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TTLL8 Gene

protein-coding   GIFtS: 33
GCID: GC22M050453

Tubulin Tyrosine Ligase-Like Family, Member 8

  Search for TTLL8
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tubulin Tyrosine Ligase-Like Family, Member 81 2
Tubulin--Tyrosine Ligase-Like Protein 82 3
Protein Monoglycylase TTLL82
EC 6.3.2.-3

External Ids:    HGNC: 340001   Entrez Gene: 1647142   Ensembl: ENSG000001388927   UniProtKB: A6PVC23   

Export aliases for TTLL8 gene to outside databases

Previous GC identifers: GC22M048795 GC22M033351


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TTLL8 Gene:
TTLL8 (tubulin tyrosine ligase-like family, member 8) is a protein-coding gene. GO annotations related to this gene include protein-glycine ligase activity, initiating and protein-glycine ligase activity. An important paralog of this gene is TTLL4.

UniProtKB/Swiss-Prot: TTLL8_HUMAN, A6PVC2
Function: Monoglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on
the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates tubulin, with a
preference for alpha-tubulin toward beta-tubulin. Has the ability to modify non-tubulin proteins such as ANP32A,
ANP32B, SET and NCL. Involved in the side-chain initiation step of the glycylation reaction by adding a single
glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation
reaction (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TTLL8 gene promoter:
         Max   Max1   p53   HNF-1   PPAR-gamma2   Cdc5   HNF-1A   En-1   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TTLL8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTLL8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.33

TTLL8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTLL8 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M050453:  view genomic region     (about GC identifiers)

Start:
50,453,552 bp from pter      End:
50,495,364 bp from pter
Size:
41,813 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TTLL8_HUMAN, A6PVC2 (See protein sequence)
Recommended Name: Protein monoglycylase TTLL8  
Size: 850 amino acids; 94676 Da

Explore the universe of human proteins at neXtProt for TTLL8: NX_A6PVC2

Explore proteomics data for TTLL8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TTLL8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000392252   ENSP00000266182   ENSP00000387509  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTLL: Tubulin tyrosine ligase-like family

    2 InterPro protein domains:
     IPR004344 TTL/TTLL_fam
     IPR027753 TTLL3/TTLL8

    Graphical View of Domain Structure for InterPro Entry A6PVC2

    ProtoNet protein and cluster: A6PVC2

    UniProtKB/Swiss-Prot: TTLL8_HUMAN, A6PVC2
    Similarity: Contains 1 TTL domain


    Find genes that share domains with TTLL8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTLL8_HUMAN, A6PVC2
    Function: Monoglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on
    the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates tubulin, with a
    preference for alpha-tubulin toward beta-tubulin. Has the ability to modify non-tubulin proteins such as ANP32A,
    ANP32B, SET and NCL. Involved in the side-chain initiation step of the glycylation reaction by adding a single
    glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation
    reaction (By similarity)

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016989sigma factor antagonist activity ----
    GO:0070735protein-glycine ligase activity ISS--
    GO:0070736protein-glycine ligase activity, initiating ISS--
         
    Find genes that share ontologies with TTLL8           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TTLL8:
     Large cells 

         1 MGI phenotypic allele for Ttll8 (no phenotypes)

    Find genes that share phenotypes with TTLL8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ttll8tm1Lex for TTLL8

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TTLL8_HUMAN, A6PVC2: Cytoplasm, cytoskeleton (By similarity). Cell projection, cilium (By similarity). Cytoplasm,
    cytoskeleton, cilium axoneme (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol2
    nucleus2
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005874microtubule IEA--
    GO:0005929cilium ISS--
    GO:0005930axoneme ISS--
    GO:0015630microtubule cytoskeleton ISS--

    Find genes that share ontologies with TTLL8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TTLL8
    Interactions:

        Search GeneGlobe Interaction Network for TTLL8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for TTLL8 (ENSP000002661824) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCP1BENSP000002806654STRING: ENSP00000280665
    ATAD5ENSP000003131714STRING: ENSP00000313171
    RFC1ENSP000002614244STRING: ENSP00000261424
    APOA1BPENSP000003572184STRING: ENSP00000357218
    EDC3ENSP000003205034STRING: ENSP00000320503
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process ----
    GO:0018094protein polyglycylation ISS--

