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TTYH1 Gene

protein-coding   GIFtS: 51
GCID: GC19P054926

Tweety Family Member 1

(Previous names: tweety (Drosophila) homolog 1, tweety homolog 1 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tweety Family Member 11 2
hTTY12 3
Tweety (Drosophila) Homolog 11
Tweety Homolog 1 (Drosophila)1
Protein Tweety Homolog 12
Tweety Homolog 12

External Ids:    HGNC: 134761   Entrez Gene: 573482   Ensembl: ENSG000001676147   OMIM: 6057845   UniProtKB: Q9H3133   

Export aliases for TTYH1 gene to outside databases

Previous GC identifers: GC19P055789 GC19P055351 GC19P059602 GC19P059618 GC19P051250


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TTYH1 Gene:
This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion
channels. The encoded protein functions as a calcium(2+)-independent, volume-sensitive large conductance
chloride(-) channel. Three transcript variants encoding distinct isoforms have been identified for this gene.
(provided by RefSeq, Jan 2011)

GeneCards Summary for TTYH1 Gene:
TTYH1 (tweety family member 1) is a protein-coding gene. Diseases associated with TTYH1 include labyrinthitis, and cerebritis. GO annotations related to this gene include volume-sensitive chloride channel activity and calcium ion binding. An important paralog of this gene is TTYH3.

UniProtKB/Swiss-Prot: TTYH1_HUMAN, Q9H313
Function: Probable chloride channel. May be involved in cell adhesion (By similarity)
Function: Isoform 3 may be a Ca(2+)-independent and swelling-activated chloride channel, possibly involved in
regulation of cell volume




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  NT_187693.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the TTYH1 gene promoter:
         USF1   AML1a   Lmo2   AP-2gamma   E47   USF-1   AP-2beta   Hand1   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTYH1 promoter sequence
   Search Chromatin IP Primers for TTYH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTYH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

TTYH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTYH1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P054926:  view genomic region     (about GC identifiers)

Start:
54,926,393 bp from pter      End:
54,948,080 bp from pter
Size:
21,688 bases      Orientation:
plus strand

2 alternative locations:
Chr19+,NW_003571054 321,949-343,243      Chr19+,NW_003571060 320,125-341,407     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TTYH1_HUMAN, Q9H313 (See protein sequence)
Recommended Name: Protein tweety homolog 1  
Size: 450 amino acids; 49051 Da
Secondary accessions: B0VJY3 B0VJY4 B0VJY5 B2VAL9 Q5U682 Q68A17 Q6L750 Q6ZTE5 Q8WUU2
Alternative splicing: 5 isoforms:  Q9H313-1   Q9H313-2   Q9H313-3   Q9H313-4   Q9H313-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TTYH1: NX_Q9H313

Explore proteomics data for TTYH1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn130, Asn205, Asn284, Asn355
  • Modification sites at PhosphoSitePlus

  • See TTYH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001005367.1  NP_001188390.1  NP_065710.1  

    ENSEMBL proteins: 
     ENSP00000391282   ENSP00000301194   ENSP00000365713   ENSP00000393592   ENSP00000402817  
     ENSP00000365714   ENSP00000471789   ENSP00000375619  
    Reactome Protein details: Q9H313

    TTYH1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR006990 Tweety

    Graphical View of Domain Structure for InterPro Entry Q9H313

    ProtoNet protein and cluster: Q9H313

    UniProtKB/Swiss-Prot: TTYH1_HUMAN, Q9H313
    Similarity: Belongs to the tweety family


    TTYH1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTYH1_HUMAN, Q9H313
    Function: Probable chloride channel. May be involved in cell adhesion (By similarity)
    Function: Isoform 3 may be a Ca(2+)-independent and swelling-activated chloride channel, possibly involved in
    regulation of cell volume

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005381iron ion transmembrane transporter activity NAS10950931
    GO:0005509calcium ion binding IEA--
    GO:0072320volume-sensitive chloride channel activity IDA16219661
         
    TTYH1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TTYH1:
     Increased S DNA content  Increased cell number in G2M,  

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ttyh1):
     cellular  embryogenesis  mortality/aging 

