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Aliases for TTLL1 Gene

Aliases for TTLL1 Gene

  • Tubulin Tyrosine Ligase-Like Family Member 1 2 3
  • Tubulin Polyglutamylase Complex Subunit 3 3 4
  • Tubulin--Tyrosine Ligase-Like Protein 1 3 4
  • C22orf7 3 4
  • PGs3 3 4
  • Catalytic Subunit Of Neural Tubulin Polyglutamylase 3
  • Tubulin Tyrosine Ligase-Like Family, Member 1 3
  • Probable Tubulin Polyglutamylase TTLL1 3
  • Tubulin Tyrosine Ligase-Like 1 2
  • Tubulin-Tyrosine Ligase 3
  • EC 6.-.-.- 4
  • HS323M22B 3
  • KIAA0173 6

External Ids for TTLL1 Gene

Previous HGNC Symbols for TTLL1 Gene

  • C22orf7

Previous GeneCards Identifiers for TTLL1 Gene

  • GC22M040037
  • GC22M041666
  • GC22M041760
  • GC22M041765
  • GC22M043414
  • GC22M026394

Summaries for TTLL1 Gene

GeneCards Summary for TTLL1 Gene

TTLL1 (Tubulin Tyrosine Ligase-Like Family Member 1) is a Protein Coding gene. GO annotations related to this gene include tubulin-glutamic acid ligase activity. An important paralog of this gene is TTLL8.

UniProtKB/Swiss-Prot for TTLL1 Gene

  • Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity).

Gene Wiki entry for TTLL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTLL1 Gene

Genomics for TTLL1 Gene

Regulatory Elements for TTLL1 Gene

Genomic Location for TTLL1 Gene

Start:
43,039,516 bp from pter
End:
43,089,428 bp from pter
Size:
49,913 bases
Orientation:
Minus strand

Genomic View for TTLL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTLL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTLL1 Gene

Proteins for TTLL1 Gene

  • Protein details for TTLL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95922-TTLL1_HUMAN
    Recommended name:
    Probable tubulin polyglutamylase TTLL1
    Protein Accession:
    O95922
    Secondary Accessions:
    • B2RDS7
    • Q9BR27
    • Q9NRS9
    • Q9UMU0

    Protein attributes for TTLL1 Gene

    Size:
    423 amino acids
    Molecular mass:
    48988 Da
    Quaternary structure:
    • Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1.
    SequenceCaution:
    • Sequence=CAB51423.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for TTLL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTLL1 Gene

Proteomics data for TTLL1 Gene at MOPED

Post-translational modifications for TTLL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTLL1 Gene

No data available for DME Specific Peptides for TTLL1 Gene

Domains for TTLL1 Gene

Gene Families for TTLL1 Gene

HGNC:
  • TTLL :Tubulin tyrosine ligase-like family

Protein Domains for TTLL1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TTLL1 Gene

Graphical View of Domain Structure for InterPro Entry

O95922

UniProtKB/Swiss-Prot:

TTLL1_HUMAN :
  • O95922
Domain:
  • Contains 1 TTL domain.
Family:
  • Belongs to the tubulin polyglutamylase family.
genes like me logo Genes that share domains with TTLL1: view

Function for TTLL1 Gene

Molecular function for TTLL1 Gene

UniProtKB/Swiss-Prot Function: Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity).

Enzyme Numbers (IUBMB) for TTLL1 Gene

Gene Ontology (GO) - Molecular Function for TTLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0070740 tubulin-glutamic acid ligase activity TAS 15890843
genes like me logo Genes that share ontologies with TTLL1: view
genes like me logo Genes that share phenotypes with TTLL1: view

Animal Models for TTLL1 Gene

MGI Knock Outs for TTLL1:

miRNA for TTLL1 Gene

miRTarBase miRNAs that target TTLL1

No data available for Transcription Factor Targeting and HOMER Transcription for TTLL1 Gene

Localization for TTLL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTLL1 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTLL1 Gene COMPARTMENTS Subcellular localization image for TTLL1 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TTLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with TTLL1: view

Pathways for TTLL1 Gene

SuperPathways for TTLL1 Gene

No Data Available

Interacting Proteins for TTLL1 Gene

Gene Ontology (GO) - Biological Process for TTLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003351 epithelial cilium movement IEA --
GO:0006464 cellular protein modification process --
GO:0018095 protein polyglutamylation TAS 15890843
GO:0035082 axoneme assembly IEA --
GO:0044782 cilium organization --
genes like me logo Genes that share ontologies with TTLL1: view

