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TTYH2 Gene

protein-coding   GIFtS: 58
GCID: GC17P072231

Tweety Family Member 2

(Previous names: tweety (Drosophila) homolog 2, tweety homolog 2 (Drosophila))
  Search for TTYH2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tweety Family Member 21 2     Tweety Homolog 2 (Drosophila)1
C17orf292 3     Protein Tweety Homolog 22
hTTY22 3     Tweety Homolog 22
Tweety (Drosophila) Homolog 21     

External Ids:    HGNC: 138771   Entrez Gene: 940152   Ensembl: ENSG000001415407   OMIM: 6088555   UniProtKB: Q9BSA43   

Export aliases for TTYH2 gene to outside databases

Previous GC identifers: GC17P075267 GC17P072673 GC17P072806 GC17P069721 GC17P067620


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TTYH2 Gene:
This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion
channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may
play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for
this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TTYH2 Gene:
TTYH2 (tweety family member 2) is a protein-coding gene. GO annotations related to this gene include chloride channel activity. An important paralog of this gene is TTYH1.

UniProtKB/Swiss-Prot: TTYH2_HUMAN, Q9BSA4
Function: Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal
transduction. May be involved in cell proliferation and cell aggregation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TTYH2 gene promoter:
         Max1   AP-4   GATA-1   GATA-2   Max   MZF-1   Pax-4a   RSRFC4   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTYH2 promoter sequence
   Search Chromatin IP Primers for TTYH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTYH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

TTYH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTYH2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P072231:  view genomic region     (about GC identifiers)

Start:
72,209,653 bp from pter      End:
72,258,159 bp from pter
Size:
48,507 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TTYH2_HUMAN, Q9BSA4 (See protein sequence)
Recommended Name: Protein tweety homolog 2  
Size: 534 amino acids; 58772 Da
Sequence caution: Sequence=AAH05168.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAC03579.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KX97 Q3B7H8 Q3B7R9 Q6AWB4 Q8NBB7 Q96PK1
Alternative splicing: 2 isoforms:  Q9BSA4-1   Q9BSA4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TTYH2: NX_Q9BSA4

Explore proteomics data for TTYH2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn31, Asn283
  • Modification sites at PhosphoSitePlus

  • See TTYH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_116035.5  NP_443101.1  

    ENSEMBL proteins: 
     ENSP00000269346   ENSP00000433089   ENSP00000462219   ENSP00000394576   ENSP00000462492  
    Reactome Protein details: Q9BSA4

    TTYH2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR006990 Tweety

    Graphical View of Domain Structure for InterPro Entry Q9BSA4

    ProtoNet protein and cluster: Q9BSA4

    UniProtKB/Swiss-Prot: TTYH2_HUMAN, Q9BSA4
    Similarity: Belongs to the tweety family


    Find genes that share domains with TTYH2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTYH2_HUMAN, Q9BSA4
    Function: Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal
    transduction. May be involved in cell proliferation and cell aggregation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005254chloride channel activity IEA--
    GO:0005515protein binding IPI18577513
         
    Find genes that share ontologies with TTYH2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for TTYH2:
     Cell division defect  Decreased Hepatitis C virus re  Decreased Wnt reporter activit  Increased G2M DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TTYH2
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    miRNA
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    miRTarBase miRNAs that target TTYH2:
    hsa-mir-335-5p (MIRT017839)

    Block miRNA regulation of human, mouse, rat TTYH2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TTYH2 (see all 28):
    hsa-miR-140-5p hsa-miR-485-5p hsa-miR-1321 hsa-miR-607 hsa-miR-125a-3p hsa-miR-1224-3p hsa-miR-29c hsa-miR-29a
    SwitchGear 3'UTR luciferase reporter plasmidTTYH2 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for TTYH2
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTYH2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TTYH2_HUMAN, Q9BSA4: Cell membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0034707chloride channel complex IEA--

