TTLL2 Gene
protein-coding GIFtS: 39
GCID: GC06P167738
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tubulin tyrosine ligase-like family, member 2(Previous name: chromosome 6 open reading frame 104 )
(Previous symbol: C6orf104)
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Aliases
for TTLL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tubulin Tyrosine Ligase-Like Family, Member 21 2 | | Tubulin--Tyrosine Ligase-Like Protein 22 3 | | C6orf1041 2 3 | | Chromosome 6 Open Reading Frame 1041 | | NYD-TSPG1 2 | | Probable Tubulin Polyglutamylase TTLL22 | | DJ366N23.31 | | EC 6.-.-.-3 | | Testis-Specific Protein NYD-TSPG2 3 | | |
Export aliases for TTLL2 gene to outside databasesPrevious GC identifers: GC06P167647 GC06P167708 GC06P167658 GC06P165211 |
Summaries
for TTLL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TTLL2_HUMAN, Q9BWV7Function: Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts whencomplexed with other proteins (By similarity)
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Genomic Views
for TTLL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TTLL2 gene promoter:
RFX1 NRSF form 1 XBP-1 NF-kappaB NRSF form 2 AREB6 POU2F1 NF-kappaB2 POU2F1a NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TTLL2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTLL2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q27TTLL2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P167738: view genomic region
(about GC identifiers)
Start:
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167,738,574 bp from pter |
End:
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167,772,991 bp from pter |
Size:
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34,418 bases |
Orientation:
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plus strand |
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Proteins
for TTLL2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TTLL2_HUMAN, Q9BWV7 (See
protein sequence)Recommended Name: Probable tubulin polyglutamylase TTLL2 Size: 592 amino acids; 67336 Da
Caution: Product of a dubious CDS prediction. May be produced at very low levels due to a premature stop codon in themRNA, leading to nonsense-mediated mRNA decay
Secondary accessions: B2RB11 B3KS77 Q7Z6R8 Q86X22Explore the universe of human proteins at neXtProt for TTLL2: NX_Q9BWV7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BWV7
TTLL2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_114155.4
ENSEMBL proteins: ENSP00000239587 ENSP00000424130 ENSP00000423198
Human Recombinant Protein Products:
TTLL2 Antibody Products:
Assay Products for TTLL2: |
Protein
Domains /
Families
for TTLL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TTLL2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BWV7ProtoNet protein and cluster: Q9BWV7 1 Blocks protein family: IPB004344 Tubulin-tyrosine ligase
UniProtKB/Swiss-Prot: TTLL2_HUMAN, Q9BWV7Similarity: Belongs to the tubulin--tyrosine ligase familySimilarity: Contains 1 TTL domain |
Function
for TTLL2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TTLL2_HUMAN, Q9BWV7Function: Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts whencomplexed with other proteins (By similarity)Enzyme Number (IUBMB): EC 6.-.-.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTLL2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTLL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TTLL2 (NM_031949) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTLL2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTLL2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004835 | tubulin-tyrosine ligase activity |
IEA | -- | | GO:0005524 | ATP binding |
-- | -- |
TTLL2 for ontologies About GeneDecksing
|
Pathways & Interactions
for TTLL2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTLL2
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006464 | cellular protein modification process |
IEA | -- |
TTLL2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TTLL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TTLL2
Search CenterWatch for drugs/clinical trials and news about TTLL2
|
Transcripts
for TTLL2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TTLL2 gene: NM_031949.4 Unigene Cluster for TTLL2: Tubulin tyrosine ligase-like family, member 2 Hs.520554 [show with all ESTs]Unigene Representative Sequence: NM_0319493 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000239587 ENST00000515138(uc003qvs.1) ENST00000512917
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTLL2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTLL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TTLL2 (NM_031949) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTLL2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTLL2 |
Additional cDNA sequence: AK093039.1 AK098527.1 AK225984.1 AK301755.1 AK314450.1 AY026506.1 BC047411.1 2 DOTS entries: DT.40126558 DT.102842417 16 AceView cDNA sequences: BX094765 BP370986 AI204535 AY026506 BC047411 BI560373 BC030650 AK098527 AA916546 BG720252 AX747876 NM_031949 AK093039 BI462156 BI463431 BP368927
GeneLoc Exon Structure
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Expression
for TTLL2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TTLL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TTLL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TTLL2
SOURCE GeneReport for Unigene cluster: Hs.520554
UniProtKB/Swiss-Prot: TTLL2_HUMAN, Q9BWV7Tissue specificity: Testis
SABiosciences Custom PCR Arrays for TTLL2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTLL2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TTLL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTLL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTLL2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL2 |
Orthologs
for TTLL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TTLL2 gene from 4/18 species (see all 18) About this table
ENSEMBL Gene Tree for TTLL2 (if available)
TreeFam Gene Tree for TTLL2 (if available) |
Paralogs
for TTLL2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TTLL2 gene
- TTLL102 TTLL42 TTLL32 TTLL12 TTLL52 TTLL112 TTLL92 TTLL72
- TTLL62 TTL2 TTLL82 TTLL132 ARPC4-TTLL32
1 SIMAP similar gene for TTLL2 using alignment to 2 protein entries: TTLL2_HUMAN (see all proteins):TTLL1
TTLL2 for paralogs About GeneDecksing
|
Genomic Variants
for TTLL2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TTLL2 (167738574 - 167772991 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for TTLL2
6 CNVs: 7546 64716 2666 8539 51845 3653
4 Indels: 81731 94211 94212 94213
1 Inversion: 37270 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTLL2 |
|
Disorders
/ Diseases
for TTLL2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TTLL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TTLL2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TTLL2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1. (PubMed id 11054573)1, 3 Trichet V.... De Sario A. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
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External Searches for TTLL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TTLL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing TTLL2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TTLL2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TTLL2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TTLL2 gene:
Search GeneIP for patents involving TTLL2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TTLL2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TTLL2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTLL2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTLL2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TTLL2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTLL2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTLL2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TTLL2 | | OriGene Custom Protein Services for TTLL2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TTLL2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTLL2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTLL2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTLL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTLL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTLL2 |
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| | | | Search Tocris compounds for TTLL2 |
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 | | | TTLL2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL2 |
|  |  |  | | | | Search ThermoFisher Antibodies for TTLL2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTLL2 |
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