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Aliases for TTLL11 Gene

Aliases for TTLL11 Gene

  • Tubulin Tyrosine Ligase Like 11 2 3
  • Tubulin Tyrosine Ligase-Like Family Member 11 2 3
  • Tubulin--Tyrosine Ligase-Like Protein 11 3 4
  • Tubulin Tyrosine Ligase Like11 3 5
  • C9orf20 3 4
  • Tubulin Tyrosine Ligase-Like Family, Member 11 3
  • Chromosome 9 Open Reading Frame 20 2
  • BA244O19.1 3
  • EC 6.-.-.- 4

External Ids for TTLL11 Gene

Previous HGNC Symbols for TTLL11 Gene

  • C9orf20

Previous GeneCards Identifiers for TTLL11 Gene

  • GC09M121664
  • GC09M123624
  • GC09M123791
  • GC09M124584
  • GC09M094322

Summaries for TTLL11 Gene

GeneCards Summary for TTLL11 Gene

TTLL11 (Tubulin Tyrosine Ligase Like 11) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is TTLL8.

UniProtKB/Swiss-Prot for TTLL11 Gene

  • Polyglutamase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL11 Gene

Genomics for TTLL11 Gene

Regulatory Elements for TTLL11 Gene

Enhancers for TTLL11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TTLL11 on UCSC Golden Path with GeneCards custom track

Promoters for TTLL11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TTLL11 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTLL11 Gene

Chromosome:
9
Start:
121,815,674 bp from pter
End:
122,093,606 bp from pter
Size:
277,933 bases
Orientation:
Minus strand

Genomic View for TTLL11 Gene

Genes around TTLL11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTLL11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTLL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL11 Gene

Proteins for TTLL11 Gene

  • Protein details for TTLL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHH1-TTL11_HUMAN
    Recommended name:
    Tubulin polyglutamylase TTLL11
    Protein Accession:
    Q8NHH1
    Secondary Accessions:
    • F8W6M1

    Protein attributes for TTLL11 Gene

    Size:
    800 amino acids
    Molecular mass:
    87612 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTLL11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTLL11 Gene

Proteomics data for TTLL11 Gene at MOPED

Post-translational modifications for TTLL11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTLL11 Gene

No data available for DME Specific Peptides for TTLL11 Gene

Domains & Families for TTLL11 Gene

Gene Families for TTLL11 Gene

Protein Domains for TTLL11 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8NHH1

UniProtKB/Swiss-Prot:

TTL11_HUMAN :
  • The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.
  • Belongs to the tubulin--tyrosine ligase family.
Domain:
  • The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.
  • Contains 1 TTL domain.
Family:
  • Belongs to the tubulin--tyrosine ligase family.
genes like me logo Genes that share domains with TTLL11: view

Function for TTLL11 Gene

Molecular function for TTLL11 Gene

UniProtKB/Swiss-Prot Function:
Polyglutamase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules.

Enzyme Numbers (IUBMB) for TTLL11 Gene

Phenotypes for TTLL11 Gene

genes like me logo Genes that share phenotypes with TTLL11: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTLL11 Gene

Localization for TTLL11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTLL11 Gene

Cytoplasm, cytoskeleton, cilium basal body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTLL11 Gene COMPARTMENTS Subcellular localization image for TTLL11 gene
Compartment Confidence
cytoskeleton 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for TTLL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IEA --
genes like me logo Genes that share ontologies with TTLL11: view

Pathways & Interactions for TTLL11 Gene

SuperPathways for TTLL11 Gene

No Data Available

Interacting Proteins for TTLL11 Gene

Selected Interacting proteins: Q8NHH1-TTL11_HUMAN for TTLL11 Gene via MINT

Symbol External ID(s) Details
--

Gene Ontology (GO) - Biological Process for TTLL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
GO:0018095 protein polyglutamylation IEA --
genes like me logo Genes that share ontologies with TTLL11: view

No data available for Pathways by source and SIGNOR curated interactions for TTLL11 Gene

Drugs & Compounds for TTLL11 Gene

No Compound Related Data Available

Transcripts for TTLL11 Gene

Unigene Clusters for TTLL11 Gene

Tubulin tyrosine ligase-like family, member 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL11 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2:
SP3: -
SP4:

Relevant External Links for TTLL11 Gene

GeneLoc Exon Structure for
TTLL11
ECgene alternative splicing isoforms for
TTLL11

