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Aliases for TTLL2 Gene

Aliases for TTLL2 Gene

  • Tubulin Tyrosine Ligase-Like Family Member 2 2 3
  • Tubulin--Tyrosine Ligase-Like Protein 2 3 4
  • Testis-Specific Protein NYD-TSPG 3 4
  • C6orf104 3 4
  • Tubulin Tyrosine Ligase-Like Family, Member 2 3
  • Probable Tubulin Polyglutamylase TTLL2 3
  • Chromosome 6 Open Reading Frame 104 2
  • DJ366N23.3 3
  • EC 6.-.-.- 4
  • NYD-TSPG 3

External Ids for TTLL2 Gene

Previous HGNC Symbols for TTLL2 Gene

  • C6orf104

Previous GeneCards Identifiers for TTLL2 Gene

  • GC06P167647
  • GC06P167708
  • GC06P167658
  • GC06P167738
  • GC06P165211

Summaries for TTLL2 Gene

GeneCards Summary for TTLL2 Gene

TTLL2 (Tubulin Tyrosine Ligase-Like Family Member 2) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is TTLL8.

UniProtKB/Swiss-Prot for TTLL2 Gene

  • Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL2 Gene

Genomics for TTLL2 Gene

Regulatory Elements for TTLL2 Gene

Genomic Location for TTLL2 Gene

167,325,086 bp from pter
167,359,503 bp from pter
34,418 bases
Plus strand

Genomic View for TTLL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTLL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL2 Gene

Proteins for TTLL2 Gene

  • Protein details for TTLL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable tubulin polyglutamylase TTLL2
    Protein Accession:
    Secondary Accessions:
    • B2RB11
    • B3KS77
    • Q7Z6R8
    • Q86X22

    Protein attributes for TTLL2 Gene

    592 amino acids
    Molecular mass:
    67336 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TTLL2 Gene

Proteomics data for TTLL2 Gene at MOPED

Post-translational modifications for TTLL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTLL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTLL2 Gene

Domains for TTLL2 Gene

Gene Families for TTLL2 Gene

Protein Domains for TTLL2 Gene


Suggested Antigen Peptide Sequences for TTLL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 TTL domain.
  • Belongs to the tubulin--tyrosine ligase family.
  • Contains 1 TTL domain.
  • Belongs to the tubulin--tyrosine ligase family.
genes like me logo Genes that share domains with TTLL2: view

Function for TTLL2 Gene

Molecular function for TTLL2 Gene

UniProtKB/Swiss-Prot Function:
Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity).

Enzyme Numbers (IUBMB) for TTLL2 Gene

Gene Ontology (GO) - Molecular Function for TTLL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TTLL2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTLL2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TTLL2 Gene

Localization for TTLL2 Gene

Subcellular locations from

Jensen Localization Image for TTLL2 Gene COMPARTMENTS Subcellular localization image for TTLL2 gene
Compartment Confidence
nucleus 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTLL2 Gene

Pathways for TTLL2 Gene

SuperPathways for TTLL2 Gene

No Data Available

Interacting Proteins for TTLL2 Gene

Gene Ontology (GO) - Biological Process for TTLL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
genes like me logo Genes that share ontologies with TTLL2: view

No data available for Pathways by source for TTLL2 Gene

Transcripts for TTLL2 Gene

mRNA/cDNA for TTLL2 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TTLL2 Gene

Tubulin tyrosine ligase-like family, member 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTLL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL2 Gene

No ASD Table

Relevant External Links for TTLL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTLL2 Gene

mRNA expression in normal human tissues for TTLL2 Gene

mRNA differential expression in normal tissues according to GTEx for TTLL2 Gene

This gene is overexpressed in Testis (35.7).

Protein differential expression in normal tissues for TTLL2 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TTLL2 Gene

SOURCE GeneReport for Unigene cluster for TTLL2 Gene Hs.520554

mRNA Expression by UniProt/SwissProt for TTLL2 Gene

Tissue specificity: Testis
genes like me logo Genes that share expressions with TTLL2: view

Expression partners for TTLL2 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TTLL2 Gene

Orthologs for TTLL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTLL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TTLL2 35
  • 74.5 (n)
  • 71.65 (a)
TTLL2 36
  • 70 (a)
(Canis familiaris)
Mammalia TTLL2 35
  • 77.71 (n)
  • 73.52 (a)
TTLL2 36
  • 72 (a)
(Mus musculus)
Mammalia Ttll2 35
  • 71.59 (n)
  • 67.96 (a)
Ttll2 16
Ttll2 36
  • 66 (a)
(Pan troglodytes)
Mammalia TTLL2 35
  • 97.11 (n)
  • 96.49 (a)
TTLL2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ttll2 35
  • 70.94 (n)
  • 68.74 (a)
(Monodelphis domestica)
Mammalia TTLL2 36
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 2 (a)
(Gallus gallus)
Aves TTLL2 35
  • 59.99 (n)
  • 53.95 (a)
TTLL2 36
  • 52 (a)
(Anolis carolinensis)
Reptilia TTLL2 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497970 35
  • 56.87 (n)
  • 51.68 (a)
(Danio rerio)
Actinopterygii ttll2 35
  • 52.76 (n)
  • 48.5 (a)
ttll2 36
  • 39 (a)
Species with no ortholog for TTLL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTLL2 Gene

Gene Tree for TTLL2 (if available)
Gene Tree for TTLL2 (if available)

Paralogs for TTLL2 Gene

(1) SIMAP similar genes for TTLL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TTLL2: view

Variants for TTLL2 Gene

Sequence variations from dbSNP and Humsavar for TTLL2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs877653 -- 167,340,203(+) CAAAG(C/T)GTCCT reference, synonymous-codon
rs909545 - 167,341,173(+) AGGGG(A/G)GAGAA reference, missense
rs909546 -- 167,341,214(+) ATCGA(C/T)GCTGC reference, synonymous-codon
rs2981975 -- 167,327,343(+) AACTG(C/T)TCTTG intron-variant
rs2981976 -- 167,330,422(+) CAGGC(A/G)TGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTLL2 Gene

Variant ID Type Subtype PubMed ID
essv22845 CNV CNV 17122850
dgv2033e1 CNV Complex 17122850
nsv464141 CNV Gain 19166990
nsv470873 CNV Gain 18288195
nsv7389 OTHER Inversion 18451855
esv24545 CNV Gain+Loss 19812545
esv34252 CNV Gain 17911159
nsv886945 CNV Loss 21882294
nsv886946 CNV Loss 21882294
esv2733230 CNV Deletion 23290073
nsv517210 CNV Gain+Loss 19592680
nsv886947 CNV Gain 21882294
nsv464145 CNV Loss 19166990
esv33288 CNV Loss 17666407

Relevant External Links for TTLL2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTLL2 Gene

Disorders for TTLL2 Gene

Relevant External Links for TTLL2

Genetic Association Database (GAD)

No disorders were found for TTLL2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TTLL2 Gene

Publications for TTLL2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1. (PMID: 11054573) Trichet V. … De Sario A. (Gene 2000) 2 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3
  5. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3

Products for TTLL2 Gene

Sources for TTLL2 Gene

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