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Aliases for TTK Gene

Aliases for TTK Gene

  • TTK Protein Kinase 2 3 5
  • Phosphotyrosine Picked Threonine-Protein Kinase 3 4
  • Monopolar Spindle 1 Kinase 2 3
  • Cancer/Testis Antigen 96 2 3
  • MPS1L1 3 4
  • MPS1 3 4
  • PYT 3 4
  • Phosphotyrosine Picked Threonine Kinase 3
  • Dual Specificity Protein Kinase TTK 3
  • Monopolar Spindle 1-Like 1 3
  • EC 4
  • CT96 3
  • MPH1 3
  • ESK 3

External Ids for TTK Gene

Previous GeneCards Identifiers for TTK Gene

  • GC06P080657
  • GC06P080709
  • GC06P080771
  • GC06P077937
  • GC06P080713

Summaries for TTK Gene

Entrez Gene Summary for TTK Gene

  • This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

GeneCards Summary for TTK Gene

TTK (TTK Protein Kinase) is a Protein Coding gene. Diseases associated with TTK include Chronic Polyneuropathy. Among its related pathways are DNA Damage and Retinoblastoma (RB) in Cancer. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TLK2.

UniProtKB/Swiss-Prot for TTK Gene

  • Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.

Tocris Summary for TTK Gene

  • Monopolar spindle 1 (Mps1) kinase, also known as TTK protein kinase, is a mitotic kinase that is critical in the regulation of cell division, as it is involved in controlling the progression of cells through mitosis. It is widely found, but is not ubiquitous, in eukaryotes.

Gene Wiki entry for TTK Gene

Additional gene information for TTK Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTK Gene

Genomics for TTK Gene

GeneHancer (GH) Regulatory Elements for TTK Gene

Promoters and enhancers for TTK Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I080002 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.4 404 3.1 PKNOX1 CLOCK SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B TTK ELOVL4 PHIP ENSG00000272129 BCKDHB LOC643562
GH06I079964 Enhancer 0.6 ENCODE dbSUPER 10.8 -38.7 -38739 2.1 ATF7 ATF2 RPL35AP18 TTK BCKDHB ELOVL4 PIR47691
GH06I079980 Enhancer 0.5 dbSUPER 12.3 -20.4 -20350 6.8 OSR2 CTCF HNF1A ZNF140 CBFA2T2 RAD21 GC06P080077 GC06P080108 GC06P080109 GC06P080111 GC06P080119 GC06P080120 GC06P080121 GC06P080122 GC06P080123 GC06P080124
GH06I080437 Enhancer 0.8 Ensembl ENCODE 5.3 +435.6 435643 4.4 ELK4 SOX13 JUN CEBPB EP300 RAD21 ATF2 MAFF JUND POLR2A ENSG00000279022 ENSG00000233967 ENSG00000260645 TTK RPL17P25
GH06I080022 Enhancer 0.5 ENCODE 0.4 +19.1 19071 1.2 JUND ZNF316 JUN FOS MAFK BCKDHB ELOVL4 ENSG00000272129 TTK LOC643562
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TTK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TTK gene promoter:

Genomic Locations for TTK Gene

Genomic Locations for TTK Gene
38,641 bases
Plus strand

Genomic View for TTK Gene

Genes around TTK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTK Gene

Proteins for TTK Gene

  • Protein details for TTK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity protein kinase TTK
    Protein Accession:
    Secondary Accessions:
    • A8K8U5
    • B2RDW2
    • E1P543
    • Q15272
    • Q5TCS0
    • Q9BW51
    • Q9NTM0

    Protein attributes for TTK Gene

    857 amino acids
    Molecular mass:
    97072 Da
    Quaternary structure:
    • Interacts with TPR; the interactions occurs in a microtubule-independent manner.
    • Sequence=AAA61239.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB87580.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TTK Gene

    Alternative splice isoforms for TTK Gene


neXtProt entry for TTK Gene

Post-translational modifications for TTK Gene

  • Ubiquitination at isoforms=219, posLast=8686, posLast=452452, isoforms=2538, isoforms=2810, and posLast=830830

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TTK (TTK)
  • Abcam antibodies for TTK

No data available for DME Specific Peptides for TTK Gene

Domains & Families for TTK Gene

Gene Families for TTK Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with TTK: view

Function for TTK Gene

Molecular function for TTK Gene

GENATLAS Biochemistry:
TTK serine/threonine kinase,expressed in testis and thymus,yeast Mps1and CDC20/Slp1 homolog,functioning at the mitotic spindle checkpoint
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the ATP-competitive kinase inhibitor, SP600125.
UniProtKB/Swiss-Prot Function:
Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.

Enzyme Numbers (IUBMB) for TTK Gene

Phenotypes From GWAS Catalog for TTK Gene

Gene Ontology (GO) - Molecular Function for TTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,TAS --
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA,TAS --
GO:0005515 protein binding IPI 19273613
genes like me logo Genes that share ontologies with TTK: view
genes like me logo Genes that share phenotypes with TTK: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTK Gene

Localization for TTK Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTK gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0005737 cytoplasm IDA 25468996
GO:0005819 spindle TAS 10366450
GO:0016020 membrane HDA,IDA 19946888
genes like me logo Genes that share ontologies with TTK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TTK Gene

