Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TUB Gene

protein-coding GIFtS: 61
GCID: GC11P008040

tubby homolog (mouse)

(Previous name: tubby (mouse) homolog )

Explore 13 diseases affiliated with
TUB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tubby Homolog (Mouse)¹ ²
Rd5¹
Tubby (Mouse) Homolog¹
Tubby Homologue²
Tubby Protein Homolog²

External Ids:	HGNC: 12406¹	Entrez Gene: 7275²	Ensembl: ENSG00000166402⁷	OMIM: 601197⁵	UniProtKB: P50607³

Export aliases for TUB gene to outside databases

Previous GC identifers: GC11P008828 GC11P008520 GC11P007999 GC11P008024 GC11P008016 GC11P007727

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TUB:

This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role

in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse,

and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to

phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TUB_HUMAN, P50607

Function: Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes

containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of

transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity).

Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages

Gene Wiki entry for TUB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TUB gene promoter:
c-Fos Spz1 AP-1 NCX/Ncx CUTL1 HEN1 S8 Ik-2 Zic1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TUB promoter sequence

Search SABiosciences Chromatin IP Primers for TUB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.5

TUB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUB gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P008040: view genomic region (about GC identifiers)

Start:	8,040,791 bp from pter	End:	8,127,659 bp from pter
Size:	86,869 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TUB_HUMAN, P50607 (See protein sequence)

Recommended Name: Tubby protein homolog

Size: 506 amino acids; 55651 Da

Subunit: Interacts with GNAQ (By similarity). Interacts with TULP1 (By similarity)

Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Secreted (By similarity). Cell membrane;

Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Binds phospholipid and is anchored to the plasma

membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C.

Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q)

subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity)

1 PDB 3D structure from and Proteopedia for TUB:

1S31 (3D)

Secondary accessions: D3DQU4 O00293 Q6B007

Alternative splicing: 2 isoforms: P50607-1 P50607-2

Explore the universe of human proteins at neXtProt for TUB: NX_P50607

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P50607

TUB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_003311.2 NP_813977.1

ENSEMBL proteins:

ENSP00000434400 ENSP00000305426 ENSP00000299506

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: TUB OriGene Custom Protein Services for TUB
	GenScript Custom Purified and Recombinant Proteins Services for TUB
	Novus Biologicals TUB Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TUB

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	TAS	11000483
GO:0005829	cytosol	IEA	--
GO:0005886	plasma membrane	IEA	--

TUB for ontologies About GeneDecksing

TUB Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of TUB
	Browse R&D Systems for Antibodies
	OriGene Antibodies: TUB OriGene Custom Antibody Services for TUB
	GenScript Superior Antibodies for TUB
	Novus Biologicals TUB Antibodies
	Abcam antibodies for TUB
	Uscn Antibodies for TUB
	ThermoFisher Antibodies for TUB

Assay Products for TUB:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TUB
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TUB

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TUB for domains About GeneDecksing

4 InterPro domains/families:

IPR025659 Tubby_C-like

IPR018066 Tubby_C_CS

IPR005398 Tubby_N

IPR000007 Tubby_C

Graphical View of Domain Structure for InterPro Entry P50607

ProtoNet protein and cluster: P50607

2 Blocks protein families:

IPB000007 Tubby

IPB005398 Tubby protein signature

UniProtKB/Swiss-Prot: TUB_HUMAN, P50607

Similarity: Belongs to the TUB family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TUB_HUMAN, P50607

Function: Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes

containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of

transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity).

Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages

Genatlas biochemistry entry for TUB:

tubby gene homolog of mouse (Tub) of mild naturity onset obesity,progressive retinal and cochlear

degeneration,expressed in cochlea,retina,brain,testis

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TUB Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TUB
		8/69 QIAGEN miScript miRNA Assays for microRNAs that regulate TUB (see all 69):
		hsa-miR-520f hsa-miR-4272 hsa-miR-128 hsa-miR-938 hsa-miR-3613-3p hsa-miR-3116 hsa-miR-2113 hsa-miR-3690

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TUB (see all 7) OriGene shRNA RFP: TUB OriGene siRNA: TUB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUB

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TUB

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TUB (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TUB (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TUB (NM_003320)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TUB
		Search LifeMap BioReagents cell lines for TUB

