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TTLL11 Gene

protein-coding   GIFtS: 45
GCID: GC09M124584

Tubulin Tyrosine Ligase-Like Family, Member 11

(Previous name: chromosome 9 open reading frame 20)
(Previous symbol: C9orf20)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tubulin Tyrosine Ligase-Like Family, Member 111 2     bA244O19.12
C9orf201 2 3     Tubulin Polyglutamylase TTLL112
Tubulin--Tyrosine Ligase-Like Protein 112 3     EC 6.-.-.-3
Chromosome 9 Open Reading Frame 201     

External Ids:    HGNC: 181131   Entrez Gene: 1581352   Ensembl: ENSG000001757647   UniProtKB: Q8NHH13   

Export aliases for TTLL11 gene to outside databases

Previous GC identifers: GC09M121664 GC09M123624 GC09M123791 GC09M094322


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TTLL11 Gene:
TTLL11 (tubulin tyrosine ligase-like family, member 11) is a protein-coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is TTLL4.

UniProtKB/Swiss-Prot: TTL11_HUMAN, Q8NHH1
Function: Polyglutamase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of
the polyglutamylation reaction rather than in the initiation step (By similarity). Required for CCSAP
localization to both spindle and cilia microtubules




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TTLL11 gene promoter:
         GR   Pbx1a   p53   Meis-1b   CP2   HOXA5   Meis-1a   GR-alpha   ATF6   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TTLL11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTLL11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.2   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q34.11

TTLL11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTLL11 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M124584:  view genomic region     (about GC identifiers)

Start:
124,584,204 bp from pter      End:
124,855,885 bp from pter
Size:
271,682 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TTL11_HUMAN, Q8NHH1 (See protein sequence)
Recommended Name: Tubulin polyglutamylase TTLL11  
Size: 538 amino acids; 58035 Da

Explore the universe of human proteins at neXtProt for TTLL11: NX_Q8NHH1

Explore proteomics data for TTLL11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TTLL11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001132914.1  NP_919228.2  

    ENSEMBL proteins: 
     ENSP00000362881   ENSP00000321346  

    TTLL11 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TTLL11

     
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    antibodies-online proteins for TTLL11 (2 products) 

     
    antibodies-online peptides for TTLL11

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    Cloud-Clone Corp. ELISAs for TTLL11
    Cloud-Clone Corp. CLIAs for TTLL11
    Search eBioscience for ELISAs for TTLL11 
    antibodies-online kits for TTLL11 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTLL: Tubulin tyrosine ligase-like family

    1 InterPro protein domain:
     IPR004344 TTL/TTLL_fam

    Graphical View of Domain Structure for InterPro Entry Q8NHH1

    ProtoNet protein and cluster: Q8NHH1

    1 Blocks protein domain: IPB004344 Tubulin-tyrosine ligase

    UniProtKB/Swiss-Prot: TTL11_HUMAN, Q8NHH1
    Similarity: Belongs to the tubulin--tyrosine ligase family
    Similarity: Contains 1 TTL domain


    Find genes that share domains with TTLL11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTL11_HUMAN, Q8NHH1
    Function: Polyglutamase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of
    the polyglutamylation reaction rather than in the initiation step (By similarity). Required for CCSAP
    localization to both spindle and cilia microtubules

         Enzyme Number (IUBMB): EC 6.-.-.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016874ligase activity IEA--
         
    Find genes that share ontologies with TTLL11           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TTLL11:
     Cell cycle / mitosis defect 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TTLL11

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate TTLL11:
    hsa-miR-495 hsa-miR-7-1* hsa-miR-7-2*
    SwitchGear 3'UTR luciferase reporter plasmidTTLL11 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TTL11_HUMAN, Q8NHH1: Cytoplasm, cytoskeleton, cilium basal body (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton2
    mitochondrion2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0005929cilium IEA--

    Find genes that share ontologies with TTLL11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TTLL11
    Interactions:

        Search GeneGlobe Interaction Network for TTLL11

    1 Interacting protein for TTLL11 (Q8NHH12) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --P310162MINT-8108126
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process IEA--
    GO:0018095protein polyglutamylation ----
    GO:0051013microtubule severing ----

    Find genes that share ontologies with TTLL11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TTLL11 (TTL11)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TTLL11 gene (2 alternative transcripts): 
    NM_001139442.1  NM_194252.2  

    Unigene Cluster for TTLL11:

    Tubulin tyrosine ligase-like family, member 11
    Hs.640663  [show with all ESTs]
    Unigene Representative Sequence: NM_001139442
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486362 ENST00000373778 ENST00000474723 ENST00000487468 ENST00000373776(uc004blt.1 uc004blu.1)
    ENST00000321582(uc011lym.1 uc011lyl.2 uc004blr.3)
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate TTLL11:
    hsa-miR-495 hsa-miR-7-1* hsa-miR-7-2*
    SwitchGear 3'UTR luciferase reporter plasmidTTLL11 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TTLL11
      QuantiFast Probe-based Assays in human, mouse, rat TTLL11

    Additional mRNA sequence: 

    AF521886.1 AF521887.1 BC089452.1 BC171751.1 

    4 DOTS entries:

    DT.99947626  DT.40265942  DT.208691  DT.99947228 

    Selected AceView cDNA sequences (see all 36):

