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Aliases for TTLL10 Gene

Aliases for TTLL10 Gene

  • Tubulin Tyrosine Ligase Like 10 2 3 5
  • Tubulin Tyrosine Ligase-Like Family, Member 5 2 3
  • Tubulin--Tyrosine Ligase-Like Protein 10 3 4
  • Tubulin Tyrosine Ligase-Like Family, Member 10 3
  • Tubulin Tyrosine Ligase-Like Family Member 10 2
  • Inactive Polyglycylase TTLL10 3
  • TTLL5 3

External Ids for TTLL10 Gene

Previous HGNC Symbols for TTLL10 Gene

  • TTLL5

Previous GeneCards Identifiers for TTLL10 Gene

  • GC01P001156
  • GC01P000380
  • GC01P001140

Summaries for TTLL10 Gene

GeneCards Summary for TTLL10 Gene

TTLL10 (Tubulin Tyrosine Ligase Like 10) is a Protein Coding gene. GO annotations related to this gene include protein-glycine ligase activity. An important paralog of this gene is TTLL4.

UniProtKB/Swiss-Prot for TTLL10 Gene

  • Inactive polyglycylase.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL10 Gene

Genomics for TTLL10 Gene

Regulatory Elements for TTLL10 Gene

Enhancers for TTLL10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G001127 2 FANTOM5 Ensembl ENCODE dbSUPER 18.5 -44.6 -44643 4.0 HDGF FOXA2 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 TTLL10 TTLL10-AS1 B3GALT6 SDF4 C1QTNF12 UBE2J2 C1orf159 AGRN VWA1 GC01M001125
GH01G001156 1.8 FANTOM5 Ensembl ENCODE dbSUPER 20.5 -15.5 -15450 4.4 HDGF ATF1 CREB3L1 ARID4B ZNF48 ZNF766 KDM4B SP5 ZHX2 ZNF592 LINC01786 TTLL10 LOC100287934 TTLL10-AS1 CICP3 UBE2J2 LINC00115 ENSG00000240731 ENSG00000272455 SLC35E2
GH01G001131 1.6 Ensembl ENCODE dbSUPER 19.9 -38.8 -38804 6.5 HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A ZNF143 ZNF207 FOS KLF13 TTLL10 TTLL10-AS1 SDF4 B3GALT6 C1QTNF12 UBE2J2 C1orf159 LINC01342 GC01M001125
GH01G001162 1.5 Ensembl ENCODE dbSUPER 18 -6.7 -6684 10.8 HNRNPUL1 PKNOX1 FOXA2 ZNF133 ARID4B ZNF2 ZNF48 GLIS2 CBX5 ZNF416 CCNL2 LOC100288379 LINC00115 ENSG00000230092 LOC100129381 ENSG00000240731 SLC35E2 FAM87B SLC35E2B TTLL10
GH01G001149 0.8 ENCODE dbSUPER 24.1 -23.6 -23576 1.8 ZFP69B KLF1 GLIS1 FOS KLF8 TTLL10 TTLL10-AS1 GC01P001160 LINC01342
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTLL10 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTLL10 Gene

Chromosome:
1
Start:
1,173,884 bp from pter
End:
1,197,935 bp from pter
Size:
24,052 bases
Orientation:
Plus strand

Genomic View for TTLL10 Gene

Genes around TTLL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTLL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTLL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL10 Gene

Proteins for TTLL10 Gene

  • Protein details for TTLL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVT0-TTL10_HUMAN
    Recommended name:
    Inactive polyglycylase TTLL10
    Protein Accession:
    Q6ZVT0
    Secondary Accessions:
    • B1AMF6
    • Q5T2W4
    • Q5T2W5
    • Q8N9X2

    Protein attributes for TTLL10 Gene

    Size:
    673 amino acids
    Molecular mass:
    75042 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTLL10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTLL10 Gene

Post-translational modifications for TTLL10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTLL10 Gene

Domains & Families for TTLL10 Gene

Gene Families for TTLL10 Gene

Protein Domains for TTLL10 Gene

Suggested Antigen Peptide Sequences for TTLL10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TTLL10: view

No data available for UniProtKB/Swiss-Prot for TTLL10 Gene

Function for TTLL10 Gene

Molecular function for TTLL10 Gene

UniProtKB/Swiss-Prot Function:
Inactive polyglycylase.

