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TTYH3 Gene

protein-coding   GIFtS: 53
GCID: GC07P002638

Tweety Family Member 3

(Previous name: tweety homolog 3 (Drosophila))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tweety Family Member 31 2
hTTY32 3
Tweety Homolog 3 (Drosophila)1
Protein Tweety Homolog 32
Tweety Homolog 32
KIAA16913

External Ids:    HGNC: 222221   Entrez Gene: 807272   Ensembl: ENSG000001362957   OMIM: 6089195   UniProtKB: Q9C0H23   

Export aliases for TTYH3 gene to outside databases

Previous GC identifers: GC07P002413 GC07P002444


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TTYH3 Gene:
This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion
channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TTYH3 Gene:
TTYH3 (tweety family member 3) is a protein-coding gene. GO annotations related to this gene include chloride channel activity and intracellular calcium activated chloride channel activity. An important paralog of this gene is TTYH1.

UniProtKB/Swiss-Prot: TTYH3_HUMAN, Q9C0H2
Function: Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal
transduction




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the TTYH3 gene promoter:
         AhR   Max1   Elk-1   HNF-4alpha2   LUN-1   Arnt   HNF-4alpha1   Pax-3   Chx10   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): TTYH3 promoter sequence
   Search Chromatin IP Primers for TTYH3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTYH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22

TTYH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTYH3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P002638:  view genomic region     (about GC identifiers)

Start:
2,671,585 bp from pter      End:
2,704,436 bp from pter
Size:
32,852 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 2,719,442-2,752,317     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TTYH3_HUMAN, Q9C0H2 (See protein sequence)
Recommended Name: Protein tweety homolog 3  
Size: 523 amino acids; 57545 Da
Miscellaneous: The current is completely inhibited by the addition of an anion permeability inhibitor. Addition of
a Ca(2+) ionophore induces an outward-rectified current in mock-transfected cells, but it introduced an overt
linear current in TTYH3-transfected cells
Sequence caution: Sequence=BAB21782.2; Type=Erroneous initiation; Sequence=EAL23958.1; Type=Erroneous gene model
prediction;
Secondary accessions: A4D201 B7WP98 Q6L749 Q6ZVG3 Q8TEG6
Alternative splicing: 4 isoforms:  Q9C0H2-1   Q9C0H2-2   Q9C0H2-3   Q9C0H2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TTYH3: NX_Q9C0H2

Explore proteomics data for TTYH3 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Ubiquitination2 at Lys316, Lys340, Lys508
  • Glycosylation2 at Asn126, Asn144, Asn351
  • Modification sites at PhosphoSitePlus

  • See TTYH3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079526.1  
    ENSEMBL proteins: 
     ENSP00000258796   ENSP00000385316   ENSP00000383227   ENSP00000385015   ENSP00000413757  
    Reactome Protein details: Q9C0H2

    TTYH3 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for TTYH3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR006990 Tweety

    Graphical View of Domain Structure for InterPro Entry Q9C0H2

    ProtoNet protein and cluster: Q9C0H2

    UniProtKB/Swiss-Prot: TTYH3_HUMAN, Q9C0H2
    Similarity: Belongs to the tweety family


    Find genes that share domains with TTYH3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTYH3_HUMAN, Q9C0H2
    Function: Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal
    transduction

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005229intracellular calcium activated chloride channel activity IDA16219661
    GO:0005254chloride channel activity IMP15010458
         
    Find genes that share ontologies with TTYH3           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TTYH3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TTYH3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TTYH3

    miRNA
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    miRTarBase miRNAs that target TTYH3:
    hsa-mir-484 (MIRT042128), hsa-mir-1296-5p (MIRT036130)

    Block miRNA regulation of human, mouse, rat TTYH3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TTYH3 (see all 52):
    hsa-miR-3130-5p hsa-miR-140-5p hsa-miR-328 hsa-miR-3607-3p hsa-miR-486-3p hsa-miR-301a hsa-miR-218 hsa-miR-133a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTYH3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TTYH3_HUMAN, Q9C0H2: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0034707chloride channel complex IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with TTYH3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TTYH3 About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47


    Find genes that share SuperPaths with TTYH3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for TTYH3
        Stimuli-sensing channels


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TTYH3
    Interactions:

        Search GeneGlobe Interaction Network for TTYH3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for TTYH3 (Q9C0H23 ENSP000002587964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    NEDD4P469343, ENSP000003455304I2D: score=1 STRING: ENSP00000345530
    MAPK3P273613, ENSP000002630254I2D: score=2 STRING: ENSP00000263025
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006821chloride transport IDA16219661
    GO:0034220ion transmembrane transport TAS--
    GO:0055085transmembrane transport TAS--
    GO:1902476chloride transmembrane transport IMP15010458

    Find genes that share ontologies with TTYH3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TTYH3

    1 HMDB Compound for TTYH3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TTYH3 gene: 
    NM_025250.2  

    Unigene Cluster for TTYH3:

    Tweety homolog 3 (Drosophila)
    Hs.440899  [show with all ESTs]
    Unigene Representative Sequence: BC152447
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258796(uc003smp.3 uc010ksn.3) ENST00000407643 ENST00000400376
    ENST00000403167(uc003smq.3) ENST00000477439 ENST00000498454 ENST00000429448

    miRNA
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    Block miRNA regulation of human, mouse, rat TTYH3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TTYH3 (see all 52):
    hsa-miR-3130-5p hsa-miR-140-5p hsa-miR-328 hsa-miR-3607-3p hsa-miR-486-3p hsa-miR-301a hsa-miR-218 hsa-miR-133a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
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    Clone
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TTYH3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TTYH3
      QuantiTect SYBR Green Assays in human, mouse, rat TTYH3
      QuantiFast Probe-based Assays in human, mouse, rat TTYH3

