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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TTYH1 Gene

protein-coding   GIFtS: 49
GCID: GC19P054926

tweety homolog 1 (Drosophila)

(Previous name: tweety (Drosophila) homolog 1 )
  Search for TTYH1
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Biological research products
for TTYH1    

Aliases
for TTYH1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tweety Homolog 1 (Drosophila)1 2
HTTY11
Tweety (Drosophila) Homolog 11
Protein Tweety Homolog 12

External Ids:    HGNC: 134761   Entrez Gene: 573482   Ensembl: ENSG000001676147   OMIM: 6057845   UniProtKB: Q9H3133   

Export aliases for TTYH1 gene to outside databases

Previous GC identifers: GC19P055789 GC19P055351 GC19P059602 GC19P059618 GC19P051250


Summaries
for TTYH1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TTYH1:
This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion
channels. The encoded protein functions as a calcium(2+)-independent, volume-sensitive large conductance chloride(-)
channel. Three transcript variants encoding distinct isoforms have been identified for this gene. (provided by RefSeq,
Jan 2011)

UniProtKB/Swiss-Prot: TTYH1_HUMAN, Q9H313
Function: Probable chloride channel. May be involved in cell adhesion (By similarity)
Function: Isoform 3 may be a Ca(2+)-independent and swelling-activated chloride channel, possibly involved in
regulation of cell volume




Genomic Views
for TTYH1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TTYH1 gene promoter:
         USF1   AML1a   Lmo2   AP-2gamma   E47   USF-1   AP-2beta   Hand1   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TTYH1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TTYH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTYH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

TTYH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTYH1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P054926:  view genomic region     (about GC identifiers)

Start:
 54,926,373 bp from pter      End:
 54,948,080 bp from pter
Size:
 21,708 bases      Orientation:
 plus strand

Proteins
for TTYH1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TTYH1_HUMAN, Q9H313 (See protein sequence)
Recommended Name: Protein tweety homolog 1  
Size: 450 amino acids; 49051 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: B0VJY3 B0VJY4 B0VJY5 B2VAL9 Q5U682 Q68A17 Q6L750 Q6ZTE5 Q8WUU2
Alternative splicing: 5 isoforms:  Q9H313-1   Q9H313-2   Q9H313-3   Q9H313-4   Q9H313-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TTYH1: NX_Q9H313

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H313

    • TTYH1 Protein expression data from MOPED and PaxDb:    About this image 
    TTYH1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001005367.1  NP_001188390.1  NP_065710.1  

    ENSEMBL proteins: 
     ENSP00000398114   ENSP00000391282   ENSP00000301194   ENSP00000365713   ENSP00000393592  
     ENSP00000402817   ENSP00000365714   ENSP00000375619  
    Reactome Protein details: Q9H313
    Human Recombinant Protein Products for TTYH1: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TTYH1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0016021integral to membrane TAS10950931
    GO:0030868smooth endoplasmic reticulum membrane IEA--
    GO:0031527filopodium membrane IEA--
    GO:0032433filopodium tip IEA--

    TTYH1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TTYH1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TTYH1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR006990 Tweety

    Graphical View of Domain Structure for InterPro Entry Q9H313

    ProtoNet protein and cluster: Q9H313

    UniProtKB/Swiss-Prot: TTYH1_HUMAN, Q9H313
    Similarity: Belongs to the tweety family


    Function
    for TTYH1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTYH1_HUMAN, Q9H313
    Function: Probable chloride channel. May be involved in cell adhesion (By similarity)
    Function: Isoform 3 may be a Ca(2+)-independent and swelling-activated chloride channel, possibly involved in
    regulation of cell volume

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005254chloride channel activity IEA--
    GO:0005381iron ion transmembrane transporter activity NAS10950931
    GO:0005509calcium ion binding IEA--
         
    TTYH1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TTYH1:
     Increased S DNA content  Increased cell number in G2M,  

         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ttyh1):
     cellular  embryogenesis  mortality/aging 

