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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TTLL3 Gene

protein-coding   GIFtS: 45
GCID: GC03P009851

Tubulin Tyrosine Ligase-Like Family, Member 3

  Search for TTLL3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tubulin Tyrosine Ligase-Like Family, Member 31 2
Tubulin--Tyrosine Ligase-Like Protein 32 3
HOTTL2 3
Tubulin Monoglycylase TTLL32
EC 6.3.2.-3

External Ids:    HGNC: 244831   Entrez Gene: 261402   Ensembl: ENSG000002140217   UniProtKB: Q9Y4R73   

Export aliases for TTLL3 gene to outside databases

Previous GC identifers: GC03P009836 GC03P009810 GC03P009811 GC03P009749 GC03P009813 GC03P009850 GC03P009788


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TTLL3 Gene: 
TTLL3 (tubulin tyrosine ligase-like family, member 3) is a protein-coding gene. GO annotations related to this gene include tubulin-tyrosine ligase activity and protein-glycine ligase activity, initiating. An important paralog of this gene is TTLL4.

UniProtKB/Swiss-Prot: TTLL3_HUMAN, Q9Y4R7
Function: Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the
gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin.
Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to
generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction

Gene Wiki entry for TTLL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TTLL3 gene promoter:
         NF-1   p300   HEN1   AREB6   E2F-1   E2F   COMP1   SEF-1 (1)   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTLL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TTLL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTLL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.3   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25.3

TTLL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTLL3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P009851:  view genomic region     (about GC identifiers)

Start:
9,849,770 bp from pter      End:
9,896,822 bp from pter
Size:
47,053 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TTLL3_HUMAN, Q9Y4R7 (See protein sequence)
Recommended Name: Tubulin monoglycylase TTLL3  
Size: 772 amino acids; 87414 Da
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Cell projection, cilium (By similarity). Cytoplasm,
cytoskeleton, cilium axoneme (By similarity)
Secondary accessions: Q4KMS8 Q6AWA3 Q6ZU95 Q8NDN8 Q96GG8 Q9H876 Q9UI99
Alternative splicing: 4 isoforms:  Q9Y4R7-1   Q9Y4R7-2   Q9Y4R7-5   Q9Y4R7-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TTLL3: NX_Q9Y4R7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y4R7

  • TTLL3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001021100.3  
    ENSEMBL proteins: 
     ENSP00000399930   ENSP00000399782   ENSP00000401686   ENSP00000414965   ENSP00000408128  
     ENSP00000394481   ENSP00000400462   ENSP00000402197   ENSP00000395912   ENSP00000392549  
     ENSP00000389904   ENSP00000398996   ENSP00000412915   ENSP00000396606   ENSP00000312148  
     ENSP00000473440   ENSP00000473376   ENSP00000399191   ENSP00000398097   ENSP00000373338  
     ENSP00000430051   ENSP00000409632   ENSP00000409246   ENSP00000403874   ENSP00000473314  
     ENSP00000446659   ENSP00000380416   ENSP00000394462  

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    Cloud-Clone Corp. Proteins for TTLL3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005874microtubule IEA--
    GO:0005929cilium ISS--
    GO:0015630microtubule cytoskeleton ISS--
    GO:0035085cilium axoneme ISS--

    TTLL3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TTLL: Tubulin tyrosine ligase-like family

    1 InterPro protein domain:
     IPR004344 Tub_tyr_ligase

    Graphical View of Domain Structure for InterPro Entry Q9Y4R7

    ProtoNet protein and cluster: Q9Y4R7

    1 Blocks protein domain: IPB004344 Tubulin-tyrosine ligase

    UniProtKB/Swiss-Prot: TTLL3_HUMAN, Q9Y4R7
    Similarity: Contains 1 TTL domain


    TTLL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTLL3_HUMAN, Q9Y4R7
    Function: Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the
    gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin.
    Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to
    generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004835tubulin-tyrosine ligase activity ----
    GO:0070735protein-glycine ligase activity IDA19524510
    GO:0070736protein-glycine ligase activity, initiating ISS--
         
    TTLL3 for ontologies           About GeneDecksing


    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTLL3

    3 Interacting proteins for TTLL3 (Q9Y4R72, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARPC5LQ9BPX52, 3MINT-65307 I2D: score=1 
    NELFCDQ8IXH72, 3MINT-64863 I2D: score=1 
    RNF130Q86XS82, 3MINT-64838 I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process ----
    GO:0006952defense response ----
    GO:0018094protein polyglycylation IDA19524510
    GO:0035082axoneme assembly ISS--
    GO:0042384cilium assembly ISS--

    TTLL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TTLL3

    Search CenterWatch for drugs/clinical trials and news about TTLL3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TTLL3 gene (2 alternative transcripts): 
    NM_015644.3  NM_001025930.3  

    Unigene Cluster for TTLL3:

    Tubulin tyrosine ligase-like family, member 3
    Hs.726435  [show with all ESTs]
    Unigene Representative Sequence: NR_037162
    18/36 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 36):
    ENST00000414814 ENST00000452597 ENST00000419081 ENST00000438596 ENST00000459758
    ENST00000417065 ENST00000439814 ENST00000418745 ENST00000430718 ENST00000427220(uc003btf.4)
    ENST00000426895 ENST00000426827 ENST00000431204 ENST00000422738 ENST00000430390
    ENST00000483051(uc003bth.4 uc011atj.2) ENST00000310252 ENST00000496526(uc010hco.1)

    miRNA
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    hsa-miR-3607-3p hsa-miR-3154 hsa-miR-513a-5p
    SwitchGear 3'UTR luciferase reporter plasmidTTLL3 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Additional mRNA sequence: 

    AF078842.1 AK023960.1 AK297289.1 AK315140.1 BC028169.1 BC113824.1 NR_037162.1 

    24/40 DOTS entries (see all 40):

    DT.120858267  DT.97862294  DT.120858347  DT.100816487  DT.91762118  DT.92389612  DT.120858170  DT.91762117 
    DT.120858167  DT.100816484  DT.91807281  DT.95198356  DT.305337  DT.91761091  DT.95147440  DT.86790120 
    DT.99974535  DT.97861105  DT.120858189  DT.453144  DT.95209709  DT.97862293  DT.120858275  DT.425915 

    24/645 AceView cDNA sequences (see all 645):

    AA366815 BM674442 BP372612 BI768100 BM923897 BQ084486 BQ055336 BQ641790 
    BM925196 CR610621 BQ945296 AW005261 BU152929 BX419888 BM719445 AI678319 
    BQ962024 BU620751 BE859023 CR609636 BI761059 BQ644584 AF006087 BP338685 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TTLL3 expression in normal human tissues (normalized intensities)      TTLL3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAAACCGT
    TTLL3 Expression
    About this image


    TTLL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Testis (Reproductive System)
     
     Prostate (Endocrine System)

    Genevestigator expression for TTLL3

    SOURCE GeneReport for Unigene cluster: Hs.726435
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TTLL3 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttll31 , 5 tubulin tyrosine ligase-like family, member 31, 5 81.51(n)1
    76.02(a)1
      6 (52.76 cM)5
    1011001  NM_133923.61  NP_598684.41 
     1133892605 
    chicken
    (Gallus gallus)
    Aves TTLL36
    Uncharacterized protein
    31(a)
    1 → many
    12(11472504-11474022)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    51(a)
    1 → many
    2(191293942-191322780)
    zebrafish
    (Danio rerio)
    Actinopterygii ttll31 tubulin tyrosine ligase-like family, member 3 57.37(n)
    51.44(a)
      724000  NM_001045305.1  NP_001038770.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TTLL3A1 Tubulin tyrosine ligase-like 3A 49.97(n)
    39.23(a)
      33947  NM_135225.1  NP_609069.1 


    ENSEMBL Gene Tree for TTLL3 (if available)
    TreeFam Gene Tree for TTLL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TTLL3 gene
    TTLL42  TTLL102  ENSG000002611472  TTLL12  TTLL52  TTLL112  TTLL92  TTLL72  
    TTLL62  TTL2  TTLL82  TTLL22  TTLL132  ARPC4-TTLL32  
    2 SIMAP similar genes for TTLL3 using alignment to 23 protein entries:     TTLL3_HUMAN (see all proteins):
    ARPC4-TTLL3    TTLL8

    TTLL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    6 SNPs in TTLL3 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360554
    A colorectal cancer sample4--see VAR_0360552 M I mis40--------
    VAR_0360544
    A colorectal cancer sample4--see VAR_0360542 G S mis40--------
    VAR_0524104
    ----see VAR_0524102 E K mis40--------
    VAR_0202074
    ----see VAR_0202072 M R mis40--------
    VAR_0524114
    ----see VAR_0524112 N H mis40--------
    VAR_0524124
    ----see VAR_0524122 A T mis40--------

    HapMap Linkage Disequilibrium report for TTLL3 (9849770 - 9896822 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TTLL3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv237238CNV Loss16902084
    nsv834615CNV Loss17160897
    nsv819644CNV Gain19587683

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TTLL3 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with TTLL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. (PubMed id 19524510)1, 2 Rogowski K....Janke C. (2009)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1. (PubMed id 11054573)1, 3 Trichet V.... De Sario A. (2000)
    4. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    6. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    7. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26140 HGNC: 24483 AceView: ARPC4andTTLL3 Ensembl:ENSG00000214021 euGenes: HUgn26140
    ECgene: TTLL3 H-InvDB: TTLL3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TTLL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TTLL3 gene:
    Search GeneIP for patents involving TTLL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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