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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TTYH2 Gene

protein-coding   GIFtS: 54
GCID: GC17P072231

tweety homolog 2 (Drosophila)

(Previous name: tweety (Drosophila) homolog 2 )
 Explore 3 diseases affiliated with
TTYH2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TTYH2    

Aliases
for TTYH2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tweety Homolog 2 (Drosophila)1 2
C17orf291 2 3
HTTY21
Tweety (Drosophila) Homolog 21
Protein Tweety Homolog 22

External Ids:    HGNC: 138771   Entrez Gene: 940152   Ensembl: ENSG000001415407   OMIM: 6088555   UniProtKB: Q9BSA43   

Export aliases for TTYH2 gene to outside databases

Previous GC identifers: GC17P075267 GC17P072673 GC17P072806 GC17P069721 GC17P067620


Summaries
for TTYH2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TTYH2:
This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion
channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play
a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TTYH2_HUMAN, Q9BSA4
Function: Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction.
May be involved in cell proliferation and cell aggregation




Genomic Views
for TTYH2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TTYH2 gene promoter:
         Max1   AP-4   GATA-1   GATA-2   Max   MZF-1   Pax-4a   RSRFC4   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TTYH2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TTYH2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTYH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

TTYH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTYH2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P072231:  view genomic region     (about GC identifiers)

Start:
 72,209,653 bp from pter      End:
 72,258,159 bp from pter
Size:
 48,507 bases      Orientation:
 plus strand

Proteins
for TTYH2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TTYH2_HUMAN, Q9BSA4 (See protein sequence)
Recommended Name: Protein tweety homolog 2  
Size: 534 amino acids; 58772 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=AAH05168.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAC03579.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KX97 Q3B7H8 Q3B7R9 Q6AWB4 Q8NBB7 Q96PK1
Alternative splicing: 2 isoforms:  Q9BSA4-1   Q9BSA4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TTYH2: NX_Q9BSA4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BSA4

    • TTYH2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_116035.5  NP_443101.1  

    ENSEMBL proteins: 
     ENSP00000269346   ENSP00000433089   ENSP00000462219   ENSP00000394576   ENSP00000462492  
    Reactome Protein details: Q9BSA4
    Human Recombinant Protein Products: 
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    Uscn Proteins for TTYH2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0034707chloride channel complex IEA--


    TTYH2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TTYH2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TTYH2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR006990 Tweety

    Graphical View of Domain Structure for InterPro Entry Q9BSA4

    ProtoNet protein and cluster: Q9BSA4

    UniProtKB/Swiss-Prot: TTYH2_HUMAN, Q9BSA4
    Similarity: Belongs to the tweety family


    Function
    for TTYH2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TTYH2_HUMAN, Q9BSA4
    Function: Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction.
    May be involved in cell proliferation and cell aggregation

    miRNA
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    hsa-miR-140-5p hsa-miR-485-5p hsa-miR-1321 hsa-miR-607 hsa-miR-125a-3p hsa-miR-1224-3p hsa-miR-29c hsa-miR-29a
    SwitchGear 3'UTR luciferase reporter plasmid: TTYH2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTYH2 (see all 4)
    OriGene shRNA RFP: TTYH2
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for TTYH2

    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005254chloride channel activity IEA--
    GO:0005515protein binding IPI18577513


    TTYH2 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for TTYH2:
     Cell division defect  Decreased Hepatitis C virus re  Decreased Wnt reporter activit  Increased G2M DNA content 


    Pathways & Interactions
    for TTYH2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ion channel transport
    		Ion channel transport1.00
    		Stimuli-sensing channels0.49
    2SLC-mediated transmembrane transport
    		Transmembrane transport of small molecules0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for TTYH2
        Transmembrane transport of small molecules
    Stimuli-sensing channels
    Ion channel transport



    TTYH2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTYH2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for TTYH2 (Q9BSA42, 3 ENSP000002693464) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    NEDD4P469343, ENSP000003455304I2D: score=1 STRING: ENSP00000345530
    IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
    GRB2ENSP000003390074STRING: ENSP00000339007
    --P310162MINT-8105993
    About this table

    Drugs & Compounds
    for TTYH2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TTYH2

    1 HMDB Compound for TTYH2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Search CenterWatch for drugs/clinical trials and news about TTYH2 

    Transcripts
    for TTYH2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TTYH2 gene (2 alternative transcripts): 
    NM_032646.5  NM_052869.1  

    Unigene Cluster for TTYH2:

    Tweety homolog 2 (Drosophila)
    Hs.27935  [show with all ESTs]
    Unigene Representative Sequence: AK126955
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269346(uc002jkc.3 uc010wqw.2) ENST00000529107 ENST00000578825
    ENST00000534346 ENST00000528128 ENST00000441391(uc002jkd.3) ENST00000528152
    ENST00000534039 ENST00000526858

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TTYH2
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate TTYH2 (see all 28):
    hsa-miR-140-5p hsa-miR-485-5p hsa-miR-1321 hsa-miR-607 hsa-miR-125a-3p hsa-miR-1224-3p hsa-miR-29c hsa-miR-29a
    SwitchGear 3'UTR luciferase reporter plasmid: TTYH2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTYH2 (see all 4)
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTYH2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTYH2

    Additional cDNA sequence: 

    AF319952.1 AK058197.1 AK091085.1 AK126955.1 AK296511.1 AK315163.1 AL831858.1 BC004233.2 
    BC005168.1 BC107492.1 BC107602.1 BX647912.1 D63134.2 U30172.1 Z49982.1 

    7 DOTS entries:

    DT.100807026  DT.453646  DT.95354236  DT.95278189  DT.100026997  DT.92432219  DT.100702426 

    24/215 AceView cDNA sequences (see all 215):