    Find genes that share ontologies with TTYH2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TTYH2 About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47


    Find genes that share SuperPaths with TTYH2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for TTYH2
        Stimuli-sensing channels


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TTYH2
    Interactions:

        Search GeneGlobe Interaction Network for TTYH2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for TTYH2 (Q9BSA42, 3 ENSP000002693464) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    NEDD4P469343, ENSP000003455304I2D: score=1 STRING: ENSP00000345530
    IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
    GRB2ENSP000003390074STRING: ENSP00000339007
    --P310162MINT-8105993
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TTYH2

    1 HMDB Compound for TTYH2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TTYH2 gene (2 alternative transcripts): 
    NM_032646.5  NM_052869.1  

    Unigene Cluster for TTYH2:

    Tweety homolog 2 (Drosophila)
    Hs.27935  [show with all ESTs]
    Unigene Representative Sequence: AK126955
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269346(uc002jkc.3 uc010wqw.2) ENST00000529107 ENST00000578825
    ENST00000534346 ENST00000528128 ENST00000441391(uc002jkd.3) ENST00000528152
    ENST00000534039 ENST00000526858
    miRNA
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    Block miRNA regulation of human, mouse, rat TTYH2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TTYH2 (see all 28):
    hsa-miR-140-5p hsa-miR-485-5p hsa-miR-1321 hsa-miR-607 hsa-miR-125a-3p hsa-miR-1224-3p hsa-miR-29c hsa-miR-29a
    SwitchGear 3'UTR luciferase reporter plasmidTTYH2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): TTYH2 (NM_052869)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TTYH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTYH2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TTYH2
      QuantiTect SYBR Green Assays in human, mouse, rat TTYH2
      QuantiFast Probe-based Assays in human, mouse, rat TTYH2

    Additional mRNA sequence: 

    AF319952.1 AK058197.1 AK091085.1 AK126955.1 AK296511.1 AK315163.1 AL831858.1 BC004233.2 
    BC005168.1 BC107492.1 BC107602.1 BX647912.1 D63134.2 U30172.1 Z49982.1 

    7 DOTS entries:

    DT.100807026  DT.453646  DT.95354236  DT.95278189  DT.100026997  DT.92432219  DT.100702426 

    Selected AceView cDNA sequences (see all 215):

    BM684648 AW136982 BI916204 AI701466 AA026053 BX108555 CB152173 BU182631 
    AI004516 BU738844 BU193178 BU181779 BP361485 AI368537 AA969690 AV725409 
    BX647912 AK058197 BM728280 BF939509 BX504194 AI371895 AA781993 BP362541 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TTYH2 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c
    SP1:        -                       -                 -                                               -     -     -                                             
    SP2:                                                                                                  -     -     -                                             
    SP3:                                -                                                                                                                           
    SP4:                                                  -                                                                                                         
    SP5:                                                                                                  -                                                         


    ECgene alternative splicing isoforms for TTYH2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TTYH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGCCTCACC
    TTYH2 Expression
    About this image


    TTYH2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Spinal Cord (Nervous System)
    TTYH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TTYH2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.27935

    UniProtKB/Swiss-Prot: TTYH2_HUMAN, Q9BSA4
    Tissue specificity: Expressed at higher level in brain and testis and at lower levels in heart, ovary, spleen and
    peripheral blood leukocytes. Up-regulated in 13 of 16 renal cell carcinoma samples examined. Up-regulated in
    colon carcinoma

