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TTN Gene

protein-coding   GIFtS: 69
GCID: GC02M179355

Titin

(Previous names: cardiomyopathy, dilated 1G (autosomal dominant))
(Previous symbol: CMD1G)
  See TTN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
titin1 2     CMH92
CMD1G1 2 5     CMPD42
Rhabdomyosarcoma Antigen MU-RMS-40.142 3     MYLK52
EOMFC2 5     connectin2
HMERF2 5     Connectin3
LGMD2J2 5     EC 2.7.11.13
TMD2 5     MPRM5
Cardiomyopathy, Dilated 1G (Autosomal Dominant)1     

External Ids:    HGNC: 124031   Entrez Gene: 72732   Ensembl: ENSG000001556577   OMIM: 1888405   UniProtKB: Q8WZ423   

Export aliases for TTN gene to outside databases

Previous GC identifers: GC02M177454 GC02M178061 GC02M179593 GC02M179216 GC02M179098 GC02M171261


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TTN Gene:
This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two
regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule,
contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline,
glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of
immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a
C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin
molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins
so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been
identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple
transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin.
Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and,
therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with
familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune
disease scleroderma. (provided by RefSeq, Feb 2012)

GeneCards Summary for TTN Gene:
TTN (titin) is a protein-coding gene. Diseases associated with TTN include scleroderma, and udd distal myopathy. GO annotations related to this gene include protein serine/threonine kinase activity and calcium ion binding. An important paralog of this gene is STK17B.

UniProtKB/Swiss-Prot: TITIN_HUMAN, Q8WZ42
Function: Key component in the assembly and functioning of vertebrate striated muscles. By providing connections
at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of
the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility
properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome
segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during
interphase

Gene Wiki entry for TTN (Titin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TTN gene promoter:
         STAT1   HNF-1   STAT1beta   IRF-1   STAT1alpha   HNF-1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TTN promoter sequence
   Search Chromatin IP Primers for TTN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31   Ensembl cytogenetic band:  2q31.2   HGNC cytogenetic band: 2q31

TTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTN gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M179355:  view genomic region     (about GC identifiers)

Start:
179,390,716 bp from pter      End:
179,695,529 bp from pter
Size:
304,814 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TITIN_HUMAN, Q8WZ42 (See protein sequence)
Recommended Name: Titin  
Size: 34350 amino acids; 3816030 Da
Cofactor: Magnesium
Subunit: Interacts with MYOM1, MYOM2, tropomyosin and myosin. Interacts with actin, primarily via the PEVK domains
and with MYPN (By similarity). Interacts with FHL2, NEB, CRYAB, LMNA/lamin-A and LMNB/lamin-B. Interacts with
TCAP/telethonin and/or ANK1 isoform Mu17/ank1.5, via the first two N-terminal immunoglobulin domains. Interacts
with TRIM63 and TRIM55, through several domains including immunoglobulin domains 141 and 142. Interacts with
ANKRD1, ANKRD2 and ANKRD23, via the region between immunoglobulin domains 77 and 78 and interacts with CAPN3, via
immunoglobulin domain 79. Interacts with NBR1 through the protein kinase domain. Interacts with CALM/calmodulin.
Isoform 6 interacts with OBSCN isoform 3. Interacts with CMYA5
Miscellaneous: In some isoforms, after the PEVK repeat region there is a long PEVK duplicated region. On account
of this region, it has been very difficult to sequence the whole protein. The length of this region (ranging from
183 to 2174 residues), may be a key elastic element of titin
Sequence caution: Sequence=AAH58824.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence starting in position 553; Sequence=AAH70170.1; Type=Miscellaneous discrepancy; Note=Contaminating
sequence. Potential poly-A sequence starting in position 627; Sequence=CAA62188.1; Type=Frameshift;
Positions=17036, 17043; Sequence=CAD12455.1; Type=Frameshift; Positions=17036, 17043;
Selected PDB 3D structures from and Proteopedia for TTN (see all 30):
1BPV (3D)        1G1C (3D)        1NCT (3D)        1NCU (3D)        1TIT (3D)        1TIU (3D)    
Secondary accessions: A6NKB1 E7EQE6 E7ET18 K7ENY1 Q10465 Q10466 Q15598 Q2XUS3 Q32Q60 Q4U1Z6
Q4ZG20 Q6NSG0 Q6PDB1 Q6PJP0 Q7KYM2 Q7KYN4 Q7KYN5 Q7LDM3 Q7Z2X3 Q8TCG8 Q8WZ51 Q8WZ52 Q8WZ53
Q8WZB3 Q92761 Q92762 Q9UD97 Q9UP84 Q9Y6L9
Alternative splicing: 13 isoforms:  Q8WZ42-1   Q8WZ42-2   Q8WZ42-3   Q8WZ42-4   Q8WZ42-5   Q8WZ42-6   Q8WZ42-7   Q8WZ42-8   
Q8WZ42-9   Q8WZ42-10   Q8WZ42-11   Q8WZ42-12   Q8WZ42-13   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TTN: NX_Q8WZ42

