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Aliases for TTPAL Gene

Aliases for TTPAL Gene

  • Tocopherol (Alpha) Transfer Protein-Like 2 3
  • C20orf121 3 4
  • Alpha-Tocopherol Transfer Protein-Like 3
  • Chromosome 20 Open Reading Frame 121 2

External Ids for TTPAL Gene

Previous HGNC Symbols for TTPAL Gene

  • C20orf121

Previous GeneCards Identifiers for TTPAL Gene

  • GC20P042538
  • GC20P043104
  • GC20P039846

Summaries for TTPAL Gene

GeneCards Summary for TTPAL Gene

TTPAL (Tocopherol (Alpha) Transfer Protein-Like) is a Protein Coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is CLVS1.

UniProtKB/Swiss-Prot for TTPAL Gene

  • May act as a protein that binds a hydrophobic ligand.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTPAL Gene

Genomics for TTPAL Gene

Regulatory Elements for TTPAL Gene

Genomic Location for TTPAL Gene

44,475,886 bp from pter
44,494,603 bp from pter
18,718 bases
Plus strand

Genomic View for TTPAL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTPAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTPAL Gene

Proteins for TTPAL Gene

  • Protein details for TTPAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-tocopherol transfer protein-like
    Protein Accession:
    Secondary Accessions:
    • E1P5X3
    • Q5QPC1
    • Q9H1G2
    • Q9NQG8

    Protein attributes for TTPAL Gene

    342 amino acids
    Molecular mass:
    38515 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TTPAL Gene

Proteomics data for TTPAL Gene at MOPED

Post-translational modifications for TTPAL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTPAL Gene

Antibody Products

No data available for DME Specific Peptides for TTPAL Gene

Domains for TTPAL Gene

Suggested Antigen Peptide Sequences for TTPAL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CRAL-TRIO domain.
  • Contains 1 CRAL-TRIO domain.
genes like me logo Genes that share domains with TTPAL: view

No data available for Gene Families for TTPAL Gene

Function for TTPAL Gene

Molecular function for TTPAL Gene

UniProtKB/Swiss-Prot Function:
May act as a protein that binds a hydrophobic ligand.

Gene Ontology (GO) - Molecular Function for TTPAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
genes like me logo Genes that share ontologies with TTPAL: view

Phenotypes for TTPAL Gene

genes like me logo Genes that share phenotypes with TTPAL: view

Animal Model Products

miRNA for TTPAL Gene

miRTarBase miRNAs that target TTPAL

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTPAL

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TTPAL Gene

Localization for TTPAL Gene

Subcellular locations from

Jensen Localization Image for TTPAL Gene COMPARTMENTS Subcellular localization image for TTPAL gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for TTPAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with TTPAL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TTPAL Gene

Pathways for TTPAL Gene

SuperPathways for TTPAL Gene

No Data Available

Interacting Proteins for TTPAL Gene

Gene Ontology (GO) - Biological Process for TTPAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with TTPAL: view

No data available for Pathways by source for TTPAL Gene

Transcripts for TTPAL Gene

Unigene Clusters for TTPAL Gene

Tocopherol (alpha) transfer protein-like:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTPAL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTPAL Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP4: -
SP6: - -

Relevant External Links for TTPAL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTPAL Gene

mRNA expression in normal human tissues for TTPAL Gene

mRNA differential expression in normal tissues according to GTEx for TTPAL Gene

This gene is overexpressed in Liver (4.1).

Protein differential expression in normal tissues for TTPAL Gene

This gene is overexpressed in Frontal cortex (42.5), Spleen (8.5), and Blymphocyte (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTPAL Gene

SOURCE GeneReport for Unigene cluster for TTPAL Gene Hs.283869

genes like me logo Genes that share expressions with TTPAL: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Expression partners for TTPAL Gene

Orthologs for TTPAL Gene

This gene was present in the common ancestor of animals.

Orthologs for TTPAL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TTPAL 35
  • 87.52 (n)
  • 91.81 (a)
  • 92 (a)
(Canis familiaris)
Mammalia TTPAL 35
  • 90.45 (n)
  • 94.74 (a)
  • 95 (a)
(Mus musculus)
Mammalia Ttpal 35
  • 87.33 (n)
  • 93.86 (a)
Ttpal 16
Ttpal 36
  • 94 (a)
(Pan troglodytes)
Mammalia TTPAL 35
  • 99.42 (n)
  • 99.71 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ttpal 35
  • 85.87 (n)
  • 92.69 (a)
(Monodelphis domestica)
Mammalia TTPAL 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia TTPAL 36
  • 82 (a)
(Gallus gallus)
Aves TTPAL 35
  • 76.81 (n)
  • 83.28 (a)
  • 79 (a)
(Anolis carolinensis)
Reptilia TTPAL 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ttpal 35
  • 66.86 (n)
  • 69.82 (a)
(Danio rerio)
Actinopterygii Dr.26556 35
ttpal 35
  • 64.87 (n)
  • 66.31 (a)
ttpal 36
  • 65 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009314 35
  • 48.35 (n)
  • 40.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10026 36
  • 25 (a)
CG10237 36
  • 29 (a)
CG10300 36
  • 24 (a)
CG10301 36
  • 20 (a)
CG10657 36
  • 26 (a)
CG11550 36
  • 23 (a)
CG12926 36
  • 29 (a)
CG1902 36
  • 24 (a)
CG2663 36
  • 27 (a)
CG30339 36
  • 24 (a)
CG3091 36
  • 20 (a)
CG31636 36
  • 29 (a)
CG3191 36
  • 22 (a)
CG33514 36
  • 26 (a)
CG33965 36
  • 26 (a)
CG33966 36
  • 26 (a)
CG3823 36
  • 22 (a)
CG5958 36
  • 31 (a)
CG5973 36
  • 26 (a)
Cralbp 36
  • 26 (a)
pinta 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
Species with no ortholog for TTPAL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTPAL Gene

Gene Tree for TTPAL (if available)
Gene Tree for TTPAL (if available)

Paralogs for TTPAL Gene

Paralogs for TTPAL Gene

(5) SIMAP similar genes for TTPAL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TTPAL: view

Variants for TTPAL Gene

Sequence variations from dbSNP and Humsavar for TTPAL Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs190075296 -- 44,481,565(+) AGAGA(A/G)AAATG intron-variant
rs190220720 -- 44,477,920(+) AAAGT(G/T)TTGGG intron-variant
rs190524136 -- 44,490,637(+) TTTTA(C/T)AGTGA utr-variant-3-prime
rs190668472 -- 44,486,909(+) AGAGA(C/G)AGCAG intron-variant
rs190055831 -- 44,479,924(+) CACTG(G/T)ACTGC intron-variant

Relevant External Links for TTPAL Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TTPAL Gene

Disorders for TTPAL Gene

No disorders were found for TTPAL Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TTPAL Gene

Publications for TTPAL Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. High-throughput mapping of a dynamic signaling network in mammalian cells. (PMID: 15761153) Barrios-Rodiles M. … Wrana J.L. (Science 2005) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 3

Products for TTPAL Gene

Sources for TTPAL Gene

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