Aliases for TTLL5 Gene
External Ids for TTLL5 Gene
Previous HGNC Symbols for TTLL5 Gene
Previous GeneCards Identifiers for TTLL5 Gene
This gene encodes a member of the tubulin tyrosine ligase like protein family. This protein interacts with two glucocorticoid receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1. This protein may function as a coregulator of glucocorticoid receptor mediated gene induction and repression. This protein may also function as an alpha tubulin polyglutamylase.[provided by RefSeq, Feb 2010]
GeneCards Summary for TTLL5 Gene
TTLL5 (Tubulin Tyrosine Ligase Like 5) is a Protein Coding gene. Diseases associated with TTLL5 include Cone-Rod Dystrophy 19 and Retinitis Pigmentosa. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is TTLL4.
UniProtKB/Swiss-Prot for TTLL5 Gene
Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (PubMed:17116691, PubMed:22493317).