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Aliases for TTYH1 Gene

Aliases for TTYH1 Gene

  • Tweety Family Member 1 2 3
  • HTTY1 3 4
  • Tweety (Drosophila) Homolog 1 2
  • Tweety Homolog 1 (Drosophila) 2
  • Protein Tweety Homolog 1 3
  • Tweety Homolog 1 3

External Ids for TTYH1 Gene

Previous GeneCards Identifiers for TTYH1 Gene

  • GC19P055789
  • GC19P055351
  • GC19P059602
  • GC19P059618
  • GC19P054926
  • GC19P051250

Summaries for TTYH1 Gene

Entrez Gene Summary for TTYH1 Gene

  • This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-independent, volume-sensitive large conductance chloride(-) channel. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for TTYH1 Gene

TTYH1 (Tweety Family Member 1) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include calcium ion binding and volume-sensitive chloride channel activity. An important paralog of this gene is TTYH2.

UniProtKB/Swiss-Prot for TTYH1 Gene

  • Probable chloride channel. May be involved in cell adhesion (By similarity).

  • Isoform 3 may be a Ca(2+)-independent and swelling-activated chloride channel, possibly involved in regulation of cell volume

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTYH1 Gene

Genomics for TTYH1 Gene

Regulatory Elements for TTYH1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TTYH1 Gene

54,415,219 bp from pter
54,436,900 bp from pter
21,682 bases
Plus strand

Genomic View for TTYH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTYH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTYH1 Gene

Proteins for TTYH1 Gene

  • Protein details for TTYH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein tweety homolog 1
    Protein Accession:
    Secondary Accessions:
    • B0VJY3
    • B0VJY4
    • B0VJY5
    • B2VAL9
    • Q5U682
    • Q68A17
    • Q6L750
    • Q6ZTE5
    • Q8WUU2

    Protein attributes for TTYH1 Gene

    450 amino acids
    Molecular mass:
    49051 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTYH1 Gene


neXtProt entry for TTYH1 Gene

Proteomics data for TTYH1 Gene at MOPED

Post-translational modifications for TTYH1 Gene

  • Glycosylation at Asn130, Asn205, Asn284, and Asn355
  • Modification sites at PhosphoSitePlus

Other Protein References for TTYH1 Gene

Antibody Products

No data available for DME Specific Peptides for TTYH1 Gene

Domains for TTYH1 Gene

Protein Domains for TTYH1 Gene


Suggested Antigen Peptide Sequences for TTYH1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9H313
  • Belongs to the tweety family.
genes like me logo Genes that share domains with TTYH1: view

No data available for Gene Families for TTYH1 Gene

Function for TTYH1 Gene

Molecular function for TTYH1 Gene

UniProtKB/Swiss-Prot Function:
Probable chloride channel. May be involved in cell adhesion (By similarity).
UniProtKB/Swiss-Prot Function:
Isoform 3 may be a Ca(2+)-independent and swelling-activated chloride channel, possibly involved in regulation of cell volume

Gene Ontology (GO) - Molecular Function for TTYH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005254 chloride channel activity --
GO:0005381 iron ion transmembrane transporter activity NAS 10950931
GO:0005509 calcium ion binding IEA --
GO:0072320 volume-sensitive chloride channel activity IDA 16219661
genes like me logo Genes that share ontologies with TTYH1: view

Phenotypes for TTYH1 Gene

genes like me logo Genes that share phenotypes with TTYH1: view

Animal Models for TTYH1 Gene

MGI Knock Outs for TTYH1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TTYH1 Gene

Localization for TTYH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTYH1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TTYH1 Gene COMPARTMENTS Subcellular localization image for TTYH1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
extracellular 2

Gene Ontology (GO) - Cellular Components for TTYH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane TAS 10950931
GO:0030868 smooth endoplasmic reticulum membrane IEA --
GO:0031527 filopodium membrane IEA --
GO:0032433 filopodium tip IEA --
genes like me logo Genes that share ontologies with TTYH1: view

Pathways for TTYH1 Gene

genes like me logo Genes that share pathways with TTYH1: view

Pathways by source for TTYH1 Gene

Interacting Proteins for TTYH1 Gene

Selected Interacting proteins: Q9H313-TTYH1_HUMAN for TTYH1 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TTYH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006821 chloride transport IDA 16219661
GO:0006826 iron ion transport NAS 10950931
GO:0007067 mitotic nuclear division IEA --
GO:0016337 single organismal cell-cell adhesion IEA --
GO:0031589 cell-substrate adhesion IEA --
genes like me logo Genes that share ontologies with TTYH1: view

