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Aliases for TTLL7 Gene

Aliases for TTLL7 Gene

  • Tubulin Tyrosine Ligase-Like Family Member 7 2 3
  • Tubulin--Tyrosine Ligase-Like Protein 7 4
  • Testis Development Protein NYD-SP30 4
  • EC 6.-.-.- 4

External Ids for TTLL7 Gene

Previous GeneCards Identifiers for TTLL7 Gene

  • GC01M084048
  • GC01M084330
  • GC01M082451

Summaries for TTLL7 Gene

GeneCards Summary for TTLL7 Gene

TTLL7 (Tubulin Tyrosine Ligase-Like Family Member 7) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is TTLL8.

UniProtKB/Swiss-Prot for TTLL7 Gene

  • Polyglutamylase which preferentially modifies beta-tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Required for neurite growth (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL7 Gene

Genomics for TTLL7 Gene

Regulatory Elements for TTLL7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TTLL7 Gene

Start:
83,865,028 bp from pter
End:
83,999,167 bp from pter
Size:
134,140 bases
Orientation:
Minus strand

Genomic View for TTLL7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTLL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL7 Gene

Proteins for TTLL7 Gene

  • Protein details for TTLL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZT98-TTLL7_HUMAN
    Recommended name:
    Tubulin polyglutamylase TTLL7
    Protein Accession:
    Q6ZT98
    Secondary Accessions:
    • Q5TAX8
    • Q5TAX9
    • Q6P990
    • Q86YS1
    • Q9H5U4

    Protein attributes for TTLL7 Gene

    Size:
    887 amino acids
    Molecular mass:
    102999 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTLL7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTLL7 Gene

Proteomics data for TTLL7 Gene at MOPED

Post-translational modifications for TTLL7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTLL7 Gene

No data available for DME Specific Peptides for TTLL7 Gene

Domains for TTLL7 Gene

Gene Families for TTLL7 Gene

HGNC:
  • TTLL :Tubulin tyrosine ligase-like family

Protein Domains for TTLL7 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TTLL7 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZT98

UniProtKB/Swiss-Prot:

TTLL7_HUMAN :
  • Q6ZT98
Domain:
  • Contains 1 TTL domain.
Family:
  • Belongs to the tubulin--tyrosine ligase family.
genes like me logo Genes that share domains with TTLL7: view

Function for TTLL7 Gene

Molecular function for TTLL7 Gene

UniProtKB/Swiss-Prot Function:
Polyglutamylase which preferentially modifies beta-tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Required for neurite growth (By similarity).

Enzyme Numbers (IUBMB) for TTLL7 Gene

Gene Ontology (GO) - Molecular Function for TTLL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TTLL7: view

Phenotypes for TTLL7 Gene

GenomeRNAi human phenotypes for TTLL7:
genes like me logo Genes that share phenotypes with TTLL7: view

Animal Model Products

miRNA for TTLL7 Gene

miRTarBase miRNAs that target TTLL7

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TTLL7 Gene

Localization for TTLL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTLL7 Gene

Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, dendrite. Perikaryon. Note=In cells with primary cilia, found in both cilia and basal bodies. In neuronal cells, found in dendrites and perikaryon (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTLL7 Gene COMPARTMENTS Subcellular localization image for TTLL7 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 1

Gene Ontology (GO) - Cellular Components for TTLL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005929 cilium IEA --
GO:0030425 dendrite IEA --
GO:0043204 perikaryon IEA --
genes like me logo Genes that share ontologies with TTLL7: view

Pathways for TTLL7 Gene

SuperPathways for TTLL7 Gene

No Data Available

Interacting Proteins for TTLL7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000260505%0d%0a9606.ENSP00000403397%0d%0a
Selected Interacting proteins: ENSP00000260505 for TTLL7 Gene via STRING

Symbol External ID(s) Details
ZDHHC17

Gene Ontology (GO) - Biological Process for TTLL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process --
GO:0007399 nervous system development IEA --
GO:0018095 protein polyglutamylation IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TTLL7: view

