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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TTLL6 Gene

protein-coding GIFtS: 44
GCID: GC17M046839

Tubulin Tyrosine Ligase-Like Family, Member 6

See related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Tubulin Tyrosine Ligase-Like Family, Member 6¹ ²
Tubulin--Tyrosine Ligase-Like Protein 6² ³
TTL.6² ³
Tubulin Polyglutamylase TTLL6²
EC 6.-.-.-³

External Ids:	HGNC: 26664¹	Entrez Gene: 284076²	Ensembl: ENSG00000170703⁷	OMIM: 610849⁵	UniProtKB: Q8N841³

Export aliases for TTLL6 gene to outside databases

Previous GC identifers: GC17M044196 GC17M042208

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TTLL6 Gene:

TTLL6 (tubulin tyrosine ligase-like family, member 6) is a protein-coding gene. Diseases associated with TTLL6 include joubert syndrome. GO annotations related to this gene include tubulin-tyrosine ligase activity and tubulin binding. An important paralog of this gene is TTLL4.

UniProtKB/Swiss-Prot: TTLL6_HUMAN, Q8N841

Function: Polyglutamylase which preferentially modifies alpha-tubulin. Mediates tubulin polyglutamylation in

cilia. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation

step (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.2 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TTLL6 gene promoter:
USF1 GATA-3 USF2 NF-kappaB GATA-1 C/EBPalpha AREB6 S8 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TTLL6 promoter sequence

Search SABiosciences Chromatin IP Primers for TTLL6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTLL6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32 Ensembl cytogenetic band: 17q21.32 HGNC cytogenetic band: 17q21.32

TTLL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTLL6 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M046839: view genomic region (about GC identifiers)

Start:	46,839,593 bp from pter	End:	46,894,576 bp from pter
Size:	54,984 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TTLL6_HUMAN, Q8N841 (See protein sequence)

Recommended Name: Tubulin polyglutamylase TTLL6

Size: 843 amino acids; 96401 Da

Subunit: Found in a complex with CEP41

Subcellular location: Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=CEP41 is required

for its transport between the basal body and the cilium

Sequence caution: Sequence=BAC04066.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: B4DZJ5 C9J233 Q24KB1 Q24KB2 Q24KB6 Q24KF3 Q24KJ5 Q24KN7 Q24KS9 Q24KX1

Q24L13 Q24L55 Q24L76 Q8IYW6 Q8NA62

Alternative splicing: 2 isoforms: Q8N841-1 Q8N841-2 (Variant in position: 9:E->V (in dbSNP:rs17853181))

Explore the universe of human proteins at neXtProt for TTLL6: NX_Q8N841

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q8N841

TTLL6 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : --

REFSEQ proteins (2 alternative transcripts):

NP_001124390.1 NP_775894.2

ENSEMBL proteins:

ENSP00000399211 ENSP00000415138 ENSP00000377043 ENSP00000365871 ENSP00000400624

ENSP00000414290

Human Recombinant Protein Products for TTLL6:

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	Novus Biologicals TTLL6 Protein Novus Biologicals TTLL6 Lysates
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	Cloud-Clone Corp. Proteins for TTLL6

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0036064	cilium basal body	IDA	--

TTLL6 for ontologies About GeneDecksing

TTLL6 Antibody Products:

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	Cloud-Clone Corp. ELISAs for TTLL6 Cloud-Clone Corp. CLIAs for TTLL6

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

TTLL: Tubulin tyrosine ligase-like family

1 InterPro protein domain:

IPR004344 Tub_tyr_ligase

Graphical View of Domain Structure for InterPro Entry Q8N841

ProtoNet protein and cluster: Q8N841

1 Blocks protein domain: IPB004344 Tubulin-tyrosine ligase

UniProtKB/Swiss-Prot: TTLL6_HUMAN, Q8N841

Similarity: Belongs to the tubulin--tyrosine ligase family

Similarity: Contains 1 TTL domain

TTLL6 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TTLL6_HUMAN, Q8N841

Function: Polyglutamylase which preferentially modifies alpha-tubulin. Mediates tubulin polyglutamylation in

cilia. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation

step (By similarity)

Enzyme Number (IUBMB): EC 6.-.-.-¹

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004835	tubulin-tyrosine ligase activity	--	--
GO:0005515	protein binding	IPI	--
GO:0015631	tubulin binding	ISS	--
GO:0016874	ligase activity	IEA	--

TTLL6 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for TTLL6:

Increased cell number in G1, s

Synthetic lethal with c-Myc af

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for TTLL6

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TTLL6

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TTLL6

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TTLL6

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TTLL6
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate TTLL6 (see all 16):
		hsa-miR-875-3p hsa-let-7d hsa-miR-486-3p hsa-let-7c hsa-miR-1205 hsa-let-7g hsa-let-7a hsa-miR-98

