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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TTLL5 Gene

protein-coding   GIFtS: 50
GCID: GC14P076127

Tubulin Tyrosine Ligase-Like Family, Member 5

(Previous name: KIAA0998)
(Previous symbol: KIAA0998)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tubulin Tyrosine Ligase-Like Family, Member 51 2     SRC1 And TIF2 Associated Binding Protein2
KIAA09981 2 3 5     Tubulin Polyglutamylase TTLL52
STAMP2 3 5     EC 6.-.-.-3
SRC1 And TIF2-Associated Modulatory Protein2 3     Tubulin--Tyrosine Ligase-Like Protein 53

External Ids:    HGNC: 199631   Entrez Gene: 230932   Ensembl: ENSG000001196857   OMIM: 6122685   UniProtKB: Q6EMB23   

Export aliases for TTLL5 gene to outside databases

Previous GC identifers: GC14P075198 GC14P056295


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TTLL5 Gene:
This gene encodes a member of the tubulin tyrosine ligase like protein family. This protein interacts with two
glucocorticoid receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1.
This protein may function as a coregulator of glucocorticoid receptor mediated gene induction and repression.
This protein may also function as an alpha tubulin polyglutamylase.(provided by RefSeq, Feb 2010)

GeneCards Summary for TTLL5 Gene: 
TTLL5 (tubulin tyrosine ligase-like family, member 5) is a protein-coding gene. Diseases associated with TTLL5 include occupational dermatitis, and heel spur. GO annotations related to this gene include tubulin-tyrosine ligase activity. An important paralog of this gene is TTLL4.

UniProtKB/Swiss-Prot: TTLL5_HUMAN, Q6EMB2
Function: Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain initiation step
of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP
localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid
receptor-mediated repression and induction and in androgen receptor-mediated induction




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TTLL5 gene promoter:
         c-Fos   Sox5   AP-1   FosB   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   CREB   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTLL5 promoter sequence
   Search SABiosciences Chromatin IP Primers for TTLL5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTLL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

TTLL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTLL5 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P076127:  view genomic region     (about GC identifiers)

Start:
76,099,968 bp from pter      End:
76,421,425 bp from pter
Size:
321,458 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TTLL5_HUMAN, Q6EMB2 (See protein sequence)
Recommended Name: Tubulin polyglutamylase TTLL5  
Size: 1281 amino acids; 143577 Da
Subunit: Interacts with the transcriptional coactivators NCOA1/SRC-1 and NCOA2/TIF2
Subcellular location: Cell projection, cilium (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By
similarity). Nucleus. Cytoplasm. Note=In ciliated cells, located in both cilia and basal bodies (By similarity).
In osteosarcoma cells, found in both cytoplasm and nucleus in the absence of steroid but located exclusively in
the nucleus in the presence of steroid
Sequence caution: Sequence=AAF23275.2; Type=Erroneous gene model prediction; Sequence=AAP75557.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: B9EGH8 B9EGH9 Q9BUB0 Q9H0G4 Q9H7W2 Q9P1V5 Q9UPZ4
Alternative splicing: 3 isoforms:  Q6EMB2-1   Q6EMB2-2   Q6EMB2-3   

Explore the universe of human proteins at neXtProt for TTLL5: NX_Q6EMB2

Explore proteomics data for TTLL5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6EMB2

  • TTLL5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TTLL5 Protein Expression
    REFSEQ proteins: NP_055887.3  
    ENSEMBL proteins: 
     ENSP00000451917   ENSP00000450713   ENSP00000286650   ENSP00000298832   ENSP00000452524  
     ENSP00000451946  

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    Cloud-Clone Corp. Proteins for TTLL5 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome IDA--
    GO:0005929cilium IEA--
    GO:0005932microtubule basal body IEA--

    TTLL5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TTLL: Tubulin tyrosine ligase-like family

    1 InterPro protein domain:
     IPR004344 Tub_tyr_ligase

    Graphical View of Domain Structure for InterPro Entry Q6EMB2

    ProtoNet protein and cluster: Q6EMB2

    1 Blocks protein domain: IPB004344 Tubulin-tyrosine ligase

    UniProtKB/Swiss-Prot: TTLL5_HUMAN, Q6EMB2
    Similarity: Belongs to the tubulin--tyrosine ligase family
    Similarity: Contains 1 TTL domain


