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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TTLL10 Gene

protein-coding   GIFtS: 46
GCID: GC01P001156

Tubulin Tyrosine Ligase-Like Family, Member 10

(Previous names: tubulin tyrosine ligase-like family, member 5)
(Previous symbol: TTLL5)
  Search for TTLL10
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tubulin Tyrosine Ligase-Like Family, Member 101 2
TTLL51 2
Tubulin Tyrosine Ligase-Like Family, Member 51 2
Tubulin--Tyrosine Ligase-Like Protein 102 3
Inactive Polyglycylase TTLL102

External Ids:    HGNC: 266931   Entrez Gene: 2541732   Ensembl: ENSG000001625717   UniProtKB: Q6ZVT03   

Export aliases for TTLL10 gene to outside databases

Previous GC identifer: GC01P000380


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TTLL10 Gene: 
TTLL10 (tubulin tyrosine ligase-like family, member 10) is a protein-coding gene. GO annotations related to this gene include tubulin-tyrosine ligase activity and protein-glycine ligase activity. An important paralog of this gene is TTLL4.

UniProtKB/Swiss-Prot: TTL10_HUMAN, Q6ZVT0
Function: Inactive polyglycylase




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004350.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TTLL10 gene promoter:
         POU2F1   Sp1   POU2F1b   POU2F1a   Pax-6   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTLL10 promoter sequence
   Search SABiosciences Chromatin IP Primers for TTLL10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTLL10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

TTLL10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTLL10 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P001156:  view genomic region     (about GC identifiers)

Start:
1,109,264 bp from pter      End:
1,133,315 bp from pter
Size:
24,052 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TTL10_HUMAN, Q6ZVT0 (See protein sequence)
Recommended Name: Inactive polyglycylase TTLL10  
Size: 673 amino acids; 75042 Da
Caution: In human, the presence of a Lys-467 instead of a Thr as well as the presence of a variant at position 448
inactivates the polyglycylase activity. It explains the absence of polyglycylation in human sperm
(PubMed:19524510)
Secondary accessions: B1AMF6 Q5T2W4 Q5T2W5 Q8N9X2
Alternative splicing: 3 isoforms:  Q6ZVT0-1   Q6ZVT0-2   Q6ZVT0-3   

Explore the universe of human proteins at neXtProt for TTLL10: NX_Q6ZVT0

Explore proteomics data for TTLL10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZVT0

  • TTLL10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TTLL10 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001123517.1  NP_694986.2  

    ENSEMBL proteins: 
     ENSP00000368592   ENSP00000368590   ENSP00000464269   ENSP00000368591  

    Human Recombinant Protein Products for TTLL10: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TTLL10 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--
    GO:0031965nuclear membrane IDA--

    TTLL10 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TTLL: Tubulin tyrosine ligase-like family

    1 InterPro protein domain:
     IPR004344 Tub_tyr_ligase

    Graphical View of Domain Structure for InterPro Entry Q6ZVT0

    ProtoNet protein and cluster: Q6ZVT0

    1 Blocks protein domain: IPB004344 Tubulin-tyrosine ligase

    UniProtKB/Swiss-Prot: TTL10_HUMAN, Q6ZVT0
    Similarity: Contains 1 TTL domain


    TTLL10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTL10_HUMAN, Q6ZVT0
    Function: Inactive polyglycylase

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004835tubulin-tyrosine ligase activity ----
    GO:0005515protein binding IPI18331838
    GO:0070735NOT protein-glycine ligase activity IDA19524510
         
    TTLL10 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TTLL10 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TTLL10 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTLL10

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TTLL10 (Q6ZVT02, 3 ENSP000003685914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NAP1L1P552092, 3, ENSP000002611824MINT-6493231 MINT-6493246 MINT-6493222 MINT-6493255 MINT-6493277 I2D: score=1 STRING: ENSP00000261182
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process ----
    GO:0018094NOT protein polyglycylation IDA19524510

    TTLL10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TTLL10 (TTL10)

    Search CenterWatch for drugs/clinical trials and news about TTLL10 / TTL10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TTLL10 gene (2 alternative transcripts): 
    NM_001130045.1  NM_153254.2  

    Unigene Cluster for TTLL10:

    Tubulin tyrosine ligase-like family, member 10
    Hs.454835  [show with all ESTs]
    Unigene Representative Sequence: AK124125
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506177 ENST00000379290(uc010nyg.1) ENST00000379288(uc001acz.2)
    ENST00000460998 ENST00000514695 ENST00000486379 ENST00000379289(uc001acy.2)

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TTLL10
    SwitchGear 3'UTR luciferase reporter plasmidTTLL10 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTLL10
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    GenScript: all cDNA clones in your preferred vector (see all 2): TTLL10 (NM_153254)
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                         Customized lentivirus expression plasmids for stable overexpression of TTLL10 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTLL10

