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Aliases for TTLL12 Gene

Aliases for TTLL12 Gene

  • Tubulin Tyrosine Ligase Like 12 2 3 5
  • Tubulin Tyrosine Ligase-Like Family, Member 12 3
  • Tubulin Tyrosine Ligase-Like Family Member 12 2
  • Tubulin--Tyrosine Ligase-Like Protein 12 3
  • DJ526I14.2 3
  • KIAA0153 4

External Ids for TTLL12 Gene

Previous GeneCards Identifiers for TTLL12 Gene

  • GC22M041888
  • GC22M043562
  • GC22M026520

Summaries for TTLL12 Gene

GeneCards Summary for TTLL12 Gene

TTLL12 (Tubulin Tyrosine Ligase Like 12) is a Protein Coding gene.

Additional gene information for TTLL12 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL12 Gene

Genomics for TTLL12 Gene

Regulatory Elements for TTLL12 Gene

Enhancers for TTLL12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H043182 1.5 Ensembl ENCODE dbSUPER 27 +3.3 3310 2 TCF12 GATA2 ATF7 NCOA1 REST ZNF592 NFIL3 SSRP1 SMARCA4 MYNN TTLL12 LOC105373051 MCAT TSPO
GH22H043197 0.6 ENCODE 21.9 -9.5 -9517 0 FOXA2 ARNT ZSCAN4 HIC1 FOSL1 JUND ZBTB33 FOS SP7 TTLL12 LOC105373051 GC22M043198
GH22H043125 1.5 Ensembl ENCODE dbSUPER 7 +59.1 59129 4 ARID4B GLI4 GLIS2 KLF7 ZNF548 RUNX3 SP3 KAT8 MIER3 GLIS1 RN7SKP80 RPL5P34 POLDIP3 RPS25P10 BIK MCAT TTLL12
GH22H043259 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.4 -75.7 -75666 5 PKNOX1 FOXA2 MLX ARNT ARID4B ZNF2 YY1 FOS SP5 JUNB TTLL12 GC22M043260 LOC101927447
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTLL12 on UCSC Golden Path with GeneCards custom track

Promoters for TTLL12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000146913 133 2001 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207

Genomic Location for TTLL12 Gene

43,166,622 bp from pter
43,187,133 bp from pter
20,512 bases
Minus strand

Genomic View for TTLL12 Gene

Genes around TTLL12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTLL12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTLL12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL12 Gene

Proteins for TTLL12 Gene

  • Protein details for TTLL12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tubulin--tyrosine ligase-like protein 12
    Protein Accession:
    Secondary Accessions:
    • Q20WK5
    • Q9UGU3

    Protein attributes for TTLL12 Gene

    644 amino acids
    Molecular mass:
    74404 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TTLL12 Gene

Post-translational modifications for TTLL12 Gene

  • Ubiquitination at posLast=8888, Lys342, Lys346, posLast=368368, posLast=419419, and Lys433
  • Modification sites at PhosphoSitePlus

Other Protein References for TTLL12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTLL12 Gene

Domains & Families for TTLL12 Gene

Gene Families for TTLL12 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TTLL12 Gene

Suggested Antigen Peptide Sequences for TTLL12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TTLL12: view

No data available for UniProtKB/Swiss-Prot for TTLL12 Gene

Function for TTLL12 Gene

Phenotypes From GWAS Catalog for TTLL12 Gene

Gene Ontology (GO) - Molecular Function for TTLL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TTLL12: view

Phenotypes for TTLL12 Gene

genes like me logo Genes that share phenotypes with TTLL12: view

Animal Model Products

CRISPR Products

miRNA for TTLL12 Gene

miRTarBase miRNAs that target TTLL12

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TTLL12
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTLL12 Gene

Localization for TTLL12 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTLL12 gene
Compartment Confidence
cytosol 3
plasma membrane 2
nucleus 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTLL12 Gene

Pathways & Interactions for TTLL12 Gene

SuperPathways for TTLL12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTLL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
genes like me logo Genes that share ontologies with TTLL12: view

No data available for Pathways by source and SIGNOR curated interactions for TTLL12 Gene

Drugs & Compounds for TTLL12 Gene

No Compound Related Data Available

Transcripts for TTLL12 Gene

Unigene Clusters for TTLL12 Gene

Tubulin tyrosine ligase-like family, member 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TTLL12
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL12 Gene

No ASD Table

Relevant External Links for TTLL12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTLL12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTLL12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTLL12 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.9).

