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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TTLL5 Gene

protein-coding GIFtS: 51
GCID: GC14P076127

tubulin tyrosine ligase-like family, member 5

(Previous name: KIAA0998 )
(Previous symbol: KIAA0998)

Explore 7 diseases affiliated with
TTLL5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tubulin Tyrosine Ligase-Like Family, Member 5¹ ²		SRC1 And TIF2 Associated Binding Protein²
KIAA0998¹ ² ³ ⁵		Tubulin Polyglutamylase TTLL5²
STAMP² ³ ⁵		EC 6.-.-.-³
SRC1 And TIF2-Associated Modulatory Protein² ³		Tubulin--Tyrosine Ligase-Like Protein 5³

External Ids:	HGNC: 19963¹	Entrez Gene: 23093²	Ensembl: ENSG00000119685⁷	OMIM: 612268⁵	UniProtKB: Q6EMB2³

Export aliases for TTLL5 gene to outside databases

Previous GC identifers: GC14P075198 GC14P056295

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TTLL5:

This gene encodes a member of the tubulin tyrosine ligase like protein family. This protein interacts with two

glucocorticoid receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1. This

protein may function as a coregulator of glucocorticoid receptor mediated gene induction and repression. This protein

may also function as an alpha tubulin polyglutamylase.(provided by RefSeq, Feb 2010)

UniProtKB/Swiss-Prot: TTLL5_HUMAN, Q6EMB2

Function: Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain initiation step of

the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to

both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and

induction and in androgen receptor-mediated induction

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TTLL5 gene promoter:
c-Fos Sox5 AP-1 FosB POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 CREB deltaCREB c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TTLL5 promoter sequence

Search SABiosciences Chromatin IP Primers for TTLL5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTLL5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q24.3

TTLL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTLL5 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P076127: view genomic region (about GC identifiers)

Start:	76,099,968 bp from pter	End:	76,421,425 bp from pter
Size:	321,458 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TTLL5_HUMAN, Q6EMB2 (See protein sequence)

Recommended Name: Tubulin polyglutamylase TTLL5

Size: 1281 amino acids; 143577 Da

Subunit: Interacts with the transcriptional coactivators NCOA1/SRC-1 and NCOA2/TIF2

Subcellular location: Cell projection, cilium (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By

similarity). Nucleus. Cytoplasm. Note=In ciliated cells, located in both cilia and basal bodies (By similarity). In

osteosarcoma cells, found in both cytoplasm and nucleus in the absence of steroid but located exclusively in the

nucleus in the presence of steroid

Sequence caution: Sequence=AAF23275.2; Type=Erroneous gene model prediction; Sequence=AAP75557.1; Type=Erroneous

initiation; Note=Translation N-terminally extended;

Secondary accessions: B9EGH8 B9EGH9 Q9BUB0 Q9H0G4 Q9H7W2 Q9P1V5 Q9UPZ4

Alternative splicing: 3 isoforms: Q6EMB2-1 Q6EMB2-2 Q6EMB2-3

Explore the universe of human proteins at neXtProt for TTLL5: NX_Q6EMB2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6EMB2

TTLL5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055887.3

ENSEMBL proteins:

ENSP00000450874 ENSP00000451917 ENSP00000450713 ENSP00000286650 ENSP00000298832

ENSP00000452524 ENSP00000451946

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	Uscn Proteins for TTLL5

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005813	centrosome	IDA	--
GO:0005929	cilium	IEA	--
GO:0005932	microtubule basal body	IEA	--

TTLL5 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for TTLL5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TTLL5 for domains About GeneDecksing

1 InterPro domain/family:

IPR004344 Tub_tyr_ligase

Graphical View of Domain Structure for InterPro Entry Q6EMB2

ProtoNet protein and cluster: Q6EMB2

1 Blocks protein family: IPB004344 Tubulin-tyrosine ligase

UniProtKB/Swiss-Prot: TTLL5_HUMAN, Q6EMB2

Similarity: Belongs to the tubulin--tyrosine ligase family

Similarity: Contains 1 TTL domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TTLL5_HUMAN, Q6EMB2

Function: Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain initiation step of

the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to

both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and

induction and in androgen receptor-mediated induction

Enzyme Number (IUBMB): EC 6.-.-.-¹

miRNA Products:		OriGene 3'-UTR Clone: TTLL5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TTLL5
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate TTLL5:
		hsa-miR-875-3p hsa-miR-1276 hsa-miR-4286 hsa-miR-2114* hsa-miR-3121-3p hsa-miR-1299
		SwitchGear 3'UTR luciferase reporter plasmid: TTLL5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTLL5 (see all 4) OriGene shRNA RFP: TTLL5 OriGene siRNA: TTLL5
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL5