Explore proteomics data for TTN at MOPED

Post-translational modifications: 

  • Autophosphorylated (By similarity)1
  • Ubiquitination2 at Lys10718, Lys10733, Lys10740, Lys29566, Lys30146
  • Modification sites at PhosphoSitePlus

  • See TTN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001243779.1  NP_001254479.1  NP_003310.4  NP_596869.4  NP_596870.2  NP_597676.3  NP_597681.3  

    ENSEMBL proteins: 
     ENSP00000343764   ENSP00000434586   ENSP00000467141   ENSP00000465570   ENSP00000401501  
     ENSP00000392336   ENSP00000408004   ENSP00000396805   ENSP00000399176   ENSP00000354117  
     ENSP00000405517   ENSP00000394672   ENSP00000340554   ENSP00000352154  
    Reactome Protein details: Q8WZ42

    TTN Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TTN
    GenScript Custom Purified and Recombinant Proteins Services for TTN
    Novus Biologicals TTN Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TTN

     
    Search eBioscience for Proteins for TTN 

    TTN Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TTN
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    OriGene Custom Antibody Services for TTN
    Novus Biologicals TTN Antibodies
    Abcam antibodies for TTN
    Cloud-Clone Corp. Antibodies for TTN
    ThermoFisher Antibodies for TTN
    LSBio Antibodies in human, mouse, rat for TTN

    TTN Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TTN
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TTN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TTN
    Cloud-Clone Corp. CLIAs for TTN
    Search eBioscience for ELISAs for TTN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: titin
    Myosin Light Chain Kinase (MLCK) family

    Selected InterPro protein domains (see all 12):
     IPR003598 Ig_sub2
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8WZ42

    ProtoNet protein and cluster: Q8WZ42

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: TITIN_HUMAN, Q8WZ42
    Domain: ZIS1 and ZIS5 regions contain multiple SPXR consensus sites for ERK- and CDK-like protein kinases as well
    as multiple SP motifs. ZIS1 could adopt a closed conformation which would block the TCAP-binding site
    Domain: The PEVK region may serve as an entropic spring of a chain of structural folds and may also be an
    interaction site to other myofilament proteins to form interfilament connectivity in the sarcomere
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 132 fibronectin type-III domains
    Similarity: Contains 152 Ig-like (immunoglobulin-like) domains
    Similarity: Contains 19 Kelch repeats
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 17 RCC1 repeats
    Similarity: Contains 14 TPR repeats
    Similarity: Contains 15 WD repeats


    Find genes that share domains with TTN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TITIN_HUMAN, Q8WZ42
    Function: Key component in the assembly and functioning of vertebrate striated muscles. By providing connections
    at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of
    the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility
    properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome
    segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during
    interphase
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Full activation of the protein kinase domain requires both phosphorylation of Tyr-32341,
    preventing it from blocking the catalytic aspartate residue, and binding of Ca/CALM to the C-terminal regulatory
    tail of the molecule which results in ATP binding to the kinase

         Genatlas biochemistry entry for TTN:
    titin,giant sarcomeric protein,extending from the M line to the Z line of striated muscle sarcomere,essential in
    the temporal and spatial control of the assembly of the highly ordered sarcomeres of striated muscles,responsible
    for the elasticity of relaxed striated muscle

