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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TTK Gene

protein-coding   GIFtS: 68
GCID: GC06P080771

TTK Protein Kinase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TTK Protein Kinase1 2     ESK2
MPS1L12 3 5     MPH12
PYT2 3 5     Dual Specificity Protein Kinase TTK2
Cancer/Testis Antigen 961 2     Monopolar Spindle 1-Like 12
Phosphotyrosine Picked Threonine-Protein Kinase2 3     Phosphotyrosine Picked Threonine Kinase2
MPS12 3     EC 2.7.12.13
CT962     

External Ids:    HGNC: 124011   Entrez Gene: 72722   Ensembl: ENSG000001127427   OMIM: 6040925   UniProtKB: P339813   

Export aliases for TTK gene to outside databases

Previous GC identifers: GC06P080657 GC06P080709 GC06P077937


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TTK Gene:
This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and
threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the
centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic
checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this
protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Nov 2009)

GeneCards Summary for TTK Gene: 
TTK (TTK protein kinase) is a protein-coding gene. Diseases associated with TTK include skin tag, and oral submucous fibrosis, and among its related super-pathways are Cell Cycle / Checkpoint Control and Cell cycle. GO annotations related to this gene include protein tyrosine kinase activity and identical protein binding. An important paralog of this gene is TLK2.

UniProtKB/Swiss-Prot: TTK_HUMAN, P33981
Function: Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation.
Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the
centromere, and for the mitotic checkpoint

Gene Wiki entry for TTK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007299.13  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TTK gene promoter:
         NF-YA   Nkx2-5   CBF-C   FOXL1   CBF-A   CBF-B   CP1A   CP1C   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TTK promoter sequence
   Search SABiosciences Chromatin IP Primers for TTK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q13-q21   Ensembl cytogenetic band:  6q14.1   HGNC cytogenetic band: 6q13-q21

TTK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTK gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P080771:  view genomic region     (about GC identifiers)

Start:
80,713,604 bp from pter      End:
80,752,244 bp from pter
Size:
38,641 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TTK_HUMAN, P33981 (See protein sequence)
Recommended Name: Dual specificity protein kinase TTK  
Size: 857 amino acids; 97072 Da
Subunit: Interacts with TPR; the interactions occurs in a microtubule-independent manner
Sequence caution: Sequence=AAA61239.1; Type=Erroneous initiation; Sequence=CAB87580.1; Type=Erroneous initiation;
6/18 PDB 3D structures from and Proteopedia for TTK (see all 18):
2X9E (3D)        2ZMC (3D)        2ZMD (3D)        3CEK (3D)        3DBQ (3D)        3GFW (3D)    
Secondary accessions: A8K8U5 B2RDW2 E1P543 Q15272 Q5TCS0 Q9BW51 Q9NTM0
Alternative splicing: 2 isoforms:  P33981-1   P33981-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TTK: NX_P33981

Explore proteomics data for TTK at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P33981

  • TTK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TTK Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001160163.1  NP_003309.2  

    ENSEMBL proteins: 
     ENSP00000422936   ENSP00000230510   ENSP00000358813   ENSP00000421406   ENSP00000424851  
     ENSP00000421636   ENSP00000427483  

    Human Recombinant Protein Products for TTK: 
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    Cloud-Clone Corp. Proteins for TTK 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005819spindle TAS10366450

    TTK for ontologies           About GeneDecksing



    TTK Antibody Products: 
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    Cloud-Clone Corp. CLIAs for TTK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: TTK protein kinase 
    TTK family

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR027084 Dual_sp_prot_kinse_Ttk
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry P33981

    ProtoNet protein and cluster: P33981

    UniProtKB/Swiss-Prot: TTK_HUMAN, P33981
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    TTK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTK_HUMAN, P33981
    Function: Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation.
    Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the
    centromere, and for the mitotic checkpoint
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by the ATP-competitive kinase inhibitor, SP600125

         Genatlas biochemistry entry for TTK:
    TTK serine/threonine kinase,expressed in testis and thymus,yeast Mps1and CDC20/Slp1 homolog,functioning at the
    mitotic spindle checkpoint

         Enzyme Number (IUBMB): EC 2.7.12.11

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI19273613
         
    TTK for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for TTK:
     Decreased focal adhesion (FA)   Decreased number of cells in m  Decreased substrate adherent c  Decreased viability 
     Increased cell death HMECs cel  Increased viability with 4OH t  Upregulation of Wnt/beta-caten 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ttk):
     cellular  reproductive system 

    TTK for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TTK 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TTK 
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    miRNA
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    hsa-miR-140-5p hsa-miR-582-5p hsa-miR-212 hsa-miR-132 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidTTK 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TTK About                                                                                                See pathways by source

    SuperPathContained pathways About
    1DNA Damage
    DNA Damage0.32
    Cell Cycle / Checkpoint Control0.32
    2Cell cycle
    Cell cycle0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for TTK
        Cell Cycle / Checkpoint Control
    DNA Damage



    1         Kegg Pathway  (Kegg details for TTK):
        Cell cycle


    TTK for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TTK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/602 Interacting proteins for TTK (P339811, 2, 3 ENSP000002305104) via UniProtKB, MINT, STRING, and/or I2D (see all 602)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000183311P074372, 3MINT-7945693 MINT-50598 I2D: score=2 
    ENSG00000224156P074372, 3MINT-7945693 MINT-50598 I2D: score=2 
    ENSG00000227739P074372, 3MINT-7945693 MINT-50598 I2D: score=2 
    ENSG00000229684P074372, 3MINT-7945693 MINT-50598 I2D: score=2 
    ENSG00000232421P074372, 3MINT-7945693 MINT-50598 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007051spindle organization TAS10366450
    GO:0007052mitotic spindle organization TAS7737118
    GO:0007094mitotic spindle assembly checkpoint TAS10366450
    GO:0008284positive regulation of cell proliferation TAS1639825

