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Aliases for TTLL9 Gene

Aliases for TTLL9 Gene

  • Tubulin Tyrosine Ligase Like 9 2 3 5
  • Tubulin--Tyrosine Ligase-Like Protein 9 3 4
  • C20orf125 3 4
  • Tubulin Tyrosine Ligase-Like Family, Member 9 3
  • Tubulin Tyrosine Ligase-Like Family Member 9 2
  • Chromosome 20 Open Reading Frame 125 2
  • EC 6.-.-.- 4

External Ids for TTLL9 Gene

Previous HGNC Symbols for TTLL9 Gene

  • C20orf125

Previous GeneCards Identifiers for TTLL9 Gene

  • GC20P029925
  • GC20P030458
  • GC20P027247

Summaries for TTLL9 Gene

GeneCards Summary for TTLL9 Gene

TTLL9 (Tubulin Tyrosine Ligase Like 9) is a Protein Coding gene. Diseases associated with TTLL9 include Primary Ciliary Dyskinesia. GO annotations related to this gene include ligase activity. An important paralog of this gene is TTLL8.

UniProtKB/Swiss-Prot for TTLL9 Gene

  • Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL9 Gene

Genomics for TTLL9 Gene

Regulatory Elements for TTLL9 Gene

Enhancers for TTLL9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TTLL9 on UCSC Golden Path with GeneCards custom track

Promoters for TTLL9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TTLL9 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTLL9 Gene

31,870,702 bp from pter
31,944,963 bp from pter
74,262 bases
Plus strand

Genomic View for TTLL9 Gene

Genes around TTLL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTLL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTLL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL9 Gene

Proteins for TTLL9 Gene

  • Protein details for TTLL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable tubulin polyglutamylase TTLL9
    Protein Accession:
    Secondary Accessions:
    • A6NH06
    • A6NIS5
    • B3KSG8
    • Q3SXZ8
    • Q5JYS3
    • Q5JYS4

    Protein attributes for TTLL9 Gene

    439 amino acids
    Molecular mass:
    51472 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI42576.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI42577.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76401.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TTLL9 Gene


neXtProt entry for TTLL9 Gene

Proteomics data for TTLL9 Gene at MOPED

Post-translational modifications for TTLL9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTLL9 Gene

Domains & Families for TTLL9 Gene

Gene Families for TTLL9 Gene

Protein Domains for TTLL9 Gene


Suggested Antigen Peptide Sequences for TTLL9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 TTL domain.
  • Contains 1 TTL domain.
genes like me logo Genes that share domains with TTLL9: view

Function for TTLL9 Gene

Molecular function for TTLL9 Gene

UniProtKB/Swiss-Prot Function:
Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity).

Enzyme Numbers (IUBMB) for TTLL9 Gene

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTLL9 Gene

Localization for TTLL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTLL9 Gene

Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for TTLL9 Gene COMPARTMENTS Subcellular localization image for TTLL9 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
cytosol 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TTLL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IEA --
genes like me logo Genes that share ontologies with TTLL9: view

Pathways & Interactions for TTLL9 Gene

SuperPathways for TTLL9 Gene

No Data Available

Interacting Proteins for TTLL9 Gene

Gene Ontology (GO) - Biological Process for TTLL9 Gene


No data available for Pathways by source and SIGNOR curated interactions for TTLL9 Gene

Drugs & Compounds for TTLL9 Gene

No Compound Related Data Available

Transcripts for TTLL9 Gene

Unigene Clusters for TTLL9 Gene

Tubulin tyrosine ligase-like family, member 9:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL9 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - - -
SP5: - - - - - -

Relevant External Links for TTLL9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTLL9 Gene

mRNA expression in normal human tissues for TTLL9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTLL9 Gene

This gene is overexpressed in Testis (x9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TTLL9 Gene

SOURCE GeneReport for Unigene cluster for TTLL9 Gene Hs.712915

genes like me logo Genes that share expression patterns with TTLL9: view

Protein tissue co-expression partners for TTLL9 Gene

- Elite partner

Primer Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTLL9 Gene

Orthologs for TTLL9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTLL9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TTLL9 35
  • 90.49 (n)
  • 92.81 (a)
TTLL9 36
  • 85 (a)
(Canis familiaris)
Mammalia TTLL9 35
  • 89.45 (n)
  • 94.24 (a)
TTLL9 36
  • 85 (a)
(Mus musculus)
Mammalia Ttll9 35
  • 85.61 (n)
  • 90.89 (a)
Ttll9 16
Ttll9 36
  • 78 (a)
(Pan troglodytes)
Mammalia TTLL9 35
  • 99.16 (n)
  • 99.09 (a)
TTLL9 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ttll9 35
  • 86.73 (n)
  • 92.33 (a)
(Monodelphis domestica)
Mammalia TTLL9 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia TTLL9 36
  • 54 (a)
(Gallus gallus)
Aves TTLL9 35
  • 71.89 (n)
  • 74.29 (a)
TTLL9 36
  • 65 (a)
(Anolis carolinensis)
Reptilia TTLL9 36
  • 75 (a)
(Danio rerio)
Actinopterygii ttll9 35
  • 69.93 (n)
  • 72.55 (a)
ttll9 36
  • 65 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10900 35
(Caenorhabditis elegans)
Secernentea ttll-9 35
  • 53.73 (n)
  • 51.27 (a)
ttll-9 36
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBY1 36
  • 10 (a)
Species with no ortholog for TTLL9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TTLL9 Gene

Gene Tree for TTLL9 (if available)
Gene Tree for TTLL9 (if available)

Paralogs for TTLL9 Gene

(3) SIMAP similar genes for TTLL9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TTLL9: view

Variants for TTLL9 Gene

Sequence variations from dbSNP and Humsavar for TTLL9 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs17093689 - 31,908,611(+) TTTCT(A/G)CTGGT reference, missense
rs998134 -- 31,923,267(+) GTTCA(A/G)AAAAA intron-variant
rs1883506 -- 31,906,181(+) TTAGG(C/T)GCGGG intron-variant
rs1977092 -- 31,888,564(+) cctcc(C/T)gggtt intron-variant
rs1977093 -- 31,907,438(+) CACTG(C/G)Aggcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTLL9 Gene

Variant ID Type Subtype PubMed ID
nsv833952 CNV Gain 17160897
nsv912836 CNV Loss 21882294
nsv3347 CNV Insertion 18451855
esv21897 CNV Gain 19812545
nsv817890 CNV Gain 17921354
nsv517635 CNV Gain 19592680

Variation tolerance for TTLL9 Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.53% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TTLL9 Gene

Disorders for TTLL9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TTLL9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
primary ciliary dyskinesia
  • kartagener syndrome
- elite association - COSMIC cancer census association via MalaCards
Search TTLL9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TTLL9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TTLL9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTLL9 Gene

Publications for TTLL9 Gene

  1. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PMID: 15890843) Janke C. … Edde B. (Science 2005) 2 3 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TTLL9 Gene

Sources for TTLL9 Gene