    Additional mRNA sequence: 

    AK093438.1 AK124125.1 BC027945.1 BC126152.1 BC126154.1 

    4 DOTS entries:

    DT.40212704  DT.97838699  DT.100737663  DT.75107711 

    24/41 AceView cDNA sequences (see all 41):

    BX117374 AI187380 BM559598 AK124125 AI805278 AI694302 AI918771 AI075914 
    BU609043 CD243534 AL045436 BM908139 BM554457 AW772075 AW139984 BI826101 
    BM559758 AA812756 BI831637 AW449508 BI827482 BM554140 AX748126 BG825818 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TTLL10    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
    SP1:                    -                                                   
    SP2:                                                                        
    SP3:                                                                        
    SP4:                    -                                                   


    ECgene alternative splicing isoforms for TTLL10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TTLL10 expression in normal human tissues (normalized intensities)      TTLL10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAGAGTCT
    TTLL10 Expression
    About this image


    TTLL10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Epithelium (Respiratory System)    fully expand to see all 2 entries
             bronchial epithelial cells   
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Testis (Reproductive System)
     
     Prostate (Endocrine System)

    See TTLL10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TTLL10

    SOURCE GeneReport for Unigene cluster: Hs.454835
        SABiosciences Custom PCR Arrays for TTLL10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TTLL10 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttll101 , 5 tubulin tyrosine ligase-like family, member 101, 5 74.43(n)1
    69.22(a)1
      4 (87.82 cM)5
    3300101  NM_029264.21  NP_083540.11 
     1560348405 
    chicken
    (Gallus gallus)
    Aves TTLL101 tubulin tyrosine ligase-like family, member 10 64.21(n)
    58.76(a)
      419426  XM_417587.3  XP_417587.3 
    lizard
    (Anolis carolinensis)
    Reptilia TTLL106
    Uncharacterized protein
    51(a)
    1 ↔ 1
    GL343647.1(300773-347681)
    zebrafish
    (Danio rerio)
    Actinopterygii ttll106
    tubulin tyrosine ligase-like family, member 10
    38(a)
    1 ↔ 1
    23(24372414-24400286)


    ENSEMBL Gene Tree for TTLL10 (if available)
    TreeFam Gene Tree for TTLL10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TTLL10 gene
    TTLL42  ENSG000002611472  TTLL32  TTLL12  TTLL52  TTLL112  TTLL92  TTLL72  
    TTLL62  TTL2  TTLL82  TTLL22  TTLL132  ARPC4-TTLL32  

    TTLL10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/600 SNPs in TTLL10 are shown (see all 600)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0398064
    A colorectal cancer sample4--see VAR_0398062 A T mis40--------
    VAR_0398074
    ----see VAR_0398072 V A mis40--------
    rs2005558741,2
    C--1107294(+) CTCAG-/CCCCAG 1 -- us2k10--------
    rs1172669271,2
    F--1107303(+) CAGGGA/GCACAG 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs1181129651,2
    F--1107305(+) GGGACA/CCAGAG 1 -- us2k11Minor allele frequency- C:0.02EA 120
    rs1170522101,2
    F--1107307(+) GACACA/GGAGCG 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs617684811,2
    C--1107312(+) AGAGCA/GGGGAA 1 -- us2k10--------
    rs1122094741,2
    C,F--1107322(+) ACCCCC/AAGGCT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1156564181,2
    C,F--1107359(+) GGCTCC/AGGAGC 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1140119931,2
    F--1107379(+) ACTCTC/TGAAAG 1 -- us2k11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for TTLL10 (1109264 - 1133315 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/28 variations for TTLL10 (see all 28):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509257CNV Insertion20534489
    dgv17n71CNV Loss21882294
    nsv470680CNV Loss18288195
    nsv871680CNV Loss21882294
    nsv482937CNV Loss15286789
    dgv12n71CNV Loss21882294
    dgv21n71CNV Loss21882294
    dgv19n71CNV Loss21882294
    dgv10n71CNV Loss21882294
    dgv20n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TTLL10
    DNA2.0 Custom Variant and Variant Library Synthesis for TTLL10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TTLL10 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TTLL10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. (PubMed id 19524510)1, 2 Rogowski K....Janke C. (2009)
    2. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PubMed id 15890843)1, 3 Janke C.... Edde B. (2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. TTLL10 is a protein polyglycylase that can modify nucl eosome assembly protein 1. (PubMed id 18331838)1 Ikegami K....Setou M. (2008)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    6. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 254173 HGNC: 26693 AceView: FLJ36119 Ensembl:ENSG00000162571 euGenes: HUgn254173
    ECgene: TTLL10 H-InvDB: TTLL10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TTLL10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TTLL10 gene:
    Search GeneIP for patents involving TTLL10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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