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004835	tubulin-tyrosine ligase activity	IEA	--

TTLL5 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TTLL5

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5/6 Interacting proteins for TTLL5 (Q6EMB2^{2, 3} ENSP00000298832⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TP53	P04637³, ENSP00000269305⁴	I2D: score=1 STRING: ENSP00000269305
TP73	O15350³, ENSP00000367545⁴	I2D: score=1 STRING: ENSP00000367545
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
CDKN1A	P38936³, ENSP00000244741⁴	I2D: score=3 STRING: ENSP00000244741
--	Q59ED0³^,²	MINT-65516 I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006464	cellular protein modification process	IEA	--

TTLL5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TTLL5
Search CenterWatch for drugs/clinical trials and news about TTLL5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TTLL5 gene:

NM_015072.4

Unigene Cluster for TTLL5:

Tubulin tyrosine ligase-like family, member 5

Hs.709609 [show with all ESTs]

Unigene Representative Sequence: NM_015072

18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):

ENST00000556265 ENST00000554132 ENST00000555290 ENST00000557003 ENST00000556977(uc001xrv.3)

ENST00000556685 ENST00000557636(uc001xry.1 uc010ask.2) ENST00000286650

ENST00000298832(uc001xrx.3 uc001xsa.3) ENST00000556173(uc001xrw.2)

ENST00000554185 ENST00000555422 ENST00000554935 ENST00000554148 ENST00000554878

ENST00000556976 ENST00000556893(uc001xrz.3) ENST00000554510

miRNA Products:		OriGene 3'-UTR Clone: TTLL5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TTLL5
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate TTLL5:
		hsa-miR-875-3p hsa-miR-1276 hsa-miR-4286 hsa-miR-2114* hsa-miR-3121-3p hsa-miR-1299
		SwitchGear 3'UTR luciferase reporter plasmid: TTLL5 3' UTR sequence

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Additional cDNA sequence:

AK309748.1 AL133586.1 AL136808.1 AL137329.1 AY237126.1 BC016625.1 BC110652.1 BC136472.1

BC136473.1 BX647530.1 CR533554.1

24/27 DOTS entries (see all 27):

DT.95086616 DT.75106893 DT.441871 DT.443528 DT.92437140 DT.97798401 DT.91650689 DT.120752890

DT.92437126 DT.95168988 DT.100782147 DT.92437141 DT.99987731 DT.100782144 DT.100782148 DT.111132

DT.120752896 DT.86841112 DT.92437128 DT.95168987 DT.95168994 DT.100716548 DT.111130 DT.120752795

1 AceView cDNA sequence:

AW889425

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TTLL5 (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19a	·	19b	^	20	^	21	^
SP1:					-										-												-		-								-
SP2:																													-		-		-		-
SP3:
SP4:					-										-
SP5:

ExUns:	22	^	23	^	24a	·	24b	^	25	^	26	^	27a	·	27b	^	28	^	29	^	30	^	31	^	32	^	33	^	34a	·	34b	^	35	^	36	^	37	^	38a	·	38b	^	39a	·	39b	·	39c	·	39d
SP1:	-												-																						-				-		-
SP2:	-
SP3:													-
SP4:
SP5:																																			-				-		-

ECgene alternative splicing isoforms for TTLL5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TTLL5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCCAGGGTA

About this image

TTLL5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Yolk Sac

Definitive Yolk Sac

Erythroid Progenitor Cells

Blood

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TTLL5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TTLL5

SOURCE GeneReport for Unigene cluster: Hs.709609

UniProtKB/Swiss-Prot: TTLL5_HUMAN, Q6EMB2

Tissue specificity: Widely expressed with highest levels in heart and skeletal muscle and low levels in other tissues

