Aliases for TTLL4 Gene
External Ids for TTLL4 Gene
Previous GeneCards Identifiers for TTLL4 Gene
GeneCards Summary for TTLL4 Gene
TTLL4 (Tubulin Tyrosine Ligase Like 4) is a Protein Coding gene. GO annotations related to this gene include ligase activity and tubulin binding. An important paralog of this gene is TTLL5.
UniProtKB/Swiss-Prot for TTLL4 Gene
Glutamylase which preferentially modifies beta-tubulin and non-tubulin proteins, such as NAP1L1, NAP1L4 and CGAS/MB21D1. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Involved in formation of short side-chains. Mediates initiation of polyglutamylation of nucleosome assembly proteins NAP1L1 and NAP1L4. Also acts as a monoglutamylase: generates monoglutamylation of CGAS/MB21D1, leading to impair the nucleotidyltransferase activity of CGAS/MB21D1.