Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TTLL6 Gene

Aliases for TTLL6 Gene

  • Tubulin Tyrosine Ligase-Like Family Member 6 2 3
  • Tubulin--Tyrosine Ligase-Like Protein 6 3 4
  • TTL.6 3 4
  • Tubulin Polyglutamylase TTLL6 3
  • EC 6.-.-.- 4

External Ids for TTLL6 Gene

Previous GeneCards Identifiers for TTLL6 Gene

  • GC17M044196
  • GC17M046839
  • GC17M042208

Summaries for TTLL6 Gene

GeneCards Summary for TTLL6 Gene

TTLL6 (Tubulin Tyrosine Ligase-Like Family Member 6) is a Protein Coding gene. GO annotations related to this gene include ligase activity and tubulin binding. An important paralog of this gene is TTLL8.

UniProtKB/Swiss-Prot for TTLL6 Gene

  • Polyglutamylase which preferentially modifies alpha-tubulin. Mediates tubulin polyglutamylation in cilia. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL6 Gene

Genomics for TTLL6 Gene

Regulatory Elements for TTLL6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TTLL6 Gene

48,757,381 bp from pter
48,817,223 bp from pter
59,843 bases
Minus strand

Genomic View for TTLL6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTLL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL6 Gene

Proteins for TTLL6 Gene

  • Protein details for TTLL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tubulin polyglutamylase TTLL6
    Protein Accession:
    Secondary Accessions:
    • B4DZJ5
    • C9J233
    • Q24KB1
    • Q24KB2
    • Q24KB6
    • Q24KF3
    • Q24KJ5
    • Q24KN7
    • Q24KS9
    • Q24KX1
    • Q24L13
    • Q24L55
    • Q24L76
    • Q8IYW6
    • Q8NA62

    Protein attributes for TTLL6 Gene

    843 amino acids
    Molecular mass:
    96401 Da
    Quaternary structure:
    • Found in a complex with CEP41
    • Sequence=BAC04066.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TTLL6 Gene


neXtProt entry for TTLL6 Gene

Proteomics data for TTLL6 Gene at MOPED

Post-translational modifications for TTLL6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTLL6 Gene

No data available for DME Specific Peptides for TTLL6 Gene

Domains for TTLL6 Gene

Gene Families for TTLL6 Gene

Protein Domains for TTLL6 Gene


Suggested Antigen Peptide Sequences for TTLL6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 TTL domain.
  • Belongs to the tubulin--tyrosine ligase family.
  • Contains 1 TTL domain.
  • Belongs to the tubulin--tyrosine ligase family.
genes like me logo Genes that share domains with TTLL6: view

Function for TTLL6 Gene

Molecular function for TTLL6 Gene

UniProtKB/Swiss-Prot Function:
Polyglutamylase which preferentially modifies alpha-tubulin. Mediates tubulin polyglutamylation in cilia. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity).

Enzyme Numbers (IUBMB) for TTLL6 Gene

Gene Ontology (GO) - Molecular Function for TTLL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22246503
GO:0015631 tubulin binding ISS --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TTLL6: view

Phenotypes for TTLL6 Gene

genes like me logo Genes that share phenotypes with TTLL6: view

Animal Model Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TTLL6 Gene

Localization for TTLL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTLL6 Gene

Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=CEP41 is required for its transport between the basal body and the cilium.

Subcellular locations from

Jensen Localization Image for TTLL6 Gene COMPARTMENTS Subcellular localization image for TTLL6 gene
Compartment Confidence
cytoskeleton 5
cytosol 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TTLL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0036064 ciliary basal body IDA 22246503
genes like me logo Genes that share ontologies with TTLL6: view

Pathways for TTLL6 Gene

SuperPathways for TTLL6 Gene

No Data Available

Interacting Proteins for TTLL6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000377043 for TTLL6 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TTLL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation IEA --
GO:0003353 positive regulation of cilium movement IEA --
GO:0006464 cellular protein modification process --
GO:0018095 protein polyglutamylation ISS --
GO:0051013 microtubule severing IEA --
genes like me logo Genes that share ontologies with TTLL6: view

No data available for Pathways by source for TTLL6 Gene

Transcripts for TTLL6 Gene

Unigene Clusters for TTLL6 Gene

Tubulin tyrosine ligase-like family, member 6:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTLL6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL6 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: - -
SP3: -

Relevant External Links for TTLL6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTLL6 Gene

mRNA expression in normal human tissues for TTLL6 Gene

mRNA differential expression in normal tissues according to GTEx for TTLL6 Gene

This gene is overexpressed in Testis (20.8), Colon - Transverse (6.5), and Kidney - Cortex (4.3).

Protein differential expression in normal tissues for TTLL6 Gene

This gene is overexpressed in Heart (54.3) and Platelet (14.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TTLL6 Gene

SOURCE GeneReport for Unigene cluster for TTLL6 Gene Hs.91930

genes like me logo Genes that share expressions with TTLL6: view

Expression partners for TTLL6 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TTLL6 Gene

Orthologs for TTLL6 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTLL6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TTLL6 35
  • 84.46 (n)
  • 77.94 (a)
TTLL6 36
  • 77 (a)
(Canis familiaris)
Mammalia TTLL6 35
  • 83.37 (n)
  • 75.68 (a)
TTLL6 36
  • 75 (a)
(Mus musculus)
Mammalia Ttll6 35
  • 77.24 (n)
  • 68.9 (a)
Ttll6 16
Ttll6 36
  • 67 (a)
(Pan troglodytes)
Mammalia TTLL6 35
  • 99.11 (n)
  • 97.67 (a)
FLJ35808 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Ttll6 35
  • 77.03 (n)
  • 68.77 (a)
(Monodelphis domestica)
Mammalia TTLL6 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia TTLL6 36
  • 76 (a)
(Anolis carolinensis)
Reptilia TTLL6 36
  • 74 (a)
(Danio rerio)
Actinopterygii ttll6 36
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG16716 36
  • 28 (a)
CG5987 36
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
Species with no ortholog for TTLL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTLL6 Gene

Gene Tree for TTLL6 (if available)
Gene Tree for TTLL6 (if available)

Paralogs for TTLL6 Gene

(5) SIMAP similar genes for TTLL6 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TTLL6: view

Variants for TTLL6 Gene

Sequence variations from dbSNP and Humsavar for TTLL6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs113507616 -- 48,765,797(+) TTCTG(C/T)CTCAG intron-variant
rs113458929 -- 48,784,708(+) GATAA(C/T)CTGCC intron-variant
rs113379002 -- 48,766,956(+) TTTGT(G/T)TTGTG intron-variant
rs113344941 -- 48,793,466(+) TGGGC(A/G)CCTGT intron-variant
rs113328693 -- 48,810,829(+) TGTAT(A/G)TATAT intron-variant

Relevant External Links for TTLL6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TTLL6 Gene

Disorders for TTLL6 Gene

Relevant External Links for TTLL6

Genetic Association Database (GAD)

No disorders were found for TTLL6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TTLL6 Gene

Publications for TTLL6 Gene

  1. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PMID: 15890843) Janke C. … Edde B. (Science 2005) 2 3 4
  2. The testis-specific apoptosis related gene TTL.6 underwent adaptive evolution in the lineage leading to humans. (PMID: 16443334) Chen X.-H. … Su B. (Gene 2006) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium. (PMID: 22246503) Lee J.E. … Gleeson J.G. (Nat. Genet. 2012) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for TTLL6 Gene

Sources for TTLL6 Gene

Back to Top