TTLL10 Gene
protein-coding GIFtS : 45
GCID: GC01 P001156
tubulin tyrosine ligase-like family, member 10 (Previous names: tubulin tyrosine ligase-like family, member 5 ) (Previous symbol: TTLL5 )
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Aliasesfor TTLL10 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Tubulin Tyrosine Ligase-Like Family, Member 10 1 2 TTLL51 2 Tubulin Tyrosine Ligase-Like Family, Member 51 2 Tubulin--Tyrosine Ligase-Like Protein 102 3 FLJ361191 Inactive Polyglycylase TTLL102
Export aliases for TTLL10 gene to outside databases Previous GC identifer: GC01P000380
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Summariesfor TTLL10 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: TTL10_HUMAN, Q6ZVT0 Function : Inactive polyglycylase
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Genomic Viewsfor TTLL10 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_004350.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TTLL10 gene promoter: POU2F1 Sp1 POU2F1b POU2F1a Pax-6 SEF-1 (1) Other transcription factors Search SABiosciences Chromatin IP Primers for TTLL10 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TTLL10
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p36.33 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36.33 TTLL10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P001156: view genomic region
(about GC identifiers )
Start:
1,109,264 bp from pter
End:
1,133,315 bp from pter
Size:
24,052 bases
Orientation:
plus strand
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Proteinsfor TTLL10 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TTL10_HUMAN, Q6ZVT0 (See
protein sequence )Recommended Name: Inactive polyglycylase TTLL10 Size : 673 amino acids; 75042 Da
Caution : In human, the presence of a Lys-467 instead of a Thr as well as the presence of a variant at position 448inactivates the polyglycylase activity. It explains the absence of polyglycylation in human sperm (PubMed:19524510)
Secondary accessions : B1AMF6 Q5T2W4 Q5T2W5 Q8N9X2Alternative splicing : 3 isoforms : Q6ZVT0-1 Q6ZVT0-2 Q6ZVT0-3 Explore the universe of human proteins at neXtProt for TTLL10: NX_Q6ZVT0 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q6ZVT0 TTLL10 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001123517.1 NP_694986.2 ENSEMBL proteins: ENSP00000368592 ENSP00000368590 ENSP00000464269 ENSP00000368591 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
TTLL10 for ontologies About GeneDecksing TTLL10 Antibody Products: Assay Products for TTLL10:
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Protein
Domains / Familiesfor TTLL10 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TTLL10 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q6ZVT0 ProtoNet protein and cluster: Q6ZVT0
1 Blocks protein family : IPB004344 Tubulin-tyrosine ligase UniProtKB/Swiss-Prot: TTL10_HUMAN, Q6ZVT0 Similarity : Contains 1 TTL domain
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Functionfor TTLL10 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: TTL10_HUMAN, Q6ZVT0 Function : Inactive polyglycylase
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TTLL10 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TTLL10 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): TTLL10 (NM_153254 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTLL10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TTLL10
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL10
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
TTLL10 for ontologies About GeneDecksing
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Pathways & Interactionsfor TTLL10 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTLL10 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for TTLL10 (Q6ZVT0 2 , 3 ENSP00000368591 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
TTLL10 for ontologies About GeneDecksing
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Drugs & Compoundsfor TTLL10 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TTLL10 Search CenterWatch for drugs/clinical trials and news about TTLL10 / TTL10
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Transcriptsfor TTLL10 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TTLL10 gene (2 alternative transcripts): NM_001130045.1 NM_153254.2 Unigene Cluster for TTLL10:
Tubulin tyrosine ligase-like family, member 10 Hs.454835 [show with all ESTs ] Unigene Representative Sequence: AK124125 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000506177 ENST00000379290 (uc010nyg.1 ) ENST00000379288 (uc001acz.2 )ENST00000460998 ENST00000514695 ENST00000486379 ENST00000379289 (uc001acy.2 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TTLL10 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TTLL10 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): TTLL10 (NM_153254 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTLL10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TTLL10
Additional cDNA sequence: AK093438.1 AK124125.1 BC027945.1 BC126152.1 BC126154.1
4 DOTS entries : DT.40212704 DT.97838699
DT.100737663 DT.75107711 24/41 AceView cDNA sequences (see all 41 ):
BM559598 BU609043 AI918771 AI075914 BX117374 AI187380 AI805278 AI694302 AK124125 BI826101 BI818250 BM908139 AK093438 AW139984 BM554140 AW772075 CD243534 BI827482 AL045436 AW449508 BM554457 AX748126 AA812756 BG825818 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for TTLL10 About this scheme ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 SP1 :       -                   SP2 :                         SP3 :                         SP4 :       -                  
ECgene alternative splicing isoforms for TTLL10
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Expression for TTLL10 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TTLL10 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGAAGAGTCT
About this image TTLL10 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See TTLL10 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TTLL10 SOURCE GeneReport for Unigene cluster: Hs.454835 SABiosciences Custom PCR Arrays for TTLL10 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TTLL10Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TTLL10 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TTLL10 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TTLL10 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL10
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Orthologsfor TTLL10 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for TTLL10 gene from 3/16 species (see all 16 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
TTLL101
tubulin tyrosine ligase-like family, member 10
64.21(n) 58.76(a)
 
419426 XM_417587.3 XP_417587.3
lizard (Anolis carolinensis)
Reptilia
TTLL106
--
51(a)
1 ↔ 1
GL343647.1(328786-347681)
zebrafish (Danio rerio)
Actinopterygii
ttll106
tubulin tyrosine ligase-like family, member 10
38(a)
1 ↔ 1
23(24372414-24400286)
ENSEMBL Gene Tree for TTLL10 (if available)TreeFam Gene Tree for TTLL10 (if available)
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Paralogsfor TTLL10 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TTLL10 gene TTLL4 2 TTLL3 2 TTLL1 2 TTLL5 2 TTLL11 2 TTLL9 2 TTLL7 2 TTLL6 2 TTL 2 TTLL8 2 TTLL2 2 TTLL13 2 ARPC4-TTLL3 2
TTLL10 for paralogs About GeneDecksing
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Genomic Variantsfor TTLL10 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TTLL10 (1109264 - 1133315 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 4 variations for TTLL10 2 CNVs : 0001 30362 2 Indels : 84000 74285
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TTLL10
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Disorders
/ Diseasesfor TTLL10 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Publicationsfor TTLL10 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TTLL10 gene integrated from 9 sources : (articles sorted by number of sources associating them with TTLL10) Utopia : connect your pdf to the dynamic world of online information
Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. (PubMed id 19524510) 1 , 2 Rogowski K....Janke C. (2009) Tubulin polyglutamylase enzymes are members of the TTL domain protein family. (PubMed id 15890843) 1 , 3 Janke C.... Edde B. (2005) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974) 2 Sjoeblom T.... Velculescu V.E. (2006) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 2 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TTLL10 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TTLL10 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TTLL10 gene
(According to HUGE )
About This Section --
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Specialized Databases showing TTLL10 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TTLL10 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TTLL10 gene: Search GeneIP for patents involving TTLL10 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TTLL10 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TTLL10 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TTLL10 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TTLL10 OriGene Protein Over-expression Lysate for TTLL10 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TTLL10 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TTLL10 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TTLL10 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TTLL10 OriGene Custom Protein Services for TTLL10 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TTLL10 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TTLL10 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TTLL10 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TTLL10 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TTLL10 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TTLL10
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TTLL10 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTLL10
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TTLL10
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