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Aliases for TTLL10 Gene

Aliases for TTLL10 Gene

  • Tubulin Tyrosine Ligase Like 10 2 3 5
  • Tubulin Tyrosine Ligase-Like Family, Member 5 2 3
  • Tubulin Tyrosine Ligase-Like Family Member 10 2 3
  • Tubulin--Tyrosine Ligase-Like Protein 10 3 4
  • Tubulin Tyrosine Ligase-Like Family, Member 10 3
  • TTLL5 3

External Ids for TTLL10 Gene

Previous HGNC Symbols for TTLL10 Gene

  • TTLL5

Previous GeneCards Identifiers for TTLL10 Gene

  • GC01P001156
  • GC01P000380
  • GC01P001140

Summaries for TTLL10 Gene

GeneCards Summary for TTLL10 Gene

TTLL10 (Tubulin Tyrosine Ligase Like 10) is a Protein Coding gene. GO annotations related to this gene include protein-glycine ligase activity. An important paralog of this gene is TTLL8.

UniProtKB/Swiss-Prot for TTLL10 Gene

  • Inactive polyglycylase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL10 Gene

Genomics for TTLL10 Gene

Regulatory Elements for TTLL10 Gene

Enhancers for TTLL10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TTLL10 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTLL10 Gene

1,173,884 bp from pter
1,197,935 bp from pter
24,052 bases
Plus strand

Genomic View for TTLL10 Gene

Genes around TTLL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTLL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTLL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL10 Gene

Proteins for TTLL10 Gene

  • Protein details for TTLL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive polyglycylase TTLL10
    Protein Accession:
    Secondary Accessions:
    • B1AMF6
    • Q5T2W4
    • Q5T2W5
    • Q8N9X2

    Protein attributes for TTLL10 Gene

    673 amino acids
    Molecular mass:
    75042 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTLL10 Gene


neXtProt entry for TTLL10 Gene

Proteomics data for TTLL10 Gene at MOPED

Post-translational modifications for TTLL10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTLL10 Gene

No data available for DME Specific Peptides for TTLL10 Gene

Domains & Families for TTLL10 Gene

Gene Families for TTLL10 Gene

Protein Domains for TTLL10 Gene


Suggested Antigen Peptide Sequences for TTLL10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 TTL domain.
  • Contains 1 TTL domain.
genes like me logo Genes that share domains with TTLL10: view

Function for TTLL10 Gene

Molecular function for TTLL10 Gene

UniProtKB/Swiss-Prot Function:
Inactive polyglycylase.

Phenotypes for TTLL10 Gene

GenomeRNAi human phenotypes for TTLL10:
genes like me logo Genes that share phenotypes with TTLL10: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTLL10 Gene

Localization for TTLL10 Gene

Subcellular locations from

Jensen Localization Image for TTLL10 Gene COMPARTMENTS Subcellular localization image for TTLL10 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTLL10 Gene

Pathways & Interactions for TTLL10 Gene

SuperPathways for TTLL10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTLL10 Gene


No data available for Pathways by source and SIGNOR curated interactions for TTLL10 Gene

Drugs & Compounds for TTLL10 Gene

No Compound Related Data Available

Transcripts for TTLL10 Gene

Unigene Clusters for TTLL10 Gene

Tubulin tyrosine ligase-like family, member 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL10 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP4: -

Relevant External Links for TTLL10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTLL10 Gene

mRNA expression in normal human tissues for TTLL10 Gene

mRNA differential expression in normal tissues according to GTEx for TTLL10 Gene

This gene is overexpressed in Testis (x32.5) and Fallopian Tube (x4.5).

SOURCE GeneReport for Unigene cluster for TTLL10 Gene Hs.454835

genes like me logo Genes that share expression patterns with TTLL10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TTLL10 Gene

Orthologs for TTLL10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTLL10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TTLL10 35
  • 79.53 (n)
  • 71.52 (a)
TTLL10 36
  • 60 (a)
(Canis familiaris)
Mammalia LOC489601 35
  • 81.45 (n)
  • 76.61 (a)
TTLL10 36
  • 63 (a)
(Mus musculus)
Mammalia Ttll10 35
  • 78.21 (n)
  • 73.68 (a)
Ttll10 16
Ttll10 36
  • 56 (a)
(Pan troglodytes)
Mammalia TTLL10 35
  • 98.46 (n)
  • 96.65 (a)
TTLL10 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Ttll10 35
  • 73.66 (n)
  • 67.07 (a)
(Monodelphis domestica)
Mammalia TTLL10 36
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 22 (a)
(Gallus gallus)
Aves TTLL10 36
  • 62 (a)
(Anolis carolinensis)
Reptilia TTLL10 36
  • 51 (a)
(Danio rerio)
Actinopterygii ttll10 36
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBY1 36
  • 11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
Species with no ortholog for TTLL10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTLL10 Gene

Gene Tree for TTLL10 (if available)
Gene Tree for TTLL10 (if available)

Paralogs for TTLL10 Gene

genes like me logo Genes that share paralogs with TTLL10: view

Variants for TTLL10 Gene

Sequence variations from dbSNP and Humsavar for TTLL10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_039806 A colorectal cancer sample
VAR_039807 -
rs1320571 - 1,185,051(+) CATCA(A/C/G)TGACA nc-transcript-variant, reference, missense
rs2274791 - 1,197,558(-) ACGAG(C/T)CCCCC downstream-variant-500B, reference, missense
rs1134002 -- 1,184,989(+) AGCCC(C/T)CTGTA nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TTLL10 Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
nsv517709 CNV Gain+Loss 19592680
nsv428334 CNV Gain 18775914
dgv2n67 CNV Gain 20364138
nsv871547 CNV Loss 21882294
dgv10n71 CNV Loss 21882294
dgv11n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
nsv470680 CNV Loss 18288195
dgv17n71 CNV Loss 21882294
dgv18n71 CNV Loss 21882294
nsv871553 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
nsv870527 CNV Gain 21882294
nsv469848 CNV Gain 16826518
nsv509257 CNV Insertion 20534489
dgv21n71 CNV Loss 21882294
nsv871744 CNV Gain 21882294
nsv482937 CNV Loss 15286789
nsv871079 CNV Loss 21882294
dgv22n71 CNV Loss 21882294
nsv829536 CNV Gain 20364138
nsv871107 CNV Loss 21882294
dgv23n71 CNV Loss 21882294
nsv870548 CNV Loss 21882294
nsv871427 CNV Loss 21882294
nsv871680 CNV Loss 21882294

Variation tolerance for TTLL10 Gene

Gene Damage Index Score: 10.13; 90.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TTLL10 Gene

Disorders for TTLL10 Gene

Relevant External Links for TTLL10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TTLL10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTLL10 Gene

Publications for TTLL10 Gene

  1. Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. (PMID: 19524510) Rogowski K. … Janke C. (Cell 2009) 3 4 67
  2. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PMID: 15890843) Janke C. … Edde B. (Science 2005) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. TTLL10 is a protein polyglycylase that can modify nucleosome assembly protein 1. (PMID: 18331838) Ikegami K. … Setou M. (FEBS Lett. 2008) 3

Products for TTLL10 Gene

Sources for TTLL10 Gene