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Aliases for TTYH3 Gene

Aliases for TTYH3 Gene

  • Tweety Family Member 3 2 3
  • HTTY3 3 4
  • Tweety Homolog 3 (Drosophila) 2
  • Protein Tweety Homolog 3 3
  • Tweety Homolog 3 3
  • KIAA1691 4

External Ids for TTYH3 Gene

Previous GeneCards Identifiers for TTYH3 Gene

  • GC07P002413
  • GC07P002444

Summaries for TTYH3 Gene

Entrez Gene Summary for TTYH3 Gene

  • This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel. [provided by RefSeq, Jul 2008]

GeneCards Summary for TTYH3 Gene

TTYH3 (Tweety Family Member 3) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include chloride channel activity and intracellular calcium activated chloride channel activity. An important paralog of this gene is TTYH1.

UniProtKB/Swiss-Prot for TTYH3 Gene

  • Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTYH3 Gene

Genomics for TTYH3 Gene

Regulatory Elements for TTYH3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TTYH3 Gene

2,631,951 bp from pter
2,664,802 bp from pter
32,852 bases
Plus strand

Genomic View for TTYH3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTYH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTYH3 Gene

Proteins for TTYH3 Gene

  • Protein details for TTYH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein tweety homolog 3
    Protein Accession:
    Secondary Accessions:
    • A4D201
    • B7WP98
    • Q6L749
    • Q6ZVG3
    • Q8TEG6

    Protein attributes for TTYH3 Gene

    523 amino acids
    Molecular mass:
    57545 Da
    Quaternary structure:
    No Data Available
    • The current is completely inhibited by the addition of an anion permeability inhibitor. Addition of a Ca(2+) ionophore induces an outward-rectified current in mock-transfected cells, but it introduced an overt linear current in TTYH3-transfected cells
    • Sequence=BAB21782.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAL23958.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TTYH3 Gene


neXtProt entry for TTYH3 Gene

Proteomics data for TTYH3 Gene at MOPED

Post-translational modifications for TTYH3 Gene

Other Protein References for TTYH3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TTYH3 Gene

Domains for TTYH3 Gene

Protein Domains for TTYH3 Gene


Suggested Antigen Peptide Sequences for TTYH3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tweety family.
  • Belongs to the tweety family.
genes like me logo Genes that share domains with TTYH3: view

No data available for Gene Families for TTYH3 Gene

Function for TTYH3 Gene

Molecular function for TTYH3 Gene

UniProtKB/Swiss-Prot Function:
Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction.

Gene Ontology (GO) - Molecular Function for TTYH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005229 intracellular calcium activated chloride channel activity IDA 16219661
GO:0005254 chloride channel activity IMP 15010458
genes like me logo Genes that share ontologies with TTYH3: view

Animal Model Products

miRNA for TTYH3 Gene

miRTarBase miRNAs that target TTYH3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTYH3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for TTYH3 Gene

Localization for TTYH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTYH3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TTYH3 Gene COMPARTMENTS Subcellular localization image for TTYH3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TTYH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0034707 chloride channel complex IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TTYH3: view

Pathways for TTYH3 Gene

genes like me logo Genes that share pathways with TTYH3: view

Pathways by source for TTYH3 Gene

Gene Ontology (GO) - Biological Process for TTYH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006821 chloride transport IDA 16219661
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport TAS --
GO:1902476 chloride transmembrane transport IMP 15010458
genes like me logo Genes that share ontologies with TTYH3: view

Drugs for TTYH3 Gene

(1) HMDB Compounds for TTYH3 Gene

Compound Synonyms Cas Number PubMed IDs
Chloride ion
  • Bertholite
genes like me logo Genes that share compounds with TTYH3: view

Transcripts for TTYH3 Gene

Unigene Clusters for TTYH3 Gene

Tweety homolog 3 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTYH3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTYH3 Gene

No ASD Table

Relevant External Links for TTYH3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTYH3 Gene

mRNA expression in normal human tissues for TTYH3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TTYH3 Gene