Expression for TTLL11 Gene

mRNA expression in normal human tissues for TTLL11 Gene

Protein differential expression in normal tissues from HIPED for TTLL11 Gene

This gene is overexpressed in Heart (29.3), Rectum (12.2), Peripheral blood mononuclear cells (7.8), Ovary (7.6), and Platelet (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TTLL11 Gene



SOURCE GeneReport for Unigene cluster for TTLL11 Gene Hs.640663

genes like me logo Genes that share expression patterns with TTLL11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TTLL11 Gene

Orthologs for TTLL11 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTLL11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TTLL11 35
  • 85.44 (n)
  • 83.4 (a)
TTLL11 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTLL11 35
  • 86.03 (n)
  • 82.79 (a)
TTLL11 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttll11 35
  • 82.32 (n)
  • 80.23 (a)
Ttll11 16
Ttll11 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TTLL11 35
  • 97.34 (n)
  • 96.46 (a)
TTLL11 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttll11 35
  • 82.52 (n)
  • 80.16 (a)
oppossum
(Monodelphis domestica)
Mammalia TTLL11 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
chicken
(Gallus gallus)
Aves TTLL11 35
  • 77.06 (n)
  • 82.26 (a)
TTLL11 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTLL11 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttll11 35
  • 71.46 (n)
  • 77.2 (a)
zebrafish
(Danio rerio)
Actinopterygii ttll11 35
  • 67.29 (n)
  • 72.95 (a)
ttll11 36
  • 56 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ttll-11 36
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
Species with no ortholog for TTLL11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTLL11 Gene

ENSEMBL:
Gene Tree for TTLL11 (if available)
TreeFam:
Gene Tree for TTLL11 (if available)

Paralogs for TTLL11 Gene

(5) SIMAP similar genes for TTLL11 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TTLL11: view

Variants for TTLL11 Gene

Sequence variations from dbSNP and Humsavar for TTLL11 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1129678 -- 121,816,059(-) TCGTA(A/G)TGTAT utr-variant-3-prime
rs7469081 -- 121,865,625(+) CTCCC(C/T)CCAAG intron-variant
rs1330338 -- 122,077,814(+) ATTAG(A/G)CCATA intron-variant
rs7847017 -- 122,056,280(+) AGTCA(C/T)ACAAT intron-variant
rs7848199 -- 122,060,160(+) cacag(C/G)gtcca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTLL11 Gene

Variant ID Type Subtype PubMed ID
dgv8279n71 CNV Loss 21882294
nsv893818 CNV Loss 21882294
esv2739007 CNV Deletion 23290073
nsv521711 CNV Loss 19592680
nsv527192 CNV Gain 19592680
nsv521251 CNV Gain 19592680
esv2739008 CNV Deletion 23290073
esv1964984 CNV Deletion 18987734
esv2739009 CNV Deletion 23290073
esv4168 CNV Deletion 18987735
nsv416918 CNV Loss 16902084
esv997735 CNV Deletion 20482838
esv1064857 CNV Deletion 17803354
esv2739010 CNV Deletion 23290073
esv3570 CNV Deletion 18987735
nsv831713 CNV Gain 17160897
nsv522145 CNV Loss 19592680
nsv509320 CNV Insertion 20534489
nsv416108 CNV Loss 16902084
nsv6701 CNV Insertion 18451855
nsv831715 CNV Gain 17160897
esv2671139 CNV Deletion 23128226
esv2675052 CNV Deletion 23128226
nsv525442 CNV Gain 19592680
esv2739011 CNV Deletion 23290073
esv2739012 CNV Deletion 23290073
nsv819467 CNV Gain 19587683

Variation tolerance for TTLL11 Gene

Gene Damage Index Score: 9.96; 89.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTLL11 Gene

Human Gene Mutation Database (HGMD)
TTLL11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTLL11 Gene

Disorders for TTLL11 Gene

Relevant External Links for TTLL11

Genetic Association Database (GAD)
TTLL11
Human Genome Epidemiology (HuGE) Navigator
TTLL11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTLL11

No disorders were found for TTLL11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTLL11 Gene

Publications for TTLL11 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PMID: 15890843) Janke C. … Edde B. (Science 2005) 2 3
  3. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Genome-wide association study of periodontal pathogen colonization. (PMID: 22699663) Divaris K. … Offenbacher S. (J. Dent. Res. 2012) 3

Products for TTLL11 Gene

Sources for TTLL11 Gene

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