    TTYH1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Ttyh1tm1Tohe for TTYH1
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    miRNA
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    hsa-miR-623 hsa-miR-371-3p hsa-miR-204 hsa-miR-519e hsa-miR-515-3p hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmid: TTYH1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Cell Line
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    In Situ Assay
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    Pathways & Interactions
    for TTYH1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ion channel transport
    		Ion channel transport1.00
    		Stimuli-sensing channels0.49
    2SLC-mediated transmembrane transport
    		Transmembrane transport of small molecules0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for TTYH1
        Transmembrane transport of small molecules
    Stimuli-sensing channels
    Ion channel transport



    TTYH1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTYH1

    1 Interacting protein for TTYH1 (Q9H3133) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319463I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006826iron ion transport NAS10950931
    GO:0007067mitosis IEA--
    GO:0007155cell adhesion ----
    GO:0016337cell-cell adhesion IEA--
    GO:0031589cell-substrate adhesion IEA--

    TTYH1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TTYH1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TTYH1

    1 HMDB Compound for TTYH1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Search CenterWatch for drugs/clinical trials and news about TTYH1 

    Transcripts
    for TTYH1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TTYH1 gene (3 alternative transcripts): 
    NM_001005367.2  NM_001201461.1  NM_020659.3  

    Unigene Cluster for TTYH1:

    Tweety homolog 1 (Drosophila)
    Hs.268728  [show with all ESTs]
    Unigene Representative Sequence: AK126690
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000444661 ENST00000423529 ENST00000301194(uc002qfq.3 uc002qft.3 uc002qfr.3)
    ENST00000376530 ENST00000445095 ENST00000425969 ENST00000487134 ENST00000376531
    ENST00000462757 ENST00000462769 ENST00000478036 ENST00000472198(uc002qfu.1)
    ENST00000461302 ENST00000476757 ENST00000489425 ENST00000492920 ENST00000476863
    ENST00000467939

    miRNA
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    hsa-miR-623 hsa-miR-371-3p hsa-miR-204 hsa-miR-519e hsa-miR-515-3p hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmid: TTYH1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: TTYH1
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    Clone
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    Additional cDNA sequence: 

    AB162930.1 AB188496.1 AF177909.1 AK126690.1 AK289468.1 AK293468.1 BC011347.1 BC019358.1 
    BC065919.1 BC127776.1 DQ655949.2 

    19 DOTS entries:

    DT.97845217  DT.312242  DT.100829500  DT.100832423  DT.121487241  DT.100787804  DT.121487209  DT.100787802 
    DT.97810195  DT.92426889  DT.100680067  DT.121487671  DT.92426894  DT.100787797  DT.121487089  DT.100649003 
    DT.121487051  DT.95125576  DT.95125578 

    24/156 AceView cDNA sequences (see all 156):

    BF061809 BM920743 CR597839 BU735799 BC019358 BC065919 AI363474 BF056286 
    BM702123 BE551927 AI220130 BM718514 AI653749 BM683560 BX350372 BU726672 
    AI589804 T08857 BM547592 CB152914 CR624363 AI199313 BQ637042 AA398006 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for TTYH1 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a ·
    SP1:                                                                                                                                      -                     
    SP2:                          -     -     -     -                             -                                                                                 
    SP3:                                                                          -                                                           -                     
    SP4:                                                                                                                                      -                     
    SP5:                                                                                                                                      -                     

    ExUns: 17b ^ 18a · 18b · 18c
    SP1:  -                     
    SP2:                        
    SP3:                        
    SP4:  -                     
    SP5:                        


    ECgene alternative splicing isoforms for TTYH1

    Expression
    for TTYH1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TTYH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTCCCCCTG
    TTYH1 Expression
    About this image

    TTYH1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    BoneMaxillary ProcessBone
    BrainMedulla OblongataBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    N2/LSB/S/F8-induced cells (Generation of midbra...)
    N2/LSB induced-cells (Generation of midbra...)
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See TTYH1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TTYH1

    SOURCE GeneReport for Unigene cluster: Hs.268728

    UniProtKB/Swiss-Prot: TTYH1_HUMAN, Q9H313
    Tissue specificity: Expressed in brain, eye, ovary and testis, and at lower levels in muscle, placenta, liver and lung