Compounds for TTYH1 Gene

(1) HMDB Compounds for TTYH1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Cl2
genes like me logo Genes that share compounds with TTYH1: view

Transcripts for TTYH1 Gene

Unigene Clusters for TTYH1 Gene

Tweety homolog 1 (Drosophila):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTYH1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTYH1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a ·
SP1: -
SP2: - - - - -
SP3: - -
SP4: -
SP5: -
SP6: - -
SP8: -
SP9: - - - -

ExUns: 17b ^ 18a · 18b · 18c
SP1: -
SP4: -

Relevant External Links for TTYH1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTYH1 Gene

mRNA expression in normal human tissues for TTYH1 Gene

mRNA differential expression in normal tissues according to GTEx for TTYH1 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (5.8), Brain - Amygdala (5.4), Brain - Caudate (basal ganglia) (5.4), and Brain - Nucleus accumbens (basal ganglia) (5.3).

Protein differential expression in normal tissues for TTYH1 Gene

This gene is overexpressed in Frontal cortex (23.1), Cervix (19.5), Spinal cord (10.6), and Retina (7.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TTYH1 Gene

SOURCE GeneReport for Unigene cluster for TTYH1 Gene Hs.268728

mRNA Expression by UniProt/SwissProt for TTYH1 Gene

Tissue specificity: Expressed in brain, eye, ovary and testis, and at lower levels in muscle, placenta, liver and lung.
genes like me logo Genes that share expressions with TTYH1: view

Expression partners for TTYH1 Gene

In Situ Assay Products

Orthologs for TTYH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTYH1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TTYH1 35
  • 90.96 (n)
  • 92.22 (a)
TTYH1 36
  • 87 (a)
(Canis familiaris)
Mammalia TTYH1 35
  • 91.04 (n)
  • 93.56 (a)
TTYH1 36
  • 92 (a)
(Mus musculus)
Mammalia Ttyh1 35
  • 86.89 (n)
  • 91.56 (a)
Ttyh1 16
Ttyh1 36
  • 87 (a)
(Pan troglodytes)
Mammalia TTYH1 35
  • 99.19 (n)
  • 99.11 (a)
TTYH1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ttyh1 35
  • 86.89 (n)
  • 91.78 (a)
(Monodelphis domestica)
Mammalia TTYH1 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia TTYH1 36
  • 66 (a)
(Anolis carolinensis)
Reptilia TTYH1 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ttyh1 35
  • 65.75 (n)
  • 62.61 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18813 35
(Danio rerio)
Actinopterygii LOC100537642 35
  • 56.98 (n)
  • 49.55 (a)
ttyh1 36
  • 35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3638 36
  • 16 (a)
tty 36
  • 11 (a)
Species with no ortholog for TTYH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTYH1 Gene

Gene Tree for TTYH1 (if available)
Gene Tree for TTYH1 (if available)

Paralogs for TTYH1 Gene

Paralogs for TTYH1 Gene

Selected SIMAP similar genes for TTYH1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TTYH1: view

Variants for TTYH1 Gene

Sequence variations from dbSNP and Humsavar for TTYH1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs889149 -- 54,429,293(-) GGGGA(A/G)GGAGG intron-variant
rs1077829 -- 54,421,559(-) GGGTC(A/G)GGGGT intron-variant
rs1862486 -- 54,428,863(-) GCAGG(A/G)GGCGT intron-variant
rs1862487 -- 54,428,672(-) CCCAC(C/T)AGGGC intron-variant
rs1862488 -- 54,424,514(-) CAGGC(C/T)TGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTYH1 Gene

Variant ID Type Subtype PubMed ID
dgv1119e1 CNV Complex 17122850
nsv833878 CNV Loss 17160897
nsv2550 CNV Insertion 18451855
nsv9756 CNV Gain 18304495
nsv2551 CNV Insertion 18451855

Relevant External Links for TTYH1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTYH1 Gene

Disorders for TTYH1 Gene

No disorders were found for TTYH1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TTYH1 Gene

Publications for TTYH1 Gene

  1. Human and mouse homologues of the Drosophila melanogaster tweety (tty) gene: a novel gene family encoding predicted transmembrane proteins. (PMID: 10950931) Campbell H.D. … Young I.G. (Genomics 2000) 2 3 4
  2. A novel human Cl(-) channel family related to Drosophila flightless locus. (PMID: 15010458) Suzuki M. … Mizuno A. (J. Biol. Chem. 2004) 3 4 23
  3. Expression and evolution of the mammalian brain gene Ttyh1. (PMID: 17116230) Matthews C.A. … Campbell H.D. (J. Neurochem. 2007) 4 23
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TTYH1 Gene

Sources for TTYH1 Gene

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