Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TTLL12 Gene

protein-coding   GIFtS: 50
GCID: GC22M043562

Tubulin Tyrosine Ligase-Like Family, Member 12

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tubulin Tyrosine Ligase-Like Family, Member 121 2
dJ526I14.22
Tubulin--Tyrosine Ligase-Like Protein 122
KIAA01533

External Ids:    HGNC: 289741   Entrez Gene: 231702   Ensembl: ENSG000001003047   UniProtKB: Q141663   

Export aliases for TTLL12 gene to outside databases

Previous GC identifers: GC22M041888 GC22M026520


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TTLL12 Gene: 
TTLL12 (tubulin tyrosine ligase-like family, member 12) is a protein-coding gene. Diseases associated with TTLL12 include prostatitis. GO annotations related to this gene include tubulin-tyrosine ligase activity.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TTLL12 gene promoter:
         p53   AML1a   MAZR   Pax-2   Pax-2a   E47   HNF-4alpha1   FOXL1   CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTLL12 promoter sequence
   Search SABiosciences Chromatin IP Primers for TTLL12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTLL12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.31   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.31

TTLL12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTLL12 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M043562:  view genomic region     (about GC identifiers)

Start:
43,562,628 bp from pter      End:
43,583,139 bp from pter
Size:
20,512 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TTL12_HUMAN, Q14166 (See protein sequence)
Recommended Name: Tubulin--tyrosine ligase-like protein 12  
Size: 644 amino acids; 74404 Da
Secondary accessions: Q20WK5 Q9UGU3

Explore the universe of human proteins at neXtProt for TTLL12: NX_Q14166

Explore proteomics data for TTLL12 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14166

  • TTLL12 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TTLL12 Protein Expression
    REFSEQ proteins: NP_055955.1  
    ENSEMBL proteins: 
     ENSP00000216129  

    Human Recombinant Protein Products for TTLL12: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TTLL12
    OriGene Protein Over-expression Lysate for TTLL12
    OriGene MassSpec for TTLL12 
    OriGene Custom Protein Services for TTLL12
    GenScript Custom Purified and Recombinant Proteins Services for TTLL12
    Novus Biologicals TTLL12 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TTLL12 


    TTLL12 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TTLL12
    OriGene Custom Antibody Services for TTLL12
    GenScript Custom Superior Antibodies Services for TTLL12
    Novus Biologicals TTLL12 Antibodies
    Abcam antibodies for TTLL12
    Cloud-Clone Corp. Antibodies for TTLL12 
    ThermoFisher Antibody for TTLL12
    LSBio Antibodies in human, mouse, rat for TTLL12 

    Assay Products for TTLL12: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TTLL12
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TTLL12
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TTLL12 
    Cloud-Clone Corp. CLIAs for TTLL12


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TTLL: Tubulin tyrosine ligase-like family

    1 InterPro protein domain:
     IPR004344 Tub_tyr_ligase

    Graphical View of Domain Structure for InterPro Entry Q14166

    ProtoNet protein and cluster: Q14166

    1 Blocks protein domain: IPB004344 Tubulin-tyrosine ligase

    UniProtKB/Swiss-Prot: TTL12_HUMAN, Q14166
    Similarity: Contains 1 TTL domain


    TTLL12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004835tubulin-tyrosine ligase activity ----
         
    TTLL12 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TTLL12:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TTLL12 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TTLL12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TTLL12 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TTLL12 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TTLL12
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate TTLL12:
    hsa-miR-298 hsa-miR-138 hsa-miR-3919 hsa-miR-4299 hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidTTLL12 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TTLL12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTLL12

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TTLL12
    Sirion Biotech Customized adenovirus for overexpression of TTLL12

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TTLL12 (see all 7)
    OriGene ORF clones in mouse, rat for TTLL12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TTLL12 (NM_015140)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TTLL12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTLL12
    Sirion Biotech Customized lentivirus for stable overexpression of TTLL12 
                         Customized lentivirus expression plasmids for stable overexpression of TTLL12 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TTLL12
    Search LifeMap BioReagents cell lines for TTLL12
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL12


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTLL12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/13 Interacting proteins for TTLL12 (Q141663 ENSP000002161294) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-BP304803, ENSP000003991684I2D: score=1 STRING: ENSP00000399168
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    DDA1Q9BW613I2D: score=1 
    IKBKEQ141643I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process IEA--

    TTLL12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TTLL12 (TTL12)

    Search CenterWatch for drugs/clinical trials and news about TTLL12 / TTL12

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TTLL12 gene: 
    NM_015140.3  

    Unigene Cluster for TTLL12:

    Tubulin tyrosine ligase-like family, member 12
    Hs.517670  [show with all ESTs]
    Unigene Representative Sequence: NM_015140
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216129(uc021wqu.1 uc003bdq.3) ENST00000484711(uc003bdp.3)
    ENST00000494035 ENST00000484118
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TTLL12
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate TTLL12:
    hsa-miR-298 hsa-miR-138 hsa-miR-3919 hsa-miR-4299 hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidTTLL12 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TTLL12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTLL12
    Clone
    Products:
         
    OriGene clones in human, mouse for TTLL12 (see all 7)
    OriGene ORF clones in mouse, rat for TTLL12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TTLL12 (NM_015140)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TTLL12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTLL12
    Sirion Biotech Customized lentivirus for stable overexpression of TTLL12 
                         Customized lentivirus expression plasmids for stable overexpression of TTLL12 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TTLL12
    OriGene qSTAR qPCR primer pairs in human, mouse for TTLL12
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TTLL12
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTLL12
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTLL12

    Additional mRNA sequence: 

    AK123789.1 AK304464.1 AL590888.1 BC001070.2 CT841516.1 D63487.1 

    17 DOTS entries:

    DT.446084  DT.100826465  DT.97846478  DT.100027458  DT.92036630  DT.100826469  DT.100831400  DT.95143183 
    DT.100702398  DT.100756613  DT.100646107  DT.100696471  DT.92434553  DT.95141170  DT.95224167  DT.97846477 
    DT.99995491 

    24/320 AceView cDNA sequences (see all 320):

    BI063381 CR593557 BM852946 BI910858 BI757261 BQ422241 AL590888 BE019584 
    BG574113 AW732354 BU151578 BM928672 BQ642273 D31334 CB131255 BM905180 
    BQ918739 BQ434700 CR599372 CF126405 BI761788 BU742936 CR597138 BQ058904 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TTLL12 expression in normal human tissues (normalized intensities)      TTLL12 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTCCCCCT
    TTLL12 Expression
    About this image


    TTLL12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Epithelium (Uncategorized)    fully expand to see all 2 entries
             gingival epithelium   
     
     Thymus (Hematopoietic System)
             Thymus
     
     Kidney (Urinary System)
             Metanephros
     
     Oral Cavity (Gastrointestinal Tract)
             gingival epithelium   
     
     Esophagus
             esophageal epithelium   

    See TTLL12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TTLL12

    SOURCE GeneReport for Unigene cluster: Hs.517670
        SABiosciences Custom PCR Arrays for TTLL12
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TTLL12
    OriGene qSTAR qPCR primer pairs in human, mouse for TTLL12
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TTLL12
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTLL12
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTLL12
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TTLL12 gene from 9/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttll121 , 5 tubulin tyrosine ligase-like family, member 121, 5 85.6(n)1
    86.07(a)1
      15 (39.40 cM)5
    2237231  NM_183017.21  NP_898838.21 
     835751195 
    chicken
    (Gallus gallus)
    Aves TTLL121 tubulin tyrosine ligase-like family, member 12 72.08(n)
    77.17(a)
      418227  NM_001012540.1  NP_001012558.1 
    lizard
    (Anolis carolinensis)
    Reptilia TTLL126
    Uncharacterized protein
    72(a)
    1 ↔ 1
    5(86721922-86753243)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.45752 Xenopus laevis transcribed sequences 78.45(n)    CF289213.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc553432 hypothetical protein MGC55343 73.57(n)   393222  BC048032.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG15501 CG1550 53.8(n)
    42.95(a)
      35732  NM_136481.2  NP_610325.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ttll-121 Protein TTLL-12 46.53(n)
    39.59(a)
      174480  NM_063589.2  NP_495990.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G775501 tubulin-tyrosine ligase 48.81(n)
    40.93(a)
      844091  NM_106404.5  NP_177879.3 
    rice
    (Oryza sativa)
    Liliopsida Os03g01790001 hypothetical protein 50.06(n)
    43.19(a)
      4331821  NM_001055690.1  NP_001049155.1 


    ENSEMBL Gene Tree for TTLL12 (if available)
    TreeFam Gene Tree for TTLL12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TTLL12 gene

    TTLL12 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TTLL12
    PGOHUM00000235406


