TTPAL Gene
protein-coding GIFtS: 44
GCID: GC20P043104
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tocopherol (alpha) transfer protein-like(Previous name: chromosome 20 open reading frame 121 )
(Previous symbol: C20orf121)
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Aliases
for TTPAL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tocopherol (Alpha) Transfer Protein-Like1 2 | | C20orf1211 2 3 | | Chromosome 20 Open Reading Frame 1211 | | DJ179M20.31 | | Alpha-Tocopherol Transfer Protein-Like2 |
Export aliases for TTPAL gene to outside databasesPrevious GC identifers: GC20P042538 GC20P039846 |
Summaries
for TTPAL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TTPAL_HUMAN, Q9BTX7Function: May act as a protein that binds a hydrophobic ligand (Potential)
|
Genomic Views
for TTPAL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TTPAL gene promoter:
COUP-TF1 AhR COUP Nkx2-5 Tal-1beta E47 HNF-4alpha1 Arnt COUP-TF c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for TTPAL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTPAL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.12TTPAL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P043104: view genomic region
(about GC identifiers)
Start:
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43,104,526 bp from pter |
End:
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43,123,244 bp from pter |
Size:
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18,719 bases |
Orientation:
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plus strand |
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Proteins
for TTPAL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TTPAL_HUMAN, Q9BTX7 (See
protein sequence)Recommended Name: Alpha-tocopherol transfer protein-like Size: 342 amino acids; 38515 Da
Secondary accessions: E1P5X3 Q5QPC1 Q9H1G2 Q9NQG8Explore the universe of human proteins at neXtProt for TTPAL: NX_Q9BTX7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BTX7
TTPAL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001034288.1 NP_001248768.1 NP_077307.2
ENSEMBL proteins: ENSP00000262605 ENSP00000361995 ENSP00000361997 ENSP00000412720
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
TTPAL for ontologies About GeneDecksing
TTPAL Antibody Products:
Assay Products for TTPAL: |
Protein
Domains /
Families
for TTPAL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TTPAL for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BTX7ProtoNet protein and cluster: Q9BTX7 3 Blocks protein families: IPB001071 Cellular retinaldehyde-binding protein signature IPB001251 Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO) IPB008273 Cellular retinaldehyde-binding/triple function
UniProtKB/Swiss-Prot: TTPAL_HUMAN, Q9BTX7Similarity: Contains 1 CRAL-TRIO domain |
Function
for TTPAL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TTPAL_HUMAN, Q9BTX7Function: May act as a protein that binds a hydrophobic ligand (Potential)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTPAL (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTPAL (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TTPAL (NM_024331) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTPAL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTPAL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTPAL |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005215 | transporter activity |
IEA | -- |
TTPAL for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for TTPAL:
|
Pathways & Interactions
for TTPAL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTPAL
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for TTPAL (Q9BTX73 ENSP000002626054) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TTPAL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TTPAL
Search CenterWatch for drugs/clinical trials and news about TTPAL
|
Transcripts
for TTPAL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TTPAL gene (3 alternative transcripts): NM_001039199.2 NM_001261839.1 NM_024331.4 Unigene Cluster for TTPAL: Tocopherol (alpha) transfer protein-like Hs.283869 [show with all ESTs]Unigene Representative Sequence: NM_0243315 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000262605(uc002xmd.1 uc010ggr.1) ENST00000372904(uc002xmc.1)
ENST00000372906 ENST00000456317 ENST00000461134
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTPAL (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTPAL (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TTPAL (NM_024331) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTPAL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTPAL |
Additional cDNA sequence: AK056178.1 AK307236.1 AK314045.1 BC003071.2 CR936621.1 9 DOTS entries: DT.40314550 DT.425475 DT.440699 DT.95161462 DT.100024331 DT.95270572 DT.120837456 DT.95256850 DT.120837486 24/95 AceView cDNA sequences (see all 95): BQ128334 BM454474 AL707926 AI690985 NM_024331 BC003071 AI360302 BQ646722 AW874112 AA325298 BG030377 BM915194 BU902299 AA074871 BU735733 BG680428 BE383204 BU621308 BM461853 BM810916 AK125126 BF978648 AI674166 BU539920
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TTPAL (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b |
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| SP1: | | | | | | | - | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TTPAL
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Expression
for TTPAL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TTPAL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTCAGTCTG
About this image
See TTPAL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TTPAL
SOURCE GeneReport for Unigene cluster: Hs.283869
SABiosciences Custom PCR Arrays for TTPAL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTPAL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TTPAL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTPAL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTPAL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTPAL |
Orthologs
for TTPAL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TTPAL gene from 4/18 species (see all 18) About this table
ENSEMBL Gene Tree for TTPAL (if available)
TreeFam Gene Tree for TTPAL (if available) |
Paralogs
for TTPAL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TTPAL gene
- RLBP12 CLVS22 CLVS12 TTPA2
5 SIMAP similar genes for TTPAL using alignment to 3 protein entries: TTPAL_HUMAN (see all proteins):DKFZp686E0870 CLVS1 CLVS2 RLBP1 TTPA
TTPAL for paralogs About GeneDecksing
|
Genomic Variants
for TTPAL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TTPAL (43104526 - 43123244 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TTPAL: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTPAL |
|
Disorders
/ Diseases
for TTPAL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TTPAL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TTPAL gene integrated from 9 sources:
(articles sorted by number of sources associating them with TTPAL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (2005)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TTPAL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TTPAL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TTPAL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TTPAL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TTPAL | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TTPAL gene:
Search GeneIP for patents involving TTPAL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TTPAL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TTPAL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTPAL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTPAL | | | OriGene Protein Over-expression Lysate for TTPAL | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TTPAL | | OriGene 3'-UTR Clone for TTPAL | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTPAL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTPAL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TTPAL | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TTPAL | | OriGene Custom Protein Services for TTPAL | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TTPAL | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTPAL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTPAL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTPAL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTPAL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTPAL |
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 |  |  |  | |
| | | | Search Tocris compounds for TTPAL |
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 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTPAL |
|  |  |  | | | | ThermoFisher Antibody for TTPAL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTPAL |
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