		SwitchGear 3'UTR luciferase reporter plasmid: TTLL6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 2): TTLL6 (NM_173623)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TTLL6
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL6

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TTLL6

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001578	microtubule bundle formation	IEA	--
GO:0006464	cellular protein modification process	--	--
GO:0018095	protein polyglutamylation	ISS	--
GO:0051013	microtubule severing	IEA	--

TTLL6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TTLL6

Search CenterWatch for drugs/clinical trials and news about TTLL6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TTLL6 gene (2 alternative transcripts):

NM_001130918.1 NM_173623.3

Unigene Cluster for TTLL6:

Tubulin tyrosine ligase-like family, member 6

Hs.91930 [show with all ESTs]

Unigene Representative Sequence: BC041368

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000433608(uc002iob.3) ENST00000416950(uc010dbi.3) ENST00000490027(uc002ioc.3)

ENST00000393382(uc021tzm.1) ENST00000376681(uc002iod.3) ENST00000424018

ENST00000509809 ENST00000456415 ENST00000470462

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TTLL6
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate TTLL6 (see all 16):
		hsa-miR-875-3p hsa-let-7d hsa-miR-486-3p hsa-let-7c hsa-miR-1205 hsa-let-7g hsa-let-7a hsa-miR-98

		SwitchGear 3'UTR luciferase reporter plasmid: TTLL6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for TTLL6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTLL6

Clone Products:		OriGene clones in human, mouse for TTLL6 (see all 12) OriGene ORF clones in mouse, rat for TTLL6 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TTLL6 (NM_173623)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TTLL6
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		Sirion Biotech Customized lentivirus for stable overexpression of TTLL6 Customized lentivirus expression plasmids for stable overexpression of TTLL6

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTLL6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTLL6

Additional mRNA sequence:

AK093127.1 AK097392.1 AK302952.1 AK310321.1 AL834151.1 BC033563.1 BC041368.2

4 DOTS entries:

DT.95328580 DT.103299 DT.100021350 DT.95148945

24/26 AceView cDNA sequences (see all 26):

AX747941 BQ082367 AK093127 BI825981 AA584926 BX109438 AL834151 Z43328

BC033563 AL040321 AW296167 AI191893 AK097392 BF873249 NM_173623 BC041368

AI798921 AI026677 BG722366 AI198624 AA435642 AW469048 AI280163 BI465115

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for TTLL6 About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11
SP1:					-		-
SP2:
SP3:									-

ECgene alternative splicing isoforms for TTLL6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TTLL6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Genevestigator expression for TTLL6

SOURCE GeneReport for Unigene cluster: Hs.91930

SABiosciences Custom PCR Arrays for TTLL6

Primer Products:		OriGene qPCR primer pairs and template standards for TTLL6 OriGene qSTAR qPCR primer pairs in human, mouse for TTLL6
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTLL6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TTLL6 gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ttll6^{1 , 5}	tubulin tyrosine ligase-like family, member 6^{1, 5}	76.56(n)¹ 68.48(a)¹		11 (59.48 cM)⁵ 237930¹ NM_172799.4¹ NP_766387.2¹ 96133786⁵
lizard (Anolis carolinensis)	Reptilia	TTLL6⁶	Uncharacterized protein	74(a)	1 ↔ 1	6(75881864-75900145)
zebrafish (Danio rerio)	Actinopterygii	ttll6⁶	tubulin tyrosine ligase-like family, member 6	44(a)	1 ↔ 1	12(28667866-28686443)
fruit fly (Drosophila melanogaster)	Insecta	CG5987⁶ CG16716⁶	--	31(a) 25(a)	many ↔ many many ↔ many	3R(23073949-23076729) 2R(15481295-15484371)

ENSEMBL Gene Tree for TTLL6 (if available)
TreeFam Gene Tree for TTLL6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TTLL6 gene