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/820 SNPs in TTLL12 are shown (see all 820)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378924131,2
    --43562188(+) GGGATC/TATAGG 1 -- int10--------
    rs1389251,2
    C,F,A,H--43562195(+) TAGGCG/ATGAGC 1 -- int15Minor allele frequency- A:0.36NA WA EA 128
    rs1423076971,2
    --43562224(+) TTCTGA/GGTCTT 1 -- int10--------
    rs175147831,2
    C,F--43562247(+) CACCAT/CGTGGC 1 -- int15Minor allele frequency- C:0.02NA 260
    rs1459702601,2
    --43562272(+) CTGACA/GGTGTC 1 -- int10--------
    rs1389261,2
    C,F,A,H--43562306(+) CGAGGG/AGCCCT 1 -- int120Minor allele frequency- A:0.42NS EA NA WA 2308
    rs734180671,2
    C,F--43562351(+) CCCACC/TCCAGG 1 -- int12Minor allele frequency- T:0.06WA 120
    rs1389271,2
    C,F,O,A,H--43562381(+) GAGGCC/TGCTAT 1 -- int112Minor allele frequency- T:0.49MN NS EA WA NA 968
    rs57514431,2
    C--43562382(+) AGGCTG/ACTATC 1 -- int14Minor allele frequency- A:0.18NA WA EA 360
    rs1389281,2
    C,F,A,H--43562407(+) AGCTGT/CGGGGC 1 -- int114Minor allele frequency- C:0.38NA EA MN WA 980

    HapMap Linkage Disequilibrium report for TTLL12 (43562628 - 43583139 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for TTLL12 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv4988n71CNV Loss21882294
    dgv4990n71CNV Loss21882294
    nsv915201CNV Loss21882294
    nsv834216CNV Loss17160897
    dgv4991n71CNV Loss21882294
    dgv4987n71CNV Loss21882294
    nsv520927CNV Loss19592680
    nsv471201CNV Loss18288195
    dgv4986n71CNV Loss21882294
    dgv4989n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TTLL12
    DNA2.0 Custom Variant and Variant Library Synthesis for TTLL12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for TTLL12:    About MalaCards
    prostatitis    


    TTLL12 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TTLL12
    Human Genome Epidemiology (HuGE) Navigator: TTLL12 (1 document)

    Export disorders for TTLL12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TTLL12 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with TTLL12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PubMed id 15890843)1, 3 Janke C.... Edde B. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    4. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    5. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2 Nagase T....Nomura N. (1995)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Proteomic analysis of a4b1 integrin adhesion complexes reveals a-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23170 HGNC: 28974 AceView: KIAA0153 Ensembl:ENSG00000100304 euGenes: HUgn23170
    ECgene: TTLL12 H-InvDB: TTLL12

    (According to HUGE)
    About This Section
    HUGE: KIAA0153

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TTLL12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TTLL12 gene:
    Search GeneIP for patents involving TTLL12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TTLL12   OriGene RNAi products in human, mouse, rat for TTLL12  
     OriGene qPCR primer pairs and template standards for TTLL12   OriGene Protein Over-expression Lysate for TTLL12  
     OriGene MassSpec something-or-other for TTLL12   OriGene clones in human, mouse for TTLL12  
     OriGene qSTAR qPCR primer pairs in human, mouse for TTLL12   OriGene Purified Protein for TTLL12  
     OriGene ORF clones in mouse, rat for TTLL12   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TTLL12   OriGene Custom Protein Services for TTLL12  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TTLL12
     QIAGEN SeqTarget long-range PCR primers for resequencing TTLL12
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTLL12
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTLL12
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTLL12
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTLL12
     GenScript Custom Purified and Recombinant Proteins Services for TTLL12 GenScript cDNA clones with any tag delivered in your preferred vector for TTLL12
     GenScript Custom Assay Services for TTLL12 GenScript Custom Superior Antibodies Services for TTLL12
     GenScript Custom overexpressing Cell Line Services for TTLL12 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TTLL12 promoter
     Search Chromatin IP Primers for TTLL12
     RT2 qPCR Primer Assay in human, mouse, rat TTLL12
     Search GNC Networks for TTLL12
     SABiosciences Custom PCR Arrays for TTLL12
     Search Tocris compounds for TTLL12 (TTL12)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TTLL12 antibodies
     TTLL12 lysates
     Antibodies for TTLL12
     See all of Abcam's Antibodies, Kits and Proteins for TTLL12
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TTLL12
     Antibodies for TTLL12
     ELISAs for TTLL12
     CLIAs for TTLL12
     Search LifeMap BioReagents cell lines for TTLL12
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL12
     SwitchGear 3'UTR luciferase reporter plasmids for TTLL12
     SwitchGear Promoter luciferase reporter plasmids for TTLL12
     ThermoFisher Antibody for TTLL12
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTLL12
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TTLL12
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TTLL12
    Customized:
     lentivirus for stable overexpression of TTLL12
     lentivirus expression plasmids for stable overexpression of TTLL12
     adenovirus for overexpression of TTLL12
     LSBio Antibodies in human, mouse, rat for TTLL12
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TTLL12 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4