Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TTLL4 Gene

protein-coding   GIFtS: 50
GCID: GC02P219575

Tubulin Tyrosine Ligase-Like Family, Member 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Tubulin Tyrosine Ligase-Like Family, Member 41 2
Tubulin--Tyrosine Ligase-Like Protein 42 3
Tubulin Polyglutamylase TTLL42
EC 6.-.-.-3
KIAA01733

External Ids:    HGNC: 289761   Entrez Gene: 96542   Ensembl: ENSG000001359127   UniProtKB: Q146793   
ORGUL members:         

Export aliases for TTLL4 gene to outside databases

Previous GC identifers: GC02P219779 GC02P219401 GC02P219283 GC02P211428


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for TTLL4 Gene:
TTLL4 (tubulin tyrosine ligase-like family, member 4) is a protein-coding gene. Diseases associated with TTLL4 include pancreatic ductal adenocarcinoma, and amyotrophic lateral sclerosis. GO annotations related to this gene include tubulin binding and ligase activity. An important paralog of this gene is TTLL10.

UniProtKB/Swiss-Prot: TTLL4_HUMAN, Q14679
Function: Polyglutamylase which preferentially modifies beta-tubulin and nucleosome assembly proteins NAP1 and
NAP2. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation
step (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TTLL4 gene promoter:
         HOXA9B   HOXA9   Pax-5   AML1a   Meis-1b   Evi-1   Gfi-1   CREB   Pax-4a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTLL4 promoter sequence
   Search Chromatin IP Primers for TTLL4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTLL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24.3-p24.1   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2p24.3-p24.1

TTLL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTLL4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P219575:  view genomic region     (about GC identifiers)

Start:
219,575,568 bp from pter      End:
219,620,139 bp from pter
Size:
44,572 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TTLL4_HUMAN, Q14679 (See protein sequence)
Recommended Name: Tubulin polyglutamylase TTLL4  
Size: 1199 amino acids; 133378 Da
Sequence caution: Sequence=BAA11490.2; Type=Erroneous initiation;
Secondary accessions: A8K6V5 Q8WW29

Explore the universe of human proteins at neXtProt for TTLL4: NX_Q14679

Explore proteomics data for TTLL4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys688
  • Modification sites at PhosphoSitePlus

  • See TTLL4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055455.3  
    ENSEMBL proteins: 
     ENSP00000393332   ENSP00000411228   ENSP00000375951   ENSP00000391342   ENSP00000396555  
     ENSP00000405485   ENSP00000415197   ENSP00000407434   ENSP00000392103   ENSP00000415845  
     ENSP00000400068   ENSP00000258398  

    TTLL4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TTLL4
    GenScript Custom Purified and Recombinant Proteins Services for TTLL4
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TTLL4

    TTLL4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TTLL4
    OriGene Custom Antibody Services for TTLL4
    Novus Biologicals TTLL4 Antibodies
    Search for Antibodies for TTLL4 at Abcam
    Cloud-Clone Corp. Antibodies for TTLL4
    ThermoFisher Antibodies for TTLL4
    LSBio Antibodies in human, mouse, rat for TTLL4

    TTLL4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TTLL4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TTLL4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TTLL4
    Cloud-Clone Corp. CLIAs for TTLL4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TTLL: Tubulin tyrosine ligase-like family

    2 InterPro protein domains:
     IPR027748 TTLL-4
     IPR004344 TTL/TTLL_fam

    Graphical View of Domain Structure for InterPro Entry Q14679

    ProtoNet protein and cluster: Q14679

    1 Blocks protein domain: IPB004344 Tubulin-tyrosine ligase

    UniProtKB/Swiss-Prot: TTLL4_HUMAN, Q14679
    Similarity: Belongs to the tubulin--tyrosine ligase family
    Similarity: Contains 1 TTL domain


    TTLL4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTLL4_HUMAN, Q14679
    Function: Polyglutamylase which preferentially modifies beta-tubulin and nucleosome assembly proteins NAP1 and
    NAP2. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation
    step (By similarity)

         Enzyme Number (IUBMB): EC 6.-.-.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015631tubulin binding ISS--
    GO:0016874ligase activity IEA--
         
    TTLL4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TTLL4:
     Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ttll4):
     adipose tissue  behavior/neurological  growth/size/body  other  skeleton 
     vision/eye 

    TTLL4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TTLL4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TTLL4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TTLL4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TTLL4

    miRNA
    Products:
        
    miRTarBase miRNAs that target TTLL4:
    hsa-mir-877-3p (MIRT037173), hsa-mir-98-5p (MIRT027603)

    Block miRNA regulation of human, mouse, rat TTLL4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TTLL4 (see all 22):
    hsa-miR-1321 hsa-miR-892b hsa-miR-3194-5p hsa-miR-3664-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidTTLL4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TTLL4
    Predesigned siRNA for gene silencing in human, mouse, rat TTLL4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TTLL4

    Clone
    Products:
         