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUB

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--
GO:0008020	G-protein coupled photoreceptor activity	IEA	--

TUB for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Tub^tm1Rok for TUB
     13 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tub):

adipose tissue	behavior/neurological	cardiovascular system	cellular	endocrine/exocrine gland
growth/size	hearing/vestibular/ear	homeostasis/metabolism	immune system	liver/biliary system
nervous system	pigmentation	vision/eye

TUB for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G beta:gamma signalling through PLC beta

	G-Protein Signaling through Tubby Protein	0.38			Transcription Transcription factor Tubby signaling pathways	0.07
	Transcription_Transcription factor Tubby signaling pathways	0.07

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TUB

Transcription Transcription factor Tubby signaling pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TUB

G-Protein Signaling through Tubby Protein

1 GeneGo (Thomson Reuters) Pathway for TUB

Transcription Transcription factor Tubby signaling pathways

TUB for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TUB

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/14 Interacting proteins for TUB (P50607³ ENSP00000305426⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABL1	P00519³, ENSP00000361423⁴	I2D: score=3 STRING: ENSP00000361423
PLCG1	P19174³, ENSP00000244007⁴	I2D: score=3 STRING: ENSP00000244007
GNAQ	P50148³, ENSP00000286548⁴	I2D: score=2 STRING: ENSP00000286548
LCK	P06239³, ENSP00000337825⁴	I2D: score=2 STRING: ENSP00000337825
PIK3R1	P27986³, ENSP00000274335⁴	I2D: score=2 STRING: ENSP00000274335

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006909	phagocytosis	IEA	--
GO:0007602	phototransduction	IEA	--
GO:0007605	sensory perception of sound	IEA	--
GO:0009584	detection of visible light	--	--
GO:0009725	response to hormone stimulus	IEA	--

TUB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TUB

1 DrugBank Compound for TUB About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
L-Alpha-Glycerophospho-D-Myo-Inositol-4,5-Bis-Phosphate	--	--	target	--	10592235

Search CenterWatch for drugs/clinical trials and news about TUB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TUB gene (2 alternative transcripts):

NM_003320.4 NM_177972.2

Unigene Clusters for TUB:

Tubby homolog (mouse)

Hs.568986 [show with all ESTs], Hs.733193 [show with all ESTs]

Unigene Representative Sequences: NM_003320, AB209618

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000534099 ENST00000305253(uc010rbk.2 uc001mfy.3 uc001mga.3)

ENST00000299506

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TUB Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TUB
		8/69 QIAGEN miScript miRNA Assays for microRNAs that regulate TUB (see all 69):
		hsa-miR-520f hsa-miR-4272 hsa-miR-128 hsa-miR-938 hsa-miR-3613-3p hsa-miR-3116 hsa-miR-2113 hsa-miR-3690

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TUB (see all 7) OriGene shRNA RFP: TUB OriGene siRNA: TUB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUB

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TUB (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TUB (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TUB (NM_003320)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUB

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TUB Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TUB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUB

Additional cDNA sequence:

AB209618.1 AK128611.1

12 DOTS entries:

DT.100649186 DT.40125226 DT.303992 DT.100773456 DT.95215754 DT.95254196 DT.109495 DT.120705945

DT.92060927 DT.120705939 DT.120705978 DT.99946648

24/72 AceView cDNA sequences (see all 72):

BM720656 NM_177972 CR619255 BE505023 CR617957 BU150872 AA338677 NM_003320

BC075032 BM679358 BC075031 AA338676 AA910482 CD674811 BE552316 AL707691

AW008025 BG029107 AL528916 AI239685 BM684164 AI239997 BM930803 CB216662

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TUB About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16	^	17
SP1:					-		-		-		-		-								-
SP2:
SP3:									-
SP4:

ECgene alternative splicing isoforms for TUB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TUB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATACAGGCGG

About this image

TUB expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Outer Nuclear Layer

Mature Rod Cells

Photoreceptors, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Primitive gut tube-like cells (A scalable, suspensi...)

