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Aliases for TTPAL Gene

Aliases for TTPAL Gene

  • Alpha Tocopherol Transfer Protein Like 2 3 5
  • Tocopherol (Alpha) Transfer Protein-Like 2 3
  • C20orf121 3 4
  • Alpha-Tocopherol Transfer Protein-Like 3
  • Chromosome 20 Open Reading Frame 121 2

External Ids for TTPAL Gene

Previous HGNC Symbols for TTPAL Gene

  • C20orf121

Previous GeneCards Identifiers for TTPAL Gene

  • GC20P042538
  • GC20P043104
  • GC20P039846

Summaries for TTPAL Gene

GeneCards Summary for TTPAL Gene

TTPAL (Alpha Tocopherol Transfer Protein Like) is a Protein Coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is CLVS1.

UniProtKB/Swiss-Prot for TTPAL Gene

  • May act as a protein that binds a hydrophobic ligand.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTPAL Gene

Genomics for TTPAL Gene

Regulatory Elements for TTPAL Gene

Enhancers for TTPAL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G044493 1.4 FANTOM5 ENCODE dbSUPER 17.4 +20.1 20073 4.8 PKNOX1 JUN CEBPG EBF1 FOSL1 ZNF664 POLR2A EED SCRT2 FOSL2 PKIG TTPAL SERINC3 RPL37AP1 LINC01430 LINC01620 OSER1 ADA STK4 PIR60204
GH20G044608 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.2 +134.5 134453 3.7 HDGF PKNOX1 MLX WRNIP1 ARID4B DMAP1 ZNF2 YY1 SLC30A9 ZNF143 PKIG SYS1 TTPAL LINC01260 ADA OSER1 STK4 PIR61280
GH20G044530 1.4 ENCODE dbSUPER 6.1 +56.1 56146 2.3 HDGF MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 ZNF143 SYS1 PKIG TTPAL PIR61280
GH20G044578 1.6 FANTOM5 ENCODE dbSUPER 5.3 +107.6 107618 9.9 HDGF PKNOX1 FOXA2 ATF1 WRNIP1 YY1 FOS JUNB TBX21 GLIS1 PKIG TTPAL OSER1 PIR61280
GH20G044594 1.6 FANTOM5 Ensembl ENCODE dbSUPER 4.9 +119.0 118950 1.3 TAL1 UBTF EBF1 ZNF644 RELA FOSL1 TCF12 ELK1 EED FOS PKIG SERINC3 ADA LINC01430 LINC01620 TTPAL PIR61280
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTPAL on UCSC Golden Path with GeneCards custom track

Promoters for TTPAL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000137521 17 1001 HDGF PKNOX1 FOXA2 MLX ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1

Genomic Location for TTPAL Gene

Chromosome:
20
Start:
44,475,883 bp from pter
End:
44,494,603 bp from pter
Size:
18,721 bases
Orientation:
Plus strand

Genomic View for TTPAL Gene

Genes around TTPAL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTPAL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTPAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTPAL Gene

Proteins for TTPAL Gene

  • Protein details for TTPAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTX7-TTPAL_HUMAN
    Recommended name:
    Alpha-tocopherol transfer protein-like
    Protein Accession:
    Q9BTX7
    Secondary Accessions:
    • E1P5X3
    • Q5QPC1
    • Q9H1G2
    • Q9NQG8

    Protein attributes for TTPAL Gene

    Size:
    342 amino acids
    Molecular mass:
    38515 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TTPAL Gene

Post-translational modifications for TTPAL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTPAL Gene

Domains & Families for TTPAL Gene

Suggested Antigen Peptide Sequences for TTPAL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TTPAL: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TTPAL Gene

Function for TTPAL Gene

Molecular function for TTPAL Gene

UniProtKB/Swiss-Prot Function:
May act as a protein that binds a hydrophobic ligand.

Gene Ontology (GO) - Molecular Function for TTPAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
genes like me logo Genes that share ontologies with TTPAL: view
genes like me logo Genes that share phenotypes with TTPAL: view

Animal Model Products

CRISPR Products

miRNA for TTPAL Gene

miRTarBase miRNAs that target TTPAL

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTPAL Gene

Localization for TTPAL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTPAL gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for TTPAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with TTPAL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TTPAL Gene

Pathways & Interactions for TTPAL Gene

SuperPathways for TTPAL Gene

No Data Available

Interacting Proteins for TTPAL Gene

Gene Ontology (GO) - Biological Process for TTPAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with TTPAL: view

No data available for Pathways by source and SIGNOR curated interactions for TTPAL Gene

Drugs & Compounds for TTPAL Gene

No Compound Related Data Available

Transcripts for TTPAL Gene

Unigene Clusters for TTPAL Gene

Tocopherol (alpha) transfer protein-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTPAL Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3:
SP4: -
SP5:
SP6: - -

Relevant External Links for TTPAL Gene

GeneLoc Exon Structure for
TTPAL
ECgene alternative splicing isoforms for
TTPAL

Expression for TTPAL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTPAL Gene

mRNA differential expression in normal tissues according to GTEx for TTPAL Gene

This gene is overexpressed in Liver (x4.1).

