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TTLL5 Gene

protein-coding   GIFtS: 49
GCID: GC14P076127

Tubulin Tyrosine Ligase-Like Family, Member 5

(Previous name: KIAA0998)
(Previous symbol: KIAA0998)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tubulin Tyrosine Ligase-Like Family, Member 51 2     SRC1 And TIF2 Associated Binding Protein2
KIAA09981 2 3 5     Tubulin Polyglutamylase TTLL52
STAMP2 3 5     EC 6.-.-.-3
SRC1 And TIF2-Associated Modulatory Protein2 3     Tubulin--Tyrosine Ligase-Like Protein 53

External Ids:    HGNC: 199631   Entrez Gene: 230932   Ensembl: ENSG000001196857   OMIM: 6122685   UniProtKB: Q6EMB23   

Export aliases for TTLL5 gene to outside databases

Previous GC identifers: GC14P075198 GC14P056295


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TTLL5 Gene:
This gene encodes a member of the tubulin tyrosine ligase like protein family. This protein interacts with two
glucocorticoid receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1.
This protein may function as a coregulator of glucocorticoid receptor mediated gene induction and repression.
This protein may also function as an alpha tubulin polyglutamylase.(provided by RefSeq, Feb 2010)

GeneCards Summary for TTLL5 Gene:
TTLL5 (tubulin tyrosine ligase-like family, member 5) is a protein-coding gene. Diseases associated with TTLL5 include occupational dermatitis, and heel spur. GO annotations related to this gene include ligase activity. An important paralog of this gene is TTLL4.

UniProtKB/Swiss-Prot: TTLL5_HUMAN, Q6EMB2
Function: Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain initiation step
of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP
localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid
receptor-mediated repression and induction and in androgen receptor-mediated induction




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TTLL5 gene promoter:
         c-Fos   Sox5   AP-1   FosB   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   CREB   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTLL5 promoter sequence
   Search Chromatin IP Primers for TTLL5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTLL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

TTLL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTLL5 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P076127:  view genomic region     (about GC identifiers)

Start:
76,099,968 bp from pter      End:
76,421,425 bp from pter
Size:
321,458 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TTLL5_HUMAN, Q6EMB2 (See protein sequence)
Recommended Name: Tubulin polyglutamylase TTLL5  
Size: 1281 amino acids; 143577 Da
Subunit: Interacts with the transcriptional coactivators NCOA1/SRC-1 and NCOA2/TIF2
Sequence caution: Sequence=AAF23275.2; Type=Erroneous gene model prediction; Sequence=AAP75557.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: B9EGH8 B9EGH9 Q9BUB0 Q9H0G4 Q9H7W2 Q9P1V5 Q9UPZ4
Alternative splicing: 3 isoforms:  Q6EMB2-1   Q6EMB2-2   Q6EMB2-3   

Explore the universe of human proteins at neXtProt for TTLL5: NX_Q6EMB2

Explore proteomics data for TTLL5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1159
  • Modification sites at PhosphoSitePlus

  • See TTLL5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055887.3  
    ENSEMBL proteins: 
     ENSP00000451917   ENSP00000450713   ENSP00000286650   ENSP00000298832   ENSP00000452524  
     ENSP00000451946  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTLL: Tubulin tyrosine ligase-like family

    1 InterPro protein domain:
     IPR004344 TTL/TTLL_fam

    Graphical View of Domain Structure for InterPro Entry Q6EMB2

    ProtoNet protein and cluster: Q6EMB2

    1 Blocks protein domain: IPB004344 Tubulin-tyrosine ligase

    UniProtKB/Swiss-Prot: TTLL5_HUMAN, Q6EMB2
    Similarity: Belongs to the tubulin--tyrosine ligase family
    Similarity: Contains 1 TTL domain


    TTLL5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTLL5_HUMAN, Q6EMB2
    Function: Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain initiation step
    of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP
    localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid
    receptor-mediated repression and induction and in androgen receptor-mediated induction

         Enzyme Number (IUBMB): EC 6.-.-.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016874ligase activity IEA--
         
    TTLL5 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ttll5):
     cellular  hearing/vestibular/ear  no phenotypic analysis  reproductive system  vision/eye 