    CF128404 AF521887 AF521886 AW629275 BM929722 AI571330 NM_194252 AA609430 
    AI741070 AI150621 AK125178 AA861826 AI185724 BF108868 BF439913 AI769213 
    BF594279 AI472951 AA676222 BX282469 AW015518 BX092305 BG771772 AA007347 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TTLL11    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                    -                             -     -     -                     
    SP2:                                                                                    
    SP3:                                                              -                     
    SP4:                                                                                    


    ECgene alternative splicing isoforms for TTLL11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TTLL11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TTLL11 Expression
    About this image

    TTLL11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TTLL11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.640663
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TTLL11 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttll111 , 5 tubulin tyrosine ligase-like family, member 111, 5 82.32(n)1
    80.23(a)1
      2 (23.90 cM)5
    744101  NM_029774.21  NP_084050.11 
     357512415 
    chicken
    (Gallus gallus)
    Aves TTLL111 tubulin tyrosine ligase-like family, member 11 77.06(n)
    82.26(a)
      417115  XM_415399.4  XP_415399.3 
    lizard
    (Anolis carolinensis)
    Reptilia TTLL116
    tubulin tyrosine ligase-like family, member 11
    70(a)
    1 ↔ 1
    AAWZ02037732(1273-13830)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ttll111 tubulin tyrosine ligase-like family, member 11 71.46(n)
    77.2(a)
      779533  XM_004916627.1  XP_004916684.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ttll111 tubulin tyrosine ligase-like family, member 11 67.29(n)
    72.95(a)
      558156  NM_001077375.1  NP_001070843.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ttll-116
    Protein TTLL-11, isoform b
    29(a)
    1 ↔ 1
    IV(8697736-8702699) WBGene00019230


    ENSEMBL Gene Tree for TTLL11 (if available)
    TreeFam Gene Tree for TTLL11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TTLL11 gene
    TTLL42  TTLL102  ENSG000002611472  TTLL32  TTLL12  TTLL52  TTLL92  TTLL72  
    TTLL62  TTL2  TTLL82  TTLL22  TTLL132  ARPC4-TTLL32  
    5 SIMAP similar genes for TTLL11 using alignment to 4 protein entries:     TTL11_HUMAN (see all proteins):
    TTLL6    TTLL13    TTLL7    TTLL5    TTLL4

    Find genes that share paralogs with TTLL11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TTLL11 (see all 3976)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1168559821,2
    C,F--124583952(+) CCTGAC/ACCTGG 1 -- int11Minor allele frequency- A:0.02NA 120
    rs70238591,2
    C,F--124584261(+) ATTAAT/CTTTTT 1 -- ut311Minor allele frequency- C:0.03WA 118
    rs1507091541,2
    C--124584414(+) CGGAAC/TGGGCG 1 -- ut310--------
    rs78690451,2
    C,F--124584495(+) CACTCG/AGCTTC 1 -- ut31 ese36Minor allele frequency- A:0.12NA WA 246
    rs1391129861,2
    C--124584560(+) AGATTC/TGCCCC 1 -- ut310--------
    rs1885812911,2
    --124584809(+) TGGGGC/TGCTCC 1 -- ut310--------
    rs1928009461,2
    --124584833(+) GCTCTC/TGTCTT 1 -- ut310--------
    rs1825230011,2
    --124585093(+) AAGTGG/TCAGCA 2 T P mis10--------
    rs1440222961,2
    --124585202(+) TGCCCC/TACGCT 1 -- int10--------
    rs1459821831,2
    C--124585208(+) ACGCTA/GCCCTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for TTLL11 (124584204 - 124834204 bp, first 250kb of TTLL11)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TTLL11 (see all 27):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739012CNV Deletion23290073
    esv2739007CNV Deletion23290073
    esv4168CNV Deletion18987735
    esv997735CNV Deletion20482838
    esv2739011CNV Deletion23290073
    esv2671139CNV Deletion23128226
    esv2675052CNV Deletion23128226
    esv2739009CNV Deletion23290073
    esv1964984CNV Deletion18987734
    esv3570CNV Deletion18987735

    Human Gene Mutation Database (HGMD): TTLL11
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TTLL11
    DNA2.0 Custom Variant and Variant Library Synthesis for TTLL11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with TTLL11           About GenesLikeMe

    Genetic Association Database (GAD): TTLL11
    Human Genome Epidemiology (HuGE) Navigator: TTLL11 (2 documents)

    Export disorders for TTLL11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TTLL11 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with TTLL11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PubMed id 20583170)1, 4 Letra A....Vieira A.R. (Am. J. Med. Genet. A 2010)
    3. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PubMed id 15890843)1, 3 Janke C.... Edde B. (Science 2005)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    5. Genome-wide association study of periodontal pathogen colonization. (PubMed id 22699663)1 Divaris K....Offenbacher S. (J. Dent. Res. 2012)
    6. CSAP localizes to polyglutamylated microtubules and promotes proper cilia function and zebrafish development. (PubMed id 22493317)2 Backer C.B.... Cheeseman I.M. (Mol. Biol. Cell 2012)
    7. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 158135 HGNC: 18113 AceView: C9orf20 Ensembl:ENSG00000175764 euGenes: HUgn158135
    ECgene: TTLL11 H-InvDB: TTLL11

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TTLL11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TTLL11 gene:
    Search GeneIP for patents involving TTLL11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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