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Aliases for TTLL10 Gene

Aliases for TTLL10 Gene

  • Tubulin Tyrosine Ligase-Like Family Member 10 2 3
  • Tubulin Tyrosine Ligase-Like Family, Member 5 2 3
  • Tubulin--Tyrosine Ligase-Like Protein 10 3 4
  • Tubulin Tyrosine Ligase-Like Family, Member 10 3
  • Inactive Polyglycylase TTLL10 3
  • TTLL5 3

External Ids for TTLL10 Gene

Previous Symbols for TTLL10 Gene

  • TTLL5

Summaries for TTLL10 Gene

GeneCards Summary for TTLL10 Gene

TTLL10 (Tubulin Tyrosine Ligase-Like Family Member 10) is a Protein Coding gene. GO annotations related to this gene include protein-glycine ligase activity. An important paralog of this gene is TTLL8.

UniProtKB/Swiss-Prot for TTLL10 Gene

  • Inactive polyglycylase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL10 Gene

Genomics for TTLL10 Gene

Genomic Location for TTLL10 Gene

Start:
1,173,884 bp from pter
End:
1,197,935 bp from pter
Size:
24,052 bases
Orientation:
Plus strand

Genomic View for TTLL10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTLL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL10 Gene

Regulatory Elements for TTLL10 Gene

Proteins for TTLL10 Gene

  • Protein details for TTLL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVT0-TTL10_HUMAN
    Recommended name:
    Inactive polyglycylase TTLL10
    Protein Accession:
    Q6ZVT0
    Secondary Accessions:
    • B1AMF6
    • Q5T2W4
    • Q5T2W5
    • Q8N9X2

    Protein attributes for TTLL10 Gene

    Size:
    673 amino acids
    Molecular mass:
    75042 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTLL10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTLL10 Gene

Proteomics data for TTLL10 Gene at MOPED

Post-translational modifications for TTLL10 Gene

No Post-translational modifications

Other Protein References for TTLL10 Gene

No data available for DME Specific Peptides for TTLL10 Gene

Domains for TTLL10 Gene

Gene Families for TTLL10 Gene

HGNC:
  • TTLL :Tubulin tyrosine ligase-like family

Protein Domains for TTLL10 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

TTL10_HUMAN
Domain:
  • Contains 1 TTL domain.:
    • Q6ZVT0
genes like me logo Genes that share domains with TTLL10: view

Function for TTLL10 Gene

Molecular function for TTLL10 Gene

UniProtKB/Swiss-Prot Function: Inactive polyglycylase.

Gene Ontology (GO) - Molecular Function for TTLL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18331838
GO:0070735 NOT protein-glycine ligase activity IDA 19524510
genes like me logo Genes that share ontologies with TTLL10: view

miRNA for TTLL10 Gene

miRTarBase miRNAs that target TTLL10

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TTLL10 Gene

Localization for TTLL10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTLL10 Gene COMPARTMENTS Subcellular localization image for TTLL10 gene
Compartment Confidence
nucleus 4
plasma membrane 4
cytosol 3
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TTLL10 Gene

Pathways for TTLL10 Gene

SuperPathways for TTLL10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTLL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process --
GO:0018094 NOT protein polyglycylation IDA 19524510
genes like me logo Genes that share ontologies with TTLL10: view

No data available for Pathways by source for TTLL10 Gene

Transcripts for TTLL10 Gene

Unigene Clusters for TTLL10 Gene

Tubulin tyrosine ligase-like family, member 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL10 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2:
SP3:
SP4: -

Relevant External Links for TTLL10 Gene

GeneLoc Exon Structure for
TTLL10
ECgene alternative splicing isoforms for
TTLL10

Expression for TTLL10 Gene

mRNA expression in normal human tissues for TTLL10 Gene

mRNA differential expression in normal tissues according to GTEx for TTLL10 Gene

This gene is overexpressed in Testis (32.5) and Fallopian Tube (4.5).

SOURCE GeneReport for Unigene cluster for TTLL10 Gene Hs.454835

genes like me logo Genes that share expressions with TTLL10: view

Orthologs for TTLL10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTLL10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTLL10 36
  • 98.46 (n)
  • 96.65 (a)
TTLL10 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TTLL10 36
  • 79.53 (n)
  • 71.52 (a)
TTLL10 37
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC489601 36
  • 81.45 (n)
  • 76.61 (a)
TTLL10 37
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttll10 36
  • 78.21 (n)
  • 73.68 (a)
Ttll10 16
Ttll10 37
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTLL10 37
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 22 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ttll10 36
  • 73.66 (n)
  • 67.07 (a)
chicken
(Gallus gallus)
Aves TTLL10 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTLL10 37
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ttll10 37
  • 40 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBY1 37
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 52 (a)
OneToOne
Species with no ortholog for TTLL10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTLL10 Gene

ENSEMBL:
Gene Tree for TTLL10 (if available)
TreeFam:
Gene Tree for TTLL10 (if available)

Paralogs for TTLL10 Gene

genes like me logo Genes that share paralogs with TTLL10: view

Variants for TTLL10 Gene

Sequence variations from dbSNP and Humsavar for TTLL10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1060778 -- 1,185,745(+) CACAG(A/G)CGTGT intron-variant, utr-variant-3-prime
rs1134002 -- 1,184,989(+) AGCCC(C/T)CTGTA synonymous-codon, reference, nc-transcript-variant
rs1320565 -- 1,184,478(+) GGGGA(C/T)GGGTC intron-variant
rs1320571 - 1,185,051(+) CATCA(A/G)TGACA missense, reference, nc-transcript-variant
rs1620694 -- 1,198,244(+) ACCTG(G/T)GCCCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TTLL10 Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
nsv517709 CNV Gain+Loss 19592680
nsv428334 CNV Gain 18775914
dgv2n67 CNV Gain 20364138
nsv871547 CNV Loss 21882294
dgv10n71 CNV Loss 21882294
dgv11n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
nsv470680 CNV Loss 18288195
dgv17n71 CNV Loss 21882294
dgv18n71 CNV Loss 21882294
nsv871553 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
nsv870527 CNV Gain 21882294
nsv469848 CNV Gain 16826518
nsv509257 CNV Insertion 20534489
dgv21n71 CNV Loss 21882294
nsv871744 CNV Gain 21882294
nsv482937 CNV Loss 15286789
nsv871079 CNV Loss 21882294
dgv22n71 CNV Loss 21882294
nsv829536 CNV Gain 20364138
nsv871107 CNV Loss 21882294
dgv23n71 CNV Loss 21882294
nsv870548 CNV Loss 21882294
nsv871427 CNV Loss 21882294
nsv871680 CNV Loss 21882294

Relevant External Links for TTLL10 Gene

HapMap Linkage Disequilibrium report
TTLL10

Disorders for TTLL10 Gene

No disorders were found for TTLL10 Gene.

No data available for UniProtKB/Swiss-Prot for TTLL10 Gene

Publications for TTLL10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PMID: 15890843) Janke C. … Edde B. (Science 2005) 2 3
  3. Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. (PMID: 19524510) Rogowski K. … Janke C. (Cell 2009) 3 4
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for TTLL10 Gene

Sources for TTLL10 Gene

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