Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TTLL3 Gene

Aliases for TTLL3 Gene

  • Tubulin Tyrosine Ligase Like 3 2 3 5
  • Tubulin--Tyrosine Ligase-Like Protein 3 3 4
  • HOTTL 3 4
  • Tubulin Tyrosine Ligase-Like Family, Member 3 3
  • Tubulin Tyrosine Ligase-Like Family Member 3 2
  • Tubulin Monoglycylase TTLL3 3
  • EC 6.3.2.- 4

External Ids for TTLL3 Gene

Previous GeneCards Identifiers for TTLL3 Gene

  • GC03P009836
  • GC03P009810
  • GC03P009811
  • GC03P009749
  • GC03P009813
  • GC03P009850
  • GC03P009788
  • GC03P009851

Summaries for TTLL3 Gene

GeneCards Summary for TTLL3 Gene

TTLL3 (Tubulin Tyrosine Ligase Like 3) is a Protein Coding gene. GO annotations related to this gene include protein-glycine ligase activity and protein-glycine ligase activity, initiating. An important paralog of this gene is ARPC4-TTLL3.

UniProtKB/Swiss-Prot for TTLL3 Gene

  • Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction.

Gene Wiki entry for TTLL3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL3 Gene

Genomics for TTLL3 Gene

Regulatory Elements for TTLL3 Gene

Enhancers for TTLL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F009808 0.9 ENCODE 22.4 +1.4 1401 3.6 HDGF TBP PKNOX1 SIN3A BMI1 RAD21 SCRT2 ZNF416 ZNF143 REST TTLL3 EMC3-AS1 TADA3 ENSG00000269886
GH03F009861 1.6 FANTOM5 Ensembl ENCODE 11.1 +55.6 55610 5.0 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF48 ZNF143 KLF13 IL17RC JAGN1 CIDEC TADA3 IL17RE ARPC4 RNU6-882P TTLL3 ARPC4-TTLL3 CAMK1
GH03F009896 1.4 Ensembl ENCODE 10.4 +92.1 92122 8.2 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YBX1 YY1 SLC30A9 CBX5 RAD18 THUMPD3-AS1 IL17RC GHRLOS JAGN1 ENSG00000269982 CRELD1 PRRT3-AS1 CYCSP10 FANCD2
GH03F009975 1.4 Ensembl ENCODE 10 +170.1 170128 4.8 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A ZNF2 FOS KLF13 SMARCB1 THUMPD3-AS1 FANCD2 ENSG00000269894 BRK1 PRRT3 CIDECP IL17RE RPUSD3 VHL JAGN1
GH03F009984 1.2 Ensembl 10.3 +176.8 176815 0.2 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 SRGAP3-AS3 SRGAP3-AS1 ATP2B2-IT1 ENSG00000230599 RNU6-882P FANCD2 RNU6-670P CYCSP10 PRRT3 RPUSD3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTLL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTLL3 Gene

Chromosome:
3
Start:
9,808,086 bp from pter
End:
9,855,138 bp from pter
Size:
47,053 bases
Orientation:
Plus strand

Genomic View for TTLL3 Gene

Genes around TTLL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTLL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTLL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL3 Gene

Proteins for TTLL3 Gene

  • Protein details for TTLL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4R7-TTLL3_HUMAN
    Recommended name:
    Tubulin monoglycylase TTLL3
    Protein Accession:
    Q9Y4R7
    Secondary Accessions:
    • Q4KMS8
    • Q6AWA3
    • Q6ZU95
    • Q8NDN8
    • Q96GG8
    • Q9H876
    • Q9UI99

    Protein attributes for TTLL3 Gene

    Size:
    772 amino acids
    Molecular mass:
    87414 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTLL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTLL3 Gene

Post-translational modifications for TTLL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for TTLL3
  • Santa Cruz Biotechnology (SCBT) Antibodies for TTLL3

No data available for DME Specific Peptides for TTLL3 Gene

Domains & Families for TTLL3 Gene

Gene Families for TTLL3 Gene

Protein Domains for TTLL3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TTLL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4R7

UniProtKB/Swiss-Prot:

TTLL3_HUMAN :
  • Contains 1 TTL domain.
Domain:
  • Contains 1 TTL domain.
genes like me logo Genes that share domains with TTLL3: view

Function for TTLL3 Gene

Molecular function for TTLL3 Gene

UniProtKB/Swiss-Prot Function:
Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction.