TTLL4² TTLL10² ENSG00000261147² TTLL3² TTLL1² TTLL5² TTLL11² TTLL9²

TTLL7² TTL² TTLL8² TTLL2² TTLL13² ARPC4-TTLL3²

5 SIMAP similar genes for TTLL6 using alignment to 7 protein entries: TTLL6_HUMAN (see all proteins):

DKFZp434A0435 TTLL13 TTLL11 TTLL7 TTLL1

TTLL6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs66477839^1,2	C	--	42220343(+)	`AAAAAC/-AAACA`	1	--	int¹		1		NA	2
rs186954426^1,2		--	46839130(+)	`GCTCCC/TAGCAA`	2	--	ds500¹		0	--	--	--	--
rs189703845^1,2	C	--	46839234(+)	`TCTCAA/CTCTGT`	2	--	ds500¹		0	--	--	--	--
rs181142828^1,2		--	46839348(+)	`TAGCTA/GCCATG`	2	--	ds500¹		0	--	--	--	--
rs185142078^1,2		--	46839357(+)	`TGCCCA/GCCACC`	2	--	ds500¹		0	--	--	--	--
rs189608794^1,2		--	46839380(+)	`TTTTTC/GTATTT`	2	--	ds500¹		0	--	--	--	--
rs148631574^1,2	C	--	46839388(+)	`TTTTTA/GGTAGA`	2	--	ds500¹		0	--	--	--	--
rs1879111^1,2	C,H	--	46839430(-)	`AGGAGT/ATCAAG`	2	--	ds500¹		7		NA WA CSA	12
rs12951535^1,2	C,F	--	46839490(+)	`TGCATG/AAGCCA`	2	--	ds500¹		2		NA	4
rs12936406^1,2	C,F,H	--	46839566(+)	`TTTCCC/TATTAT`	2	--	ds500¹		18		NS EA NA WA	2342

HapMap Linkage Disequilibrium report for TTLL6 (46839593 - 46894576 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for TTLL6: --

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing TTLL6

DNA2.0 Custom Variant and Variant Library Synthesis for TTLL6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 610849 OMIM disorders: --

2 diseases for TTLL6: About MalaCards

joubert syndrome

TTLL6 for disorders About GeneDecksing

Genetic Association Database (GAD): TTLL6

Export disorders for TTLL6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TTLL6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TTLL6)

Utopia: connect your pdf to the dynamic
world of online information

Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PubMed id 15890843)^{1, 2, 3} Janke C.... Edde B. (2005)
The testis-specific apoptosis related gene TTL.6 underwent adaptive evolution in the lineage leading to humans. (PubMed id 16443334)^{1, 2, 9} Chen X.-H.... Su B. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium. (PubMed id 22246503)² Lee J.E....Gleeson J.G. (2012)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)² Zody M.C.... Nusbaum C. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 284076	HGNC: 26664	AceView: FLJ35808	Ensembl:ENSG00000170703	euGenes: HUgn284076
ECgene: TTLL6	H-InvDB: TTLL6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TTLL6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TTLL6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TTLL6 gene:
Search GeneIP for patents involving TTLL6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for TTLL6
	OriGene qPCR primer pairs and template standards for TTLL6		OriGene Protein Over-expression Lysate for TTLL6
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TTLL6
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	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTLL6
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	GenScript Custom Purified and Recombinant Proteins Services for TTLL6		GenScript cDNA clones with any tag delivered in your preferred vector for TTLL6
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	GenScript Custom overexpressing Cell Line Services for TTLL6		CloneReady with Over 120,000 Genes
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL6

	SwitchGear 3'UTR luciferase reporter plasmids for TTLL6
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTLL6

	inGenious Targeting Laboratory - Custom generated mouse model solutions for TTLL6
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TTLL6

Customized:

	lentivirus for stable overexpression of TTLL6
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Customized transgenic rodents for:

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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TTLL6 gene at Home site.

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TTLL6 Gene

Tubulin Tyrosine Ligase-Like Family, Member 6

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TTLL6 Gene

Tubulin Tyrosine Ligase-Like Family, Member 6

Aliasesfor TTLL6 gene

Summariesfor TTLL6 gene

Genomic Viewsfor TTLL6 gene

Proteinsfor TTLL6 gene

Protein Domains /Familiesfor TTLL6 gene

Functionfor TTLL6 gene

Pathways & Interactionsfor TTLL6 gene

Drugs & Compoundsfor TTLL6 gene

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Expression for TTLL6 gene

Orthologsfor TTLL6 gene

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Genomic Variantsfor TTLL6 gene

Disorders / Diseasesfor TTLL6 gene

Publicationsfor TTLL6 gene

External Searches for TTLL6 gene

Genome Databases showing TTLL6 gene

Other Databases showing TTLL6 gene

Specialized Databases showing TTLL6 gene

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Aliases
for TTLL6 gene

Summaries
for TTLL6 gene

Genomic Views
for TTLL6 gene

Proteins
for TTLL6 gene

Protein Domains /
Families
for TTLL6 gene

Function
for TTLL6 gene

Pathways & Interactions
for TTLL6 gene

Drugs & Compounds
for TTLL6 gene

Transcripts
for TTLL6 gene

Expression
for TTLL6 gene

Orthologs
for TTLL6 gene

Paralogs
for TTLL6 gene

Genomic Variants
for TTLL6 gene

Disorders / Diseases
for TTLL6 gene

Publications
for TTLL6 gene

Intellectual Property
for TTLL6 gene

Products
for TTLL6 gene