Aliases for TUB Gene
External Ids for TUB Gene
Previous GeneCards Identifiers for TUB Gene
This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TUB Gene
TUB (Tubby Bipartite Transcription Factor) is a Protein Coding gene. Diseases associated with TUB include retinal dystrophy and obesity and retinitis pigmentosa. Among its related pathways are ADP signalling through P2Y purinoceptor 12 and Transcription_Transcription factor Tubby signaling pathways. GO annotations related to this gene include G-protein coupled photoreceptor activity. An important paralog of this gene is WDR35.
UniProtKB/Swiss-Prot for TUB Gene
Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.