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    In Situ
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    Orthologs
    for TTYH1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TTYH1 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ttyh11 , 5 tweety homolog 1 (Drosophila)1, 5 86.89(n)1
    91.56(a)1    		   7 (2.38 cM)5
    577761  NM_001109765.11  NP_001103235.11 
     41194085 
    lizard
    (Anolis carolinensis)    		 Reptilia TTYH16
    		 --
    		 44(a)
    		 1 ↔ 1
    		 GL343329.1(1110754-1137735)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.188132 Xenopus laevis transcribed sequence with strong similarity more 80.94(n)    BI446660.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005376421 protein tweety homolog 1-like 56.08(n)
    49.29(a)    		   100537642  XM_003200152.1  XP_003200200.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG36386
    tty6
    		 tweety
    		 16(a)
    12(a)
    		 many ↔ many
    many ↔ many
    		 X(1109747-1130717)
    X(21199695-21210649)
    worm
    (Caenorhabditis elegans)    		 Secernentea ttyh-16
    		 Protein tweety homolog 1
    		 15(a)
    		 1 → many
    		 X(11368655-11374292)


    ENSEMBL Gene Tree for TTYH1 (if available)
    TreeFam Gene Tree for TTYH1 (if available) 

    Paralogs
    for TTYH1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TTYH1 gene
    TTYH32  TTYH22  
    2 SIMAP similar genes for TTYH1 using alignment to 7 protein entries:     TTYH1_HUMAN (see all proteins):
    TTYH2    TTYH3

    TTYH1 for paralogs           About GeneDecksing



    Genomic Variants
    for TTYH1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/549 NCBI SNPs in TTYH1 are shown (see all 549)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1125891081,2
    		C--51248932(+) TTCTAC/ACACCA 3 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1839090091,2
    		--54924633(+) CTCTAC/TTGGGT 3 -- us2k10--------
    rs1509969141,2
    		--54924643(+) TTGCAC/TAGTCA 3 -- us2k10--------
    rs1407144421,2
    		--54924761(+) TGGCTA/GTGGAC 3 -- us2k10--------
    rs1496765991,2
    		--54924836(+) GCCTTC/TATTTT 3 -- us2k10--------
    rs761376071,2
    		F--54924910(+) CTAACC/TGCTCA 3 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1887076121,2
    		--54924956(+) GCCACC/TTGGTT 3 -- us2k10--------
    rs1454584471,2
    		--54924974(+) GTGGAA/GAACAT 3 -- us2k10--------
    rs1389878431,2
    		C--54925036(+) AGAGG-/GTGTG 
     TGTGTGT    GTGTG     		3 -- us2k10--------
    rs118813601,2
    		C,H--54925077(+) GTGTGA/TGAGAG 3 -- us2k12Minor allele frequency- T:0.00NA CSA 3

    HapMap Linkage Disequilibrium report for TTYH1 (54926373 - 54948080 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for TTYH1
         3 CNVs: 4088 5116 30923

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    Disorders / Diseases
    for TTYH1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TTYH1 for disorders           About MalaCards

    TTYH1 for disorders           About GeneDecksing

    OMIM gene information: 605784    OMIM disorders: --


    Export disorders for TTYH1 gene to outside databases

    Publications
    for TTYH1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TTYH1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TTYH1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human and mouse homologues of the Drosophila melanogaster tweety (tty) gene: a novel gene family encoding predicted transmembrane proteins. (PubMed id 10950931)1, 2, 3 Campbell H.D.... Young I.G. (2000)
    2. A novel human Cl(-) channel family related to Drosophila flightless locus. (PubMed id 15010458)1, 2, 9 Suzuki M. and Mizuno A. (2004)
    3. Expression and evolution of the mammalian brain gene Ttyh1. (PubMed id 17116230)2, 9 Matthews C.A....Campbell H.D. (2007)
    4. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    5. The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels. (PubMed id 18577513)1 He Y....Hooper J.D. (2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    8. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    External Searches for TTYH1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TTYH1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57348 HGNC: 13476 AceView: TTYH1 Ensembl:ENSG00000167614 euGenes: HUgn57348
    ECgene: TTYH1 H-InvDB: TTYH1

    Other Databases showing TTYH1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TTYH1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TTYH1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TTYH1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TTYH1 gene:
    Search GeneIP for patents involving TTYH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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