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI9642272
    GO:0003676nucleic acid binding ----
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA9804419
    GO:0004713protein tyrosine kinase activity IEA--
         
    Find genes that share ontologies with TTN           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TTN:
     Decreased substrate adherent c  Increased cell death HMECs cel 

         13 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Ttn):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     growth/size/body  homeostasis/metabolism  immune system  mortality/aging  muscle 
     normal  skeleton  vision/eye 

    Find genes that share phenotypes with TTN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TTN: Ttntm1.1Her Ttntm1Mgot

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TTN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TTN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TTN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TTN

    miRNA
    Products:
        
    miRTarBase miRNAs that target TTN:
    hsa-mir-26a-5p (MIRT050140)

    Block miRNA regulation of human, mouse, rat TTN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TTN (see all 18):
    hsa-miR-522 hsa-miR-451 hsa-miR-1304 hsa-miR-144 hsa-miR-629* hsa-miR-1323 hsa-miR-532-5p hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidTTN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TTN
    Predesigned siRNA for gene silencing in human, mouse, rat TTN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TTN

    Clone
    Products:
         
    OriGene clones in human, mouse for TTN (see all 8)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TTN (NM_138565)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TTN
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TTN

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TTN
    Browse ESI BIO Cell Lines and PureStem Progenitors for TTN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TITIN_HUMAN, Q8WZ42: Cytoplasm (Probable). Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol4
    extracellular4
    golgi apparatus4
    endoplasmic reticulum1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000794condensed nuclear chromosome IDA9548712
    GO:0005576extracellular region TAS--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with TTN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TTN About    
    See pathways by source

    SuperPathContained pathways About
    1Striated Muscle Contraction
    Striated Muscle Contraction0.82
    Muscle contraction0.61
    Striated Muscle Contraction0.82
    2Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94
    3Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Dilated cardiomyopathy0.75
    4Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43


    Find genes that share SuperPaths with TTN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TTN
        Striated Muscle Contraction

    2 Reactome Pathways for TTN
        Platelet degranulation
    Striated Muscle Contraction


    2 Kegg Pathways  (Kegg details for TTN):
        Hypertrophic cardiomyopathy (HCM)
    Dilated cardiomyopathy

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TTN: 
              Interferons & Receptors in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TTN

    Selected Interacting proteins for TTN (Q8WZ421, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 125)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OBSL1O751471, 2, 3EBI-681210,EBI-1223896 MINT-7979729 MINT-7979611 MINT-7979766 MINT-7979747 MINT-7979789 MINT-7979631 MINT-7979704 MINT-7979686 I2D: score=1 
    OBSCNQ5VST91, 2, 3EBI-681210,EBI-941850 MINT-7979881 MINT-7979650 MINT-7979863 MINT-7979665 MINT-7979826 MINT-7979808 MINT-7979844 I2D: score=3 
    NEBP209291, 2, 3EBI-681210,EBI-1049657 MINT-2882539 MINT-7032264 MINT-2882627 MINT-2882669 MINT-7032305 MINT-7032278 I2D: score=2 
    CALM1P621581, 2, 3EBI-681210,EBI-397435 MINT-7899812 I2D: score=1 
    CALM2P621581, 2, 3EBI-681210,EBI-397435 MINT-7899812 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0002576platelet degranulation TAS--
    GO:0003007heart morphogenesis ----
    GO:0003300cardiac muscle hypertrophy IMP11846417
    GO:0006468protein phosphorylation ----

    Find genes that share ontologies with TTN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TTN (TITIN)

    1 HMDB Compound for TTN    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    Selected Novoseek inferred chemical compound relationships for TTN gene (see all 24)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ryanodine 54.5 27 11074791 (4), 9546812 (2), 14592894 (2), 16637922 (2) (see all 19)
    proline 43.5 9 8760502 (1), 16339921 (1), 9675168 (1), 8937992 (1) (see all 8)
    acetylcholine 40.5 12 9521611 (1), 9854961 (1), 14592910 (1), 16720217 (1) (see all 12)
    actomyosin 40.1 8 12815860 (3), 16453158 (2), 8534821 (1)
    leupeptin 37 3 11519738 (1), 9648223 (1), 8276755 (1)
    valine 31.6 5 8760502 (1), 16339921 (1), 9675168 (1), 10364572 (1)
    pip2 23.5 5 15833278 (1), 9657390 (1)
    lysine 21.5 5 8760502 (1), 16339921 (1), 9675168 (1), 10364572 (1)
    ethyl methanesulfonate 14.9 1 15259051 (1)
    calcium 14.8 36 18690715 (6), 11519738 (4), 14706862 (3), 14593205 (1) (see all 18)