See TUB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TUB

SOURCE GeneReport for Unigene clusters: Hs.568986 Hs.733193

SABiosciences Custom PCR Arrays for TUB

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TUB Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TUB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUB

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUB gene from 8/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TUB¹	tubby homolog (mouse)	72.14(n) 79.06(a)		423061 XM_420992.3 XP_420992.2
lizard (Anolis carolinensis)	Reptilia	TUB⁶	--	74(a)	1 ↔ 1	GL343294.1(761819-802370)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.12141²	Transcribed sequence with moderate similarity to protein more	75.44(n)		BX708616.1
zebrafish (Danio rerio)	Actinopterygii	tub¹	tubby homolog (mouse)	73.54(n) 78.96(a)		568677 XM_692022.2 XP_697114.2
fruit fly (Drosophila melanogaster)	Insecta	Tulp³ king-tubby¹	king tubby¹	63(a)³ 54.41(n)¹ 48.88(a)¹		37400¹ NM_206189.1¹ NP_995911.1¹
worm (Caenorhabditis elegans)	Secernentea	tub-1^{1 , 3}	Tub family protein tub-1³ Protein TUB-1¹	50(a)³ 49.55(n)¹ 48.17(a)¹		II(8154693-8156859)³ 174312¹ NM_063309.3¹ NP_495710.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	AtTLP7⁶ ATTLP9⁶ (see all 11)	tubby-like F-box protein 9 (see all 11)	27(a) 26(a) (see all 11)	many ↔ many many ↔ many (see all 11)	1(19891014-19893504) 3(1936124-1938221)
rice (Oryza sativa)	Liliopsida	AK070139.1²	--	77.24(n)		AK070139.1

ENSEMBL Gene Tree for TUB (if available)
TreeFam Gene Tree for TUB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TUB gene

TULP2² TULP4² TULP1² WDR35² TULP3²

3 SIMAP similar genes for TUB using alignment to 4 protein entries: TUB_HUMAN (see all proteins):

TULP3 TULP2 TULP1

TUB for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150936269^1,2	C,	other	8060574(+)	`GAGATC/TGGTAA`	2	R W	mis¹		1		NA	4544
rs16935849^1,2	C,F,H,	--	7793645(+)	`NNNNCG/ATAGGA`	5	--	ds500¹ ese³		20		NA NS EA WA	2454
rs182624375^1,2	C,	--	7793914(+)	`GGTGCA/GGTATC`	5	--	ds500¹		0	--	--	--	--
rs78409636^1,2	F,	--	7794243(+)	`CACTTC/GTGTGT`	5	--	ut3¹ nc-transcript-variant		1		WA	118
rs78915431^1,2	F,	--	7794519(+)	`CTGTGC/TCGCCT`	5	--	ut3¹ nc-transcript-variant		1		WA	118
rs138011349^1,2		--	8058326(+)	`TCCCCA/GGTTGT`	1	--	us2k¹		0	--	--	--	--
rs112405094^1,2		--	8058341(+)	`CAGGGG/AGTCAT`	1	--	us2k¹		1		CSA	2
rs12271874^1,2	H,	--	8058366(+)	`TAGCAC/TGGGCC`	1	--	us2k¹		5		NS EA WA	534
rs190969304^1,2		--	8058415(+)	`AGGAAA/GCTGGC`	1	--	us2k¹		0	--	--	--	--
rs182223813^1,2		--	8058448(+)	`ACCTTC/TTTTCC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TUB (8040791 - 8127659 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TUB
1 Indel: 71276
Human Gene Mutation Database (HGMD): TUB

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TUB

DNA2.0 Custom Variant and Variant Library Synthesis for TUB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TUB for disorders           About GeneDecksing

OMIM gene information: 601197    OMIM disorders: --

13 diseases for TUB:    About MalaCards

otitis externa obesity pontiac fever ecthyma

autism spectrum disorder folliculitis retinal degeneration pneumonia

retinitis prostate cancer prostatitis tuberculosis

neuronitis

Human Genome Epidemiology (HuGE) Navigator: TUB (10 documents)

Export disorders for TUB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TUB gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with TUB)