No data available for Pathways by source for TTLL1 Gene

Transcripts for TTLL1 Gene

Unigene Clusters for TTLL1 Gene

Tubulin tyrosine ligase-like family, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTLL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1: -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: - - - - - - - - -
SP7: -
SP8: - -

Relevant External Links for TTLL1 Gene

GeneLoc Exon Structure for
TTLL1
ECgene alternative splicing isoforms for
TTLL1

Expression for TTLL1 Gene

mRNA expression in normal human tissues for TTLL1 Gene

SOURCE GeneReport for Unigene cluster for TTLL1 Gene Hs.660298

mRNA Expression by UniProt/SwissProt for TTLL1 Gene

O95922-TTLL1_HUMAN
Tissue specificity: Expressed in a wide range of tissues. Has a stronger expression in heart, brain and testis.
genes like me logo Genes that share expressions with TTLL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for TTLL1 Gene

Orthologs for TTLL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTLL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTLL1 35
  • 99.21 (n)
  • 100 (a)
TTLL1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TTLL1 35
  • 89.28 (n)
  • 96.93 (a)
TTLL1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTLL1 35
  • 90.46 (n)
  • 98.58 (a)
TTLL1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttll1 35
  • 86.68 (n)
  • 96.93 (a)
Ttll1 16
Ttll1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTLL1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTLL1 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttll1 35
  • 86.52 (n)
  • 97.4 (a)
chicken
(Gallus gallus)
Aves TTLL1 35
  • 78.96 (n)
  • 94.33 (a)
TTLL1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTLL1 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttll1 35
  • 77.83 (n)
  • 89.59 (a)
zebrafish
(Danio rerio)
Actinopterygii ttll1 35
  • 77.41 (n)
  • 87.38 (a)
ttll1 36
  • 84 (a)
OneToOne
zgc63993 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010336 35
  • 63.66 (n)
  • 69.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32238 35
  • 63.9 (n)
  • 68.91 (a)
CG32238 36
  • 56 (a)
OneToMany
CG8918 36
  • 44 (a)
OneToMany
CG7474 37
  • 67 (a)
CG8918 37
  • 54 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBY1 36
  • 10 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11289 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4984 36
  • 77 (a)
OneToOne
Species with no ortholog for TTLL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTLL1 Gene

ENSEMBL:
Gene Tree for TTLL1 (if available)
TreeFam:
Gene Tree for TTLL1 (if available)

Paralogs for TTLL1 Gene

Selected SIMAP similar genes for TTLL1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TTLL1 Gene

genes like me logo Genes that share paralogs with TTLL1: view

Variants for TTLL1 Gene

Sequence variations from dbSNP and Humsavar for TTLL1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs1040431 -- 43,060,677(+) TGCCA(C/G)TTCTG intron-variant
rs1052160 -- 43,063,840(-) CATCT(C/T)ACCAA reference, synonymous-codon, nc-transcript-variant
rs1132079 -- 43,059,525(-) CAGGA(A/G)GACTA synonymous-codon, reference, nc-transcript-variant
rs1980457 -- 43,054,344(+) CACAC(C/T)GTGCT intron-variant
rs2038063 -- 43,053,502(+) AACCC(C/T)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTLL1 Gene

Variant ID Type Subtype PubMed ID
nsv834213 CNV Loss 17160897
nsv3645 CNV Insertion 18451855
esv28713 CNV Loss 19812545
nsv834214 CNV Gain 17160897
nsv459889 CNV Gain 19166990
dgv836e199 CNV Deletion 23128226
esv2724296 CNV Deletion 23290073
nsv829259 CNV Loss 20364138
esv2724297 CNV Deletion 23290073
esv1431679 CNV Deletion 17803354
esv1508177 CNV Deletion 17803354
esv2724298 CNV Deletion 23290073
esv2663131 CNV Deletion 23128226

Relevant External Links for TTLL1 Gene

HapMap Linkage Disequilibrium report
TTLL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTLL1 Gene

Disorders for TTLL1 Gene

(1) University of Copenhagen DISEASES for TTLL1 Gene

Relevant External Links for TTLL1

Genetic Association Database (GAD)
TTLL1
Human Genome Epidemiology (HuGE) Navigator
TTLL1
genes like me logo Genes that share disorders with TTLL1: view

No data available for UniProtKB/Swiss-Prot for TTLL1 Gene

Publications for TTLL1 Gene

  1. Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1. (PMID: 11054573) Trichet V. … De Sario A. (Gene 2000) 2 3 4 23
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PMID: 12529303) Collins J.E. … Dunham I. (Genome Res. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for TTLL1 Gene

Sources for TTLL1 Gene

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