    TTYH1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ttyh1tm1Tohe for TTYH1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TTYH1
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    SwitchGear 3'UTR luciferase reporter plasmidTTYH1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TTYH1_HUMAN, Q9H313: Cell membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum2
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane TAS10950931
    GO:0030868smooth endoplasmic reticulum membrane IEA--
    GO:0031527filopodium membrane IEA--
    GO:0032433filopodium tip IEA--

    TTYH1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TTYH1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for TTYH1
        Stimuli-sensing channels



    TTYH1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TTYH1
    Interactions:

        Search GeneGlobe Interaction Network for TTYH1

    1 Interacting protein for TTYH1 (Q9H3133) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319463I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006821chloride transport IDA16219661
    GO:0006826iron ion transport NAS10950931
    GO:0007067mitosis IEA--
    GO:0016337cell-cell adhesion IEA--
    GO:0031589cell-substrate adhesion IEA--

    TTYH1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TTYH1

    1 HMDB Compound for TTYH1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TTYH1 gene (3 alternative transcripts): 
    NM_001005367.2  NM_001201461.1  NM_020659.3  

    Unigene Cluster for TTYH1:

    Tweety homolog 1 (Drosophila)
    Hs.268728  [show with all ESTs]
    Unigene Representative Sequence: AK126690
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000423529 ENST00000301194(uc002qfq.3 uc002qft.3 uc002qfr.3)
    ENST00000376530 ENST00000445095 ENST00000425969 ENST00000487134 ENST00000376531
    ENST00000462757 ENST00000462769 ENST00000478036 ENST00000472198(uc002qfu.1)
    ENST00000461302 ENST00000476757 ENST00000489425 ENST00000492920 ENST00000476863
    ENST00000467939 ENST00000391739(uc010yey.2)
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate TTYH1:
    hsa-miR-623 hsa-miR-371-3p hsa-miR-204 hsa-miR-519e hsa-miR-515-3p hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidTTYH1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): TTYH1 (NM_001201461)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTYH1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TTYH1
      QuantiTect SYBR Green Assays in human, mouse, rat TTYH1
      QuantiFast Probe-based Assays in human, mouse, rat TTYH1

    Additional mRNA sequence: 

    AB162930.1 AB188496.1 AF177909.1 AK126690.1 AK289468.1 AK293468.1 BC011347.1 BC019358.1 
    BC065919.1 BC127776.1 DQ655949.2 

    19 DOTS entries:

    DT.97845217  DT.312242  DT.100829500  DT.100832423  DT.121487241  DT.100787804  DT.100787802  DT.97810195 
    DT.121487209  DT.92426889  DT.100680067  DT.121487671  DT.92426894  DT.100787797  DT.121487089  DT.100649003 
    DT.121487051  DT.95125576  DT.95125578 

    Selected AceView cDNA sequences (see all 156):

    AI919390 BU726672 BF056286 BE551927 BX350372 BI823662 BQ879433 BC011347 
    AI220130 BM664825 BM547592 BQ637042 BG056329 AI363474 AI653749 AB188496 
    CR597839 BE855432 AA398006 BM543494 BC019358 BM920743 AI199313 BM671903 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TTYH1 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a ·
    SP1:                                                                                                                                      -                     
    SP2:                          -     -     -     -                             -                                                                                 
    SP3:                                                                          -                                                           -                     
    SP4:                                                                                                                                      -                     
    SP5:                                                                                                                                      -                     

    ExUns: 17b ^ 18a · 18b · 18c
    SP1:  -                     
    SP2:                        
    SP3:                        
    SP4:  -                     
    SP5:                        


    ECgene alternative splicing isoforms for TTYH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TTYH1 expression in normal human tissues (normalized intensities)      TTYH1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTCCCCCTG
    TTYH1 Expression
    About this image


    TTYH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
             N2/LSB induced-cells
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Metencephalon
             Floor plate-like cells
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
     
     Testis (Reproductive System)
    TTYH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TTYH1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.268728

    UniProtKB/Swiss-Prot: TTYH1_HUMAN, Q9H313
    Tissue specificity: Expressed in brain, eye, ovary and testis, and at lower levels in muscle, placenta, liver and
    lung