    OriGene clones in human, mouse for TTLL4 (see all 6)
    OriGene ORF clones in mouse, rat for TTLL4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TTLL4 (NM_014640)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TTLL4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTLL4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TTLL4
    Browse ESI BIO Cell Lines and PureStem Progenitors for TTLL4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TTLL4_HUMAN, Q14679: Cell projection, cilium (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By
    similarity). Note=Located in cilia. In some cells, also found in basal bodies (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton2
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0005929cilium IEA--

    TTLL4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TTLL4
    Interactions:

        Search GeneGlobe Interaction Network for TTLL4

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process ----
    GO:0018095protein polyglutamylation ISS--

    TTLL4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TTLL4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TTLL4 gene: 
    NM_014640.4  

    Unigene Cluster for TTLL4:

    Tubulin tyrosine ligase-like family, member 4
    Hs.471405  [show with all ESTs]
    Unigene Representative Sequence: NM_014640
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000457313(uc010zkl.1) ENST00000415717 ENST00000392102(uc002viy.3)
    ENST00000437755 ENST00000442769 ENST00000424644 ENST00000417196 ENST00000461181
    ENST00000494428 ENST00000467841 ENST00000480472 ENST00000475950 ENST00000480929
    ENST00000465558(uc010zkm.1) ENST00000434241 ENST00000491899 ENST00000448224
    ENST00000436668
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TTLL4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TTLL4 (see all 22):
    hsa-miR-1321 hsa-miR-892b hsa-miR-3194-5p hsa-miR-3664-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidTTLL4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TTLL4
    Predesigned siRNA for gene silencing in human, mouse, rat TTLL4
    Clone
    Products:
         
    OriGene clones in human, mouse for TTLL4 (see all 6)
    OriGene ORF clones in mouse, rat for TTLL4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TTLL4 (NM_014640)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TTLL4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTLL4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TTLL4
    OriGene qSTAR qPCR primer pairs in human, mouse for TTLL4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TTLL4
      QuantiTect SYBR Green Assays in human, mouse, rat TTLL4
      QuantiFast Probe-based Assays in human, mouse, rat TTLL4

    Additional mRNA sequence: 

    AK091026.1 AK291770.1 AK296054.1 AK302728.1 AL833511.1 BC021707.2 D79995.1 

    9 DOTS entries:

    DT.454985  DT.100768712  DT.95214937  DT.121000979  DT.121000951  DT.100768708  DT.97861809  DT.121000989 
    DT.91729125 

    Selected AceView cDNA sequences (see all 140):

    BF589124 AL119721 BM699793 CA446910 N30473 BI910645 AA604678 AU121903 
    BQ425194 AI804193 BU754563 AJ346437 AU122569 BQ884084 AI087927 BM450150 
    BE300671 AU133094 BX098067 BQ233286 BQ683112 BU196548 W90432 AK091026 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TTLL4 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^
    SP1:                                -     -           -     -     -     -           -     -                       -                       -                     
    SP2:                                -     -           -     -     -     -           -     -     -     -           -                       -                     
    SP3:                                                                                -     -     -                 -                       -                     
    SP4:                                                                                -     -                       -                       -                     
    SP5:                                                  -     -     -     -           -     -                       -                                             

    ExUns: 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d
    SP1:                                                      
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for TTLL4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TTLL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCATCAGCT
    TTLL4 Expression
    About this image

    TTLL4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TTLL4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.471405
        Custom PCR Arrays for TTLL4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TTLL4
    OriGene qSTAR qPCR primer pairs in human, mouse for TTLL4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TTLL4
    QuantiTect SYBR Green Assays in human, mouse, rat TTLL4
    QuantiFast Probe-based Assays in human, mouse, rat TTLL4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for TTLL4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttll41 , 5 tubulin tyrosine ligase-like family, member 41, 5 84.36(n)1
    80.79(a)1
      1 (38.54 cM)5
    675341  NM_001014974.11  NP_001014974.11 
     746617455 
    chicken
    (Gallus gallus)
    Aves TTLL41 tubulin tyrosine ligase-like family, member 4 62.25(n)
    60.6(a)
      424209  XM_422058.4  XP_422058.4 
    lizard
    (Anolis carolinensis)
    Reptilia TTLL46
    tubulin tyrosine ligase-like family, member 4
    56(a)
    1 ↔ 1
    1(95913110-95934307)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.169252 Transcribed sequence with moderate similarity to protein more 79.5(n)    AL851633.2 
    zebrafish
    (Danio rerio)
    Actinopterygii BG799694.12   -- 75.65(n)    BG799694.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG39646
    CG168336
    --
    34(a)
    31(a)
    1 ↔ many
    1 ↔ many
    2L(3862681-3867507)
    2L(10989305-10997700)
    worm
    (Caenorhabditis elegans)
    Secernentea ttll-41 ttll-4 47.32(n)
    40.36(a)
      176427  NM_001027814.2  NP_001022985.1 


