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Aliases for TTLL12 Gene

Aliases for TTLL12 Gene

  • Tubulin Tyrosine Ligase-Like Family Member 12 2 3
  • Tubulin Tyrosine Ligase-Like Family, Member 12 3
  • DJ526I14.2 3
  • KIAA0153 4

External Ids for TTLL12 Gene

Previous GeneCards Identifiers for TTLL12 Gene

  • GC22M041888
  • GC22M043562
  • GC22M026520

Summaries for TTLL12 Gene

GeneCards Summary for TTLL12 Gene

TTLL12 (Tubulin Tyrosine Ligase-Like Family Member 12) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL12 Gene

Genomics for TTLL12 Gene

Regulatory Elements for TTLL12 Gene

Genomic Location for TTLL12 Gene

Chromosome:
22
Start:
43,166,622 bp from pter
End:
43,187,133 bp from pter
Size:
20,512 bases
Orientation:
Minus strand

Genomic View for TTLL12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTLL12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL12 Gene

Proteins for TTLL12 Gene

  • Protein details for TTLL12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14166-TTL12_HUMAN
    Recommended name:
    Tubulin--tyrosine ligase-like protein 12
    Protein Accession:
    Q14166
    Secondary Accessions:
    • Q20WK5
    • Q9UGU3

    Protein attributes for TTLL12 Gene

    Size:
    644 amino acids
    Molecular mass:
    74404 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TTLL12 Gene

Proteomics data for TTLL12 Gene at MOPED

Post-translational modifications for TTLL12 Gene

  • Ubiquitination at Lys 88, Lys 342, Lys 346, Lys 368, Lys 419, and Lys 433
  • Modification sites at PhosphoSitePlus

Other Protein References for TTLL12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTLL12 Gene

Domains & Families for TTLL12 Gene

Gene Families for TTLL12 Gene

Protein Domains for TTLL12 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TTLL12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14166

UniProtKB/Swiss-Prot:

TTL12_HUMAN :
  • Contains 1 TTL domain.
Domain:
  • Contains 1 TTL domain.
genes like me logo Genes that share domains with TTLL12: view

Function for TTLL12 Gene

Gene Ontology (GO) - Molecular Function for TTLL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with TTLL12: view

Phenotypes for TTLL12 Gene

genes like me logo Genes that share phenotypes with TTLL12: view

Animal Model Products

miRNA for TTLL12 Gene

miRTarBase miRNAs that target TTLL12

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTLL12

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TTLL12 Gene

Localization for TTLL12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTLL12 Gene COMPARTMENTS Subcellular localization image for TTLL12 gene
Compartment Confidence
cytosol 2
plasma membrane 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTLL12 Gene

Pathways & Interactions for TTLL12 Gene

SuperPathways for TTLL12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTLL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
genes like me logo Genes that share ontologies with TTLL12: view

No data available for Pathways by source and SIGNOR curated interactions for TTLL12 Gene

Drugs & Compounds for TTLL12 Gene

No Compound Related Data Available

Transcripts for TTLL12 Gene

Unigene Clusters for TTLL12 Gene

Tubulin tyrosine ligase-like family, member 12:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTLL12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL12 Gene

No ASD Table

Relevant External Links for TTLL12 Gene

GeneLoc Exon Structure for
TTLL12
ECgene alternative splicing isoforms for
TTLL12

Expression for TTLL12 Gene

mRNA expression in normal human tissues for TTLL12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTLL12 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.9).

Protein differential expression in normal tissues from HIPED for TTLL12 Gene

This gene is overexpressed in Lymph node (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTLL12 Gene



SOURCE GeneReport for Unigene cluster for TTLL12 Gene Hs.517670

genes like me logo Genes that share expression patterns with TTLL12: view

Protein tissue co-expression partners for TTLL12 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TTLL12 Gene

Orthologs for TTLL12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TTLL12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TTLL12 35
  • 87.63 (n)
  • 86.49 (a)
TTLL12 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTLL12 35
  • 87.41 (n)
  • 87.68 (a)
TTLL12 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttll12 35
  • 85.6 (n)
  • 86.07 (a)
Ttll12 16
Ttll12 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TTLL12 35
  • 99.38 (n)
  • 99.07 (a)
TTLL12 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttll12 35
  • 85.13 (n)
  • 85.76 (a)
oppossum
(Monodelphis domestica)
Mammalia TTLL12 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves TTLL12 35
  • 71.81 (n)
  • 76.69 (a)
TTLL12 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTLL12 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486512 35
  • 71.44 (n)
  • 69.15 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4575 35
zebrafish
(Danio rerio)
Actinopterygii ttll12 35
  • 64.74 (n)
  • 63.5 (a)
zgc55343 35
ttll12 36
  • 64 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004284 35
  • 55.63 (n)
  • 46.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1550 35
  • 53.75 (n)
  • 42.62 (a)
CG1550 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ttll-12 35
  • 46.72 (n)
  • 39.83 (a)
ttll-12 36
  • 35 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G77550 35
  • 49.49 (n)
  • 41.44 (a)
rice
(Oryza sativa)
Liliopsida Os03g0179000 35
  • 50.09 (n)
  • 42.81 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToOne
Species with no ortholog for TTLL12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTLL12 Gene

ENSEMBL:
Gene Tree for TTLL12 (if available)
TreeFam:
Gene Tree for TTLL12 (if available)

Paralogs for TTLL12 Gene

Pseudogenes.org Pseudogenes for TTLL12 Gene

genes like me logo Genes that share paralogs with TTLL12: view

No data available for Paralogs for TTLL12 Gene

Variants for TTLL12 Gene

Sequence variations from dbSNP and Humsavar for TTLL12 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs9463 -- 43,166,699(+) AAGGC(A/G)ACGGG utr-variant-3-prime
rs13570 -- 43,166,961(-) GCTCA(C/T)GGGCA utr-variant-3-prime
rs47340 -- 43,166,823(-) TGCAC(A/C)TGATG utr-variant-3-prime
rs107402 -- 43,167,705(+) GGAAC(A/G)AAGCC utr-variant-3-prime
rs138925 -- 43,166,189(+) TAGGC(A/G)TGAGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TTLL12 Gene

Variant ID Type Subtype PubMed ID
nsv834214 CNV Gain 17160897
esv33816 CNV Gain 17666407
dgv4986n71 CNV Loss 21882294
dgv4987n71 CNV Loss 21882294
nsv915201 CNV Loss 21882294
dgv4988n71 CNV Loss 21882294
nsv459890 CNV Gain 19166990
nsv520927 CNV Loss 19592680
nsv915217 CNV Gain 21882294
dgv4989n71 CNV Loss 21882294
dgv4990n71 CNV Loss 21882294
dgv4991n71 CNV Loss 21882294
nsv471201 CNV Loss 18288195
nsv834216 CNV Loss 17160897

Variation tolerance for TTLL12 Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.79; 93.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTLL12 Gene

HapMap Linkage Disequilibrium report
TTLL12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTLL12 Gene

Disorders for TTLL12 Gene

Relevant External Links for TTLL12

Genetic Association Database (GAD)
TTLL12
Human Genome Epidemiology (HuGE) Navigator
TTLL12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTLL12
genes like me logo Genes that share disorders with TTLL12: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTLL12 Gene

Publications for TTLL12 Gene

  1. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PMID: 15890843) Janke C. … Edde B. (Science 2005) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  4. Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH). (PMID: 23918034) KA1hnisch J. … . (Clin Oral Investig 2014) 67
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 67

Products for TTLL12 Gene

Sources for TTLL12 Gene

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