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TTLL7 Gene

protein-coding   GIFtS: 45
GCID: GC01M084330

Tubulin Tyrosine Ligase-Like Family, Member 7

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tubulin Tyrosine Ligase-Like Family, Member 71 2
Testis Development Protein NYD-SP302 3
Tubulin--Tyrosine Ligase-Like Protein 72 3
Tubulin Polyglutamylase TTLL72
EC 6.-.-.-3

External Ids:    HGNC: 262421   Entrez Gene: 797392   Ensembl: ENSG000001379417   UniProtKB: Q6ZT983   

Export aliases for TTLL7 gene to outside databases

Previous GC identifers: GC01M084048 GC01M082451


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TTLL7 Gene:
TTLL7 (tubulin tyrosine ligase-like family, member 7) is a protein-coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is TTLL4.

UniProtKB/Swiss-Prot: TTLL7_HUMAN, Q6ZT98
Function: Polyglutamylase which preferentially modifies beta-tubulin. Involved in the side-chain initiation step
of the polyglutamylation reaction rather than in the elongation step. Required for neurite growth (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TTLL7 gene promoter:
         FOXF2   POU2F2   NF-AT   POU2F2C   POU2F1   NF-AT2   POU2F1a   STAT3   POU2F2B   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTLL7 promoter sequence
   Search Chromatin IP Primers for TTLL7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTLL7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

TTLL7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTLL7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M084330:  view genomic region     (about GC identifiers)

Start:
84,330,711 bp from pter      End:
84,464,833 bp from pter
Size:
134,123 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TTLL7_HUMAN, Q6ZT98 (See protein sequence)
Recommended Name: Tubulin polyglutamylase TTLL7  
Size: 887 amino acids; 102999 Da
Secondary accessions: Q5TAX8 Q5TAX9 Q6P990 Q86YS1 Q9H5U4
Alternative splicing: 3 isoforms:  Q6ZT98-1   Q6ZT98-2   Q6ZT98-3   

Explore the universe of human proteins at neXtProt for TTLL7: NX_Q6ZT98

Explore proteomics data for TTLL7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TTLL7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078962.4  
    ENSEMBL proteins: 
     ENSP00000435334   ENSP00000260505   ENSP00000434146   ENSP00000432921  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTLL: Tubulin tyrosine ligase-like family

    2 InterPro protein domains:
     IPR027745 TTLL7
     IPR004344 TTL/TTLL_fam

    Graphical View of Domain Structure for InterPro Entry Q6ZT98

    ProtoNet protein and cluster: Q6ZT98

    1 Blocks protein domain: IPB004344 Tubulin-tyrosine ligase

    UniProtKB/Swiss-Prot: TTLL7_HUMAN, Q6ZT98
    Similarity: Belongs to the tubulin--tyrosine ligase family
    Similarity: Contains 1 TTL domain


    Find genes that share domains with TTLL7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTLL7_HUMAN, Q6ZT98
    Function: Polyglutamylase which preferentially modifies beta-tubulin. Involved in the side-chain initiation step
    of the polyglutamylation reaction rather than in the elongation step. Required for neurite growth (By similarity)

         Enzyme Number (IUBMB): EC 6.-.-.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016874ligase activity IEA--
         
    Find genes that share ontologies with TTLL7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TTLL7:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TTLL7
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    miRNA
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    miRTarBase miRNAs that target TTLL7:
    hsa-mir-92a-3p (MIRT049432)

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    Selected qRT-PCR Assays for microRNAs that regulate TTLL7 (see all 11):
    hsa-miR-30c hsa-miR-548p hsa-miR-200a hsa-miR-545 hsa-miR-30d hsa-miR-141 hsa-miR-1184 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidTTLL7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TTLL7

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TTLL7_HUMAN, Q6ZT98: Cell projection, cilium (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By
    similarity). Cell projection, dendrite (By similarity). Perikaryon (By similarity). Note=In cells with primary
    cilia, found in both cilia and basal bodies. In neuronal cells, found in dendrites and perikaryon (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton2
    cytosol1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0005929cilium IEA--
    GO:0030425dendrite IEA--
    GO:0043204perikaryon IEA--

    Find genes that share ontologies with TTLL7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TTLL7
    Interactions:

        Search GeneGlobe Interaction Network for TTLL7

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process ----
    GO:0007399nervous system development IEA--
    GO:0018095protein polyglutamylation IEA--
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with TTLL7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TTLL7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TTLL7 gene: 
    NM_024686.4  

    Unigene Cluster for TTLL7:

    Tubulin tyrosine ligase-like family, member 7
    Hs.445826  [show with all ESTs]
    Unigene Representative Sequence: NM_024686
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000472688 ENST00000480174(uc001djb.3) ENST00000477524(uc001djd.3 uc001djg.3)
    ENST00000488014(uc001dje.3) ENST00000260505(uc001djc.3) ENST00000474957(uc001djf.3)
    ENST00000480533 ENST00000472937 ENST00000485638 ENST00000464289 ENST00000474702
    ENST00000482783 ENST00000467670
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TTLL7 (see all 11):
    hsa-miR-30c hsa-miR-548p hsa-miR-200a hsa-miR-545 hsa-miR-30d hsa-miR-141 hsa-miR-1184 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidTTLL7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TTLL7
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      QuantiTect SYBR Green Assays in human, mouse, rat TTLL7
      QuantiFast Probe-based Assays in human, mouse, rat TTLL7

