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Aliases for TTL Gene

Aliases for TTL Gene

  • Tubulin Tyrosine Ligase 2 3
  • EC 4 63
  • Tubulin-Tyrosine Ligase 3
  • 2410003M22Rik 3

External Ids for TTL Gene

Previous GeneCards Identifiers for TTL Gene

  • GC02P113146
  • GC02P113334
  • GC02P112956
  • GC02P113239
  • GC02P105693

Summaries for TTL Gene

Entrez Gene Summary for TTL Gene

  • TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TTL Gene

TTL (Tubulin Tyrosine Ligase) is a Protein Coding gene. GO annotations related to this gene include tubulin-tyrosine ligase activity. An important paralog of this gene is TTLL8.

UniProtKB/Swiss-Prot for TTL Gene

  • Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTL Gene

Genomics for TTL Gene

Regulatory Elements for TTL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TTL Gene

112,482,154 bp from pter
112,541,739 bp from pter
59,586 bases
Plus strand

Genomic View for TTL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for TTL Gene

Proteins for TTL Gene

  • Protein details for TTL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tubulin--tyrosine ligase
    Protein Accession:
    Secondary Accessions:
    • Q585T3
    • Q7Z302
    • Q8N426

    Protein attributes for TTL Gene

    377 amino acids
    Molecular mass:
    43212 Da
    Name=K(+); Xref=ChEBI:CHEBI:29103;
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.

neXtProt entry for TTL Gene

Proteomics data for TTL Gene at MOPED

Post-translational modifications for TTL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTL Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for TTL

Domains & Families for TTL Gene

Gene Families for TTL Gene

Protein Domains for TTL Gene


Suggested Antigen Peptide Sequences for TTL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 TTL domain.
  • Belongs to the tubulin--tyrosine ligase family.
  • Contains 1 TTL domain.
  • Belongs to the tubulin--tyrosine ligase family.
genes like me logo Genes that share domains with TTL: view

Function for TTL Gene

Molecular function for TTL Gene

GENATLAS Biochemistry:
tetracycline transporter-like
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate
UniProtKB/Swiss-Prot Function:
Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.

Enzyme Numbers (IUBMB) for TTL Gene

Gene Ontology (GO) - Molecular Function for TTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004835 tubulin-tyrosine ligase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with TTL: view
genes like me logo Genes that share phenotypes with TTL: view

Animal Models for TTL Gene

MGI Knock Outs for TTL:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTL

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for TTL Gene

Localization for TTL Gene

Subcellular locations from

Jensen Localization Image for TTL Gene COMPARTMENTS Subcellular localization image for TTL gene
Compartment Confidence
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTL Gene

Pathways & Interactions for TTL Gene

SuperPathways for TTL Gene

No Data Available

Interacting Proteins for TTL Gene

SIGNOR curated interactions for TTL Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for TTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0006464 cellular protein modification process IEA --
GO:0030516 regulation of axon extension IEA --
genes like me logo Genes that share ontologies with TTL: view

No data available for Pathways by source for TTL Gene

Drugs & Compounds for TTL Gene

(5) Drugs for TTL Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
L-Tyrosine Approved Nutra 0
Potassium Experimental Pharma 0
Magnesium Nutra 0
tyrosine Nutra 547

(4) Additional Compounds for TTL Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
genes like me logo Genes that share compounds with TTL: view

Transcripts for TTL Gene

Unigene Clusters for TTL Gene

Tubulin tyrosine ligase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTL Gene

No ASD Table

Relevant External Links for TTL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTL Gene

mRNA expression in normal human tissues for TTL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TTL Gene

This gene is overexpressed in Fetal Brain (31.6), Frontal cortex (24.7), and Retina (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTL Gene

SOURCE GeneReport for Unigene cluster for TTL Gene Hs.358997

genes like me logo Genes that share expression patterns with TTL: view

Protein tissue co-expression partners for TTL Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTL Gene

Orthologs for TTL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TTL 35
  • 90.19 (n)
  • 94.16 (a)
TTL 36
  • 94 (a)
(Canis familiaris)
Mammalia TTL 35
  • 91.69 (n)
  • 95.23 (a)
TTL 36
  • 95 (a)
(Mus musculus)
Mammalia Ttl 35
  • 88.77 (n)
  • 95.23 (a)
Ttl 16
Ttl 36
  • 95 (a)
(Pan troglodytes)
Mammalia TTL 35
  • 98.59 (n)
  • 98.67 (a)
TTL 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ttl 35
  • 88.86 (n)
  • 94.69 (a)
(Monodelphis domestica)
Mammalia TTL 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia TTL 36
  • 86 (a)
(Gallus gallus)
Aves TTL 35
  • 79.13 (n)
  • 88.86 (a)
TTL 36
  • 89 (a)
(Anolis carolinensis)
Reptilia TTL 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ttl 35
  • 74.2 (n)
  • 81.38 (a)
(Danio rerio)
Actinopterygii Dr.11411 35
ttl 35
  • 69.41 (n)
  • 78.42 (a)
ttl 36
  • 72 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBY1 36
  • 9 (a)
PBY1 38
Species with no ortholog for TTL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTL Gene

Gene Tree for TTL (if available)
Gene Tree for TTL (if available)

Paralogs for TTL Gene Pseudogenes for TTL Gene

genes like me logo Genes that share paralogs with TTL: view

Variants for TTL Gene

Sequence variations from dbSNP and Humsavar for TTL Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7506 -- 112,532,124(+) TACTG(G/T)GATCG utr-variant-3-prime
rs11644 -- 112,531,455(+) GGACA(A/G)GTGAC utr-variant-3-prime
rs1127264 -- 112,531,011(+) TTGCC(C/T)AGGCT utr-variant-3-prime
rs1127296 -- 112,532,537(+) gcttg(A/G)ggctg utr-variant-3-prime
rs1465817 -- 112,528,915(+) AAAGA(A/T)GAGAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TTL Gene

Variant ID Type Subtype PubMed ID
nsv1013 CNV Insertion 18451855
nsv524578 CNV Loss 19592680
nsv874877 CNV Loss 21882294

Variation tolerance for TTL Gene

Residual Variation Intolerance Score: 21.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTL Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTL Gene

Disorders for TTL Gene

Relevant External Links for TTL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TTL: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTL Gene

Publications for TTL Gene

  1. Sesterterpenes as tubulin tyrosine ligase inhibitors. First insight of structure-activity relationships and discovery of new lead. (PMID: 19459643) Dal Piaz F. … De Tommasi N. (J. Med. Chem. 2009) 23 67
  2. Parthenolide inhibits tubulin carboxypeptidase activity. (PMID: 17409447) Fonrose X. … LafanechA"re L. (Cancer Res. 2007) 23 67
  3. The testis-specific apoptosis related gene TTL.6 underwent adaptive evolution in the lineage leading to humans. (PMID: 16443334) Chen X.-H. … Su B. (Gene 2006) 23 67
  4. Normal and prostate cancer cells display distinct molecular profiles of alpha-tubulin posttranslational modifications. (PMID: 16541425) Soucek K. … Eiserich J.P. (Prostate 2006) 23 67
  5. Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends. (PMID: 16954346) Peris L. … Job D. (J. Cell Biol. 2006) 23 67

Products for TTL Gene

Sources for TTL Gene

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