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Aliases for TTLL8 Gene

Aliases for TTLL8 Gene

  • Tubulin Tyrosine Ligase-Like Family Member 8 2 3
  • Tubulin--Tyrosine Ligase-Like Protein 8 4
  • EC 6.3.2.- 4

External Ids for TTLL8 Gene

Previous GeneCards Identifiers for TTLL8 Gene

  • GC22M048795
  • GC22M050453
  • GC22M033351

Summaries for TTLL8 Gene

GeneCards Summary for TTLL8 Gene

TTLL8 (Tubulin Tyrosine Ligase-Like Family Member 8) is a Protein Coding gene. GO annotations related to this gene include protein-glycine ligase activity and protein-glycine ligase activity, initiating. An important paralog of this gene is TTLL1.

UniProtKB/Swiss-Prot for TTLL8 Gene

  • Monoglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates tubulin, with a preference for alpha-tubulin toward beta-tubulin. Has the ability to modify non-tubulin proteins such as ANP32A, ANP32B, SET and NCL. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL8 Gene

Genomics for TTLL8 Gene

Regulatory Elements for TTLL8 Gene

Genomic Location for TTLL8 Gene

Start:
50,015,123 bp from pter
End:
50,058,207 bp from pter
Size:
43,085 bases
Orientation:
Minus strand

Genomic View for TTLL8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTLL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL8 Gene

Proteins for TTLL8 Gene

  • Protein details for TTLL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6PVC2-TTLL8_HUMAN
    Recommended name:
    Protein monoglycylase TTLL8
    Protein Accession:
    A6PVC2
    Secondary Accessions:
    • B5MDV0

    Protein attributes for TTLL8 Gene

    Size:
    850 amino acids
    Molecular mass:
    94676 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTLL8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTLL8 Gene

Proteomics data for TTLL8 Gene at MOPED

Post-translational modifications for TTLL8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTLL8 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TTLL8 Gene

Domains for TTLL8 Gene

Gene Families for TTLL8 Gene

HGNC:
  • TTLL :Tubulin tyrosine ligase-like family

Protein Domains for TTLL8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TTLL8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6PVC2

UniProtKB/Swiss-Prot:

TTLL8_HUMAN :
  • A6PVC2
Domain:
  • Contains 1 TTL domain.
genes like me logo Genes that share domains with TTLL8: view

Function for TTLL8 Gene

Molecular function for TTLL8 Gene

UniProtKB/Swiss-Prot Function: Monoglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates tubulin, with a preference for alpha-tubulin toward beta-tubulin. Has the ability to modify non-tubulin proteins such as ANP32A, ANP32B, SET and NCL. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction (By similarity).

Enzyme Numbers (IUBMB) for TTLL8 Gene

Gene Ontology (GO) - Molecular Function for TTLL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016989 sigma factor antagonist activity --
GO:0070735 protein-glycine ligase activity ISS --
GO:0070736 protein-glycine ligase activity, initiating ISS --
genes like me logo Genes that share ontologies with TTLL8: view

Phenotypes for TTLL8 Gene

GenomeRNAi human phenotypes for TTLL8:
genes like me logo Genes that share phenotypes with TTLL8: view

Animal Model Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TTLL8 Gene

Localization for TTLL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTLL8 Gene

Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTLL8 Gene COMPARTMENTS Subcellular localization image for TTLL8 gene
Compartment Confidence
cytoskeleton 4
cytosol 2
nucleus 2
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TTLL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005874 microtubule IEA --
GO:0005929 cilium ISS --
GO:0005930 axoneme ISS --
GO:0015630 microtubule cytoskeleton ISS --
genes like me logo Genes that share ontologies with TTLL8: view

Pathways for TTLL8 Gene

SuperPathways for TTLL8 Gene

No Data Available

Interacting Proteins for TTLL8 Gene

Gene Ontology (GO) - Biological Process for TTLL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process --
GO:0018094 protein polyglycylation ISS --
GO:0042384 cilium assembly IEA --
genes like me logo Genes that share ontologies with TTLL8: view

No data available for Pathways by source for TTLL8 Gene

Transcripts for TTLL8 Gene

mRNA/cDNA for TTLL8 Gene

(1) Selected AceView cDNA sequences:
(9) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTLL8

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TTLL8
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL8 Gene

No ASD Table

Relevant External Links for TTLL8 Gene

GeneLoc Exon Structure for
TTLL8
ECgene alternative splicing isoforms for
TTLL8

Expression for TTLL8 Gene

mRNA expression in normal human tissues for TTLL8 Gene

mRNA differential expression in normal tissues according to GTEx for TTLL8 Gene

This gene is overexpressed in Testis (50.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TTLL8 Gene

genes like me logo Genes that share expressions with TTLL8: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TTLL8 Gene

Orthologs for TTLL8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTLL8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTLL8 35
  • 94.55 (n)
  • 92.57 (a)
cow
(Bos Taurus)
Mammalia TTLL8 35
  • 77.79 (n)
  • 68.68 (a)
TTLL8 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTLL8 35
  • 80.87 (n)
  • 74.63 (a)
TTLL8 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttll8 35
  • 73.21 (n)
  • 66.98 (a)
Ttll8 16
Ttll8 36
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTLL8 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTLL8 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTLL8 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta TTLL3A 36
  • 24 (a)
ManyToMany
TTLL3B 36
  • 24 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBY1 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for TTLL8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TTLL8 Gene

ENSEMBL:
Gene Tree for TTLL8 (if available)
TreeFam:
Gene Tree for TTLL8 (if available)

Paralogs for TTLL8 Gene

Selected SIMAP similar genes for TTLL8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TTLL8: view

Variants for TTLL8 Gene

Sequence variations from dbSNP and Humsavar for TTLL8 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs79298 -- 50,030,504(+) GGTGC(G/T)CATTT missense, reference
rs137889 -- 50,027,549(+) AAAAA(-/AAA)GGATG downstream-variant-500B
rs137890 -- 50,028,113(+) GACTC(C/T)GAAGG intron-variant
rs137891 -- 50,028,114(+) ACTCT(A/G)AAGGC intron-variant
rs137892 -- 50,029,052(+) ACACC(A/G)TCCTG intron-variant

Relevant External Links for TTLL8 Gene

HapMap Linkage Disequilibrium report
TTLL8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TTLL8 Gene

Disorders for TTLL8 Gene

Relevant External Links for TTLL8

Genetic Association Database (GAD)
TTLL8
genes like me logo Genes that share disorders with TTLL8: view

No data available for UniProtKB/Swiss-Prot for TTLL8 Gene

Publications for TTLL8 Gene

  1. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PMID: 15890843) Janke C. … Edde B. (Science 2005) 2 3
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 4
  3. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for TTLL8 Gene

Sources for TTLL8 Gene

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