    Find genes that share compounds with TTN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TTN gene (7 alternative transcripts): 
    NM_001256850.1  NM_001267550.1  NM_003319.4  NM_133378.4  NM_133379.4  NM_133432.3  NM_133437.3  

    Unigene Cluster for TTN:

    Titin
    Hs.134602  [show with all ESTs]
    Unigene Representative Sequence: NM_001267550
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342992(uc002umw.1 uc002una.1 uc010frf.1 uc010fre.1 uc002umz.1 uc021vsy.1)
    ENST00000460472(uc002umq.3 uc021vtb.1) ENST00000589042 ENST00000591111
    ENST00000414766 ENST00000426232 ENST00000446966(uc002umx.1) ENST00000425332(uc010zfk.1)
    ENST00000448510 ENST00000360870(uc010frg.1 uc002unb.2) ENST00000436599
    ENST00000470257(uc002und.3) ENST00000412264 ENST00000342175(uc021vsz.1)
    ENST00000359218(uc021vta.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TTN (see all 18):
    hsa-miR-522 hsa-miR-451 hsa-miR-1304 hsa-miR-144 hsa-miR-629* hsa-miR-1323 hsa-miR-532-5p hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidTTN 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat TTN

    Additional mRNA sequence: 

    AF321609.2 AF525413.1 AK056602.1 AK090903.1 AK091732.1 AK092284.1 AK096883.1 AK125056.1 
    AK129531.1 AK129757.1 AK129919.1 AL713647.1 AL832094.1 AL832351.1 AL833110.1 AL833292.1 
    BC013396.2 BC017983.1 BC026297.1 BC029400.1 BC030823.1 BC058824.1 BC070170.1 BC107797.1 
    BX537998.1 DQ248309.1 EF212153.1 EF212154.1 EF212155.1 EF212156.1 EU428784.1 X64697.1 
    X64698.1 X69490.1 X83270.1 X90568.1 X90569.1 X98114.1 X98115.1 

    Selected DOTS entries (see all 59):

    DT.40305982  DT.87017845  DT.91943853  DT.102839578  DT.75106611  DT.100042202  DT.120958407  DT.120958414 
    DT.91775084  DT.120958266  DT.95208755  DT.100664174  DT.75136394  DT.120958289  DT.120958437  DT.220534 
    DT.95152671  DT.100042738  DT.100651430  DT.100913562  DT.101985634  DT.411096  DT.432606  DT.100642525 

    Selected AceView cDNA sequences (see all 481):

