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TTLL12 Gene

protein-coding   GIFtS: 51
GCID: GC22M043562

Tubulin Tyrosine Ligase-Like Family, Member 12

  Search for TTLL12
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tubulin Tyrosine Ligase-Like Family, Member 121 2
dJ526I14.22
Tubulin--Tyrosine Ligase-Like Protein 122
KIAA01533

External Ids:    HGNC: 289741   Entrez Gene: 231702   Ensembl: ENSG000001003047   UniProtKB: Q141663   

Export aliases for TTLL12 gene to outside databases

Previous GC identifers: GC22M041888 GC22M026520


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TTLL12 Gene:
TTLL12 (tubulin tyrosine ligase-like family, member 12) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TTLL12 gene promoter:
         p53   AML1a   MAZR   Pax-2   Pax-2a   E47   HNF-4alpha1   FOXL1   CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTLL12 promoter sequence
   Search Chromatin IP Primers for TTLL12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTLL12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.31   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.31

TTLL12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTLL12 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M043562:  view genomic region     (about GC identifiers)

Start:
43,562,628 bp from pter      End:
43,583,139 bp from pter
Size:
20,512 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TTL12_HUMAN, Q14166 (See protein sequence)
Recommended Name: Tubulin--tyrosine ligase-like protein 12  
Size: 644 amino acids; 74404 Da
Secondary accessions: Q20WK5 Q9UGU3

Explore the universe of human proteins at neXtProt for TTLL12: NX_Q14166

Explore proteomics data for TTLL12 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys88, Lys342, Lys346, Lys368, Lys419, Lys433
  • Modification sites at PhosphoSitePlus

  • See TTLL12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055955.1  
    ENSEMBL proteins: 
     ENSP00000216129   ENSP00000476297  

    TTLL12 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for TTLL12 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTLL: Tubulin tyrosine ligase-like family

    2 InterPro protein domains:
     IPR027749 TTLL12
     IPR004344 TTL/TTLL_fam

    Graphical View of Domain Structure for InterPro Entry Q14166

    ProtoNet protein and cluster: Q14166

    1 Blocks protein domain: IPB004344 Tubulin-tyrosine ligase

    UniProtKB/Swiss-Prot: TTL12_HUMAN, Q14166
    Similarity: Contains 1 TTL domain


    Find genes that share domains with TTLL12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         2 GenomeRNAi human phenotypes for TTLL12:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TTLL12
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TTLL12

    miRNA
    Products:
        
    miRTarBase miRNAs that target TTLL12:
    hsa-mir-324-3p (MIRT042997), hsa-mir-296-3p (MIRT038373), hsa-let-7e-5p (MIRT051428), hsa-mir-18a-3p (MIRT040865), hsa-mir-16-5p (MIRT031972), hsa-mir-193b-3p (MIRT041561), hsa-mir-106a-5p (MIRT048325), hsa-mir-7-5p (MIRT025922), hsa-let-7b-5p (MIRT032468), hsa-mir-34a-5p (MIRT025542), hsa-mir-30b-5p (MIRT046157)

    Block miRNA regulation of human, mouse, rat TTLL12 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TTLL12:
    hsa-miR-298 hsa-miR-138 hsa-miR-3919 hsa-miR-4299 hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidTTLL12 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat TTLL12

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTLL12

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TTLL12
    Interactions:

        Search GeneGlobe Interaction Network for TTLL12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for TTLL12 (Q141663 ENSP000002161294) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-BP304803, ENSP000003991684I2D: score=1 STRING: ENSP00000399168
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    DDA1Q9BW613I2D: score=1 
    IKBKEQ141643I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process IEA--

    Find genes that share ontologies with TTLL12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TTLL12 (TTL12)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TTLL12 gene: 
    NM_015140.3  

    Unigene Cluster for TTLL12:

    Tubulin tyrosine ligase-like family, member 12
    Hs.517670  [show with all ESTs]
    Unigene Representative Sequence: NM_015140
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216129(uc021wqu.1 uc003bdq.3) ENST00000484711(uc003bdp.3)
    ENST00000494035 ENST00000484118
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TTLL12 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TTLL12:
    hsa-miR-298 hsa-miR-138 hsa-miR-3919 hsa-miR-4299 hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidTTLL12 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TTLL12
    Predesigned siRNA for gene silencing in human, mouse, rat TTLL12
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TTLL12
      QuantiTect SYBR Green Assays in human, mouse, rat TTLL12
      QuantiFast Probe-based Assays in human, mouse, rat TTLL12

    Additional mRNA sequence: 

    AK123789.1 AK304464.1 AL590888.1 BC001070.2 CT841516.1 D63487.1 

    17 DOTS entries:

    DT.446084  DT.100826465  DT.97846478  DT.100027458  DT.92036630  DT.100826469  DT.100831400  DT.95143183 
    DT.100702398  DT.100756613  DT.100646107  DT.100696471  DT.92434553  DT.95141170  DT.95224167  DT.97846477 
    DT.99995491 

    Selected AceView cDNA sequences (see all 320):