    ENSEMBL Gene Tree for TTLL4 (if available)
    TreeFam Gene Tree for TTLL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TTLL4 gene
    TTLL102  ENSG000002611472  TTLL32  TTLL12  TTLL52  TTLL112  TTLL92  TTLL72  
    TTLL62  TTL2  TTLL82  TTLL22  TTLL132  ARPC4-TTLL32  
    4 SIMAP similar genes for TTLL4 using alignment to 11 protein entries:     TTLL4_HUMAN (see all proteins):
    TTLL11    TTLL5    TTLL9    TTLL1

    TTLL4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TTLL4 (see all 1014)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1866820591,2
    --219573691(+) GATCCA/GCCCGC 1 -- us2k10--------
    rs1129487941,2
    C--219573790(+) AGCCAC/TGATGG 1 -- us2k12Minor allele frequency- T:0.07CSA WA 120
    rs1898628651,2
    --219574026(+) CTCCTG/TTCTCA 1 -- us2k10--------
    rs1473889831,2
    --219574119(+) CCATGA/TTGCCC 1 -- us2k10--------
    rs1840138771,2
    --219574171(+) GTTGGG/TATTAC 1 -- us2k10--------
    rs730809101,2
    C,F--219574174(+) GGGATT/GACAAG 1 -- us2k13Minor allele frequency- G:0.08WA 122
    rs1889571951,2
    --219574241(+) TAAAAC/TATCTC 1 -- us2k10--------
    rs2014235451,2
    --219574416(+) TCAAC-/TTTTTT 1 -- us2k10--------
    rs1141481611,2
    C,F--219574570(+) AATTCT/ACCCAT 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs745351931,2
    F--219574666(+) TTCATC/TAGATT 1 -- us2k11Minor allele frequency- T:0.16WA 118

    HapMap Linkage Disequilibrium report for TTLL4 (219575568 - 219620139 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TTLL4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv272187CNV Insertion20981092
    esv270386CNV Insertion20981092
    nsv518750CNV Loss19592680
    nsv875863CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TTLL4
    DNA2.0 Custom Variant and Variant Library Synthesis for TTLL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    6 diseases for TTLL4:    
    About MalaCards
    pancreatic ductal adenocarcinoma    amyotrophic lateral sclerosis    pancreatitis    lateral sclerosis
    pancreatic cancer    adenocarcinoma


    TTLL4 for disorders           About GeneDecksing


    Export disorders for TTLL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TTLL4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TTLL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1. (PubMed id 11054573)1, 3 Trichet V.... De Sario A. (Gene 2000)
    3. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)1, 2 Nagase T.... Nomura N. (DNA Res. 1996)
    4. Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1. (PubMed id 22959728)1  ....Zheng J.G. (Neurobiol. Aging 2013)
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    6. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Involvement of the tubulin tyrosine ligase-like family member 4 polyglutamylase in PELP1 polyglutamylation and chromatin remodeling in pancreatic cancer cells. (PubMed id 20442285)9 Kashiwaya K....Nakamura Y. (Cancer Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9654 HGNC: 28976 AceView: TTLL4 Ensembl:ENSG00000135912 euGenes: HUgn9654
    ECgene: TTLL4 H-InvDB: TTLL4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0173

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TTLL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TTLL4 gene:
    Search GeneIP for patents involving TTLL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TTLL4   OriGene RNAi products in human, mouse, rat for TTLL4  
     OriGene qPCR primer pairs and template standards for TTLL4   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TTLL4  
     OriGene qSTAR qPCR primer pairs in human, mouse for TTLL4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TTLL4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TTLL4   OriGene Custom Protein Services for TTLL4  

     
     
     Block miRNA regulation of human, mouse, rat TTLL4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TTLL4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTLL4 Predesigned siRNA for gene silencing in human, mouse, rat TTLL4
     QuantiFast Probe-based Assays in human, mouse, rat TTLL4 QuantiTect SYBR Green Assays in human, mouse, rat TTLL4
     Custom PCR Arrays for TTLL4 Search Chromatin IP Primers for TTLL4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TTLL4  Search GeneGlobe Interaction Network for TTLL4
     Regulatory tfbs in TTLL4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TTLL4 GenScript cDNA clones with any tag delivered in your preferred vector for TTLL4
     GenScript Custom Assay Services for TTLL4 GenScript Custom overexpressing Cell Line Services for TTLL4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TTLL4
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TTLL4 antibodies
     Search for Antibodies for TTLL4 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TTLL4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TTLL4
     Antibodies for TTLL4
     ELISAs for TTLL4
     CLIAs for TTLL4



     Browse ESI BIO Cell Lines and PureStem Progenitors for TTLL4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL4
     SwitchGear 3'UTR luciferase reporter plasmids for TTLL4
     SwitchGear Promoter luciferase reporter plasmids for TTLL4
     ThermoFisher Antibodies for TTLL4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTLL4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TTLL4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TTLL4
     LSBio Antibodies in human, mouse, rat for TTLL4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TTLL4 gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4