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Aliases for TTLL4 Gene

Aliases for TTLL4 Gene

  • Tubulin Tyrosine Ligase-Like Family Member 4 2 3
  • Tubulin--Tyrosine Ligase-Like Protein 4 4
  • EC 6.-.-.- 4
  • KIAA0173 4

External Ids for TTLL4 Gene

Previous GeneCards Identifiers for TTLL4 Gene

  • GC02P219779
  • GC02P219401
  • GC02P219283
  • GC02P219575
  • GC02P211428

Summaries for TTLL4 Gene

GeneCards Summary for TTLL4 Gene

TTLL4 (Tubulin Tyrosine Ligase-Like Family Member 4) is a Protein Coding gene. GO annotations related to this gene include ligase activity and tubulin binding. An important paralog of this gene is TTLL8.

UniProtKB/Swiss-Prot for TTLL4 Gene

  • Polyglutamylase which preferentially modifies beta-tubulin and nucleosome assembly proteins NAP1 and NAP2. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL4 Gene

Genomics for TTLL4 Gene

Regulatory Elements for TTLL4 Gene

Genomic Location for TTLL4 Gene

218,710,835 bp from pter
218,755,416 bp from pter
44,582 bases
Plus strand

Genomic View for TTLL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTLL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL4 Gene

Proteins for TTLL4 Gene

  • Protein details for TTLL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tubulin polyglutamylase TTLL4
    Protein Accession:
    Secondary Accessions:
    • A8K6V5
    • Q8WW29

    Protein attributes for TTLL4 Gene

    1199 amino acids
    Molecular mass:
    133378 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA11490.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TTLL4 Gene

Proteomics data for TTLL4 Gene at MOPED

Post-translational modifications for TTLL4 Gene

  • Ubiquitination at Lys688
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TTLL4 Gene

Domains for TTLL4 Gene

Gene Families for TTLL4 Gene

  • TTLL :Tubulin tyrosine ligase-like family

Protein Domains for TTLL4 Gene


Suggested Antigen Peptide Sequences for TTLL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q14679
  • Contains 1 TTL domain.
  • Belongs to the tubulin--tyrosine ligase family.
genes like me logo Genes that share domains with TTLL4: view

Function for TTLL4 Gene

Molecular function for TTLL4 Gene

UniProtKB/Swiss-Prot Function: Polyglutamylase which preferentially modifies beta-tubulin and nucleosome assembly proteins NAP1 and NAP2. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity).

Enzyme Numbers (IUBMB) for TTLL4 Gene

Gene Ontology (GO) - Molecular Function for TTLL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015631 tubulin binding ISS 21074048
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TTLL4: view
genes like me logo Genes that share phenotypes with TTLL4: view

Animal Model Products

CRISPR Products

miRNA for TTLL4 Gene

miRTarBase miRNAs that target TTLL4

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TTLL4 Gene

Localization for TTLL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTLL4 Gene

Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Located in cilia. In some cells, also found in basal bodies (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for TTLL4 Gene COMPARTMENTS Subcellular localization image for TTLL4 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for TTLL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005929 cilium IEA --
genes like me logo Genes that share ontologies with TTLL4: view

Pathways for TTLL4 Gene

SuperPathways for TTLL4 Gene

No Data Available

Interacting Proteins for TTLL4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000258398 for TTLL4 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TTLL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process --
GO:0018095 protein polyglutamylation ISS 21074048
genes like me logo Genes that share ontologies with TTLL4: view

No data available for Pathways by source for TTLL4 Gene

Transcripts for TTLL4 Gene

Unigene Clusters for TTLL4 Gene

Tubulin tyrosine ligase-like family, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTLL4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - - - -
SP7: - -
SP8: -
SP9: - - - -

ExUns: 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d
SP6: -

Relevant External Links for TTLL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTLL4 Gene

mRNA expression in normal human tissues for TTLL4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTLL4 Gene

SOURCE GeneReport for Unigene cluster for TTLL4 Gene Hs.471405

genes like me logo Genes that share expressions with TTLL4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTLL4 Gene

Orthologs for TTLL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTLL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TTLL4 35
  • 99.44 (n)
  • 99.5 (a)
TTLL4 36
  • 99 (a)
(Bos Taurus)
Mammalia TTLL4 35
  • 86.07 (n)
  • 81.8 (a)
TTLL4 36
  • 81 (a)
(Canis familiaris)
Mammalia TTLL4 35
  • 86.92 (n)
  • 84.06 (a)
TTLL4 36
  • 86 (a)
(Mus musculus)
Mammalia Ttll4 35
  • 84.36 (n)
  • 80.79 (a)
Ttll4 16
Ttll4 36
  • 80 (a)
(Monodelphis domestica)
Mammalia TTLL4 36
  • 72 (a)
(Rattus norvegicus)
Mammalia Ttll4 35
  • 84.21 (n)
  • 81.28 (a)
(Gallus gallus)
Aves TTLL4 35
  • 62.25 (n)
  • 60.6 (a)
TTLL4 36
  • 56 (a)
(Anolis carolinensis)
Reptilia TTLL4 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16925 35
ttll4 35
  • 57.01 (n)
  • 51.54 (a)
(Danio rerio)
Actinopterygii ttll4 36
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG16833 36
  • 31 (a)
CG3964 36
  • 34 (a)
(Caenorhabditis elegans)
Secernentea ttll-4 35
  • 47.32 (n)
  • 40.36 (a)
ttll-4 36
  • 38 (a)
Species with no ortholog for TTLL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTLL4 Gene

Gene Tree for TTLL4 (if available)
Gene Tree for TTLL4 (if available)

Paralogs for TTLL4 Gene

genes like me logo Genes that share paralogs with TTLL4: view

Variants for TTLL4 Gene

Sequence variations from dbSNP and Humsavar for TTLL4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs586194 -- 218,745,710(+) TGGGA(A/G)CAGAG reference, synonymous-codon
rs608047 -- 218,751,187(+) TCATT(G/T)GACAT intron-variant
rs755112 -- 218,741,329(+) cCTAA(C/T)TTTTA intron-variant
rs933993 -- 218,714,848(-) GAGGA(C/T)TGTTT intron-variant
rs1078802 -- 218,742,025(-) TATGA(C/T)GGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTLL4 Gene

Variant ID Type Subtype PubMed ID
esv270386 CNV Insertion 20981092
esv272187 CNV Insertion 20981092
nsv875863 CNV Gain 21882294
nsv518750 CNV Loss 19592680

Relevant External Links for TTLL4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTLL4 Gene

Disorders for TTLL4 Gene

No disorders were found for TTLL4 Gene.

No data available for UniProtKB/Swiss-Prot for TTLL4 Gene

Publications for TTLL4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 3 4
  3. Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1. (PMID: 11054573) Trichet V. … De Sario A. (Gene 2000) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Involvement of the tubulin tyrosine ligase-like family member 4 polyglutamylase in PELP1 polyglutamylation and chromatin remodeling in pancreatic cancer cells. (PMID: 20442285) Kashiwaya K. … Nakamura Y. (Cancer Res. 2010) 23

Products for TTLL4 Gene

Sources for TTLL4 Gene

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