    TTLL5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTLL5_HUMAN, Q6EMB2
    Function: Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain initiation step
    of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP
    localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid
    receptor-mediated repression and induction and in androgen receptor-mediated induction

         Enzyme Number (IUBMB): EC 6.-.-.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004835tubulin-tyrosine ligase activity ----
    GO:0016874ligase activity IEA--
         
    TTLL5 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Ttll5 (no phenotypes)

    TTLL5 for phenotypes           About GeneDecksing

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidTTLL5 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTLL5

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/6 Interacting proteins for TTLL5 (Q6EMB22, 3 ENSP000002988324) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    TP73O153503, ENSP000003675454I2D: score=1 STRING: ENSP00000367545
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CDKN1AP389363, ENSP000002447414I2D: score=3 STRING: ENSP00000244741
    --Q59ED03, 2MINT-65516 I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006464cellular protein modification process IEA--

    TTLL5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TTLL5

    Search CenterWatch for drugs/clinical trials and news about TTLL5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TTLL5 gene: 
    NM_015072.4  

    Unigene Cluster for TTLL5:

    Tubulin tyrosine ligase-like family, member 5
    Hs.709609  [show with all ESTs]
    Unigene Representative Sequence: NM_015072
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000556265 ENST00000554132 ENST00000555290 ENST00000556977(uc001xrv.3)
    ENST00000556685 ENST00000557636(uc001xry.1 uc010ask.2) ENST00000286650
    ENST00000298832(uc001xrx.3 uc001xsa.3) ENST00000556173(uc001xrw.2)
    ENST00000554185 ENST00000555422 ENST00000554935 ENST00000554148 ENST00000554878
    ENST00000556976 ENST00000556893(uc001xrz.3) ENST00000554510 ENST00000555018

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate TTLL5:
    hsa-miR-875-3p hsa-miR-1276 hsa-miR-4286 hsa-miR-2114* hsa-miR-3121-3p hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidTTLL5 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK309748.1 AL133586.1 AL136808.1 AL137329.1 AY237126.1 BC016625.1 BC110652.1 BC136472.1 
    BC136473.1 BX647530.1 CR533554.1 

    24/27 DOTS entries (see all 27):

    DT.95086616  DT.75106893  DT.441871  DT.443528  DT.92437140  DT.97798401  DT.91650689  DT.120752890 
    DT.92437126  DT.95168988  DT.100782147  DT.92437141  DT.99987731  DT.100782144  DT.100782148  DT.111132 
    DT.120752896  DT.86841112  DT.92437128  DT.95168987  DT.95168994  DT.100716548  DT.111130  DT.120752795 

    1 AceView cDNA sequence:

    AW889425 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TTLL5 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^
    SP1:              -                             -                                   -     -                       -                                             
    SP2:                                                                                      -     -     -     -                                                   
    SP3:                                                                                                                                                            
    SP4:              -                             -                                                                                                               
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39a · 39b · 39c · 39d
    SP1:  -                                   -                                                                 -           -     -                           
    SP2:  -                                                                                                                                                   
    SP3:                                      -                                                                                                               
    SP4:                                                                                                                                                      
    SP5:                                                                                                        -           -     -                           


    ECgene alternative splicing isoforms for TTLL5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TTLL5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCAGGGTA
    TTLL5 Expression
    About this image


    See TTLL5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TTLL5

    SOURCE GeneReport for Unigene cluster: Hs.709609

    UniProtKB/Swiss-Prot: TTLL5_HUMAN, Q6EMB2
    Tissue specificity: Widely expressed with highest levels in heart and skeletal muscle and low levels in other
    tissues