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTYH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TTYH1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttyh11 , 5 tweety homolog 1 (Drosophila)1, 5 86.89(n)1
    91.56(a)1
      7 (2.38 cM)5
    577761  NM_021324.51  NP_067299.21 
     41194085 
    lizard
    (Anolis carolinensis)
    Reptilia TTYH16
    tweety family member 1
    45(a)
    1 ↔ 1
    GL343329.1(1110754-1137735)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.188132 Xenopus laevis transcribed sequence with strong similarity more 80.94(n)    BI446660.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005376421 protein tweety homolog 1-like 56.98(n)
    49.55(a)
      100537642  XM_003200152.2  XP_003200200.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG36386
    tty6
    tweety
    16(a)
    11(a)
    many ↔ many
    many ↔ many
    X(1109747-1130717)
    X(21199695-21210649)


    ENSEMBL Gene Tree for TTYH1 (if available)
    TreeFam Gene Tree for TTYH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for TTYH1 gene
    TTYH32  TTYH22  
    2 SIMAP similar genes for TTYH1 using alignment to 6 protein entries:     TTYH1_HUMAN (see all proteins):
    TTYH2    TTYH3

    TTYH1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TTYH1 (see all 752)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1826879651,2
    C--51248894(+) AGGCTC/TGAGCC 3 -- us2k10--------
    rs1872430761,2
    C--51248905(+) ACTGCA/GCCTGG 3 -- us2k10--------
    rs104240621,2
    C--51248917(+) CCCCAG/CTTACC 3 -- us2k1 tfbs310Minor allele frequency- C:0.25WA NA CSA EA 369
    rs1125891081,2
    C,F--51248932(+) TTCTAC/ACACCA 3 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1392688901,2
    C--51248945(+) CCAGAC/TTGTTC 3 -- us2k10--------
    rs1441616821,2
    --51249015(+) AAACAA/CTTTAG 3 -- us2k10--------
    rs1929135821,2
    --51249068(+) GGATAG/TAAATT 3 -- us2k10--------
    rs1390489681,2
    --51249111(+) TTTTT-/ACTTTTT 3 -- us2k10--------
    rs787527331,2
    --51249133(+) TTTTTG/TTGTGT 3 -- us2k11Minor allele frequency- T:0.50NA 2
    rs105669591,2
    C--51253063(+) TATAT-/ATGCTTA 3 -- int12Minor allele frequency- AT:0.25NA 4

    HapMap Linkage Disequilibrium report for TTYH1 (54926393 - 54948080 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TTYH1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2551CNV Insertion18451855
    nsv2550CNV Insertion18451855
    nsv833878CNV Loss17160897
    nsv9756CNV Gain18304495
    dgv1119e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TTYH1
    DNA2.0 Custom Variant and Variant Library Synthesis for TTYH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605784    OMIM disorders: --

    4 diseases for TTYH1:    About MalaCards
    labyrinthitis    cerebritis    endotheliitis    neuronitis


    TTYH1 for disorders           About GeneDecksing


    Export disorders for TTYH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TTYH1 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with TTYH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human and mouse homologues of the Drosophila melanogaster tweety (tty) gene: a novel gene family encoding predicted transmembrane proteins. (PubMed id 10950931)1, 2, 3 Campbell H.D.... Young I.G. (Genomics 2000)
    2. A novel human Cl(-) channel family related to Drosophila flightless locus. (PubMed id 15010458)1, 2, 9 Suzuki M. and Mizuno A. (J. Biol. Chem. 2004)
    3. Expression and evolution of the mammalian brain gene Ttyh1. (PubMed id 17116230)2, 9 Matthews C.A....Campbell H.D. (J. Neurochem. 2007)
    4. Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR. (PubMed id 24316981)1 Kleinman C.L....Jabado N. (Nat. Genet. 2014)
    5. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PubMed id 23720494)1 Evans D.M....Whitfield J.B. (Hum. Mol. Genet. 2013)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels. (PubMed id 18577513)1 He Y....Hooper J.D. (J. Biol. Chem. 2008)
    8. The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels. (PubMed id 16219661)1 Suzuki M. (Exp. Physiol. 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57348 HGNC: 13476 AceView: TTYH1 Ensembl:ENSG00000167614 euGenes: HUgn57348
    ECgene: TTYH1 H-InvDB: TTYH1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TTYH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TTYH1 gene:
    Search GeneIP for patents involving TTYH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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