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Aliases for TTYH2 Gene

Aliases for TTYH2 Gene

  • Tweety Family Member 2 2 3 5
  • C17orf29 3 4
  • HTTY2 3 4
  • Tweety (Drosophila) Homolog 2 2
  • Tweety Homolog 2 (Drosophila) 2
  • Tweety Homolog 2 3

External Ids for TTYH2 Gene

Previous GeneCards Identifiers for TTYH2 Gene

  • GC17P072231
  • GC17P075267
  • GC17P072673
  • GC17P072806
  • GC17P069721
  • GC17P067620

Summaries for TTYH2 Gene

Entrez Gene Summary for TTYH2 Gene

  • This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TTYH2 Gene

TTYH2 (Tweety Family Member 2) is a Protein Coding gene. Diseases associated with TTYH2 include Renal Cell Carcinoma. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include chloride channel activity. An important paralog of this gene is TTYH1.

UniProtKB/Swiss-Prot for TTYH2 Gene

  • Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTYH2 Gene

Genomics for TTYH2 Gene

Regulatory Elements for TTYH2 Gene

Enhancers for TTYH2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TTYH2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTYH2 Gene

74,213,514 bp from pter
74,262,020 bp from pter
48,507 bases
Plus strand

Genomic View for TTYH2 Gene

Genes around TTYH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTYH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTYH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTYH2 Gene

Proteins for TTYH2 Gene

  • Protein details for TTYH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein tweety homolog 2
    Protein Accession:
    Secondary Accessions:
    • B3KX97
    • Q3B7H8
    • Q3B7R9
    • Q6AWB4
    • Q8NBB7
    • Q96PK1

    Protein attributes for TTYH2 Gene

    534 amino acids
    Molecular mass:
    58772 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH05168.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC03579.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TTYH2 Gene


neXtProt entry for TTYH2 Gene

Proteomics data for TTYH2 Gene at MOPED

Post-translational modifications for TTYH2 Gene

  • Glycosylation at Asn 31 and Asn 283
  • Modification sites at PhosphoSitePlus

Other Protein References for TTYH2 Gene

No data available for DME Specific Peptides for TTYH2 Gene

Domains & Families for TTYH2 Gene

Protein Domains for TTYH2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tweety family.
  • Belongs to the tweety family.
genes like me logo Genes that share domains with TTYH2: view

No data available for Gene Families for TTYH2 Gene

Function for TTYH2 Gene

Molecular function for TTYH2 Gene

UniProtKB/Swiss-Prot Function:
Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation.
genes like me logo Genes that share phenotypes with TTYH2: view

Animal Model Products

miRNA for TTYH2 Gene

miRTarBase miRNAs that target TTYH2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTYH2 Gene

Localization for TTYH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTYH2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TTYH2 Gene COMPARTMENTS Subcellular localization image for TTYH2 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for TTYH2 Gene

Pathways & Interactions for TTYH2 Gene

genes like me logo Genes that share pathways with TTYH2: view

Pathways by source for TTYH2 Gene

Gene Ontology (GO) - Biological Process for TTYH2 Gene


No data available for SIGNOR curated interactions for TTYH2 Gene

Drugs & Compounds for TTYH2 Gene

(1) Additional Compounds for TTYH2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
genes like me logo Genes that share compounds with TTYH2: view

Transcripts for TTYH2 Gene

Unigene Clusters for TTYH2 Gene

Tweety homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTYH2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c
SP1: - - - - - -
SP2: - - -
SP3: -
SP4: -
SP5: -

Relevant External Links for TTYH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTYH2 Gene

mRNA expression in normal human tissues for TTYH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTYH2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.2) and Brain - Substantia nigra (x5.1).

