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Aliases for TUB Gene

Aliases for TUB Gene

  • Tubby Bipartite Transcription Factor 2 3
  • Tubby (Mouse) Homolog 2
  • Tubby Homolog (Mouse) 2
  • Tubby Protein Homolog 3
  • Tubby Homologue 3
  • Tubby Homolog 3
  • RDOB 3
  • Rd5 3

External Ids for TUB Gene

Summaries for TUB Gene

Entrez Gene Summary for TUB Gene

  • This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TUB Gene

TUB (Tubby Bipartite Transcription Factor) is a Protein Coding gene. Diseases associated with TUB include retinal dystrophy and obesity and obesity. Among its related pathways are ADP signalling through P2Y purinoceptor 12 and Transcription_Transcription factor Tubby signaling pathways. GO annotations related to this gene include G-protein coupled photoreceptor activity. An important paralog of this gene is WDR35.

UniProtKB/Swiss-Prot for TUB Gene

  • Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.

Gene Wiki entry for TUB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUB Gene

Genomics for TUB Gene

Genomic Location for TUB Gene

Start:
8,019,195 bp from pter
End:
8,106,112 bp from pter
Size:
86,918 bases
Orientation:
Plus strand

Genomic View for TUB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TUB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUB Gene

Regulatory Elements for TUB Gene

Proteins for TUB Gene

  • Protein details for TUB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50607-TUB_HUMAN
    Recommended name:
    Tubby protein homolog
    Protein Accession:
    P50607
    Secondary Accessions:
    • D3DQU4
    • O00293
    • Q6B007

    Protein attributes for TUB Gene

    Size:
    506 amino acids
    Molecular mass:
    55651 Da
    Quaternary structure:
    • Interacts with GNAQ. Interacts with TULP1.

    Three dimensional structures from OCA and Proteopedia for TUB Gene

    Alternative splice isoforms for TUB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TUB Gene

Proteomics data for TUB Gene at MOPED

Post-translational modifications for TUB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TUB Gene

No data available for DME Specific Peptides for TUB Gene

Domains for TUB Gene

Protein Domains for TUB Gene

UniProtKB/Swiss-Prot:

TUB_HUMAN
Family:
  • Belongs to the TUB family.:
    • P50607
genes like me logo Genes that share domains with TUB: view

No data available for Gene Families for TUB Gene

Function for TUB Gene

Molecular function for TUB Gene

GENATLAS Biochemistry: tubby gene homolog of mouse (Tub) of mild naturity onset obesity,progressive retinal and cochlear degeneration,expressed in cochlea,retina,brain,testis
UniProtKB/Swiss-Prot Function: Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.

Gene Ontology (GO) - Molecular Function for TUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008020 G-protein coupled photoreceptor activity IEA --
GO:0032403 protein complex binding IDA 20889716
genes like me logo Genes that share ontologies with TUB: view
genes like me logo Genes that share phenotypes with TUB: view

Animal Models for TUB Gene

MGI Knock Outs for TUB:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TUB Gene

Localization for TUB Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUB Gene

Cytoplasm. Nucleus. Secreted. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUB Gene COMPARTMENTS Subcellular localization image for TUB gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 3
cytoskeleton 2
extracellular 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for TUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS 11000483
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with TUB: view

Pathways for TUB Gene

genes like me logo Genes that share pathways with TUB: view

Pathways by source for TUB Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for TUB Gene
1 Qiagen pathway for TUB Gene

Gene Ontology (GO) - Biological Process for TUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006909 phagocytosis IEA --
GO:0007602 phototransduction IEA --
GO:0007605 sensory perception of sound IEA --
GO:0009584 detection of visible light IEA --
GO:0009725 response to hormone IEA --
genes like me logo Genes that share ontologies with TUB: view

Compounds for TUB Gene

(1) Drugbank Compounds for TUB Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Alpha-Glycerophospho-D-Myo-Inositol-4,5-Bis-Phosphate
target
genes like me logo Genes that share compounds with TUB: view

Transcripts for TUB Gene

Unigene Clusters for TUB Gene

Tubby homolog (mouse):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TUB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - - -
SP2:
SP3: -
SP4:

