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Aliases for TTK Gene

Aliases for TTK Gene

  • TTK Protein Kinase 2 3 5
  • Phosphotyrosine Picked Threonine-Protein Kinase 3 4
  • Monopolar Spindle 1 Kinase 2 3
  • Cancer/Testis Antigen 96 2 3
  • MPS1L1 3 4
  • MPS1 3 4
  • PYT 3 4
  • Phosphotyrosine Picked Threonine Kinase 3
  • Monopolar Spindle 1-Like 1 3
  • EC 2.7.12.1 4
  • CT96 3
  • MPH1 3
  • ESK 3

External Ids for TTK Gene

Previous GeneCards Identifiers for TTK Gene

  • GC06P080657
  • GC06P080709
  • GC06P080771
  • GC06P077937
  • GC06P080713

Summaries for TTK Gene

Entrez Gene Summary for TTK Gene

  • This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

GeneCards Summary for TTK Gene

TTK (TTK Protein Kinase) is a Protein Coding gene. Diseases associated with TTK include chronic polyneuropathy. Among its related pathways are RB in Cancer and Cell cycle. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TLK1.

UniProtKB/Swiss-Prot for TTK Gene

  • Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.

Tocris Summary for TTK Gene

Gene Wiki entry for TTK Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTK Gene

Genomics for TTK Gene

Regulatory Elements for TTK Gene

Promoters for TTK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TTK on UCSC Golden Path with GeneCards custom track

Genomic Location for TTK Gene

Chromosome:
6
Start:
80,003,887 bp from pter
End:
80,042,527 bp from pter
Size:
38,641 bases
Orientation:
Plus strand

Genomic View for TTK Gene

Genes around TTK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTK Gene

Proteins for TTK Gene

  • Protein details for TTK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33981-TTK_HUMAN
    Recommended name:
    Dual specificity protein kinase TTK
    Protein Accession:
    P33981
    Secondary Accessions:
    • A8K8U5
    • B2RDW2
    • E1P543
    • Q15272
    • Q5TCS0
    • Q9BW51
    • Q9NTM0

    Protein attributes for TTK Gene

    Size:
    857 amino acids
    Molecular mass:
    97072 Da
    Quaternary structure:
    • Interacts with TPR; the interactions occurs in a microtubule-independent manner.
    SequenceCaution:
    • Sequence=AAA61239.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB87580.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TTK Gene

    Alternative splice isoforms for TTK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTK Gene

Proteomics data for TTK Gene at MOPED

Post-translational modifications for TTK Gene

  • Ubiquitination at Lys 19, Lys 86, Lys 452, Lys 538, Lys 810, and Lys 830
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TTK (TTK)

No data available for DME Specific Peptides for TTK Gene

Domains & Families for TTK Gene

Gene Families for TTK Gene

Graphical View of Domain Structure for InterPro Entry

P33981

UniProtKB/Swiss-Prot:

TTK_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with TTK: view

Function for TTK Gene

Molecular function for TTK Gene

GENATLAS Biochemistry:
TTK serine/threonine kinase,expressed in testis and thymus,yeast Mps1and CDC20/Slp1 homolog,functioning at the mitotic spindle checkpoint
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the ATP-competitive kinase inhibitor, SP600125.
UniProtKB/Swiss-Prot Function:
Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.

Enzyme Numbers (IUBMB) for TTK Gene

Gene Ontology (GO) - Molecular Function for TTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with TTK: view
genes like me logo Genes that share phenotypes with TTK: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TTK

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTK Gene

Localization for TTK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTK Gene COMPARTMENTS Subcellular localization image for TTK gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTK Gene

Pathways & Interactions for TTK Gene

SuperPathways for TTK Gene

Superpath Contained pathways
1 RB in Cancer
2 Cell cycle
genes like me logo Genes that share pathways with TTK: view

Pathways by source for TTK Gene

1 BioSystems pathway for TTK Gene
1 KEGG pathway for TTK Gene

SIGNOR curated interactions for TTK Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for TTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007051 spindle organization TAS 10366450
GO:0007093 mitotic cell cycle checkpoint IEA --
GO:0007094 mitotic spindle assembly checkpoint TAS 10366450
GO:0051304 chromosome separation IEA --
genes like me logo Genes that share ontologies with TTK: view

Drugs & Compounds for TTK Gene

(6) Drugs for TTK Gene - From: DrugBank, ApexBio, Tocris, Novoseek, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One Experimental Pharma Target 0
AZ3146 Pharma Mps1 inhibitor,potent and selective, Potent and selective Mps1 kinase inhibitor 0
Vaccines Pharma 6085

(3) Additional Compounds for TTK Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Mps BAY 2a
1382477-96-4
Mps1-IN-1 dihydrochloride
TC Mps1 12
1206170-62-8
genes like me logo Genes that share compounds with TTK: view

Transcripts for TTK Gene

Unigene Clusters for TTK Gene

TTK protein kinase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTK Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^
SP1: - - -
SP2: -
SP3: -
SP4: - -
SP5: - -
SP6: -
SP7:

ExUns: 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24
SP1: -
SP2:
SP3: - -
SP4:
SP5:
SP6:
SP7:

Relevant External Links for TTK Gene

GeneLoc Exon Structure for
TTK
ECgene alternative splicing isoforms for
TTK

Expression for TTK Gene

mRNA expression in normal human tissues for TTK Gene

mRNA differential expression in normal tissues according to GTEx for TTK Gene

This gene is overexpressed in Testis (x13.1).