SABiosciences Custom PCR Arrays for TTLL5

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TTLL5 gene from 5/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TTLL5¹	tubulin tyrosine ligase-like family, member 5	66.67(n) 64.22(a)		423367 NM_001031204.1 NP_001026375.1
lizard (Anolis carolinensis)	Reptilia	TTLL5⁶	--	61(a)	1 ↔ 1	1(22039723-22175454)
zebrafish (Danio rerio)	Actinopterygii	LOC100538301¹	tubulin polyglutamylase TTLL5-like	70.76(n) 76.35(a)		100538301 XM_003200400.1 XP_003200448.1
fruit fly (Drosophila melanogaster)	Insecta	CG31108⁶	--	29(a)	1 ↔ 1	3R(20938587-20948631)
worm (Caenorhabditis elegans)	Secernentea	ttll-5¹	Protein TTLL-5	47.76(n) 39.39(a)		179582 NM_073517.5 NP_505918.2

ENSEMBL Gene Tree for TTLL5 (if available)
TreeFam Gene Tree for TTLL5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TTLL5 gene

TTLL10² TTLL4² TTLL3² TTLL1² TTLL11² TTLL9² TTLL7² TTLL6²

TTL² TTLL8² TTLL2² TTLL13² ARPC4-TTLL3²

5 SIMAP similar genes for TTLL5 using alignment to 6 protein entries: TTLL5_HUMAN (see all proteins):

DKFZp434E199 TTLL11 TTLL4 TTLL1 TTLL9

TTLL5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76424929^1,2	F,	--	56298883(+)	`AGATAC/TAAGAT`	1	--	int¹		1		WA	118
rs12588000^1,2	C,F,H,	--	56299241(+)	`GGTAGG/ATCAGA`	1	--	int¹		5		NS EA CSA	420
rs75151375^1,2	F,	--	56299297(+)	`AGTAGG/TTACTT`	1	--	int¹		1		WA	118
rs73307514^1,2	C,	--	56300310(+)	`CCCTCT/GGCTCC`	1	--	int¹		2		WA	120
rs7146707^1,2	C,F,H,	--	56301119(+)	`CTCATG/TAAATT`	1	--	int¹		5		NS EA WA	536
rs7148034^1,2	H	--	56301239(+)	`TTTAAT/CATGTA`	1	--	int¹		4		NS EA	420
rs75369768^1,2	F,	--	56301543(+)	`ATTTTA/TAAATT`	1	--	int¹		1		WA	118
rs200934027^1,2	C	--	56301795(+)	`GCAAGA/CAAGCC`	1	--	int¹		0	--	--	--	--
rs2110567^1,2	C,H	--	56301987(+)	`CAAGTC/TTAAAG`	1	--	int¹		5		NS EA NA	420
rs80317062^1,2	F,	--	56303186(+)	`AATACT/GTTCAC`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for TTLL5 (76099968 - 76349968 bp, first 250kb of TTLL5)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for TTLL5
4 CNVs: 101985 35271 43905 1954

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTLL5

DNA2.0 Custom Variant and Variant Library Synthesis for TTLL5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TTLL5 for disorders           About GeneDecksing

OMIM gene information: 612268    OMIM disorders: --

7 diseases for TTLL5:    About MalaCards

heel spur occupational dermatitis impotence fanconi's anemia

anemia dermatitis osteosarcoma

Export disorders for TTLL5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TTLL5 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with TTLL5)

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STAMP, a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression. (PubMed id 17116691)^{1, 2} He Y. and Simons S.S. Jr. (2007)
Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PubMed id 15890843)^{1, 3} Janke C.... Edde B. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)^{1, 2} Heilig R.... Weissenbach J. (2003)
Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)^{1, 2} Nagase T.... Ohara O. (1999)
CSAP localizes to polyglutamylated microtubules and promotes proper cilia function and zebrafish development. (PubMed id 22493317)² Backer C.B.... Cheeseman I.M. (2012)
Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PubMed id 21998595)¹ N'Diaye A....Haiman C.A. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)¹ Prakash T....Taylor T.D. (2010)
A genome-scale protein interaction profile of Drosoph ila p53 uncovers additional nodes of the human p53 network. (PubMed id 20308539)¹ Lunardi A....Collavin L. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23093	HGNC: 19963	AceView: KIAA0998.2	Ensembl:ENSG00000119685	euGenes: HUgn23093
ECgene: TTLL5	H-InvDB: TTLL5

(According to HUGE)
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HUGE: KIAA0998

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TTLL5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TTLL5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TTLL5 gene:
Search GeneIP for patents involving TTLL5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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TTLL5 Gene

tubulin tyrosine ligase-like family, member 5

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TTLL5 Gene

tubulin tyrosine ligase-like family, member 5

Aliasesfor TTLL5 gene

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Protein Domains /Familiesfor TTLL5 gene

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