    TTLL5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ttll5tm1.1N for TTLL5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TTLL5
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TTLL5

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    miRTarBase miRNAs that target TTLL5:
    hsa-mir-335-5p (MIRT017876)

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    6 qRT-PCR Assays for microRNAs that regulate TTLL5:
    hsa-miR-875-3p hsa-miR-1276 hsa-miR-4286 hsa-miR-2114* hsa-miR-3121-3p hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidTTLL5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TTLL5

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    GenScript: all cDNA clones in your preferred vector: TTLL5 (NM_015072)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTLL5

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TTLL5_HUMAN, Q6EMB2: Cell projection, cilium (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By
    similarity). Nucleus. Cytoplasm. Note=In ciliated cells, located in both cilia and basal bodies (By similarity).
    In osteosarcoma cells, found in both cytoplasm and nucleus in the absence of steroid but located exclusively in
    the nucleus in the presence of steroid
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol2
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome IDA--
    GO:0005929cilium IEA--

    TTLL5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TTLL5
    Interactions:

        Search GeneGlobe Interaction Network for TTLL5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for TTLL5 (Q6EMB22, 3 ENSP000002988324) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    TP73O153503, ENSP000003675454I2D: score=1 STRING: ENSP00000367545
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CDKN1AP389363, ENSP000002447414I2D: score=3 STRING: ENSP00000244741
    DCP1BENSP000002806654STRING: ENSP00000280665
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006464cellular protein modification process IEA--

    TTLL5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TTLL5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TTLL5 gene: 
    NM_015072.4  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000556265 ENST00000554132 ENST00000555290 ENST00000556977(uc001xrv.3)
    ENST00000556685 ENST00000557636(uc001xry.1 uc010ask.2) ENST00000286650
    ENST00000298832(uc001xrx.3 uc001xsa.3) ENST00000556173(uc001xrw.2)
    ENST00000554185 ENST00000555422 ENST00000554935 ENST00000554148 ENST00000554878
    ENST00000556976 ENST00000556893(uc001xrz.3) ENST00000554510 ENST00000555018

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate TTLL5:
    hsa-miR-875-3p hsa-miR-1276 hsa-miR-4286 hsa-miR-2114* hsa-miR-3121-3p hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidTTLL5 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TTLL5
    Predesigned siRNA for gene silencing in human, mouse, rat TTLL5
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    GenScript: all cDNA clones in your preferred vector: TTLL5 (NM_015072)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTLL5
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TTLL5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TTLL5
      QuantiTect SYBR Green Assays in human, mouse, rat TTLL5
      QuantiFast Probe-based Assays in human, mouse, rat TTLL5

    1 AceView cDNA sequence:

    AW889425 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TTLL5 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^
    SP1:              -                             -                                   -     -                       -                                             
    SP2:                                                                                      -     -     -     -                                                   
    SP3:                                                                                                                                                            
    SP4:              -                             -                                                                                                               
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39a · 39b · 39c · 39d
    SP1:  -                                   -                                                                 -           -     -                           
    SP2:  -                                                                                                                                                   
    SP3:                                      -                                                                                                               
    SP4:                                                                                                                                                      
    SP5:                                                                                                        -           -     -                           


    ECgene alternative splicing isoforms for TTLL5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TTLL5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCAGGGTA
    TTLL5 Expression
    About this image

    TTLL5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TTLL5 Protein Expression

    UniProtKB/Swiss-Prot: TTLL5_HUMAN, Q6EMB2
    Tissue specificity: Widely expressed with highest levels in heart and skeletal muscle and low levels in other
    tissues

