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Aliases for TTLL13P Gene

Aliases for TTLL13P Gene

  • Tubulin Tyrosine Ligase-Like Family Member 13, Pseudogene 2 3
  • Tubulin Tyrosine Ligase-Like Family, Member 13 2 3
  • Tubulin--Tyrosine Ligase-Like Protein 13 3 4
  • TTLL13 3 4
  • Tubulin Tyrosine Ligase-Like Family Member 13 Pseudogene 4
  • Tubulin Polyglutamylase TTLL13 3
  • EC 6.-.-.- 4

External Ids for TTLL13P Gene

Previous HGNC Symbols for TTLL13P Gene

  • TTLL13

Summaries for TTLL13P Gene

GeneCards Summary for TTLL13P Gene

TTLL13P (Tubulin Tyrosine Ligase-Like Family Member 13, Pseudogene) is a Pseudogene. GO annotations related to this gene include ligase activity. An important paralog of this gene is TTLL8.

UniProtKB/Swiss-Prot for TTLL13P Gene

  • Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL13P Gene

Genomics for TTLL13P Gene

Genomic Location for TTLL13P Gene

Chromosome:
15
Start:
90,249,530 bp from pter
End:
90,265,482 bp from pter
Size:
15,953 bases
Orientation:
Plus strand

Genomic View for TTLL13P Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTLL13P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL13P Gene

No data available for Regulatory Elements for TTLL13P Gene

Proteins for TTLL13P Gene

  • Protein details for TTLL13P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NNM8-TTL13_HUMAN
    Recommended name:
    Tubulin polyglutamylase TTLL13P
    Protein Accession:
    A6NNM8

    Protein attributes for TTLL13P Gene

    Size:
    815 amino acids
    Molecular mass:
    93645 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BC036668; Type=Frameshift; Positions=298; Evidence={ECO:0000305};

    Alternative splice isoforms for TTLL13P Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTLL13P Gene

Proteomics data for TTLL13P Gene at MOPED

Post-translational modifications for TTLL13P Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTLL13P Gene

Domains & Families for TTLL13P Gene

Gene Families for TTLL13P Gene

Protein Domains for TTLL13P Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TTLL13P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NNM8

UniProtKB/Swiss-Prot:

TTL13_HUMAN :
  • The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.
  • Belongs to the tubulin--tyrosine ligase family.
Domain:
  • The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.
  • Contains 1 TTL domain.
Family:
  • Belongs to the tubulin--tyrosine ligase family.
genes like me logo Genes that share domains with TTLL13P: view

Function for TTLL13P Gene

Molecular function for TTLL13P Gene

UniProtKB/Swiss-Prot Function:
Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity).

Enzyme Numbers (IUBMB) for TTLL13P Gene

Gene Ontology (GO) - Molecular Function for TTLL13P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TTLL13P: view

Phenotypes for TTLL13P Gene

GenomeRNAi human phenotypes for TTLL13P:
genes like me logo Genes that share phenotypes with TTLL13P: view

miRNA for TTLL13P Gene

miRTarBase miRNAs that target TTLL13P

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TTLL13P Gene

Localization for TTLL13P Gene

Gene Ontology (GO) - Cellular Components for TTLL13P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with TTLL13P: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for TTLL13P Gene

Pathways & Interactions for TTLL13P Gene

SuperPathways for TTLL13P Gene

No Data Available

Interacting Proteins for TTLL13P Gene

Gene Ontology (GO) - Biological Process for TTLL13P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
genes like me logo Genes that share ontologies with TTLL13P: view

No data available for Pathways by source and SIGNOR curated interactions for TTLL13P Gene

Drugs & Compounds for TTLL13P Gene

No Compound Related Data Available

Transcripts for TTLL13P Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL13P Gene

No ASD Table

Relevant External Links for TTLL13P Gene

GeneLoc Exon Structure for
TTLL13P
ECgene alternative splicing isoforms for
TTLL13P

Expression for TTLL13P Gene

mRNA expression in normal human tissues for TTLL13P Gene

Protein differential expression in normal tissues from HIPED for TTLL13P Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TTLL13P Gene



genes like me logo Genes that share expression patterns with TTLL13P: view

Protein tissue co-expression partners for TTLL13P Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTLL13P Gene

Orthologs for TTLL13P Gene

This gene was present in the common ancestor of animals.

Orthologs for TTLL13P Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Ttll13 16
Ttll13 36
  • 49 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 49 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 46 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 56 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 74 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG16716 36
  • 21 (a)
ManyToMany
CG5987 36
  • 29 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToMany
Species with no ortholog for TTLL13P:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TTLL13P Gene

ENSEMBL:
Gene Tree for TTLL13P (if available)
TreeFam:
Gene Tree for TTLL13P (if available)

Paralogs for TTLL13P Gene

genes like me logo Genes that share paralogs with TTLL13P: view

Variants for TTLL13P Gene

Sequence variations from dbSNP and Humsavar for TTLL13P Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
VAR_057318 -
VAR_057319 -

Variation tolerance for TTLL13P Gene

Gene Damage Index Score: 18.97; 98.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTLL13P Gene

HapMap Linkage Disequilibrium report
TTLL13P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TTLL13P Gene

Disorders for TTLL13P Gene

Relevant External Links for TTLL13P

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTLL13P
genes like me logo Genes that share disorders with TTLL13P: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTLL13P Gene

Publications for TTLL13P Gene

  1. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PMID: 15890843) Janke C. … Edde B. (Science 2005) 2 67
  2. Multivalent microtubule recognition by tubulin tyrosine ligase-like family glutamylases. (PMID: 25959773) Garnham C.P. … Roll-Mecak A. (Cell 2015) 67
  3. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for TTLL13P Gene

Sources for TTLL13P Gene

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