    AI803531 BX501046 AI269724 AI332429 F36665 X83270 BX507270 BX500025 
    BQ926050 BX501304 AA086447 CF552750 BX953355 BU743014 F28302 BX096752 
    BC058824 AI051675 F34840 AI338273 F16872 AJ710712 CF552550 F27402 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TTN (see all 38)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23b · 23c ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 45 ^ 46 ^ 47 ^ 48 ^ 49 ^ 50 ^ 51 ^ 52 ^ 53 ^ 54 ^ 55 ^ 56 ^ 57 ^ 58 ^ 59a · 59b ^ 60a · 60b ^ 61 ^ 62 ^ 63 ^ 64a · 64b ^ 65 ^ 66 ^ 67 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 68 ^ 69 ^ 70 ^ 71 ^ 72 ^ 73 ^ 74 ^ 75 ^ 76 ^ 77 ^ 78 ^ 79 ^ 80 ^ 81 ^ 82 ^ 83a · 83b ^ 84 ^ 85 ^ 86 ^ 87 ^ 88 ^ 89 ^ 90 ^ 91 ^ 92 ^
    SP1:                                                                                                        -     -     -     -                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 93 ^ 94a · 94b ^ 95 ^ 96a · 96b · 96c ^ 97 ^ 98 ^ 99 ^ 100 ^ 101 ^ 102 ^ 103 ^ 104 ^ 105 ^ 106 ^ 107 ^ 108 ^ 109 ^ 110 ^ 111 ^ 112 ^ 113 ^ 114 ^ 115 ^
    SP1:                    -                                                                                                                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 116 ^ 117 ^ 118 ^ 119 ^ 120 ^ 121 ^ 122 ^ 123 ^ 124 ^ 125 ^ 126 ^ 127 ^ 128 ^ 129 ^ 130 ^ 131a · 131b ^ 132a · 132b ^ 133 ^ 134 ^ 135 ^ 136 ^ 137 ^ 138 ^ 139 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 140 ^ 141a · 141b ^ 142 ^ 143 ^ 144 ^ 145 ^ 146 ^ 147 ^ 148 ^ 149 ^ 150a · 150b ^ 151a · 151b · 151c ^ 152a · 152b ^ 153a · 153b ^ 154 ^ 155 ^ 156 ^ 157 ^ 158 ^ 159 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 160 ^ 161 ^ 162 ^ 163 ^ 164 ^ 165 ^ 166 ^ 167 ^ 168 ^ 169 ^ 170 ^ 171 ^ 172 ^ 173 ^ 174 ^ 175 ^ 176 ^ 177 ^ 178 ^ 179a ·
    SP1:                                                                                                                        
    SP2:                                                                                                                        
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for TTN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TTN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGTATAAA
    TTN Expression
    About this image


    TTN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 19 entries
             Mononuclear Myocytes Hyoid Arch Muscles
             Extraocular Muscles
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Cardiomyocytes Myocardium
             Cardiomyocyte-like progenitor cells
     
     Limb (Muscoskeletal System)    fully expand to see all 7 entries
             Multinuclear Myocytes Forelimb Dorsal Muscles
             Autopod
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Long Bone
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    TTN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TTN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.134602

    UniProtKB/Swiss-Prot: TITIN_HUMAN, Q8WZ42
    Tissue specificity: Isoforms 3, 7 and 8 are expressed in cardiac muscle. Isoform 4 is expressed in vertebrate
    skeletal muscle. Isoform 6 is expressed in skeletal muscle (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TTN: 
              Interferons & Receptors in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TTN gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttn1 , 5 titin1, 5 86.69(n)1
    91.56(a)1
      2 (45.13 cM)5
    221381  NM_011652.31  NP_035782.31 
     767039805 
    chicken
    (Gallus gallus)
    Aves TTN1 titin 73.65(n)
    75.25(a)
      424126  XM_004942701.1  XP_004942758.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia 480534122   -- 76.61(n)    48053412 
    zebrafish
    (Danio rerio)
    Actinopterygii AY081167.12   -- 78.18(n)   317731  AY081167.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F21C10.73   -- 40(a)
    (best of 3)
      V(9115384-9124640)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MEK16
    Meiosis-specific serine/threonine protein kinase, ...
    25(a)
    1 → many
    XV(995018-996511) YOR351C


    ENSEMBL Gene Tree for TTN (if available)
    TreeFam Gene Tree for TTN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for TTN gene
    STK17B2  DAPK22  MYLK22  STK17A2  MYLK32  OBSCN2  DAPK32  SPEG2  
    MYLK42  DAPK12  MYLK2  
    Selected SIMAP similar genes for TTN using alignment to 13 protein entries:     TITIN_HUMAN (see all proteins) (see all similar genes):
    MYLK4    ROBO1    STK17B    DAPK3    BRSK2    STK17A
    MYLK    CAMK2A    DAPK1    PRKD1    DAPK2    RPS6KA1
    PALLD    CAMK4    PRKCH    DKFZp686I10125    FGFR3    PHKG2

    Find genes that share paralogs with TTN           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TTN
    PGOHUM00000240442


