Aliases for TTYH1 Gene
External Ids for TTYH1 Gene
Previous GeneCards Identifiers for TTYH1 Gene
This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-independent, volume-sensitive large conductance chloride(-) channel. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for TTYH1 Gene
TTYH1 (Tweety Family Member 1) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include calcium ion binding and iron ion transmembrane transporter activity. An important paralog of this gene is TTYH2.
UniProtKB/Swiss-Prot for TTYH1 Gene
Probable chloride channel. May be involved in cell adhesion (By similarity).
Isoform 3 may be a Ca(2+)-independent and swelling-activated chloride channel, possibly involved in regulation of cell volume.