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Aliases for TTLL3 Gene

Aliases for TTLL3 Gene

  • Tubulin Tyrosine Ligase-Like Family Member 3 2 3
  • Tubulin--Tyrosine Ligase-Like Protein 3 3 4
  • HOTTL 3 4
  • Tubulin Tyrosine Ligase-Like Family, Member 3 3
  • Tubulin Monoglycylase TTLL3 3
  • EC 6.3.2.- 4

External Ids for TTLL3 Gene

Summaries for TTLL3 Gene

GeneCards Summary for TTLL3 Gene

TTLL3 (Tubulin Tyrosine Ligase-Like Family Member 3) is a Protein Coding gene. Diseases associated with TTLL3 include colorectal cancer. Among its related pathways are Fcgamma receptor (FCGR) dependent phagocytosis and Fcgamma receptor (FCGR) dependent phagocytosis. GO annotations related to this gene include protein-glycine ligase activity and protein-glycine ligase activity, initiating. An important paralog of this gene is TTLL8.

UniProtKB/Swiss-Prot for TTLL3 Gene

  • Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction.

Gene Wiki entry for TTLL3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL3 Gene

Genomics for TTLL3 Gene

Genomic Location for TTLL3 Gene

Start:
9,808,086 bp from pter
End:
9,855,138 bp from pter
Size:
47,053 bases
Orientation:
Plus strand

Genomic View for TTLL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTLL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL3 Gene

Regulatory Elements for TTLL3 Gene

Proteins for TTLL3 Gene

  • Protein details for TTLL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4R7-TTLL3_HUMAN
    Recommended name:
    Tubulin monoglycylase TTLL3
    Protein Accession:
    Q9Y4R7
    Secondary Accessions:
    • Q4KMS8
    • Q6AWA3
    • Q6ZU95
    • Q8NDN8
    • Q96GG8
    • Q9H876
    • Q9UI99

    Protein attributes for TTLL3 Gene

    Size:
    772 amino acids
    Molecular mass:
    87414 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTLL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTLL3 Gene

Proteomics data for TTLL3 Gene at MOPED

Post-translational modifications for TTLL3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TTLL3 Gene

Domains for TTLL3 Gene

Gene Families for TTLL3 Gene

HGNC:
  • TTLL :Tubulin tyrosine ligase-like family

Protein Domains for TTLL3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TTLL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4R7

UniProtKB/Swiss-Prot:

TTLL3_HUMAN
Domain:
  • Contains 1 TTL domain.:
    • Q9Y4R7
genes like me logo Genes that share domains with TTLL3: view

Function for TTLL3 Gene

Molecular function for TTLL3 Gene

UniProtKB/Swiss-Prot Function: Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction.

Enzyme Numbers (IUBMB) for TTLL3 Gene

Gene Ontology (GO) - Molecular Function for TTLL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070735 protein-glycine ligase activity IDA 19524510
GO:0070736 protein-glycine ligase activity, initiating ISS --
genes like me logo Genes that share ontologies with TTLL3: view

miRNA for TTLL3 Gene

miRTarBase miRNAs that target TTLL3

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TTLL3 Gene

Localization for TTLL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTLL3 Gene

Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme.

Gene Ontology (GO) - Cellular Components for TTLL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005874 microtubule IEA --
GO:0005929 cilium ISS --
GO:0005930 axoneme ISS --
GO:0015630 microtubule cytoskeleton ISS --
genes like me logo Genes that share ontologies with TTLL3: view

No data available for Subcellular locations from COMPARTMENTS for TTLL3 Gene

Pathways for TTLL3 Gene

genes like me logo Genes that share pathways with TTLL3: view

Pathways by source for TTLL3 Gene

Gene Ontology (GO) - Biological Process for TTLL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process --
GO:0006952 defense response --
GO:0018094 protein polyglycylation IDA 19524510
GO:0035082 axoneme assembly ISS --
GO:0042384 cilium assembly ISS --
genes like me logo Genes that share ontologies with TTLL3: view

Transcripts for TTLL3 Gene

Unigene Clusters for TTLL3 Gene

Tubulin tyrosine ligase-like family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL3 Gene

No ASD Table

Relevant External Links for TTLL3 Gene

GeneLoc Exon Structure for
TTLL3
ECgene alternative splicing isoforms for
TTLL3

Expression for TTLL3 Gene

mRNA expression in normal human tissues for TTLL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TTLL3 Gene

SOURCE GeneReport for Unigene cluster for TTLL3 Gene Hs.726435

genes like me logo Genes that share expressions with TTLL3: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTLL3 Gene

Orthologs for TTLL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTLL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
OneToMany
TTLL3 35
  • 99.16 (n)
  • 98.47 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 73 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 73 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ttll3 35
  • 81.51 (n)
  • 76.02 (a)
Ttll3 16
Ttll3 36
  • 65 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ttll3 35
  • 81.36 (n)
  • 79.55 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 33 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ttll3 36
  • 40 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta TTLL3A 36
  • 23 (a)
ManyToMany
TTLL3B 36
  • 23 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBY1 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for TTLL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTLL3 Gene

ENSEMBL:
Gene Tree for TTLL3 (if available)
TreeFam:
Gene Tree for TTLL3 (if available)

Paralogs for TTLL3 Gene

genes like me logo Genes that share paralogs with TTLL3: view

Variants for TTLL3 Gene

Sequence variations from dbSNP and Humsavar for TTLL3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
VAR_020207 -
VAR_036054 A colorectal cancer sample
VAR_036055 A colorectal cancer sample
VAR_052410 -
VAR_052411 -

Structural Variations from Database of Genomic Variants (DGV) for TTLL3 Gene

Variant ID Type Subtype PubMed ID
nsv834615 CNV Loss 17160897
nsv237238 CNV Loss 16902084
nsv819644 CNV Gain 19587683

Relevant External Links for TTLL3 Gene

HapMap Linkage Disequilibrium report
TTLL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTLL3 Gene

Disorders for TTLL3 Gene

(1) MalaCards Diseases for TTLL3 Gene

Search for TTLL3 Gene in MalaCards »
genes like me logo Genes that share disorders with TTLL3: view

No data available for UniProtKB/Swiss-Prot for TTLL3 Gene

Publications for TTLL3 Gene

  1. Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1. (PMID: 11054573) Trichet V. … De Sario A. (Gene 2000) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. (PMID: 19524510) Rogowski K. … Janke C. (Cell 2009) 3 4
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for TTLL3 Gene

Sources for TTLL3 Gene

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