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for TTN (see all 8499)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289334051,2,,4
    CCardiomyopathy, familial hypertrophic 9 (CMH9)4 pathogenic1179039730(-) GGAACG/TCATTT 14 R L mis10--------
    VAR_0401444
    A metastatic melanoma sample4--see VAR_0401442 E K mis40--------
    VAR_0400924
    A metastatic melanoma sample4--see VAR_0400922 A T mis40--------
    VAR_0401564
    A lung small cell carcinoma sample4--see VAR_0401562 Q H mis40--------
    VAR_0266924
    Cardiomyopathy, dilated 1G (CMD1G)4--see VAR_0266922 S N mis40--------
    VAR_0402124
    A metastatic melanoma sample4--see VAR_0402122 A T mis40--------
    VAR_0266894
    Cardiomyopathy, dilated 1G (CMD1G)4--see VAR_0266892 W R mis40--------
    VAR_0400794
    A metastatic melanoma sample4--see VAR_0400792 V M mis40--------
    VAR_0402724
    A lung small cell carcinoma sample4--see VAR_0402722 K E mis40--------
    VAR_0401984
    A lung neuroendocrine carcinoma sample4--see VAR_0401982 E K mis40--------

    HapMap Linkage Disequilibrium report for TTN (179390716 - 179640716 bp, first 250kb of TTN)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TTN (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv821308CNV Duplication20802225
    esv272047CNV Insertion20981092
    esv1134788CNV Insertion17803354
    nsv3058CNV Insertion18451855
    nsv10202CNV Loss18304495
    esv26878CNV Loss19812545
    nsv834467CNV Loss17160897
    nsv834470CNV Gain17160897
    nsv522036CNV Gain19592680
    nsv834468CNV Gain17160897

    Human Gene Mutation Database (HGMD): TTN
    Locus Specific Mutation Databases (LSDB): TTN

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TTN
    DNA2.0 Custom Variant and Variant Library Synthesis for TTN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 188840   
    OMIM disorders: 613765  604145  600334  608807  603689  611705  
    UniProtKB/Swiss-Prot: TITIN_HUMAN, Q8WZ42
  • Hereditary myopathy with early respiratory failure (HMERF) [MIM:603689]: Autosomal dominant, adult-onset
    myopathy with early respiratory muscle involvement. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Cardiomyopathy, familial hypertrophic 9 (CMH9) [MIM:613765]: A hereditary heart disorder characterized by
    ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms
    include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The
    disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of
    cardiac failure and sudden cardiac death. Note=The disease is caused by mutations affecting the gene represented
    in this entry
  • Cardiomyopathy, dilated 1G (CMD1G) [MIM:604145]: A disorder characterized by ventricular dilation and
    impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of
    premature death. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Tardive tibial muscular dystrophy (TMD) [MIM:600334]: Autosomal dominant, late-onset distal myopathy.
    Muscle weakness and atrophy are usually confined to the anterior compartment of the lower leg, in particular the
    tibialis anterior muscle. Clinical symptoms usually occur at age 35-45 years or much later. Note=The disease is
    caused by mutations affecting the gene represented in this entry
  • Limb-girdle muscular dystrophy 2J (LGMD2J) [MIM:608807]: An autosomal recessive degenerative myopathy
    characterized by progressive weakness of the pelvic and shoulder girdle muscles. Severe disability is observed
    within 20 years of onset. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Early-onset myopathy with fatal cardiomyopathy (EOMFC) [MIM:611705]: Early-onset myopathies are inherited
    muscle disorders that manifest typically from birth or infancy with hypotonia, muscle weakness, and delayed motor
    development. EOMFC is a titinopathy that, in contrast with the previously described examples, involves both heart
    and skeletal muscle, has a congenital onset, and is purely recessive. This phenotype is due to homozygous
    out-of-frame TTN deletions, which lead to a total absence of titin's C-terminal end from striated muscles and to
    secondary CAPN3 depletion. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for TTN (see all 30):    
    About MalaCards
    scleroderma    udd distal myopathy    cardiomyopathy, dilated, 1g    hereditary myopathy with early respiratory failure
    ttn-related dilated cardiomyopathy    cardiomyopathy, familial hypertrophic, 9    rhabdomyosarcoma    antenatal multiminicore disease with arthrogryposis multiplex congenita
    distal myopathy markesbery-griggs type    salih myopathy    ttn-related familial hypertrophic cardiomyopathy    limb-girdle muscular dystrophy type 2j
    respiratory failure    casp10-related autoimmune lymphoproliferative syndrome    morvan's fibrillary chorea    rigid spine syndrome
    newborn respiratory distress syndrome    familial hypertrophic cardiomyopathy    rippling muscle disease    mucinous adenocarcinoma