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TTLL5 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttll51 , 5 tubulin tyrosine ligase-like family, member 51, 5 88.08(n)1
    89.13(a)1
      12 (39.81 cM)5
    3202441  NM_001081423.21  NP_001074892.21 
     858246595 
    chicken
    (Gallus gallus)
    Aves TTLL51 tubulin tyrosine ligase-like family, member 5 66.67(n)
    64.22(a)
      423367  NM_001031204.1  NP_001026375.1 
    lizard
    (Anolis carolinensis)
    Reptilia TTLL56
    Uncharacterized protein
    58(a)
    1 ↔ 1
    1(22039723-22188632)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005383011 tubulin polyglutamylase TTLL5-like 70.76(n)
    76.35(a)
      100538301  XM_003200400.1  XP_003200448.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG311086
    --
    31(a)
    1 ↔ 1
    3R(20938587-20948631)
    worm
    (Caenorhabditis elegans)
    Secernentea ttll-51 Protein TTLL-5 47.76(n)
    39.39(a)
      179582  NM_073517.5  NP_505918.2 


    ENSEMBL Gene Tree for TTLL5 (if available)
    TreeFam Gene Tree for TTLL5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TTLL5 gene
    TTLL42  TTLL102  ENSG000002611472  TTLL32  TTLL12  TTLL112  TTLL92  TTLL72  
    TTLL62  TTL2  TTLL82  TTLL22  TTLL132  ARPC4-TTLL32  
    5 SIMAP similar genes for TTLL5 using alignment to 6 protein entries:     TTLL5_HUMAN (see all proteins):
    DKFZp434E199    TTLL11    TTLL4    TTLL1    TTLL9

    TTLL5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5424 SNPs in TTLL5 are shown (see all 5424)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs348175391,2
    C--56337391(+) ATGTCT/-TTAGA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs3774551621,2
    C--56345124(+) TTTAT-/ACACACA 1 -- int10--------
    rs2010675681,2
    --56347081(+) CTCTT-/TTCTTGGT 1 -- int10--------
    rs339594051,2
    C--56378292(+) GCTCTT/-TTTTT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs340410471,2
    C--56382997(+) TTCTT-/A/AA  
            
    AAAAA
    1 -- int10--------
    rs725206911,2
    C--56384274(+) CCTAT-/AGGGAGC 1 -- int10--------
    rs776057761,2
    C--56384276(+) CTATAG/TGAGCA 1 -- int10--------
    rs343870371,2
    C,F--56391219(+) GGGAC-/TTTTTT 1 -- int13Minor allele frequency- T:0.33NA CSA 6
    rs1386257521,2
    C--56391669(+) AGGTT-/TTGTTGTT 1 -- cds10--------
    rs353997211,2
    C--56397957(+) TATAG-/CTCTCTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for TTLL5 (76099968 - 76349968 bp, first 250kb of TTLL5)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for TTLL5 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2659565CNV Deletion23128226
    esv2664273CNV Deletion23128226
    esv2491325CNV Deletion19546169
    esv2748875CNV Deletion23290073
    esv2386292CNV Deletion18987734
    nsv1358CNV Insertion18451855
    nsv902101CNV Loss21882294
    nsv1359CNV Loss18451855
    nsv902100CNV Loss21882294
    nsv518383CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612268    OMIM disorders: --

    7 diseases for TTLL5:    About MalaCards
    occupational dermatitis    heel spur    impotence    fanconi's anemia
    dermatitis    osteosarcoma    anemia


    TTLL5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TTLL5

    Export disorders for TTLL5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TTLL5 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with TTLL5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PubMed id 21998595)1, 4 N'Diaye A....Haiman C.A. (2011)
    2. STAMP, a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression. (PubMed id 17116691)1, 2 He Y. and Simons S.S. Jr. (2007)
    3. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PubMed id 15890843)1, 3 Janke C.... Edde B. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    6. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (1999)
    7. CSAP localizes to polyglutamylated microtubules and promotes proper cilia function and zebrafish development. (PubMed id 22493317)2 Backer C.B.... Cheeseman I.M. (2012)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
    10. A genome-scale protein interaction profile of Drosoph ila p53 uncovers additional nodes of the human p53 network. (PubMed id 20308539)1 Lunardi A....Collavin L. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23093 HGNC: 19963 AceView: KIAA0998.2 Ensembl:ENSG00000119685 euGenes: HUgn23093
    ECgene: TTLL5 H-InvDB: TTLL5

    (According to HUGE)
    About This Section
    HUGE: KIAA0998

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TTLL5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TTLL5 gene:
    Search GeneIP for patents involving TTLL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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