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Aliases for TTLL13P Gene

Aliases for TTLL13P Gene

  • Tubulin Tyrosine Ligase Like 13, Pseudogene 2 3 5
  • Tubulin Tyrosine Ligase-Like Family Member 13, Pseudogene 2 3
  • Tubulin Tyrosine Ligase-Like Family, Member 13 2 3
  • Tubulin--Tyrosine Ligase-Like Protein 13 3 4
  • TTLL13 3 4
  • Tubulin Tyrosine Ligase-Like Family Member 13 Pseudogene 4
  • Tubulin Polyglutamylase TTLL13 3
  • EC 6.-.-.- 4

External Ids for TTLL13P Gene

Previous HGNC Symbols for TTLL13P Gene

  • TTLL13

Summaries for TTLL13P Gene

GeneCards Summary for TTLL13P Gene

TTLL13P (Tubulin Tyrosine Ligase Like 13, Pseudogene) is a Pseudogene. GO annotations related to this gene include ligase activity.

UniProtKB/Swiss-Prot for TTLL13P Gene

  • Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL13P Gene

Genomics for TTLL13P Gene

Regulatory Elements for TTLL13P Gene

Enhancers for TTLL13P Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F090248 1 ENCODE 19.2 -0.1 -102 1.1 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 ZNF48 YY1 ZNF121 GLIS2 SP3 TTLL13P CIB1 ENSG00000228998 NIFKP5 ENSG00000270322 GC15P090245
GH15F090263 1.1 ENCODE 13.2 +16.2 16220 3.7 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 KLF13 ENSG00000228998 LOC100631255 ENSG00000259314 POLG TTLL13P ARPIN RPL36AP43 GDPGP1 NIFKP5 ENSG00000259212
GH15F089892 1.2 ENCODE 10.5 -355.6 -355623 2.3 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 POLG ARPIN LOC100631255 AP3S2 RPL36AP43 ENSG00000259314 ENSG00000228998 NIFKP5 ENSG00000259212 TTLL13P
GH15F090157 1.7 FANTOM5 Ensembl ENCODE 6.8 -86.0 -85998 12.3 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A YBX1 FEZF1 DMAP1 CIB1 ENSG00000228998 LOC100631255 ENSG00000259314 POLG SEMA4B GDPGP1 NGRN NIFKP5 ENSG00000259212
GH15F090141 1.3 Ensembl ENCODE 7.6 -106.7 -106735 2.8 PKNOX1 ARNT SIN3A ZNF2 ZNF143 KLF13 SP3 JUNB REST TBX21 CIB1 NGRN GDPGP1 POLG IDH2 TTLL13P SEMA4B GC15M090124
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTLL13P on UCSC Golden Path with GeneCards custom track

Promoters for TTLL13P Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000413358 70 1201 PKNOX1 ARID4B SIN3A FEZF1 ZNF48 YY1 ZNF121 GLIS2 SP3 SP5

Genomic Location for TTLL13P Gene

Chromosome:
15
Start:
90,249,530 bp from pter
End:
90,265,482 bp from pter
Size:
15,953 bases
Orientation:
Plus strand

Genomic View for TTLL13P Gene

Genes around TTLL13P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTLL13P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTLL13P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL13P Gene

Proteins for TTLL13P Gene

  • Protein details for TTLL13P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NNM8-TTL13_HUMAN
    Recommended name:
    Tubulin polyglutamylase TTLL13P
    Protein Accession:
    A6NNM8

    Protein attributes for TTLL13P Gene

    Size:
    815 amino acids
    Molecular mass:
    93645 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BC036668; Type=Frameshift; Positions=298; Evidence={ECO:0000305};

    Alternative splice isoforms for TTLL13P Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTLL13P Gene

Post-translational modifications for TTLL13P Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTLL13P Gene

Domains & Families for TTLL13P Gene

Gene Families for TTLL13P Gene

Protein Domains for TTLL13P Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TTLL13P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NNM8

UniProtKB/Swiss-Prot:

TTL13_HUMAN :
  • The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.
  • Belongs to the tubulin--tyrosine ligase family.
Domain:
  • The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.
  • Contains 1 TTL domain.
Family:
  • Belongs to the tubulin--tyrosine ligase family.
genes like me logo Genes that share domains with TTLL13P: view

Function for TTLL13P Gene

Molecular function for TTLL13P Gene

UniProtKB/Swiss-Prot Function:
Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity).