    10 diseases from the University of Copenhagen DISEASES database for TTN:
    Myopathy     Thymoma     Neuropathy     Newborn respiratory distress syndrome
    Dilated cardiomyopathy     Hypertrophic cardiomyopathy     Familial hypertrophic cardiomyopathy     Hypersensitivity reaction type II disease
    Meconium aspiration syndrome     Diastolic heart failure

    Find genes that share disorders with TTN           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TTN gene (see all 41)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lgmd2a 80.4 15 10987085 (2), 14959561 (1), 9642272 (1), 11294923 (1) (see all 7)
    lgmd2g 78.1 6 14959561 (1), 15316618 (1), 12379311 (1)
    myasthenia gravis 75.5 31 9467662 (3), 11766610 (2), 11063835 (2), 9065023 (2) (see all 24)
    thymoma 73.5 59 9451594 (4), 10896269 (4), 11182151 (4), 11706095 (4) (see all 23)
    muscular dystrophy limb-girdle 72.8 4 16115818 (1), 8537379 (1), 18477606 (1), 15043707 (1)
    lgmd1a 68.8 2 15316618 (1)
    distal myopathies 67.9 5 17337483 (2), 15728284 (1), 16793270 (1), 18948003 (1)
    lgmd2h 67.3 4 14959561 (1), 15316618 (1)
    muscular dystrophies 64.7 19 11829483 (3), 16115818 (2), 11294923 (1), 8064303 (1) (see all 12)
    lgmd2f 64.6 4 14959561 (1), 15316618 (1)

    GeneTests: TTN
    GeneReviews: TTN
    Genetic Association Database (GAD): TTN
    Human Genome Epidemiology (HuGE) Navigator: TTN (9 documents)

    Export disorders for TTN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TTN gene, integrated from 10 sources (see all 504):
    (articles sorted by number of sources associating them with TTN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Familial dilated cardiomyopathy locus maps to chromosome 2q31. (PubMed id 10051295)1, 2, 3 Siu B.L.... Seidman C.E. (Circulation 1999)
    2. Cardiac ankyrin repeat protein gene (ANKRD1) mutations in hypertrophic cardiomyopathy. (PubMed id 19608031)1, 4, 9 Arimura T....Kimura A. (J. Am. Coll. Cardiol. 2009)
    3. Functional analysis of titin/connectin N2-B mutations found in cardiomyopathy. (PubMed id 16465475)1, 2, 9 Matsumoto Y.... Kimura A. (J. Muscle Res. Cell Motil. 2005)
    4. Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin. (PubMed id 12145747)1, 2, 9 Hackman P.... Udd B. (Am. J. Hum. Genet. 2002)
    5. Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy. (PubMed id 11788824)1, 2, 9 Gerull B.... Thierfelder L. (Nat. Genet. 2002)
    6. Titin mutations as the molecular basis for dilated cardiomyopathy. (PubMed id 11846417)1, 2, 9 Itoh-Satoh M.... Kimura A. (Biochem. Biophys. Res. Commun. 2002)
    7. Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity. (PubMed id 10850961)1, 2, 9 Freiburg A.... Labeit S. (Circ. Res. 2000)
    8. Association of the chaperone alphaB-crystallin with titin in heart muscle. (PubMed id 14676215)1, 2, 9 Bullard B.... Linke W.A. (J. Biol. Chem. 2004)
    9. Structural evidence for a possible role of reversible disulphide bridge formation in the elasticity of the muscle protein titin. (PubMed id 11525170)1, 2, 9 Mayans O.... Wilmanns M. (Structure 2001)
    10. The three-dimensional structure of a type I module from titin: a prototype of intracellular fibronectin type III domains. (PubMed id 9782056)1, 2, 9 Goll C.M.... Nilges M. (Structure 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7273 HGNC: 12403 AceView: TTN Ensembl:ENSG00000155657 euGenes: HUgn7273
    ECgene: TTN Kegg: 7273 H-InvDB: TTN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TTN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TTN Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=TTN[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/Titin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TTN gene:
    Search GeneIP for patents involving TTN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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