    Additional mRNA sequence: 

    AB051478.2 AB162931.1 AF318350.1 AK074158.1 AK096851.1 AK124608.1 AL833825.1 BC041603.1 
    BC069027.1 BC131824.1 BC152447.1 

    15 DOTS entries:

    DT.92441807  DT.455412  DT.95353193  DT.91670593  DT.95159886  DT.100785358  DT.102836573  DT.100770149 
    DT.92441803  DT.101976407  DT.91647338  DT.95133122  DT.95133178  DT.99968582  DT.91891385 

    Selected AceView cDNA sequences (see all 322):

    CK000957 CF140296 CF126772 AA513345 AI816927 AK096851 AA639605 AI434580 
    BE858133 AI061351 BM675108 BM772887 AI590648 BM740822 BU183311 AW081058 
    AB162931 BM756011 BM713637 BM759597 CA426761 BC041603 CB105378 BQ940755 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TTYH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTAAAATA
    TTYH3 Expression
    About this image


    TTYH3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
    TTYH3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TTYH3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.440899

    UniProtKB/Swiss-Prot: TTYH3_HUMAN, Q9C0H2
    Tissue specificity: Expressed in excitable tissues. Expressed in the brain, heart, skeletal muscle, colon, spleen,
    kidney and peripheral blood leukocytes

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TTYH3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttyh31 , 5 tweety homolog 3 (Drosophila)1, 5 88.95(n)1
    94.83(a)1
      5 (79.16 cM)5
    783391  NM_175274.41  NP_780483.21 
     1406205865 
    chicken
    (Gallus gallus)
    Aves TTYH31 tweety homolog 3 (Drosophila) 74.19(n)
    79.18(a)
      416470  XM_414776.4  XP_414776.3 
    lizard
    (Anolis carolinensis)
    Reptilia TTYH36
    tweety family member 3
    76(a)
    1 ↔ 1
    GL343340.1(259146-300094)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.185702 Transcribed sequence with weak similarity to protein more 80.32(n)    141993040 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5563141 protein tweety homolog 3-like 70.64(n)
    71.35(a)
      556314  XM_679082.5  XP_684174.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta tty1 tweety 44.83(n)
    28.83(a)
      33109  NM_001272838.1  NP_001259767.1 


    ENSEMBL Gene Tree for TTYH3 (if available)
    TreeFam Gene Tree for TTYH3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TTYH3 gene
    TTYH12  TTYH22  
    3 SIMAP similar genes for TTYH3 using alignment to 3 protein entries:     TTYH3_HUMAN (see all proteins):
    TTYH2    TTYH1    DKFZp761E0417

    Find genes that share paralogs with TTYH3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TTYH3 (see all 906)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs47218981,2
    C,A,H--2642325(+) CGGGCT/CGTGCA 1 -- int15Minor allele frequency- C:0.35WA NA EA 362
    rs47218991,2
    C,A,H--2642325(+) GGGCCA/GTGCAG 1 -- int10--------
    rs583881531,2
    C--2642326(+) GGGCCA/GTGCAG 1 -- int15Minor allele frequency- G:0.35WA NA EA 362
    rs47219001,2
    C,F,A,H--2642368(+) GGCTGG/AATGCT 1 -- int125Minor allele frequency- A:0.28NA NS EA CSA WA 2482
    rs1148066591,2
    F--2669618(+) GTGGGC/TGTCCT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1855846221,2
    --2669619(+) TGGGCA/GTCCTG 1 -- us2k10--------
    rs1912394141,2
    --2669687(+) GGCCAA/GGTACC 1 -- us2k10--------
    rs2021132341,2
    --2669728(+) GGGGG-/TTTGGG 1 -- us2k10--------
    rs361219441,2
    C--2669731(+) GGTTG-/AGGGGG 1 -- us2k10--------
    rs789081911,2
    C--2669731(+) GGGTTA/GGGGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TTYH3 (2671585 - 2704436 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TTYH3 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5618CNV Insertion18451855
    dgv401n21CNV Loss19592680
    nsv887305CNV Loss21882294
    nsv471227CNV Loss18288195
    dgv7121n71CNV Loss21882294
    nsv464257CNV Loss19166990
    dgv7122n71CNV Loss21882294
    nsv887300CNV Loss21882294
    dgv7116n71CNV Loss21882294
    nsv887303CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TTYH3
    DNA2.0 Custom Variant and Variant Library Synthesis for TTYH3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608919    OMIM disorders: --


    Find genes that share disorders with TTYH3           About GenesLikeMe


    Export disorders for TTYH3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TTYH3 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with TTYH3)
        Utopia: connect your pdf to the dynamic
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    1. A novel human Cl(-) channel family related to Drosophila flightless locus. (PubMed id 15010458)1, 2 Suzuki M. and Mizuno A. (J. Biol. Chem. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    4. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (Nat. Biotechnol. 2013)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
    PubMed
    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80727 HGNC: 22222 AceView: TTYH3 Ensembl:ENSG00000136295 euGenes: HUgn80727
    ECgene: TTYH3 H-InvDB: TTYH3

    (According to HUGE)
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    HUGE: KIAA1691

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TTYH3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TTYH3 gene:
    Search GeneIP for patents involving TTYH3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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