Gene Ontology (GO) - Molecular Function for TTLL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18331838
GO:0005524 ATP binding IEA --
GO:0070735 protein-glycine ligase activity TAS --
genes like me logo Genes that share ontologies with TTLL10: view

Phenotypes for TTLL10 Gene

MGI mutant phenotypes for TTLL10:
inferred from 1 alleles
GenomeRNAi human phenotypes for TTLL10:
genes like me logo Genes that share phenotypes with TTLL10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTLL10 Gene

Localization for TTLL10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTLL10 gene
Compartment Confidence
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TTLL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TTLL10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TTLL10 Gene

Pathways & Interactions for TTLL10 Gene

SuperPathways for TTLL10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTLL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
GO:0018094 protein polyglycylation TAS --
genes like me logo Genes that share ontologies with TTLL10: view

No data available for Pathways by source and SIGNOR curated interactions for TTLL10 Gene

Drugs & Compounds for TTLL10 Gene

No Compound Related Data Available

Transcripts for TTLL10 Gene

Unigene Clusters for TTLL10 Gene

Tubulin tyrosine ligase-like family, member 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL10 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2:
SP3:
SP4: -

Relevant External Links for TTLL10 Gene

GeneLoc Exon Structure for
TTLL10
ECgene alternative splicing isoforms for
TTLL10

Expression for TTLL10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTLL10 Gene

mRNA differential expression in normal tissues according to GTEx for TTLL10 Gene

This gene is overexpressed in Testis (x32.5) and Fallopian Tube (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of TTLL10 Gene:

TTLL10

SOURCE GeneReport for Unigene cluster for TTLL10 Gene:

Hs.454835

Evidence on tissue expression from TISSUES for TTLL10 Gene

  • Stomach(2.1)
genes like me logo Genes that share expression patterns with TTLL10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTLL10 Gene

Orthologs for TTLL10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTLL10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTLL10 34 35
  • 98.46 (n)
dog
(Canis familiaris)
Mammalia LOC489601 34
  • 81.45 (n)
TTLL10 35
  • 63 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TTLL10 34 35
  • 79.53 (n)
mouse
(Mus musculus)
Mammalia Ttll10 34 16 35
  • 78.21 (n)
rat
(Rattus norvegicus)
Mammalia Ttll10 34
  • 73.66 (n)
oppossum
(Monodelphis domestica)
Mammalia TTLL10 35
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 22 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TTLL10 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTLL10 35
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ttll10 35
  • 40 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBY1 35
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
OneToOne
Species where no ortholog for TTLL10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTLL10 Gene

ENSEMBL:
Gene Tree for TTLL10 (if available)
TreeFam:
Gene Tree for TTLL10 (if available)

Paralogs for TTLL10 Gene

genes like me logo Genes that share paralogs with TTLL10: view

Variants for TTLL10 Gene

Sequence variations from dbSNP and Humsavar for TTLL10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs139755178 A colorectal cancer sample 1,180,222(+) CTAAC(A/G)CCGCC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1000034101 -- 1,178,288(+) GGCAC(A/G)GTGGC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000132549 -- 1,179,978(+) ATGTC(C/T)GGGCT intron-variant, upstream-variant-2KB
rs1000228326 -- 1,185,198(+) TGTCC(A/G)TGGCG intron-variant, utr-variant-3-prime
rs1000283500 -- 1,190,190(+) GTCAT(A/C)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTLL10 Gene

Variant ID Type Subtype PubMed ID
dgv2n67 CNV gain 20364138
esv3335892 CNV duplication 20981092
nsv1003578 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1110655 CNV insertion 24896259
nsv1160644 CNV deletion 26073780
nsv1160772 CNV duplication 26073780
nsv428334 CNV gain 18775914
nsv469848 CNV gain 16826518
nsv470680 CNV loss 18288195
nsv482937 CNV loss 15286789
nsv509257 CNV insertion 20534489
nsv517709 CNV gain+loss 19592680
nsv544947 CNV loss 21841781
nsv544954 CNV loss 21841781
nsv544956 CNV loss 21841781
nsv829536 CNV gain 20364138
nsv950452 CNV deletion 24416366

Variation tolerance for TTLL10 Gene

Gene Damage Index Score: 10.13; 90.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTLL10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTLL10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTLL10 Gene

Disorders for TTLL10 Gene

Relevant External Links for TTLL10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTLL10

No disorders were found for TTLL10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTLL10 Gene

Publications for TTLL10 Gene

  1. Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. (PMID: 19524510) Rogowski K. … Janke C. (Cell 2009) 3 4 64
  2. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PMID: 15890843) Janke C. … Edde B. (Science 2005) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64

Products for TTLL10 Gene

Sources for TTLL10 Gene

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