Utopia: connect your pdf to the dynamic
world of online information

Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. (PubMed id 8612280)^{1, 2, 3} Kleyn P.W.... Moore K.J. (1996)
Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases. (PubMed id 9096357)^{1, 2, 9} North M.A.... Nishina P.M. (1997)
Identification of tubby and tubby-like protein 1 as eat-me signals by phage display. (PubMed id 19837063)^{1, 2} Caberoy N.B.... Li W. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The tubby-like proteins, a family with roles in neuronal development and function. (PubMed id 11801719)^{1, 9} Ikeda A....Naggert J.K. (2002)
The global gene-expression profiles of U-937 human mac rophages treated with Tat peptide and Tat-FITC conjugate. (PubMed id 22632162)¹ Lin C.W....Jan M.S. (2012)
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)¹ Speliotes E.K....Loos R.J. (2010)
Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis. (PubMed id 20978472)¹ Caberoy N.B....Li W. (2010)
Inherited genetic variant predisposes to aggressive b ut not indolent prostate cancer. (PubMed id 20080650)¹ Xu J....Isaacs W.B. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7275	HGNC: 12406	AceView: TUB	Ensembl:ENSG00000166402	euGenes: HUgn7275
ECgene: TUB	H-InvDB: TUB

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TUB	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TUB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TUB gene:
Search GeneIP for patents involving TUB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of TUB

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for TUB		OriGene shRNA RFP for TUB
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TUB		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TUB
	OriGene Protein Over-expression Lysate for TUB		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TUB		OriGene 3'-UTR Clone for TUB
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TUB		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TUB
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TUB		OriGene Custom Protein Services for TUB
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TUB
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TUB
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUB
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUB
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUB
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUB

	GenScript Custom Purified and Recombinant Proteins Services for TUB		GenScript cDNA clones with any tag delivered in your preferred vector for TUB
	GenScript Custom Assay Services for TUB		GenScript Superior Antibodies for TUB
	GenScript Custom overexpressing Cell Line Services for TUB		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TUB promoter
	Search Chromatin IP Primers for TUB
	RT² qPCR Primer Assay in human, mouse, rat TUB
	GNC Network for TUB
	SABiosciences PCR Arrays including human, mouse, rat TUB

Search Tocris compounds for TUB

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TUB antibodies
	TUB proteins

	Antibodies for TUB
	See all of Abcam's Antibodies, Kits and Proteins for TUB
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

TUB Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TUB

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUB

	Browse SwitchGear 3'UTR luciferase reporter plasmids for TUB
	SwitchGear Promoter luciferase reporter plasmids for TUB

ThermoFisher Antibodies for TUB

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUB

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TUB gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

TUB Gene

tubby homolog (mouse)

Aliases
for TUB gene

Summaries
for TUB gene

Genomic Views
for TUB gene

Proteins
for TUB gene

Protein Domains /
Families
for TUB gene

Function
for TUB gene

Pathways & Interactions
for TUB gene

Drugs & Compounds
for TUB gene

Transcripts
for TUB gene

Expression
for TUB gene

Orthologs
for TUB gene

Paralogs
for TUB gene

Genomic Variants
for TUB gene

Disorders / Diseases
for TUB gene

Publications
for TUB gene

External Searches for TUB gene

Genome Databases showing TUB gene

Other Databases showing TUB gene

Specialized Databases showing TUB gene

Intellectual Property
for TUB gene

Products
for TUB gene

View Random Gene

Advanced Search

Export list of displayed genes

TUB Gene

tubby homolog (mouse)

Aliasesfor TUB gene

Summariesfor TUB gene

Genomic Viewsfor TUB gene

Proteinsfor TUB gene

Protein Domains /Familiesfor TUB gene

Functionfor TUB gene

Pathways & Interactionsfor TUB gene

Drugs & Compoundsfor TUB gene

Transcriptsfor TUB gene

Expression for TUB gene

Orthologsfor TUB gene

Paralogsfor TUB gene

Genomic Variantsfor TUB gene

Disorders / Diseasesfor TUB gene

Publicationsfor TUB gene

External Searches for TUB gene

Genome Databases showing TUB gene

Other Databases showing TUB gene

Specialized Databases showing TUB gene

Intellectual Propertyfor TUB gene

Productsfor TUB gene

View Random Gene

Aliases
for TUB gene

Summaries
for TUB gene

Genomic Views
for TUB gene

Proteins
for TUB gene

Protein Domains /
Families
for TUB gene

Function
for TUB gene

Pathways & Interactions
for TUB gene

Drugs & Compounds
for TUB gene

Transcripts
for TUB gene

Expression
for TUB gene

Orthologs
for TUB gene

Paralogs
for TUB gene

Genomic Variants
for TUB gene

Disorders / Diseases
for TUB gene

Publications
for TUB gene

Intellectual Property
for TUB gene

Products
for TUB gene