Enzyme Numbers (IUBMB) for TTLL13P Gene

Gene Ontology (GO) - Molecular Function for TTLL13P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TTLL13P: view

Phenotypes for TTLL13P Gene

GenomeRNAi human phenotypes for TTLL13P:
genes like me logo Genes that share phenotypes with TTLL13P: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TTLL13P

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TTLL13P Gene

Localization for TTLL13P Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTLL13P gene
Compartment Confidence
cytoskeleton 3
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for TTLL13P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with TTLL13P: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TTLL13P Gene

Pathways & Interactions for TTLL13P Gene

SuperPathways for TTLL13P Gene

No Data Available

Interacting Proteins for TTLL13P Gene

Selected Interacting proteins: A6NNM8-TTL13_HUMAN for TTLL13P Gene via IID

Symbol External ID(s) Details
CSTF3

Gene Ontology (GO) - Biological Process for TTLL13P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
genes like me logo Genes that share ontologies with TTLL13P: view

No data available for Pathways by source and SIGNOR curated interactions for TTLL13P Gene

Transcripts for TTLL13P Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL13P Gene

No ASD Table

Relevant External Links for TTLL13P Gene

GeneLoc Exon Structure for
TTLL13P
ECgene alternative splicing isoforms for
TTLL13P

Expression for TTLL13P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTLL13P Gene

Protein differential expression in normal tissues from HIPED for TTLL13P Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TTLL13P Gene



Protein tissue co-expression partners for TTLL13P Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TTLL13P Gene:

TTLL13P
genes like me logo Genes that share expression patterns with TTLL13P: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTLL13P Gene

Orthologs for TTLL13P Gene

This gene was present in the common ancestor of animals.

Orthologs for TTLL13P Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 56 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 54 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 49 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ttll13 35
  • 49 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 46 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 74 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5987 35
  • 29 (a)
ManyToMany
CG16716 35
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 66 (a)
OneToMany
Species where no ortholog for TTLL13P was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TTLL13P Gene

ENSEMBL:
Gene Tree for TTLL13P (if available)
TreeFam:
Gene Tree for TTLL13P (if available)

Paralogs for TTLL13P Gene

No data available for Paralogs for TTLL13P Gene

Variants for TTLL13P Gene

Sequence variations from dbSNP and Humsavar for TTLL13P Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10083656 -- 90,256,553(+) TCTTT(C/T)TTTCT intron-variant
rs10083710 -- 90,256,570(+) CTTTC(C/T)TTCTT intron-variant
rs10083711 -- 90,256,574(+) CTTTC(C/T)TTCTT intron-variant
rs10083712 -- 90,256,587(+) TTTCT(C/T)TCTTT intron-variant
rs1104971 -- 90,251,906(+) GTCTC(A/G)CTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTLL13P Gene

Variant ID Type Subtype PubMed ID
nsv1052652 CNV gain 25217958
nsv833087 CNV loss 17160897
nsv94314 CNV deletion 16902084
nsv94838 CNV deletion 16902084
esv3637218 CNV gain 21293372
esv3637217 CNV loss 21293372
esv3552835 CNV deletion 23714750
esv3194606 CNV deletion 24192839
esv2760054 CNV gain 17122850
esv2751541 CNV gain 17911159

Variation tolerance for TTLL13P Gene

Gene Damage Index Score: 18.97; 98.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTLL13P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTLL13P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTLL13P Gene

Disorders for TTLL13P Gene

Relevant External Links for TTLL13P

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTLL13P

No disorders were found for TTLL13P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTLL13P Gene

Publications for TTLL13P Gene

  1. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PMID: 15890843) Janke C. … Edde B. (Science 2005) 2 3 64
  2. Multivalent microtubule recognition by tubulin tyrosine ligase-like family glutamylases. (PMID: 25959773) Garnham C.P. … Roll-Mecak A. (Cell 2015) 4 64
  3. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for TTLL13P Gene

Sources for TTLL13P Gene

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