Pathways & Interactions for TTK Gene

genes like me logo Genes that share pathways with TTK: view

Pathways by source for TTK Gene

1 Cell Signaling Technology pathway for TTK Gene
1 BioSystems pathway for TTK Gene
1 KEGG pathway for TTK Gene

SIGNOR curated interactions for TTK Gene

Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for TTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007051 spindle organization TAS 10366450
GO:0007052 mitotic spindle organization TAS 7737118
GO:0007093 mitotic cell cycle checkpoint IEA --
GO:0007094 mitotic spindle assembly checkpoint TAS 10366450
genes like me logo Genes that share ontologies with TTK: view

Drugs & Compounds for TTK Gene

(13) Drugs for TTK Gene - From: DrugBank, ClinicalTrials, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One Experimental Pharma Target 0
Adjuvants, Immunologic Pharma 2702
Freund's Adjuvant Pharma 105
Vaccines Pharma 6921
AZ3146 Pharma Mps1 inhibitor,potent and selective 0

(2) Additional Compounds for TTK Gene - From:

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(6) ApexBio Compounds for TTK Gene

Compound Action Cas Number
AZ3146 Mps1 inhibitor,potent and selective 1124329-14-1
MPI-0479605 Mps1 inhibitor,selective and ATP competitive 1246529-32-7
Mps1-IN-1 1125593-20-5
Mps1-IN-2 Mps1 kinase inhibitor 1228817-38-6
Mps1-IN-3 1609584-72-6
NMS-P715 MPS1 kinase inhibitor 1202055-34-2
genes like me logo Genes that share compounds with TTK: view

Drug Products

Transcripts for TTK Gene

Unigene Clusters for TTK Gene

TTK protein kinase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTK Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^
SP1: - - -
SP2: -
SP3: -
SP4: - -
SP5: - -
SP6: -

ExUns: 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24
SP1: -
SP3: - -

Relevant External Links for TTK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTK Gene

mRNA differential expression in normal tissues according to GTEx for TTK Gene

This gene is overexpressed in Testis (x13.1).

Protein differential expression in normal tissues from HIPED for TTK Gene

This gene is overexpressed in Cervix (22.7), Bone (15.5), Heart (10.2), Testis (9.9), and Placenta (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTK Gene

Protein tissue co-expression partners for TTK Gene

NURSA nuclear receptor signaling pathways regulating expression of TTK Gene:


SOURCE GeneReport for Unigene cluster for TTK Gene:


mRNA Expression by UniProt/SwissProt for TTK Gene:

Tissue specificity: Present in rapidly proliferating cell lines.

Evidence on tissue expression from TISSUES for TTK Gene

  • Eye(4)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with TTK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTK Gene

Orthologs for TTK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TTK 33 34
  • 99.38 (n)
(Canis familiaris)
Mammalia TTK 33 34
  • 90.11 (n)
(Bos Taurus)
Mammalia TTK 33 34
  • 89.21 (n)
(Rattus norvegicus)
Mammalia Ttk 33
  • 82.55 (n)
(Mus musculus)
Mammalia Ttk 33 16 34
  • 81.2 (n)
(Monodelphis domestica)
Mammalia TTK 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia TTK 34
  • 66 (a)
(Gallus gallus)
Aves TTK 33 34
  • 70.02 (n)
(Anolis carolinensis)
Reptilia TTK 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ttk 33
  • 63.16 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398219 33
(Danio rerio)
Actinopterygii ttk 33 34
  • 54.23 (n)
mps1 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2362 33
fruit fly
(Drosophila melanogaster)
Insecta CG7643 35
  • 44 (a)
ald 34
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MPS1 34 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
Species where no ortholog for TTK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTK Gene

Gene Tree for TTK (if available)
Gene Tree for TTK (if available)

Paralogs for TTK Gene

Paralogs for TTK Gene Pseudogenes for TTK Gene

genes like me logo Genes that share paralogs with TTK: view

Variants for TTK Gene

Sequence variations from dbSNP and Humsavar for TTK Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1057520011 likely-pathogenic, Pancreatic Neoplasms 80,038,006(+) G/T coding_sequence_variant, missense_variant
rs1000011676 -- 80,015,438(+) A/G intron_variant
rs1000079763 -- 80,016,845(+) A/C intron_variant
rs1000156218 -- 80,039,955(+) A/G intron_variant
rs1000179964 -- 80,034,517(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TTK Gene

Variant ID Type Subtype PubMed ID
nsv5370 CNV deletion 18451855

Variation tolerance for TTK Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTK Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTK Gene

Disorders for TTK Gene

MalaCards: The human disease database

(1) MalaCards diseases for TTK Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
chronic polyneuropathy
- elite association - COSMIC cancer census association via MalaCards
Search TTK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TTK

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TTK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTK Gene

Publications for TTK Gene

  1. Expression of TTK, a novel human protein kinase, is associated with cell proliferation. (PMID: 1639825) Mills GB … Hogg D (The Journal of biological chemistry 1992) 2 3 4 22 58
  2. Mutational analysis of TTK gene in gastric and colorectal cancers with microsatellite instability. (PMID: 20057968) Ahn CH … Lee SH (Cancer research and treatment : official journal of Korean Cancer Association 2009) 3 22 44 58
  3. Breast cancer risk associated with genotypic polymorphism of the mitotic checkpoint genes: a multigenic study on cancer susceptibility. (PMID: 17210994) Lo YL … Shen CY (Carcinogenesis 2007) 3 22 44 58
  4. Genetic variation in the major mitotic checkpoint genes does not affect familial breast cancer risk. (PMID: 17268814) Vaclavicek A … Försti A (Breast cancer research and treatment 2007) 3 22 44 58
  5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 44 58

Products for TTK Gene

  • Addgene plasmids for TTK

Sources for TTK Gene

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