Aliases for TTL Gene
External Ids for TTL Gene
TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008]
GeneCards Summary for TTL Gene
TTL (Tubulin Tyrosine Ligase) is a Protein Coding gene. GO annotations related to this gene include tubulin-tyrosine ligase activity. An important paralog of this gene is TTLL8.
UniProtKB/Swiss-Prot for TTL Gene
Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.