    AW136982 AA434395 AA434490 BM684648 AI092771 AI623520 BM926191 BM680366 
    AI185794 BU176461 BI916204 AI701466 AA026053 BU557342 BQ431604 BC004233 
    CD245723 BM673997 AI654422 BP348907 BX108555 CB152173 AW072658 BX335861 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TTYH2 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c
    SP1:        -                       -                 -                                               -     -     -                                             
    SP2:                                                                                                  -     -     -                                             
    SP3:                                -                                                                                                                           
    SP4:                                                  -                                                                                                         
    SP5:                                                                                                  -                                                         


    ECgene alternative splicing isoforms for TTYH2

    Expression
    for TTYH2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TTYH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGGCCTCACC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TTYH2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TTYH2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TTYH2

    SOURCE GeneReport for Unigene cluster: Hs.27935

    UniProtKB/Swiss-Prot: TTYH2_HUMAN, Q9BSA4
    Tissue specificity: Expressed at higher level in brain and testis and at lower levels in heart, ovary, spleen and
    peripheral blood leukocytes. Up-regulated in 13 of 16 renal cell carcinoma samples examined. Up-regulated in colon
    carcinoma

        SABiosciences Custom PCR Arrays for TTYH2
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    In Situ
    Assay Products:     
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    Orthologs
    for TTYH2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TTYH2 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008588791 protein tweety homolog 2-like 74.95(n)
    71.69(a)    		   100858879  XM_003642353.1  XP_003642401.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TTYH26
    		 --
    		 70(a)
    		 1 ↔ 1
    		 2(98163948-98238772)
    African clawed frog
    (Xenopus laevis)    		 Amphibia ttyh2-prov2 tweety homolog 2 (Drosophila) 74.03(n)    BC046859.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufi03f072 Transcribed sequence with weak similarity to protein more 75.52(n)    BM775924.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta bbx3
    tty1    		 DNA binding3
    tweety1    		 28(a)
    (best of 2)3
    43.31(n)1
    30.35(a)1    		   13
    331091  NM_080712.61  NP_542443.41 
    worm
    (Caenorhabditis elegans)    		 Secernentea ttyh-11 Protein TTYH-1 39.46(n)
    21.94(a)    		   181328  NM_077502.3  NP_509903.1 


    ENSEMBL Gene Tree for TTYH2 (if available)
    TreeFam Gene Tree for TTYH2 (if available) 

    Paralogs
    for TTYH2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TTYH2 gene
    TTYH12  TTYH32  
    3 SIMAP similar genes for TTYH2 using alignment to 5 protein entries:     TTYH2_HUMAN (see all proteins):
    DKFZp761E0417    TTYH1    TTYH3

    TTYH2 for paralogs           About GeneDecksing



    Genomic Variants
    for TTYH2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1036 NCBI SNPs in TTYH2 are shown (see all 1036)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1171775461,2
    		--72211599(+) GATGAA/GCCTAC 1 -- int11Minor allele frequency- G:0.01NA 120
    rs1469157851,2
    		--72211695(+) CATCGA/GCCACT 1 -- int10--------
    rs1817712841,2
    		--72211791(+) ATGAGC/GGTGGT 1 -- int10--------
    rs1174454071,2
    		--72211829(+) GTGTTA/GTTTAA 1 -- int11Minor allele frequency- G:0.01NA 120
    rs1421919181,2
    		C,--72211846(+) TCCTG-/TTTTTG 1 -- int10--------
    rs2006566771,2
    		--72211885(+) CTCCT-/GGGATG 1 -- int10--------
    rs1862949851,2
    		--72211888(+) CCTGGA/GTGTCT 1 -- int10--------
    rs1152692091,2
    		F,--72211989(+) CCAGGC/TGTGGG 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1393493441,2
    		--72212017(+) GGCAGA/CAGGTC 1 -- int10--------
    rs1145459361,2
    		F,--72212056(+) CGGCTG/CGGCTC 1 -- int11Minor allele frequency- C:0.04WA 118

    HapMap Linkage Disequilibrium report for TTYH2 (72209653 - 72258159 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for TTYH2
         6 CNVs: 34522 67261 8852 53066 5336 7171

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    Disorders / Diseases
    for TTYH2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TTYH2 for disorders           About GeneDecksing

    OMIM gene information: 608855    OMIM disorders: --

    3 diseases for TTYH2:    About MalaCards
    renal cell carcinoma    colon carcinoma    carcinoma


    Export disorders for TTYH2 gene to outside databases

    Publications
    for TTYH2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TTYH2 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with TTYH2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma. (PubMed id 11597145)1, 2, 3 Rae F.K....Clements J.A. (2001)
    2. TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation. (PubMed id 17569141)1, 2, 9 Toiyama Y.... Kusunoki M. (2007)
    3. A novel human Cl(-) channel family related to Drosophila flightless locus. (PubMed id 15010458)1, 2 Suzuki M. and Mizuno A. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2). (PubMed id 18260827)1, 9 He Y....Hooper J.D. (2008)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Expanding the substantial interactome of NEMO using p rotein microarrays. (PubMed id 20098747)1 Fenner B.J....Prehn J.H. (2010)
    8. The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels. (PubMed id 18577513)1 He Y....Hooper J.D. (2008)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (2006)

    External Searches for TTYH2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing TTYH2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 94015 HGNC: 13877 AceView: TTYH2 Ensembl:ENSG00000141540 euGenes: HUgn94015
    ECgene: TTYH2 H-InvDB: TTYH2

    Other Databases showing TTYH2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TTYH2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TTYH2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TTYH2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TTYH2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TTYH2 gene:
    Search GeneIP for patents involving TTYH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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