Enzyme Numbers (IUBMB) for TTLL3 Gene

Gene Ontology (GO) - Molecular Function for TTLL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0070735 protein-glycine ligase activity IDA 19524510
GO:0070736 protein-glycine ligase activity, initiating ISS --
genes like me logo Genes that share ontologies with TTLL3: view
genes like me logo Genes that share phenotypes with TTLL3: view

Animal Models for TTLL3 Gene

MGI Knock Outs for TTLL3:

Animal Model Products

  • Taconic Biosciences Mouse Models for TTLL3

miRNA for TTLL3 Gene

miRTarBase miRNAs that target TTLL3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TTLL3 Gene

Localization for TTLL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTLL3 Gene

Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTLL3 gene
Compartment Confidence
cytoskeleton 5

Gene Ontology (GO) - Cellular Components for TTLL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0005929 cilium ISS --
GO:0005930 axoneme ISS --
genes like me logo Genes that share ontologies with TTLL3: view

Pathways & Interactions for TTLL3 Gene

SuperPathways for TTLL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTLL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
GO:0018094 protein polyglycylation IDA 19524510
GO:0035082 axoneme assembly ISS --
GO:0060271 cilium assembly ISS --
genes like me logo Genes that share ontologies with TTLL3: view

No data available for Pathways by source and SIGNOR curated interactions for TTLL3 Gene

Transcripts for TTLL3 Gene

Unigene Clusters for TTLL3 Gene

Tubulin tyrosine ligase-like family, member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL3 Gene

No ASD Table

Relevant External Links for TTLL3 Gene

GeneLoc Exon Structure for
TTLL3
ECgene alternative splicing isoforms for
TTLL3

Expression for TTLL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTLL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TTLL3 Gene

This gene is overexpressed in Platelet (62.1) and Adipocyte (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TTLL3 Gene



Protein tissue co-expression partners for TTLL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TTLL3 Gene:

TTLL3

SOURCE GeneReport for Unigene cluster for TTLL3 Gene:

Hs.726435
genes like me logo Genes that share expression patterns with TTLL3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTLL3 Gene

Orthologs for TTLL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTLL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTLL3 34
  • 99.16 (n)
-- 35
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ttll3 34 16 35
  • 81.51 (n)
rat
(Rattus norvegicus)
Mammalia Ttll3 34
  • 81.36 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 73 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 45 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 44 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 33 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 54 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ttll3 35
  • 40 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta TTLL3A 35
  • 23 (a)
ManyToMany
TTLL3B 35
  • 23 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBY1 35
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
OneToMany
Species where no ortholog for TTLL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTLL3 Gene

ENSEMBL:
Gene Tree for TTLL3 (if available)
TreeFam:
Gene Tree for TTLL3 (if available)

Paralogs for TTLL3 Gene

Variants for TTLL3 Gene

Sequence variations from dbSNP and Humsavar for TTLL3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_036054 A colorectal cancer sample
VAR_036055 A colorectal cancer sample
rs1057278 -- 9,835,235(+) CCAGG(A/G)CTGAG nc-transcript-variant, reference, missense, utr-variant-3-prime
rs1057281 -- 9,835,303(+) CAGAG(A/G)CGCAG nc-transcript-variant, reference, synonymous-codon, utr-variant-3-prime
rs1061154 -- 9,831,577(+) GTGCT(C/G)TGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTLL3 Gene

Variant ID Type Subtype PubMed ID
nsv834615 CNV loss 17160897
nsv819644 CNV gain 19587683
nsv237238 CNV deletion 16902084
nsv1010768 CNV gain 25217958
esv3595249 CNV gain 21293372
esv3342578 CNV duplication 20981092

Variation tolerance for TTLL3 Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.09; 75.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTLL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTLL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTLL3 Gene

Disorders for TTLL3 Gene

Relevant External Links for TTLL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTLL3

No disorders were found for TTLL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTLL3 Gene

Publications for TTLL3 Gene

  1. Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. (PMID: 19524510) Rogowski K. … Janke C. (Cell 2009) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1. (PMID: 11054573) Trichet V. … De Sario A. (Gene 2000) 2 3 64
  4. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for TTLL3 Gene

Sources for TTLL3 Gene

Content
Loading form....