Protein differential expression in normal tissues from HIPED for TTPAL Gene

This gene is overexpressed in Frontal cortex (42.5), Spleen (8.5), and Blymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTPAL Gene



NURSA nuclear receptor signaling pathways regulating expression of TTPAL Gene:

TTPAL

SOURCE GeneReport for Unigene cluster for TTPAL Gene:

Hs.283869

Evidence on tissue expression from TISSUES for TTPAL Gene

  • Liver(4.4)
genes like me logo Genes that share expression patterns with TTPAL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTPAL Gene

Orthologs for TTPAL Gene

This gene was present in the common ancestor of animals.

Orthologs for TTPAL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTPAL 34 35
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia TTPAL 34 35
  • 90.45 (n)
cow
(Bos Taurus)
Mammalia TTPAL 34 35
  • 87.52 (n)
mouse
(Mus musculus)
Mammalia Ttpal 34 16 35
  • 87.33 (n)
oppossum
(Monodelphis domestica)
Mammalia TTPAL 35
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttpal 34
  • 85.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TTPAL 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTPAL 34 35
  • 76.81 (n)
lizard
(Anolis carolinensis)
Reptilia TTPAL 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttpal 34
  • 66.86 (n)
zebrafish
(Danio rerio)
Actinopterygii ttpal 34 35
  • 64.87 (n)
Dr.26556 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009314 34
  • 48.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5958 35
  • 31 (a)
ManyToMany
CG10237 35
  • 29 (a)
ManyToMany
CG12926 35
  • 29 (a)
ManyToMany
CG31636 35
  • 29 (a)
ManyToMany
CG2663 35
  • 27 (a)
ManyToMany
pinta 35
  • 27 (a)
ManyToMany
CG10657 35
  • 26 (a)
ManyToMany
CG33514 35
  • 26 (a)
ManyToMany
CG33965 35
  • 26 (a)
ManyToMany
CG33966 35
  • 26 (a)
ManyToMany
CG5973 35
  • 26 (a)
ManyToMany
Cralbp 35
  • 26 (a)
ManyToMany
CG10026 35
  • 25 (a)
ManyToMany
CG10300 35
  • 24 (a)
ManyToMany
CG1902 35
  • 24 (a)
ManyToMany
CG30339 35
  • 24 (a)
ManyToMany
CG11550 35
  • 23 (a)
ManyToMany
CG3191 35
  • 22 (a)
ManyToMany
CG3823 35
  • 22 (a)
ManyToMany
CG10301 35
  • 20 (a)
ManyToMany
CG3091 35
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
ManyToMany
Species where no ortholog for TTPAL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTPAL Gene

ENSEMBL:
Gene Tree for TTPAL (if available)
TreeFam:
Gene Tree for TTPAL (if available)

Paralogs for TTPAL Gene

Paralogs for TTPAL Gene

(5) SIMAP similar genes for TTPAL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TTPAL: view

Variants for TTPAL Gene

Sequence variations from dbSNP and Humsavar for TTPAL Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000009529 -- 44,477,068(+) TCCAG(A/G)CAGAG intron-variant
rs1000027553 -- 44,474,772(+) GCAAA(C/T)AAAAC upstream-variant-2KB
rs1000104577 -- 44,485,944(+) GAGCC(-/CT)GTTTT intron-variant
rs1001005752 -- 44,490,443(+) GAGGC(C/T)CTGGG utr-variant-3-prime
rs1001226701 -- 44,476,322(+) ATGTC(C/T)GCCTG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TTPAL Gene

Variant ID Type Subtype PubMed ID
nsv1061719 CNV gain 25217958
nsv586065 CNV gain 21841781

Variation tolerance for TTPAL Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTPAL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTPAL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTPAL Gene

Disorders for TTPAL Gene

Relevant External Links for TTPAL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTPAL

No disorders were found for TTPAL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTPAL Gene

Publications for TTPAL Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  4. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 3 64
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64

Products for TTPAL Gene

Sources for TTPAL Gene

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