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Aliases for TTLL4 Gene

Aliases for TTLL4 Gene

  • Tubulin Tyrosine Ligase Like 4 2 3 5
  • Tubulin Tyrosine Ligase-Like Family Member 4 2
  • Tubulin--Tyrosine Ligase-Like Protein 4 4
  • EC 6.-.-.- 4
  • KIAA0173 4

External Ids for TTLL4 Gene

Previous GeneCards Identifiers for TTLL4 Gene

  • GC02P219779
  • GC02P219401
  • GC02P219283
  • GC02P219575
  • GC02P211428

Summaries for TTLL4 Gene

GeneCards Summary for TTLL4 Gene

TTLL4 (Tubulin Tyrosine Ligase Like 4) is a Protein Coding gene. GO annotations related to this gene include ligase activity and tubulin binding. An important paralog of this gene is TTLL8.

UniProtKB/Swiss-Prot for TTLL4 Gene

  • Polyglutamylase which preferentially modifies beta-tubulin and nucleosome assembly proteins NAP1 and NAP2. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL4 Gene

Genomics for TTLL4 Gene

Regulatory Elements for TTLL4 Gene

Promoters for TTLL4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TTLL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTLL4 Gene

Chromosome:
2
Start:
218,710,835 bp from pter
End:
218,755,416 bp from pter
Size:
44,582 bases
Orientation:
Plus strand

Genomic View for TTLL4 Gene

Genes around TTLL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTLL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTLL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL4 Gene

Proteins for TTLL4 Gene

  • Protein details for TTLL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14679-TTLL4_HUMAN
    Recommended name:
    Tubulin polyglutamylase TTLL4
    Protein Accession:
    Q14679
    Secondary Accessions:
    • A8K6V5
    • Q8WW29

    Protein attributes for TTLL4 Gene

    Size:
    1199 amino acids
    Molecular mass:
    133378 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA11490.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TTLL4 Gene

Proteomics data for TTLL4 Gene at MOPED

Post-translational modifications for TTLL4 Gene

  • Ubiquitination at Lys 688
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TTLL4 Gene

Domains & Families for TTLL4 Gene

Gene Families for TTLL4 Gene

Protein Domains for TTLL4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TTLL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14679

UniProtKB/Swiss-Prot:

TTLL4_HUMAN :
  • The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.
  • Belongs to the tubulin--tyrosine ligase family.
Domain:
  • The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.
  • Contains 1 TTL domain.
Family:
  • Belongs to the tubulin--tyrosine ligase family.
genes like me logo Genes that share domains with TTLL4: view

Function for TTLL4 Gene

Molecular function for TTLL4 Gene

UniProtKB/Swiss-Prot Function:
Polyglutamylase which preferentially modifies beta-tubulin and nucleosome assembly proteins NAP1 and NAP2. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step.

Enzyme Numbers (IUBMB) for TTLL4 Gene

Gene Ontology (GO) - Molecular Function for TTLL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0015631 tubulin binding ISS 21074048
genes like me logo Genes that share ontologies with TTLL4: view
genes like me logo Genes that share phenotypes with TTLL4: view

Animal Models for TTLL4 Gene

MGI Knock Outs for TTLL4:

Animal Model Products

miRNA for TTLL4 Gene

miRTarBase miRNAs that target TTLL4

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TTLL4 Gene

Localization for TTLL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTLL4 Gene

Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Located in cilia. In some cells, also found in basal bodies. {ECO:0000250 UniProtKB:Q80UG8}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTLL4 Gene COMPARTMENTS Subcellular localization image for TTLL4 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for TTLL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IEA --
genes like me logo Genes that share ontologies with TTLL4: view

Pathways & Interactions for TTLL4 Gene

SuperPathways for TTLL4 Gene

No Data Available

Interacting Proteins for TTLL4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000258398%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000258398 for TTLL4 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for TTLL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
GO:0018200 peptidyl-glutamic acid modification ISS --
genes like me logo Genes that share ontologies with TTLL4: view