No data available for Pathways by source for TTLL7 Gene

Transcripts for TTLL7 Gene

Unigene Clusters for TTLL7 Gene

Tubulin tyrosine ligase-like family, member 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTLL7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL7 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - - - - - - - - -
SP2: - -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:

ExUns: 21b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for TTLL7 Gene

GeneLoc Exon Structure for
TTLL7
ECgene alternative splicing isoforms for
TTLL7

Expression for TTLL7 Gene

mRNA expression in normal human tissues for TTLL7 Gene

Protein differential expression in normal tissues for TTLL7 Gene

This gene is overexpressed in Frontal cortex (49.5) and Rectum (19.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TTLL7 Gene

SOURCE GeneReport for Unigene cluster for TTLL7 Gene Hs.445826

mRNA Expression by UniProt/SwissProt for TTLL7 Gene

Q6ZT98-TTLL7_HUMAN
Tissue specificity: Highly expressed in the nervous system including spinal cord, thalamus, hippocampus, hypothalamus and cerebellum.
genes like me logo Genes that share expressions with TTLL7: view

Expression partners for TTLL7 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TTLL7 Gene

Orthologs for TTLL7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTLL7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TTLL7 35
  • 92.37 (n)
  • 94.25 (a)
TTLL7 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTLL7 35
  • 93.31 (n)
  • 95.26 (a)
TTLL7 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttll7 35
  • 84.78 (n)
  • 87.82 (a)
Ttll7 16
Ttll7 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TTLL7 35
  • 99.66 (n)
  • 99.89 (a)
TTLL7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttll7 35
  • 81.89 (n)
  • 84.23 (a)
oppossum
(Monodelphis domestica)
Mammalia TTLL7 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTLL7 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTLL7 35
  • 74.95 (n)
  • 76.27 (a)
TTLL7 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTLL7 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttll7 35
  • 72.56 (n)
  • 75.23 (a)
zebrafish
(Danio rerio)
Actinopterygii ttll7 35
  • 70.53 (n)
  • 79.8 (a)
ttll7 36
  • 66 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for TTLL7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTLL7 Gene

ENSEMBL:
Gene Tree for TTLL7 (if available)
TreeFam:
Gene Tree for TTLL7 (if available)

Paralogs for TTLL7 Gene

Selected SIMAP similar genes for TTLL7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TTLL7: view

Variants for TTLL7 Gene

Sequence variations from dbSNP and Humsavar for TTLL7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs481354 -- 83,943,710(-) atttt(C/G)agtat intron-variant
rs484716 -- 83,985,980(-) AGTGT(G/T)TGGCA intron-variant
rs512737 -- 83,969,498(-) AGAAG(G/T)AGACT intron-variant
rs514801 -- 83,969,213(-) TCTGA(A/C)TTTTT intron-variant
rs522892 -- 83,981,297(-) ccata(G/T)tttta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTLL7 Gene

Variant ID Type Subtype PubMed ID
nsv871551 CNV Loss 21882294
esv2714218 CNV Deletion 23290073
esv1612380 CNV Deletion 17803354
esv1339682 CNV Insertion 17803354
esv2664430 CNV Deletion 23128226
esv2714229 CNV Deletion 23290073
esv26427 CNV Loss 19812545
nsv823353 CNV Loss 20364138

Relevant External Links for TTLL7 Gene

HapMap Linkage Disequilibrium report
TTLL7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTLL7 Gene

Disorders for TTLL7 Gene

Relevant External Links for TTLL7

Genetic Association Database (GAD)
TTLL7

No disorders were found for TTLL7 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TTLL7 Gene

Publications for TTLL7 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PMID: 15890843) Janke C. … Edde B. (Science 2005) 2 3
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Genome-wide scan of copy number variation in late-onset Alzheimer's disease. (PMID: 20061627) Heinzen E.L. … Goldstein D.B. (J. Alzheimers Dis. 2010) 3

Products for TTLL7 Gene

Sources for TTLL7 Gene

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