    Additional mRNA sequence: 

    AK026686.1 AK094174.1 AK126792.1 AK225574.1 

    15 DOTS entries:

    DT.210355  DT.101963397  DT.101981583  DT.99997248  DT.99930437  DT.95196105  DT.100000988  DT.121416140 
    DT.91638479  DT.92420183  DT.100781135  DT.101981584  DT.121416125  DT.40279508  DT.91744409 

    Selected AceView cDNA sequences (see all 102):

    AI374651 AA626351 AI298905 BC048970 AA322804 AA339154 BM719741 CD678562 
    AK026686 AL118758 BF514197 AK126792 AA417343 BC032829 AA461320 CA503234 
    Z44270 Z40229 Z40034 AY170843 BC028350 N62893 Z43975 CA433870 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TTLL7 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
    SP1:        -     -     -     -     -     -     -     -     -                                                                                                   
    SP2:              -                       -                                                                                                                     
    SP3:                                                                                                                                            -     -         
    SP4:                                      -                                                                                                                     
    SP5:                                                                                                                                                            

    ExUns: 21b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for TTLL7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TTLL7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAAATTGT
    TTLL7 Expression
    About this image

    TTLL7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TTLL7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445826

    UniProtKB/Swiss-Prot: TTLL7_HUMAN, Q6ZT98
    Tissue specificity: Highly expressed in the nervous system including spinal cord, thalamus, hippocampus,
    hypothalamus and cerebellum

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TTLL7 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttll71 , 5 tubulin tyrosine ligase-like family, member 71, 5 84.78(n)1
    87.82(a)1
      3 (72.28 cM)5
    708921  NM_027594.11  NP_081870.11 
     1468523675 
    chicken
    (Gallus gallus)
    Aves TTLL71 tubulin tyrosine ligase-like family, member 7 74.95(n)
    76.27(a)
      424543  XM_004936660.1  XP_004936717.1 
    lizard
    (Anolis carolinensis)
    Reptilia TTLL76
    tubulin tyrosine ligase-like family, member 7
    73(a)
    1 ↔ 1
    GL343194.1(9214348-9317627)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ttll71 tubulin tyrosine ligase-like family, member 7 72.56(n)
    75.23(a)
      100038218  NM_001142660.1  NP_001136132.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ttll71 tubulin tyrosine ligase-like family, member 7 70.53(n)
    79.8(a)
      565243  NM_001080595.1  NP_001074064.1 


    ENSEMBL Gene Tree for TTLL7 (if available)
    TreeFam Gene Tree for TTLL7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TTLL7 gene
    TTLL42  TTLL102  ENSG000002611472  TTLL32  TTLL12  TTLL52  TTLL112  TTLL92  
    TTLL62  TTL2  TTLL82  TTLL22  TTLL132  ARPC4-TTLL32  
    3 SIMAP similar genes for TTLL7 using alignment to 5 protein entries:     TTLL7_HUMAN (see all proteins):
    TTLL11    TTLL13    TTLL6

    Find genes that share paralogs with TTLL7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TTLL7 (see all 2455)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446731211,2
    --84334666(+) TTATTA/TTTTTT 1 -- ds50010--------
    rs1836537541,2
    --84334705(+) CCAGGC/GTAGAA 1 -- ds50010--------
    rs1890940771,2
    --84334740(+) TGCAAC/TCTCCG 1 -- ds50010--------
    rs66669841,2
    C,F,H--84334804(+) CAAGCG/ACTTAC 1 -- ds50019Minor allele frequency- A:0.17NA WA CSA EA 369
    rs121276571,2
    C--84334938(+) acaggC/Tgtgag 1 -- ds5001 ese30--------
    rs67011911,2
    C--84334956(+) gcccaC/GccTGT 1 -- ds5001 ese30--------
    rs1161740421,2
    F--84334986(+) TATGAT/CCTCAC 1 -- ds50011Minor allele frequency- C:0.01NA 120
    rs1512138311,2
    C--84335165(+) CTAAAC/TCTTTT 1 -- ut310--------
    rs1928860251,2
    --84335235(+) TTTCAA/GGTCAA 1 -- ut310--------
    rs1854849961,2
    --84335280(+) AATTGA/GATCTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TTLL7 (84330711 - 84464833 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TTLL7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1612380CNV Deletion17803354
    esv2664430CNV Deletion23128226
    esv2714218CNV Deletion23290073
    esv2714229CNV Deletion23290073
    esv1339682CNV Insertion17803354
    nsv823353CNV Loss20364138
    nsv871551CNV Loss21882294
    esv26427CNV Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with TTLL7           About GenesLikeMe

    Genetic Association Database (GAD): TTLL7

    Export disorders for TTLL7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TTLL7 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with TTLL7)
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    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PubMed id 15890843)1, 3 Janke C.... Edde B. (Science 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    6. Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study. (PubMed id 23006423)1 Niu N....Wang L. (BMC Cancer 2012)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Genome-wide scan of copy number variation in late-onset Alzheimer's disease. (PubMed id 20061627)1 Heinzen E.L....Goldstein D.B. (J. Alzheimers Dis. 2010)
    9. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    10. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79739 HGNC: 26242 AceView: FLJ23033 Ensembl:ENSG00000137941 euGenes: HUgn79739
    ECgene: TTLL7 H-InvDB: TTLL7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TTLL7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TTLL7 gene:
    Search GeneIP for patents involving TTLL7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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