    BM928672 BM794692 BI061556 BI063381 BM852946 W86730 BE279380 CR599372 
    CF786040 BQ642273 BI910858 BU742936 CR610976 BQ422241 BE019584 BQ678319 
    BQ058904 BC001070 BQ918739 BI757261 CR593557 BU151578 BM766431 BI761788 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TTLL12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTCCCCCT
    TTLL12 Expression
    About this image


    TTLL12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Thymus (Hematopoietic System)
             Thymus
     
     Kidney (Urinary System)
             Metanephros
     
     Brain (Nervous System)
             Medulla Oblongata
     
     Esophagus (Gastrointestinal Tract)
    TTLL12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TTLL12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517670
        Custom PCR Arrays for TTLL12
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TTLL12 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttll121 , 5 tubulin tyrosine ligase-like family, member 121, 5 85.6(n)1
    86.07(a)1
      15 (39.40 cM)5
    2237231  NM_183017.21  NP_898838.21 
     835751195 
    chicken
    (Gallus gallus)
    Aves TTLL121 tubulin tyrosine ligase-like family, member 12 71.81(n)
    76.69(a)
      418227  NM_001012540.1  NP_001012558.1 
    lizard
    (Anolis carolinensis)
    Reptilia TTLL126
    tubulin tyrosine ligase-like family, member 12
    72(a)
    1 ↔ 1
    5(86721922-86753243)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.45752 Xenopus laevis transcribed sequences 78.45(n)    CF289213.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc553432 hypothetical protein MGC55343 73.57(n)   393222  BC048032.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG15501 CG1550 53.75(n)
    42.62(a)
      35732  NM_136481.2  NP_610325.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ttll-121 ttll-12 46.72(n)
    39.83(a)
      174480  NM_063589.3  NP_495990.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G775501 AT1G77550 49.49(n)
    41.44(a)
      844091  NM_106404.5  NP_177879.3 
    rice
    (Oryza sativa)
    Liliopsida Os03g01790001 Os03g0179000 50.09(n)
    42.81(a)
      4331821  NM_001055690.1  NP_001049155.1 


    ENSEMBL Gene Tree for TTLL12 (if available)
    TreeFam Gene Tree for TTLL12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TTLL12 gene

    Find genes that share paralogs with TTLL12           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TTLL12
    PGOHUM00000235406


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TTLL12 (see all 820)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378924131,2
    --43562188(+) GGGATC/TATAGG 1 -- int10--------
    rs1389251,2
    C,F,A,H--43562195(+) TAGGCG/ATGAGC 1 -- int15Minor allele frequency- A:0.36NA WA EA 128
    rs1423076971,2
    --43562224(+) TTCTGA/GGTCTT 1 -- int10--------
    rs175147831,2
    C,F--43562247(+) CACCAT/CGTGGC 1 -- int15Minor allele frequency- C:0.02NA 260
    rs1459702601,2
    --43562272(+) CTGACA/GGTGTC 1 -- int10--------
    rs1389261,2
    C,F,A,H--43562306(+) CGAGGG/AGCCCT 1 -- int120Minor allele frequency- A:0.42NS EA NA WA 2308
    rs734180671,2
    C,F--43562351(+) CCCACC/TCCAGG 1 -- int12Minor allele frequency- T:0.06WA 120
    rs1389271,2
    C,F,O,A,H--43562381(+) GAGGCC/TGCTAT 1 -- int112Minor allele frequency- T:0.49MN NS EA WA NA 968
    rs57514431,2
    C--43562382(+) AGGCTG/ACTATC 1 -- int14Minor allele frequency- A:0.18NA WA EA 360
    rs1389281,2
    C,F,A,H--43562407(+) AGCTGT/CGGGGC 1 -- int114Minor allele frequency- C:0.38NA EA MN WA 980

    HapMap Linkage Disequilibrium report for TTLL12 (43562628 - 43583139 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TTLL12 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4988n71CNV Loss21882294
    dgv4990n71CNV Loss21882294
    nsv915201CNV Loss21882294
    nsv834216CNV Loss17160897
    dgv4991n71CNV Loss21882294
    dgv4987n71CNV Loss21882294
    nsv520927CNV Loss19592680
    nsv471201CNV Loss18288195
    dgv4986n71CNV Loss21882294
    dgv4989n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TTLL12
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with TTLL12           About GenesLikeMe

    Genetic Association Database (GAD): TTLL12
    Human Genome Epidemiology (HuGE) Navigator: TTLL12 (1 document)

    Export disorders for TTLL12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TTLL12 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with TTLL12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PubMed id 15890843)1, 3 Janke C.... Edde B. (Science 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    4. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    5. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2 Nagase T.... Nomura N. (DNA Res. 1995)
    6. Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH). (PubMed id 23918034)1 KA1hnisch J.... . (Clin Oral Investig 2014)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (Proteomics 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23170 HGNC: 28974 AceView: KIAA0153 Ensembl:ENSG00000100304 euGenes: HUgn23170
    ECgene: TTLL12 H-InvDB: TTLL12

    (According to HUGE)
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    HUGE: KIAA0153

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TTLL12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TTLL12 gene:
    Search GeneIP for patents involving TTLL12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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