Relevant External Links for TUB Gene

GeneLoc Exon Structure for
TUB
ECgene alternative splicing isoforms for
TUB

Expression for TUB Gene

mRNA expression in normal human tissues for TUB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TUB Gene

SOURCE GeneReport for Unigene cluster for TUB Gene Hs.568986

genes like me logo Genes that share expressions with TUB: view

Orthologs for TUB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUB 36
  • 99.58 (n)
  • 99.64 (a)
TUB 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TUB 36
  • 90.02 (n)
  • 93.08 (a)
TUB 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TUB 36
  • 91.67 (n)
  • 95.16 (a)
TUB 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tub 36
  • 90.85 (n)
  • 95.12 (a)
Tub 16
Tub 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TUB 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TUB 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tub 36
  • 90.04 (n)
  • 95.33 (a)
chicken
(Gallus gallus)
Aves TUB 36
  • 71.9 (n)
  • 79.34 (a)
TUB 37
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TUB 37
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12141 36
tub 36
  • 74.53 (n)
  • 81.63 (a)
zebrafish
(Danio rerio)
Actinopterygii tub 36
  • 73.92 (n)
  • 80.5 (a)
TUB 37
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta king-tubby 37
  • 44 (a)
OneToMany
Tulp 38
  • 63 (a)
worm
(Caenorhabditis elegans)
Secernentea tub-1 36
  • 57.18 (n)
  • 61.26 (a)
tub-1 37
  • 44 (a)
OneToMany
tub-1 38
  • 50 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6835 36
rice
(Oryza sativa)
Liliopsida Os03g0351400 36
  • 52.01 (n)
  • 46.06 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13886 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 62 (a)
OneToMany
Species with no ortholog for TUB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TUB Gene

ENSEMBL:
Gene Tree for TUB (if available)
TreeFam:
Gene Tree for TUB (if available)

Paralogs for TUB Gene

Paralogs for TUB Gene

Selected SIMAP similar genes for TUB Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TUB: view

Variants for TUB Gene

Sequence variations from dbSNP and Humsavar for TUB Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1113785 -- 8,073,103(-) CTATA(G/T)AGGAA intron-variant
rs1317500 -- 8,089,574(-) TGCCC(A/G)TGAGG intron-variant
rs1406094 -- 8,040,379(+) CTGGG(A/C)GTCCC intron-variant
rs1406095 -- 8,073,135(-) GATAA(A/G)AGTTC intron-variant
rs1406096 -- 8,072,994(-) ggact(C/G)tctct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUB Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241
nsv428249 CNV Loss 18775914
esv1001231 CNV Insertion 20482838
esv25122 CNV Loss 19812545

Relevant External Links for TUB Gene

HapMap Linkage Disequilibrium report
TUB
Human Gene Mutation Database (HGMD)
TUB

Disorders for TUB Gene

UniProtKB/Swiss-Prot

TUB_HUMAN
  • Retinal dystrophy and obesity (RDOB) [MIM:616188]: A disease characterized by obesity, night blindness, decreased visual acuity, and electrophysiological features of a rod cone dystrophy. {ECO:0000269 PubMed:24375934}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TUB

Genetic Association Database (GAD)
TUB
Human Genome Epidemiology (HuGE) Navigator
TUB
genes like me logo Genes that share disorders with TUB: view

Publications for TUB Gene

  1. Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. (PMID: 8612280) Kleyn P.W. … Moore K.J. (Cell 1996) 2 3 4
  2. Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases. (PMID: 9096357) North M.A. … Nishina P.M. (Proc. Natl. Acad. Sci. U.S.A. 1997) 3 4 23
  3. The tubby-like proteins, a family with roles in neuronal development and function. (PMID: 11801719) Ikeda A. … Naggert J.K. (J. Cell. Sci. 2002) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Identification of TUB as a novel candidate gene influencing body weight in humans. (PMID: 16443771) Shiri-Sverdlov R. … Wijmenga C. (Diabetes 2006) 3 49

Products for TUB Gene

Sources for TUB Gene

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