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Aliases for TTLL9 Gene

Aliases for TTLL9 Gene

  • Tubulin Tyrosine Ligase-Like Family Member 9 2 3
  • Tubulin--Tyrosine Ligase-Like Protein 9 3 4
  • C20orf125 3 4
  • Tubulin Tyrosine Ligase-Like Family, Member 9 3
  • Probable Tubulin Polyglutamylase TTLL9 3
  • Chromosome 20 Open Reading Frame 125 2
  • DJ310O13.1 3
  • EC 6.-.-.- 4

External Ids for TTLL9 Gene

Previous Symbols for TTLL9 Gene

  • C20orf125

Summaries for TTLL9 Gene

GeneCards Summary for TTLL9 Gene

TTLL9 (Tubulin Tyrosine Ligase-Like Family Member 9) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is TTLL8.

UniProtKB/Swiss-Prot for TTLL9 Gene

  • Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL9 Gene

Genomics for TTLL9 Gene

Genomic Location for TTLL9 Gene

Start:
31,870,702 bp from pter
End:
31,944,967 bp from pter
Size:
74,266 bases
Orientation:
Plus strand

Genomic View for TTLL9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTLL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL9 Gene

Regulatory Elements for TTLL9 Gene

Proteins for TTLL9 Gene

  • Protein details for TTLL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3SXZ7-TTLL9_HUMAN
    Recommended name:
    Probable tubulin polyglutamylase TTLL9
    Protein Accession:
    Q3SXZ7
    Secondary Accessions:
    • A6NH06
    • A6NIS5
    • B3KSG8
    • Q3SXZ8
    • Q5JYS3
    • Q5JYS4

    Protein attributes for TTLL9 Gene

    Size:
    439 amino acids
    Molecular mass:
    51472 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI42576.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI42577.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76401.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TTLL9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTLL9 Gene

Proteomics data for TTLL9 Gene at MOPED

Post-translational modifications for TTLL9 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TTLL9 Gene

Domains for TTLL9 Gene

Gene Families for TTLL9 Gene

HGNC:
  • TTLL :Tubulin tyrosine ligase-like family

Protein Domains for TTLL9 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

TTLL9_HUMAN
Domain:
  • Contains 1 TTL domain.:
    • Q3SXZ7
genes like me logo Genes that share domains with TTLL9: view

Function for TTLL9 Gene

Molecular function for TTLL9 Gene

UniProtKB/Swiss-Prot Function: Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity).

Enzyme Numbers (IUBMB) for TTLL9 Gene

Gene Ontology (GO) - Molecular Function for TTLL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TTLL9: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TTLL9 Gene

Localization for TTLL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTLL9 Gene

Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTLL9 Gene COMPARTMENTS Subcellular localization image for TTLL9 gene
Compartment Confidence
cytoskeleton 3
cytosol 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TTLL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
GO:0005929 cilium IEA --
genes like me logo Genes that share ontologies with TTLL9: view

Pathways for TTLL9 Gene

SuperPathways for TTLL9 Gene

No Data Available

Interacting Proteins for TTLL9 Gene

Gene Ontology (GO) - Biological Process for TTLL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
genes like me logo Genes that share ontologies with TTLL9: view

No data available for Pathways by source for TTLL9 Gene

Transcripts for TTLL9 Gene

Unigene Clusters for TTLL9 Gene

Tubulin tyrosine ligase-like family, member 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL9 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6:

Relevant External Links for TTLL9 Gene

GeneLoc Exon Structure for
TTLL9
ECgene alternative splicing isoforms for
TTLL9

Expression for TTLL9 Gene

mRNA expression in normal human tissues for TTLL9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTLL9 Gene

This gene is overexpressed in Testis (9.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TTLL9 Gene

SOURCE GeneReport for Unigene cluster for TTLL9 Gene Hs.712915

genes like me logo Genes that share expressions with TTLL9: view

Orthologs for TTLL9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTLL9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTLL9 36
  • 99.16 (n)
  • 99.09 (a)
TTLL9 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TTLL9 36
  • 90.49 (n)
  • 92.81 (a)
TTLL9 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTLL9 36
  • 89.45 (n)
  • 94.24 (a)
TTLL9 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttll9 36
  • 85.61 (n)
  • 90.89 (a)
Ttll9 16
Ttll9 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTLL9 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTLL9 37
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttll9 36
  • 86.73 (n)
  • 92.33 (a)
chicken
(Gallus gallus)
Aves TTLL9 36
  • 71.89 (n)
  • 74.29 (a)
TTLL9 37
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTLL9 37
  • 75 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10900 36
zebrafish
(Danio rerio)
Actinopterygii ttll9 36
  • 69.93 (n)
  • 72.55 (a)
ttll9 37
  • 65 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ttll-9 36
  • 53.73 (n)
  • 51.27 (a)
ttll-9 37
  • 43 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBY1 37
  • 10 (a)
OneToMany
Species with no ortholog for TTLL9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TTLL9 Gene

ENSEMBL:
Gene Tree for TTLL9 (if available)
TreeFam:
Gene Tree for TTLL9 (if available)

Paralogs for TTLL9 Gene

Selected SIMAP similar genes for TTLL9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TTLL9: view

Variants for TTLL9 Gene

Sequence variations from dbSNP and Humsavar for TTLL9 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs998134 -- 31,923,267(+) GTTCA(A/G)AAAAA intron-variant
rs1883506 -- 31,906,181(+) TTAGG(C/T)GCGGG intron-variant
rs1977092 -- 31,888,564(+) cctcc(C/T)gggtt intron-variant
rs1977093 -- 31,907,438(+) CACTG(C/G)Aggcc intron-variant
rs1977094 -- 31,907,439(+) ACTGC(A/G)ggccg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTLL9 Gene

Variant ID Type Subtype PubMed ID
nsv833952 CNV Gain 17160897
nsv912836 CNV Loss 21882294
nsv3347 CNV Insertion 18451855
esv21897 CNV Gain 19812545
nsv817890 CNV Gain 17921354
nsv517635 CNV Gain 19592680

Relevant External Links for TTLL9 Gene

HapMap Linkage Disequilibrium report
TTLL9

Disorders for TTLL9 Gene

No disorders were found for TTLL9 Gene.

No data available for UniProtKB/Swiss-Prot for TTLL9 Gene

Publications for TTLL9 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PMID: 15890843) Janke C. … Edde B. (Science 2005) 2 3
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TTLL9 Gene

Sources for TTLL9 Gene

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