TTLL6 Gene

Aliases
for TTLL6 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC17M044196 GC17M042208

Summaries
for TTLL6 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for TTLL6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000017.10  NT_010783.16  NC_018928.2  

SwitchGear Promoter luciferase reporter plasmid: TTLL6 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTLL6

TTLL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046839:  view genomic region     (about GC identifiers)

Proteins
for TTLL6 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for TTLL6: NX_Q8N841

Explore proteomics data for TTLL6 at MOPED


See TTLL6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

TTLL6 Human Recombinant Protein Products:

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	antibodies-online kits for TTLL6 (4 products)

Domains /
Families
for TTLL6 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q8N841

Find genes that share domains with TTLL6           About GenesLikeMe

Function
for TTLL6 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Enzyme Number (IUBMB): EC 6.-.-.-¹

     Gene Ontology (GO): 3 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for TTLL6

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		Selected qRT-PCR Assays for microRNAs that regulate TTLL6 (see all 16):
		hsa-miR-875-3p hsa-let-7d hsa-miR-486-3p hsa-let-7c hsa-miR-1205 hsa-let-7g hsa-let-7a hsa-miR-98
		SwitchGear 3'UTR luciferase reporter plasmid: TTLL6 3' UTR sequence

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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TTLL6

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL6

Localization
for TTLL6 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytoskeleton	5
cytosol	1
mitochondrion	1
nucleus	1
plasma membrane	1

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for TTLL6 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 4 biological process terms:    About this table

Drugs & Compounds
for TTLL6 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for TTLL6 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for TTLL6 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TTLL6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for TTLL6 OriGene qSTAR qPCR primer pairs in human, mouse for TTLL6
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TTLL6
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL6

Orthologs
for TTLL6 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for TTLL6 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for TTLL6 gene

TTLL4²  TTLL10²  ENSG00000261147²  TTLL3²  TTLL1²  TTLL5²  TTLL11²  TTLL9²  

TTLL7²  TTL²  TTLL8²  TTLL2²  TTLL13²  ARPC4-TTLL3²  

5 SIMAP similar genes for TTLL6 using alignment to 6 protein entries:     TTLL6_HUMAN (see all proteins):

DKFZp434A0435    TTLL13    TTLL11    TTLL7    TTLL1

Find genes that share paralogs with TTLL6           About GenesLikeMe

Genomic Variants
for TTLL6 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TTLL6 (see all 1127)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs664778391,2	C	--	42220343(+)	AAAAAC/-AAACA	1	--	int1		1		NA	2
rs1869544261,2		--	46839130(+)	GCTCCC/TAGCAA	2	--	ds5001		0	--	--	--	--
rs1897038451,2	C	--	46839234(+)	TCTCAA/CTCTGT	2	--	ds5001		0	--	--	--	--
rs1811428281,2		--	46839348(+)	TAGCTA/GCCATG	2	--	ds5001		0	--	--	--	--
rs1851420781,2		--	46839357(+)	TGCCCA/GCCACC	2	--	ds5001		0	--	--	--	--
rs1896087941,2		--	46839380(+)	TTTTTC/GTATTT	2	--	ds5001		0	--	--	--	--
rs1486315741,2	C	--	46839388(+)	TTTTTA/GGTAGA	2	--	ds5001		0	--	--	--	--
rs18791111,2	C,H	--	46839430(-)	AGGAGT/ATCAAG	2	--	ds5001		7		NA WA CSA	12
rs129515351,2	C,F	--	46839490(+)	TGCATG/AAGCCA	2	--	ds5001		2		NA	4
rs129364061,2	C,F,H	--	46839566(+)	TTTCCC/TATTAT	2	--	ds5001		18		NS EA NA WA	2342

HapMap Linkage Disequilibrium report for TTLL6 (46839593 - 46894576 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TTLL6: --

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TTLL6

DNA2.0 Custom Variant and Variant Library Synthesis for TTLL6

Disorders / Diseases
for TTLL6 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for TTLL6 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TTLL6 gene integrated from 10 sources: (articles sorted by number of sources associating them with TTLL6)

Utopia: connect your pdf to the dynamic world of online information

1. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PubMed id 15890843)^{1, 2, 3} Janke C.... Edde B. (Science 2005)
2. The testis-specific apoptosis related gene TTL.6 underwent adaptive evolution in the lineage leading to humans. (PubMed id 16443334)^{1, 2, 9} Chen X.-H.... Su B. (Gene 2006)
3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
4. CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium. (PubMed id 22246503)² Lee J.E....Gleeson J.G. (Nat. Genet. 2012)
5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
6. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)² Zody M.C.... Nusbaum C. (Nature 2006)
7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S.... Malek J. (Genome Res. 2004)
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

External Searches for TTLL6 gene

Genome Databases showing TTLL6 gene

Other Databases showing TTLL6 gene

Specialized Databases showing TTLL6 gene

Products
for TTLL6 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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