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTYH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TTYH2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttyh21 , 5 tweety homolog 2 (Drosophila)1, 5 84.4(n)1
    82.89(a)1
      11 (79.85 cM)5
    1171601  NM_053273.21  NP_444503.21 
     1146754315 
    chicken
    (Gallus gallus)
    Aves TTYH21 tweety homolog 2 (Drosophila) 75.04(n)
    72.85(a)
      100858879  XM_003642353.2  XP_003642401.2 
    lizard
    (Anolis carolinensis)
    Reptilia TTYH26
    tweety family member 2
    70(a)
    1 ↔ 1
    2(98163948-98238772)
    African clawed frog
    (Xenopus laevis)
    Amphibia ttyh2-prov2 tweety homolog 2 (Drosophila) 74.03(n)    BC046859.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi03f072 Transcribed sequence with weak similarity to protein more 75.52(n)    BM775924.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bbx3 DNA binding 28(a)
    (best of 2)
      1   --


    ENSEMBL Gene Tree for TTYH2 (if available)
    TreeFam Gene Tree for TTYH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TTYH2 gene
    TTYH12  TTYH32  
    3 SIMAP similar genes for TTYH2 using alignment to 5 protein entries:     TTYH2_HUMAN (see all proteins):
    DKFZp761E0417    TTYH1    TTYH3

    Find genes that share paralogs with TTYH2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TTYH2 (see all 1232)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1171775461,2
    F--72211599(+) GATGAA/GCCTAC 1 -- int11Minor allele frequency- G:0.01NA 120
    rs1469157851,2
    C--72211695(+) CATCGA/GCCACT 1 -- int10--------
    rs1817712841,2
    --72211791(+) ATGAGC/GGTGGT 1 -- int10--------
    rs1174454071,2
    F--72211829(+) GTGTTA/GTTTAA 1 -- int11Minor allele frequency- G:0.01NA 120
    rs1421919181,2
    C--72211846(+) TCCTG-/TTTTTG 1 -- int10--------
    rs2006566771,2
    --72211885(+) CTCCT-/GGGATG 1 -- int10--------
    rs1862949851,2
    --72211888(+) CCTGGA/GTGTCT 1 -- int10--------
    rs1152692091,2
    C,F--72211989(+) CCAGGC/TGTGGG 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1393493441,2
    --72212017(+) GGCAGA/CAGGTC 1 -- int10--------
    rs1139399071,2
    C--72212052(+) TCTGCG/AGCTGG 1 -- int11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for TTYH2 (72209653 - 72258159 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TTYH2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv12e196CNV Duplication17116639
    nsv509673CNV Insertion20534489
    esv33995CNV Loss17666407
    nsv833539CNV Loss17160897
    esv27340CNV Loss19812545
    esv2751770CNV Gain17911159
    nsv833538CNV Gain17160897
    dgv372n27CNV Gain19166990
    nsv517569CNV Gain+Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608855    OMIM disorders: --


    Find genes that share disorders with TTYH2           About GenesLikeMe

    Genetic Association Database (GAD): TTYH2

    Export disorders for TTYH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TTYH2 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with TTYH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma. (PubMed id 11597145)1, 2, 3 Rae F.K....Clements J.A. (Genomics 2001)
    2. TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation. (PubMed id 17569141)1, 2, 9 Toiyama Y.... Kusunoki M. (World J. Gastroenterol. 2007)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. A novel human Cl(-) channel family related to Drosophila flightless locus. (PubMed id 15010458)1, 2 Suzuki M. and Mizuno A. (J. Biol. Chem. 2004)
    5. N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2). (PubMed id 18260827)1, 9 He Y....Hooper J.D. (Biochem. J. 2008)
    6. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PubMed id 21706016)1 Bisson N....Pawson T. (Nat. Biotechnol. 2011)
    7. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PubMed id 21130836)4 Luciano M....Deary I.J. (Biol Psychol 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    10. Expanding the substantial interactome of NEMO using protein microarrays. (PubMed id 20098747)1 Fenner B.J....Prehn J.H. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 94015 HGNC: 13877 AceView: TTYH2 Ensembl:ENSG00000141540 euGenes: HUgn94015
    ECgene: TTYH2 H-InvDB: TTYH2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TTYH2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TTYH2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TTYH2 gene:
    Search GeneIP for patents involving TTYH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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