    Find genes that share ontologies with TTLL8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TTLL8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TTLL8 gene: 
    NM_001080447.1  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000433387 ENST00000477219 ENST00000266182 ENST00000440475
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    1 AceView cDNA sequence:

    H55115 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TTLL8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TTLL8 Expression
    About this image

    TTLL8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TTLL8 Protein Expression
        Custom PCR Arrays for TTLL8
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TTLL8 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttll81 , 5 tubulin tyrosine ligase-like family, member 81, 5 73.21(n)1
    66.98(a)1
      15 (44.39 cM)5
    2395911  NM_172818.31  NP_766406.21 
     888906335 
    lizard
    (Anolis carolinensis)
    Reptilia TTLL86
    tubulin tyrosine ligase-like family, member 8
    64(a)
    1 ↔ 1
    GL344581.1(308-6057)
    fruit fly
    (Drosophila melanogaster)
    Insecta TTLL3A6
    TTLL3B6
    Tubulin tyrosine ligase-like 3B
    24(a)
    24(a)
    many ↔ many
    many ↔ many
    2L(6736449-6740176)
    2L(6732866-6736149)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PBY16
    Putative tubulin tyrosine ligase associated with P...
    12(a)
    1 → many
    II(432036-434297) YBR094W


    ENSEMBL Gene Tree for TTLL8 (if available)
    TreeFam Gene Tree for TTLL8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TTLL8 gene
    TTLL42  TTLL102  ENSG000002611472  TTLL32  TTLL12  TTLL52  TTLL112  TTLL92  
    TTLL72  TTLL62  TTL2  TTLL22  TTLL132  ARPC4-TTLL32  
    1 SIMAP similar gene for TTLL8 using alignment to 3 protein entries:     TTLL8_HUMAN (see all proteins):
    TTLL3

    Find genes that share paralogs with TTLL8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TTLL8 (see all 1052)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58459121,2
    C--33369361(+) GCCCAC/-CGCAC 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs716493341,2
    C--33373378(+) TTAAC-/TTTTTT 1 -- int10--------
    rs96283151,2,,4
    C,F,A,H--33377848(+) GTCCTC/TCACGG 2 K E mis1 ese332Minor allele frequency- N:0.00EA NA NS CSA WA EU 3958
    rs345001801,2
    C--33384284(+) AAAAA-/GTGTGTG 1 -- int10--------
    rs1394178781,2
    C--33394721(+) GGTGCA/GCGCCA 1 -- us2k10--------
    rs1851565331,2
    C--33394776(+) GCTGCA/GGCCCC 1 -- us2k10--------
    rs1810524261,2
    --34408261(+) GGTGCA/GCGCCT 1 -- ds50010--------
    rs1509321711,2
    C--34408438(+) ATCCCA/GACACT 1 -- ds50010--------
    rs1392923781,2
    --34408480(+) CTTAGA/GAGTTT 1 -- ds50010--------
    rs1387962501,2
    C--34408612(+) GAACCC/TGGGAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TTLL8 (50453552 - 50495364 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TTLL8: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TTLL8
    DNA2.0 Custom Variant and Variant Library Synthesis for TTLL8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with TTLL8           About GenesLikeMe

    Genetic Association Database (GAD): TTLL8

    Export disorders for TTLL8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TTLL8 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TTLL8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PubMed id 15890843)1, 3 Janke C.... Edde B. (Science 2005)
    2. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PubMed id 18854154)1 KAPnig R....Chanda S.K. (Cell 2008)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    4. The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I.... Wright H. (Nature 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 164714 HGNC: 34000 AceView: LOC164714.2 Ensembl:ENSG00000138892 euGenes: HUgn164714
    ECgene: TTLL8 H-InvDB: TTLL8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TTLL8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TTLL8 gene:
    Search GeneIP for patents involving TTLL8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Custom PCR Arrays for TTLL8 Search Chromatin IP Primers for TTLL8
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     Search Addgene for plasmids for TTLL8
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      eBioscience FlowRNA Probe Sets
           
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