This gene is overexpressed in Amniocyte (18.3), Peripheral blood mononuclear cells (12.7), Adrenal (10.9), Urine (10.0), and Bone (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTYH3 Gene

SOURCE GeneReport for Unigene cluster for TTYH3 Gene Hs.440899

mRNA Expression by UniProt/SwissProt for TTYH3 Gene

Tissue specificity: Expressed in excitable tissues. Expressed in the brain, heart, skeletal muscle, colon, spleen, kidney and peripheral blood leukocytes.
genes like me logo Genes that share expressions with TTYH3: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for TTYH3 Gene

Orthologs for TTYH3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTYH3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TTYH3 35
  • 91.57 (n)
  • 95.21 (a)
TTYH3 36
  • 94 (a)
(Canis familiaris)
Mammalia TTYH3 35
  • 88.84 (n)
  • 91.99 (a)
TTYH3 36
  • 86 (a)
(Mus musculus)
Mammalia Ttyh3 35
  • 88.95 (n)
  • 94.83 (a)
Ttyh3 16
Ttyh3 36
  • 93 (a)
(Pan troglodytes)
Mammalia TTYH3 35
  • 99.36 (n)
  • 99.62 (a)
TTYH3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ttyh3 35
  • 88.38 (n)
  • 94.83 (a)
(Monodelphis domestica)
Mammalia TTYH3 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia TTYH3 36
  • 73 (a)
(Gallus gallus)
Aves TTYH3 35
  • 74.19 (n)
  • 79.18 (a)
TTYH3 36
  • 74 (a)
(Anolis carolinensis)
Reptilia TTYH3 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.18570 35
ttyh3 35
  • 70.92 (n)
  • 74.85 (a)
(Danio rerio)
Actinopterygii LOC556314 35
  • 70.64 (n)
  • 71.35 (a)
ttyh3a 36
  • 69 (a)
ttyh3b 36
  • 64 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7521 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000860 35
  • 48.08 (n)
  • 30 (a)
fruit fly
(Drosophila melanogaster)
Insecta tty 35
  • 44.83 (n)
  • 28.83 (a)
CG3638 36
  • 17 (a)
tty 36
  • 13 (a)
Species with no ortholog for TTYH3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTYH3 Gene

Gene Tree for TTYH3 (if available)
Gene Tree for TTYH3 (if available)

Paralogs for TTYH3 Gene

Paralogs for TTYH3 Gene

(3) SIMAP similar genes for TTYH3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TTYH3: view

Variants for TTYH3 Gene

Sequence variations from dbSNP and Humsavar for TTYH3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs13310777 -- 2,631,850(+) GGGCG(A/G)GGCGC upstream-variant-2KB
rs13226672 -- 2,660,056(+) ACCGG(G/T)CCCCC intron-variant
rs13226070 -- 2,642,598(+) tgata(C/T)gtgcc intron-variant
rs13225657 -- 2,651,976(+) CACAC(A/G)TGCAC intron-variant
rs12670393 -- 2,633,213(+) TCACC(C/T)GGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTYH3 Gene

Variant ID Type Subtype PubMed ID
dgv7116n71 CNV Loss 21882294
nsv887300 CNV Loss 21882294
nsv471227 CNV Loss 18288195
dgv401n21 CNV Loss 19592680
dgv7121n71 CNV Loss 21882294
nsv887303 CNV Loss 21882294
dgv7122n71 CNV Loss 21882294
nsv471238 CNV Gain 18288195
nsv887305 CNV Loss 21882294
nsv5618 CNV Insertion 18451855
nsv464257 CNV Loss 19166990
nsv823983 CNV Gain 20364138

Relevant External Links for TTYH3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTYH3 Gene

Disorders for TTYH3 Gene

No disorders were found for TTYH3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TTYH3 Gene

Publications for TTYH3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. A novel human Cl(-) channel family related to Drosophila flightless locus. (PMID: 15010458) Suzuki M. … Mizuno A. (J. Biol. Chem. 2004) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2). (PMID: 18260827) He Y. … Hooper J.D. (Biochem. J. 2008) 23

Products for TTYH3 Gene

Sources for TTYH3 Gene

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