Protein differential expression in normal tissues from HIPED for TTLL12 Gene

This gene is overexpressed in Lymph node (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTLL12 Gene

Protein tissue co-expression partners for TTLL12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TTLL12 Gene:


SOURCE GeneReport for Unigene cluster for TTLL12 Gene:


Evidence on tissue expression from TISSUES for TTLL12 Gene

  • Bone marrow(4.2)
genes like me logo Genes that share expression patterns with TTLL12: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTLL12 Gene

Orthologs for TTLL12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TTLL12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TTLL12 33 34
  • 99.38 (n)
(Bos Taurus)
Mammalia TTLL12 33 34
  • 87.63 (n)
(Canis familiaris)
Mammalia TTLL12 34 33
  • 87.41 (n)
(Mus musculus)
Mammalia Ttll12 33 16 34
  • 85.6 (n)
(Rattus norvegicus)
Mammalia Ttll12 33
  • 85.13 (n)
(Monodelphis domestica)
Mammalia TTLL12 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 68 (a)
-- 34
  • 61 (a)
(Gallus gallus)
Aves TTLL12 33 34
  • 71.81 (n)
(Anolis carolinensis)
Reptilia TTLL12 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486512 33
  • 71.44 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4575 33
(Danio rerio)
Actinopterygii ttll12 33 34
  • 64.74 (n)
zgc55343 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004284 33
  • 55.63 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1550 34 33
  • 53.75 (n)
(Caenorhabditis elegans)
Secernentea ttll-12 33 34
  • 46.72 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G77550 33
  • 49.49 (n)
(Oryza sativa)
Liliopsida Os03g0179000 33
  • 50.09 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
Species where no ortholog for TTLL12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTLL12 Gene

Gene Tree for TTLL12 (if available)
Gene Tree for TTLL12 (if available)

Paralogs for TTLL12 Gene Pseudogenes for TTLL12 Gene

genes like me logo Genes that share paralogs with TTLL12: view

No data available for Paralogs for TTLL12 Gene

Variants for TTLL12 Gene

Sequence variations from dbSNP and Humsavar for TTLL12 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000009589 -- 43,170,537(+) GAACC(G/T)CAAAA intron-variant
rs1000120986 -- 43,170,042(+) TCTGG(C/T)CTCAA intron-variant
rs1000148118 -- 43,175,825(+) CAGCC(A/C)CCATG intron-variant
rs1000268178 -- 43,184,065(+) GTGGC(A/G)CCATT intron-variant
rs1000313251 -- 43,166,622(+) AGAAA(C/T)AAGAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TTLL12 Gene

Variant ID Type Subtype PubMed ID
dgv844e214 CNV gain 21293372
esv2762124 CNV gain 21179565
esv33816 CNV gain 17666407
esv3647857 CNV loss 21293372
nsv1072641 CNV deletion 25765185
nsv1144974 CNV deletion 24896259
nsv459890 CNV gain 19166990
nsv471201 CNV loss 18288195
nsv520927 CNV loss 19592680
nsv589087 CNV gain 21841781
nsv834214 CNV gain 17160897
nsv834216 CNV loss 17160897

Variation tolerance for TTLL12 Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.79; 93.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTLL12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTLL12 Gene

Disorders for TTLL12 Gene

Relevant External Links for TTLL12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TTLL12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTLL12 Gene

Publications for TTLL12 Gene

  1. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PMID: 15890843) Janke C … Eddé B (Science (New York, N.Y.) 2005) 2 3 60
  2. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 60
  5. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1995) 3 4 60

Products for TTLL12 Gene

Sources for TTLL12 Gene

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