Protein differential expression in normal tissues from HIPED for TTYH2 Gene

This gene is overexpressed in Breast (57.7) and Colon muscle (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TTYH2 Gene

SOURCE GeneReport for Unigene cluster for TTYH2 Gene Hs.27935

mRNA Expression by UniProt/SwissProt for TTYH2 Gene

Tissue specificity: Expressed at higher level in brain and testis and at lower levels in heart, ovary, spleen and peripheral blood leukocytes. Up-regulated in 13 of 16 renal cell carcinoma samples examined. Up-regulated in colon carcinoma.
genes like me logo Genes that share expression patterns with TTYH2: view

Protein tissue co-expression partners for TTYH2 Gene

Primer Products

Orthologs for TTYH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTYH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TTYH2 35
  • 85.8 (n)
  • 83.11 (a)
TTYH2 36
  • 83 (a)
(Canis familiaris)
Mammalia TTYH2 35
  • 86.85 (n)
  • 92.02 (a)
TTYH2 36
  • 88 (a)
(Mus musculus)
Mammalia Ttyh2 35
  • 84.4 (n)
  • 82.89 (a)
Ttyh2 16
Ttyh2 36
  • 83 (a)
(Pan troglodytes)
Mammalia TTYH2 35
  • 96.94 (n)
  • 95.68 (a)
TTYH2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Ttyh2 35
  • 84.02 (n)
  • 82.89 (a)
(Monodelphis domestica)
Mammalia TTYH2 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia TTYH2 36
  • 71 (a)
(Gallus gallus)
Aves TTYH2 35
  • 75.04 (n)
  • 72.85 (a)
TTYH2 36
  • 70 (a)
(Anolis carolinensis)
Reptilia TTYH2 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76161 35
ttyh2 35
  • 68.66 (n)
  • 67.6 (a)
African clawed frog
(Xenopus laevis)
Amphibia ttyh2-prov 35
(Danio rerio)
Actinopterygii ttyh2l 35
  • 66.29 (n)
  • 61.63 (a)
wufi03f07 35
ttyh2 36
  • 66 (a)
ttyh2l 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta bbx 37
  • 28 (a)
tty 37
  • 28 (a)
CG3638 36
  • 16 (a)
tty 36
  • 13 (a)
Species with no ortholog for TTYH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTYH2 Gene

Gene Tree for TTYH2 (if available)
Gene Tree for TTYH2 (if available)

Paralogs for TTYH2 Gene

Paralogs for TTYH2 Gene

(3) SIMAP similar genes for TTYH2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TTYH2: view

Variants for TTYH2 Gene

Sequence variations from dbSNP and Humsavar for TTYH2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_037460 -
rs11538876 - 74,222,608(+) AGCAC(C/G/T)ACTCC reference, missense
rs35682745 - 74,244,029(+) TGGCC(A/G)CTGAT reference, missense
rs35999669 - 74,244,038(+) ATGGC(G/T)CTGCG reference, missense
rs12600564 - 74,252,373(+) CACCA(C/T)CAGGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TTYH2 Gene

Variant ID Type Subtype PubMed ID
dgv12e196 CNV Duplication 17116639
dgv372n27 CNV Gain 19166990
nsv517569 CNV Gain+Loss 19592680
esv2751770 CNV Gain 17911159
nsv509673 CNV Insertion 20534489
nsv833538 CNV Gain 17160897
esv27340 CNV Loss 19812545
nsv833539 CNV Loss 17160897
esv33995 CNV Loss 17666407

Variation tolerance for TTYH2 Gene

Residual Variation Intolerance Score: 87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.84; 94.79% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TTYH2 Gene

Disorders for TTYH2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TTYH2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
- elite association - COSMIC cancer census association via MalaCards
Search TTYH2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TTYH2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TTYH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTYH2 Gene

Publications for TTYH2 Gene

  1. TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma. (PMID: 11597145) Rae F.K. … Clements J.A. (Genomics 2001) 2 3 4 67
  2. The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels. (PMID: 18577513) He Y. … Hooper J.D. (J. Biol. Chem. 2008) 2 3
  3. N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2). (PMID: 18260827) He Y. … Hooper J.D. (Biochem. J. 2008) 3 23
  4. TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation. (PMID: 17569141) Toiyama Y. … Kusunoki M. (World J. Gastroenterol. 2007) 3 23
  5. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PMID: 21706016) Bisson N. … Pawson T. (Nat. Biotechnol. 2011) 3

Products for TTYH2 Gene

Sources for TTYH2 Gene