Protein differential expression in normal tissues from HIPED for TTK Gene

This gene is overexpressed in Cervix (22.7), Bone (15.5), Heart (10.2), Testis (9.9), and Placenta (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTK Gene



SOURCE GeneReport for Unigene cluster for TTK Gene Hs.169840

mRNA Expression by UniProt/SwissProt for TTK Gene

P33981-TTK_HUMAN
Tissue specificity: Present in rapidly proliferating cell lines.
genes like me logo Genes that share expression patterns with TTK: view

Protein tissue co-expression partners for TTK Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TTK Gene

Orthologs for TTK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTK 35
  • 99.38 (n)
  • 99.18 (a)
TTK 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TTK 36
  • 68 (a)
OneToOne
TTK 35
  • 89.21 (n)
  • 86.57 (a)
dog
(Canis familiaris)
Mammalia TTK 35
  • 90.11 (n)
  • 87.46 (a)
TTK 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttk 16
Ttk 35
  • 81.2 (n)
  • 76.27 (a)
Ttk 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTK 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTK 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttk 35
  • 82.55 (n)
  • 78.68 (a)
chicken
(Gallus gallus)
Aves TTK 36
  • 60 (a)
OneToOne
TTK 35
  • 70.02 (n)
  • 64.11 (a)
lizard
(Anolis carolinensis)
Reptilia TTK 36
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398219 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ttk 35
  • 63.16 (n)
  • 56.01 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2362 35
zebrafish
(Danio rerio)
Actinopterygii ttk 36
  • 37 (a)
OneToOne
mps1 35
ttk 35
  • 54.23 (n)
  • 48.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7643 37
  • 44 (a)
ald 36
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MPS1 36
  • 25 (a)
OneToMany
MPS1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToOne
Species with no ortholog for TTK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTK Gene

ENSEMBL:
Gene Tree for TTK (if available)
TreeFam:
Gene Tree for TTK (if available)

Paralogs for TTK Gene

Paralogs for TTK Gene

Pseudogenes.org Pseudogenes for TTK Gene

genes like me logo Genes that share paralogs with TTK: view

Variants for TTK Gene

Sequence variations from dbSNP and Humsavar for TTK Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs192130 -- 80,004,778(+) GCTCA(C/T)TGTTA intron-variant
rs239552 -- 80,008,628(-) TTTTC(C/T)CCCCA intron-variant
rs239553 -- 80,009,773(-) TTCCT(A/G)ACAGC intron-variant
rs239554 -- 80,009,798(-) TAGGA(C/T)TTCAG intron-variant
rs239567 -- 80,014,745(+) AAGTA(C/T)TGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTK Gene

Variant ID Type Subtype PubMed ID
nsv5370 CNV Loss 18451855
nsv886306 CNV Loss 21882294
dgv6931n71 CNV Loss 21882294

Variation tolerance for TTK Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTK Gene

HapMap Linkage Disequilibrium report
TTK
Human Gene Mutation Database (HGMD)
TTK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTK Gene

Disorders for TTK Gene

MalaCards: The human disease database

(1) MalaCards diseases for TTK Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic polyneuropathy
- elite association - COSMIC cancer census association via MalaCards
Search TTK in MalaCards View complete list of genes associated with diseases

Relevant External Links for TTK

Genetic Association Database (GAD)
TTK
Human Genome Epidemiology (HuGE) Navigator
TTK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTK
genes like me logo Genes that share disorders with TTK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTK Gene

Publications for TTK Gene

  1. Expression of TTK, a novel human protein kinase, is associated with cell proliferation. (PMID: 1639825) Mills G.B. … Hogg D. (J. Biol. Chem. 1992) 2 3 4 23 67
  2. Mutational analysis of TTK gene in gastric and colorectal cancers with microsatellite instability. (PMID: 20057968) Ahn C.H. … Lee S.H. (Cancer Res Treat 2009) 3 23
  3. Vaccination with multiple peptides derived from novel cancer-testis antigens can induce specific T-cell responses and clinical responses in advanced esophageal cancer. (PMID: 19459850) Kono K. … Fujii H. (Cancer Sci. 2009) 3 23
  4. Detection of novel cancer-testis antigen-specific T-cell responses in TIL, regional lymph nodes, and PBL in patients with esophageal squamous cell carcinoma. (PMID: 18452554) Mizukami Y. … Fujii H. (Cancer Sci. 2008) 3 23
  5. TTK/Mps1 controls nuclear targeting of c-Abl by 14-3-3-coupled phosphorylation in response to oxidative stress. (PMID: 18794806) Nihira K. … Yoshida K. (Oncogene 2008) 3 23

Products for TTK Gene

Sources for TTK Gene

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