650)1, 4 Xu J....Isaacs W.B. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations. (PubMed id 19077438)1, 4 Chung W.K....Tiwari H.K. (2009)
    7. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (2009)
    8. TUB is a candidate gene for late-onset obesity in women. (PubMed id 17955208)1, 4 Snieder H....O'Dell S.D. (2008)
    9. Polymorphisms of the TUB gene are associated with body composition and eating behavior in middle-aged women. (PubMed id 18183286)1, 4 van Vliet-Ostaptchouk J.V....van der Schouw Y.T. (2008)
    10. Identification of TUB as a novel candidate gene influencing body weight in humans. (PubMed id 16443771)1, 4 Shiri-Sverdlov R....Wijmenga C. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7275 HGNC: 12406 AceView: TUB Ensembl:ENSG00000166402 euGenes: HUgn7275
    ECgene: TUB H-InvDB: TUB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TUB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TUB gene:
    Search GeneIP for patents involving TUB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of TUB
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TUB   OriGene RNAi products in human, mouse, rat for TUB  
     OriGene qPCR primer pairs and template standards for TUB   OriGene Protein Over-expression Lysate for TUB  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TUB  
     OriGene qSTAR qPCR primer pairs in human, mouse for TUB   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TUB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TUB   OriGene Custom Protein Services for TUB  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TUB
     QIAGEN SeqTarget long-range PCR primers for resequencing TUB
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUB
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUB
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUB
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUB
     GenScript Custom Purified and Recombinant Proteins Services for TUB GenScript cDNA clones with any tag delivered in your preferred vector for TUB
     GenScript Custom Assay Services for TUB GenScript Superior Antibodies for TUB
     GenScript Custom overexpressing Cell Line Services for TUB CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TUB promoter
     Search Chromatin IP Primers for TUB
     RT2 qPCR Primer Assay in human, mouse, rat TUB
     GNC Network for TUB
     SABiosciences PCR Arrays including human, mouse, rat TUB
     Search Tocris compounds for TUB
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TUB antibodies
     TUB proteins
     Antibodies for TUB
     See all of Abcam's Antibodies, Kits and Proteins for TUB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TUB
     Antibodies for TUB
     ELISAs for TUB
     CLIAs for TUB
     Search LifeMap BioReagents cell lines for TUB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUB
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TUB
     SwitchGear Promoter luciferase reporter plasmids for TUB
     ThermoFisher Antibody for TUB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUB
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TUB
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TUB
    Customized:
     lentivirus for stable overexpression of TUB
     lentivirus expression plasmids for stable overexpression of TUB
     adenovirus for overexpression of TUB
     LSBio Antibodies in human, mouse, rat for TUB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TUB gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4