Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TTLL12 Gene

Aliases for TTLL12 Gene

  • Tubulin Tyrosine Ligase-Like Family Member 12 2 3
  • Tubulin Tyrosine Ligase-Like Family, Member 12 3
  • Tubulin--Tyrosine Ligase-Like Protein 12 3
  • DJ526I14.2 3
  • KIAA0153 4

External Ids for TTLL12 Gene

Summaries for TTLL12 Gene

GeneCards Summary for TTLL12 Gene

TTLL12 (Tubulin Tyrosine Ligase-Like Family Member 12) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL12 Gene

Genomics for TTLL12 Gene

Genomic Location for TTLL12 Gene

Start:
43,166,622 bp from pter
End:
43,187,133 bp from pter
Size:
20,512 bases
Orientation:
Minus strand

Genomic View for TTLL12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTLL12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL12 Gene

Regulatory Elements for TTLL12 Gene

Proteins for TTLL12 Gene

  • Protein details for TTLL12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14166-TTL12_HUMAN
    Recommended name:
    Tubulin--tyrosine ligase-like protein 12
    Protein Accession:
    Q14166
    Secondary Accessions:
    • Q20WK5
    • Q9UGU3

    Protein attributes for TTLL12 Gene

    Size:
    644 amino acids
    Molecular mass:
    74404 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TTLL12 Gene

Proteomics data for TTLL12 Gene at MOPED

Post-translational modifications for TTLL12 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys88, Lys342, Lys346, Lys368, Lys419, and Lys433

Other Protein References for TTLL12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTLL12 Gene

Domains for TTLL12 Gene

Gene Families for TTLL12 Gene

HGNC:
  • TTLL :Tubulin tyrosine ligase-like family

Protein Domains for TTLL12 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

TTL12_HUMAN
Domain:
  • Contains 1 TTL domain.:
    • Q14166
genes like me logo Genes that share domains with TTLL12: view

Function for TTLL12 Gene

Phenotypes for TTLL12 Gene

GenomeRNAi human phenotypes for TTLL12:
genes like me logo Genes that share phenotypes with TTLL12: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for TTLL12 Gene

Localization for TTLL12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTLL12 Gene COMPARTMENTS Subcellular localization image for TTLL12 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for TTLL12 Gene

Pathways for TTLL12 Gene

SuperPathways for TTLL12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTLL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
genes like me logo Genes that share ontologies with TTLL12: view

No data available for Pathways by source for TTLL12 Gene

Transcripts for TTLL12 Gene

Unigene Clusters for TTLL12 Gene

Tubulin tyrosine ligase-like family, member 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL12 Gene

No ASD Table

Relevant External Links for TTLL12 Gene

GeneLoc Exon Structure for
TTLL12
ECgene alternative splicing isoforms for
TTLL12

Expression for TTLL12 Gene

mRNA expression in normal human tissues for TTLL12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTLL12 Gene

This gene is overexpressed in Esophagus - Mucosa (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTLL12 Gene

SOURCE GeneReport for Unigene cluster for TTLL12 Gene Hs.517670

genes like me logo Genes that share expressions with TTLL12: view

Orthologs for TTLL12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TTLL12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTLL12 36
  • 99.38 (n)
  • 99.07 (a)
TTLL12 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TTLL12 36
  • 87.63 (n)
  • 86.49 (a)
TTLL12 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTLL12 36
  • 87.41 (n)
  • 87.68 (a)
TTLL12 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttll12 36
  • 85.6 (n)
  • 86.07 (a)
Ttll12 16
Ttll12 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTLL12 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 68 (a)
OneToMany
-- 37
  • 61 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ttll12 36
  • 85.13 (n)
  • 85.76 (a)
chicken
(Gallus gallus)
Aves TTLL12 36
  • 71.81 (n)
  • 76.69 (a)
TTLL12 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTLL12 37
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4575 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486512 36
  • 71.44 (n)
  • 69.15 (a)
zebrafish
(Danio rerio)
Actinopterygii ttll12 36
  • 64.74 (n)
  • 63.5 (a)
ttll12 37
  • 64 (a)
OneToOne
zgc55343 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004284 36
  • 55.63 (n)
  • 46.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1550 36
  • 53.75 (n)
  • 42.62 (a)
CG1550 37
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ttll-12 36
  • 46.72 (n)
  • 39.83 (a)
ttll-12 37
  • 35 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G77550 36
  • 49.49 (n)
  • 41.44 (a)
rice
(Oryza sativa)
Liliopsida Os03g0179000 36
  • 50.09 (n)
  • 42.81 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 49 (a)
OneToOne
Species with no ortholog for TTLL12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTLL12 Gene

ENSEMBL:
Gene Tree for TTLL12 (if available)
TreeFam:
Gene Tree for TTLL12 (if available)

Paralogs for TTLL12 Gene

Pseudogenes.org Pseudogenes for TTLL12 Gene

genes like me logo Genes that share paralogs with TTLL12: view

No data available for Paralogs for TTLL12 Gene

Variants for TTLL12 Gene

Sequence variations from dbSNP and Humsavar for TTLL12 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs9463 -- 43,166,699(+) AAGGC(A/G)ACGGG utr-variant-3-prime
rs13570 -- 43,166,961(-) GCTCA(C/T)GGGCA utr-variant-3-prime
rs47340 -- 43,166,823(-) TGCAC(A/C)TGATG utr-variant-3-prime
rs107402 -- 43,167,705(+) GGAAC(A/G)AAGCC utr-variant-3-prime
rs138925 -- 43,166,189(+) TAGGC(A/G)TGAGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TTLL12 Gene

Variant ID Type Subtype PubMed ID
nsv834214 CNV Gain 17160897
esv33816 CNV Gain 17666407
dgv4986n71 CNV Loss 21882294
dgv4987n71 CNV Loss 21882294
nsv915201 CNV Loss 21882294
dgv4988n71 CNV Loss 21882294
nsv459890 CNV Gain 19166990
nsv520927 CNV Loss 19592680
nsv915217 CNV Gain 21882294
dgv4989n71 CNV Loss 21882294
dgv4990n71 CNV Loss 21882294
dgv4991n71 CNV Loss 21882294
nsv471201 CNV Loss 18288195
nsv834216 CNV Loss 17160897

Relevant External Links for TTLL12 Gene

HapMap Linkage Disequilibrium report
TTLL12

Disorders for TTLL12 Gene

Relevant External Links for TTLL12

Genetic Association Database (GAD)
TTLL12
Human Genome Epidemiology (HuGE) Navigator
TTLL12
genes like me logo Genes that share disorders with TTLL12: view

No data available for UniProtKB/Swiss-Prot for TTLL12 Gene

Publications for TTLL12 Gene

  1. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PMID: 15890843) Janke C. … Edde B. (Science 2005) 2 3
  4. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 3 4
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4

Products for TTLL12 Gene

  • antibodies-online peptides for TTLL12
  • antibodies-online antibodies for TTLL12
  • antibodies-online kits for TTLL12

Sources for TTLL12 Gene

Back to Top

Content