No data available for Pathways by source and SIGNOR curated interactions for TTLL4 Gene

Drugs & Compounds for TTLL4 Gene

No Compound Related Data Available

Transcripts for TTLL4 Gene

Unigene Clusters for TTLL4 Gene

Tubulin tyrosine ligase-like family, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - - - -
SP6:
SP7: - -
SP8: -
SP9: - - - -
SP10:

ExUns: 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TTLL4 Gene

GeneLoc Exon Structure for
TTLL4
ECgene alternative splicing isoforms for
TTLL4

Expression for TTLL4 Gene

mRNA expression in normal human tissues for TTLL4 Gene

Protein differential expression in normal tissues from HIPED for TTLL4 Gene

This gene is overexpressed in Amniocyte (36.2), Cervix (26.2), and Blymphocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TTLL4 Gene



SOURCE GeneReport for Unigene cluster for TTLL4 Gene Hs.471405

genes like me logo Genes that share expression patterns with TTLL4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TTLL4 Gene

Orthologs for TTLL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTLL4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TTLL4 35
  • 86.07 (n)
  • 81.8 (a)
TTLL4 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTLL4 35
  • 86.92 (n)
  • 84.06 (a)
TTLL4 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttll4 35
  • 84.36 (n)
  • 80.79 (a)
Ttll4 16
Ttll4 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TTLL4 35
  • 99.44 (n)
  • 99.5 (a)
TTLL4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttll4 35
  • 84.21 (n)
  • 81.28 (a)
oppossum
(Monodelphis domestica)
Mammalia TTLL4 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTLL4 35
  • 62.25 (n)
  • 60.6 (a)
TTLL4 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTLL4 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16925 35
ttll4 35
  • 57.01 (n)
  • 51.54 (a)
zebrafish
(Danio rerio)
Actinopterygii ttll4 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG16833 36
  • 31 (a)
OneToMany
CG3964 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ttll-4 35
  • 47.32 (n)
  • 40.36 (a)
ttll-4 36
  • 38 (a)
OneToOne
Species with no ortholog for TTLL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTLL4 Gene

ENSEMBL:
Gene Tree for TTLL4 (if available)
TreeFam:
Gene Tree for TTLL4 (if available)

Paralogs for TTLL4 Gene

genes like me logo Genes that share paralogs with TTLL4: view

Variants for TTLL4 Gene

Sequence variations from dbSNP and Humsavar for TTLL4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2114664 - 218,738,929(+) CAAGC(A/G)TATCA nc-transcript-variant, reference, missense
rs11542786 - 218,737,726(+) GAAAA(A/G)CAGCT nc-transcript-variant, reference, missense
rs3731877 - 218,737,776(+) CACCT(C/G)AGAAA nc-transcript-variant, reference, missense
rs3731875 - 218,738,767(-) GGTTC(A/G)GGAAA nc-transcript-variant, reference, missense
rs17851914 - 218,740,122(+) TAGAT(A/G)GTTTG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TTLL4 Gene

Variant ID Type Subtype PubMed ID
esv270386 CNV Insertion 20981092
esv272187 CNV Insertion 20981092
nsv875863 CNV Gain 21882294
nsv518750 CNV Loss 19592680

Variation tolerance for TTLL4 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.24; 96.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTLL4 Gene

HapMap Linkage Disequilibrium report
TTLL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTLL4 Gene

Disorders for TTLL4 Gene

Relevant External Links for TTLL4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTLL4

No disorders were found for TTLL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTLL4 Gene

Publications for TTLL4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1. (PMID: 11054573) Trichet V. … De Sario A. (Gene 2000) 2 3
  3. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1. (PMID: 22959728) . … Zheng J.G. (Neurobiol. Aging 2013) 3

Products for TTLL4 Gene

Sources for TTLL4 Gene

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