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TTLL5 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttll51 , 5 tubulin tyrosine ligase-like family, member 51, 5 88.08(n)1
    89.13(a)1
      12 (39.81 cM)5
    3202441  NM_001081423.21  NP_001074892.21 
     858246595 
    chicken
    (Gallus gallus)
    Aves TTLL51 tubulin tyrosine ligase-like family, member 5 66.03(n)
    63.42(a)
      423367  NM_001031204.1  NP_001026375.1 
    lizard
    (Anolis carolinensis)
    Reptilia TTLL56
    tubulin tyrosine ligase-like family, member 5
    60(a)
    1 ↔ 1
    1(22039723-22188632)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ttll51 tubulin tyrosine ligase-like family, member 5 49.12(n)
    40.91(a)
      100158545  NM_001127979.1  NP_001121451.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005383011 tubulin polyglutamylase TTLL5-like 71.38(n)
    77.84(a)
      100538301  XM_003200400.2  XP_003200448.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG311086
    --
    32(a)
    1 ↔ 1
    3R(20938587-20948631)
    worm
    (Caenorhabditis elegans)
    Secernentea ttll-56
    Protein TTLL-5, isoform b
    30(a)
    1 ↔ 1
    V(11509136-11512321) WBGene00008331


    ENSEMBL Gene Tree for TTLL5 (if available)
    TreeFam Gene Tree for TTLL5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TTLL5 gene
    TTLL42  TTLL102  ENSG000002611472  TTLL32  TTLL12  TTLL112  TTLL92  TTLL72  
    TTLL62  TTL2  TTLL82  TTLL22  TTLL132  ARPC4-TTLL32  
    5 SIMAP similar genes for TTLL5 using alignment to 5 protein entries:     TTLL5_HUMAN (see all proteins):
    DKFZp434E199    TTLL11    TTLL4    TTLL1    TTLL9

    TTLL5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TTLL5 (see all 5424)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs348175391,2
    C--56337391(+) ATGTCT/-TTAGA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs3774551621,2
    C--56345124(+) TTTAT-/ACACACA 1 -- int10--------
    rs2010675681,2
    --56347081(+) CTCTT-/TTCTTGGT 1 -- int10--------
    rs339594051,2
    C--56378292(+) GCTCTT/-TTTTT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs340410471,2
    C--56382997(+) TTCTT-/A/AA  
            
    AAAAA
    1 -- int10--------
    rs725206911,2
    C--56384274(+) CCTAT-/AGGGAGC 1 -- int10--------
    rs776057761,2
    C--56384276(+) CTATAG/TGAGCA 1 -- int10--------
    rs343870371,2
    C,F--56391219(+) GGGAC-/TTTTTT 1 -- int13Minor allele frequency- T:0.33NA CSA 6
    rs1386257521,2
    C--56391669(+) AGGTT-/TTGTTGTT 1 -- cds10--------
    rs353997211,2
    C--56397957(+) TATAG-/CTCTCTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for TTLL5 (76099968 - 76349968 bp, first 250kb of TTLL5)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TTLL5 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659565CNV Deletion23128226
    esv2664273CNV Deletion23128226
    esv2491325CNV Deletion19546169
    esv2748875CNV Deletion23290073
    esv2386292CNV Deletion18987734
    nsv1358CNV Insertion18451855
    nsv902101CNV Loss21882294
    nsv1359CNV Loss18451855
    nsv902100CNV Loss21882294
    nsv518383CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 612268    OMIM disorders: --

    7 diseases for TTLL5:    
    About MalaCards
    occupational dermatitis    heel spur    impotence    fanconi's anemia
    dermatitis    osteosarcoma    ovarian cancer


    TTLL5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TTLL5

    Export disorders for TTLL5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TTLL5 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with TTLL5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PubMed id 21998595)1, 4 N'Diaye A....Haiman C.A. (PLoS Genet. 2011)
    2. STAMP, a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression. (PubMed id 17116691)1, 2 He Y. and Simons S.S. Jr. (Mol. Cell. Biol. 2007)
    3. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PubMed id 15890843)1, 3 Janke C.... Edde B. (Science 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    6. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. CSAP localizes to polyglutamylated microtubules and promotes proper cilia function and zebrafish development. (PubMed id 22493317)2 Backer C.B.... Cheeseman I.M. (Mol. Biol. Cell 2012)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 23093 HGNC: 19963 AceView: KIAA0998.2 Ensembl:ENSG00000119685 euGenes: HUgn23093
    ECgene: TTLL5 H-InvDB: TTLL5

    (According to HUGE)
    About This Section

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    HUGE: KIAA0998

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TTLL5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TTLL5 gene:
    Search GeneIP for patents involving TTLL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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