    TTK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TTK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TTK

    1 DrugBank Compound for TTK    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One-- --target--10592235

    3 Novoseek inferred chemical compound relationships for TTK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 29.6 5 8254211 (2), 17981789 (1), 11393570 (1), 1639825 (1)
    threonine 25.9 5 1639825 (2), 8254211 (2)
    serine 10.8 5 1639825 (2), 8254211 (2)

    Search CenterWatch for drugs/clinical trials and news about TTK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TTK gene (2 alternative transcripts): 
    NM_001166691.1  NM_003318.4  

    Unigene Cluster for TTK:

    TTK protein kinase
    Hs.169840  [show with all ESTs]
    Unigene Representative Sequence: NM_001166691
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509894 ENST00000230510(uc003pjb.4) ENST00000369798(uc003pjc.3)
    ENST00000509313 ENST00000502580 ENST00000511260 ENST00000504040 ENST00000430061
    ENST00000515751 ENST00000504590
    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate TTK:
    hsa-miR-140-5p hsa-miR-582-5p hsa-miR-212 hsa-miR-132 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidTTK 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK095599.1 AK292460.1 AK315696.1 BC000633.2 BC032858.2 X70500.1 

    9 DOTS entries:

    DT.100019275  DT.92030142  DT.212400  DT.92427570  DT.92427574  DT.100670812  DT.121322298  DT.95367140 
    DT.99957561 

    24/101 AceView cDNA sequences (see all 101):

    CR624652 BM905869 BM836070 AA993767 AI973225 AU136576 AU132784 AA421620 
    AA470077 AK095599 AU124846 BQ420892 BQ929926 AU118786 AU119487 BP369979 
    BX447327 BU508578 BC000633 BI462468 CD642431 BG502738 BF515437 AU124386 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TTK (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^
    SP1:                    -     -           -                                                                                                                     
    SP2:                                      -                                                                                                                     
    SP3:                                                                                                                                                        -   
    SP4:                    -     -                                                                                                                                 
    SP5:                          -           -                                                                                                                     

    ExUns: 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24
    SP1:              -                                             
    SP2:                                                            
    SP3:  -           -                                             
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for TTK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TTK expression in normal human tissues (normalized intensities)      TTK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTGAATT
    TTK Expression
    About this image


    TTK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Gonad
             XX Germ Cells Ovigerous Cord
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow

    See TTK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TTK

    SOURCE GeneReport for Unigene cluster: Hs.169840

    UniProtKB/Swiss-Prot: TTK_HUMAN, P33981
    Tissue specificity: Present in rapidly proliferating cell lines

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TTK gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttk1 , 5 Ttk protein kinase1, 5 81.2(n)1
    76.27(a)1
      9 (45.61 cM)5
    221371  NM_009445.21  NP_033471.21 
     838346895 
    chicken
    (Gallus gallus)
    Aves TTK1 TTK protein kinase 69.58(n)
    63.95(a)
      421849  XM_419867.3  XP_419867.3 
    lizard
    (Anolis carolinensis)
    Reptilia TTK6
    TTK protein kinase
    56(a)
    1 ↔ 1
    1(199248885-199310737)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3982192 Mps1/TTK 76.05(n)    AF250290.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mps12 monopolar spindle 1 72.4(n)   317763  AF488735.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG76433 protein amino acid phosphorylation
    protein kinase
    44(a)   90C1   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MPS1(YDL028C)4 Dual-specificity kinase required for spindle pole body more   --   4(403291-400997) 851533  NP_010256.1 


    ENSEMBL Gene Tree for TTK (if available)
    TreeFam Gene Tree for TTK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TTK gene
    TLK22  TLK12  

    TTK for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TTK
    PGOHUM00000250931


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/945 SNPs in TTK are shown (see all 945)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2402121,2
    C,F,O,A,H--80712351(+) cttacG/Attgtt 2 -- us2k113Minor allele frequency- A:0.37MN NS EA WA NA CSA 968
    rs2402131,2
    C,F,A,H--80712416(+) AAAGAG/AAGCAA 2 -- us2k1 tfbs3 trp311Minor allele frequency- A:0.37NS EA WA NA CSA 718
    rs1902776981,2
    --80712438(+) TTAAAA/TAGTTT 2 -- us2k10--------
    rs2402141,2
    C,A,H--80712498(+) ttaatC/Aaatta 2 -- us2k1 tfbs35Minor allele frequency- A:0.45NA WA EA 362
    rs793639161,2
    C,F--80712748(+) TCAGTT/CAAGTG 2 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1408011581,2
    C--80712841(+) ACTCAA/GTCTGC 2 -- us2k10--------
    rs737479361,2
    C--80712899(+) AAAAAA/GTTTAA 2 -- us2k13Minor allele frequency- G:0.07WA EA 240
    rs2402151,2
    C,F,H--80712939(+) taaaaA/Caaaca 2 -- us2k15Minor allele frequency- C:0.10NS EA WA 532
    rs1496935051,2
    --80712959(+) AGGAAC/GATCAG 2 -- us2k10--------
    rs117543351,2
    C,F,A,H--80713014(+) tgtaaG/Atgaag 2 -- us2k18Minor allele frequency- A:0.01NS EA NA 546

    HapMap Linkage Disequilibrium report for TTK (80713604 - 80752244 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TTK:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv886306CNV Loss21882294
    dgv6931n71CNV Loss21882294
    nsv5370CNV Loss18451855

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604092    OMIM disorders: --

    14 diseases for TTK:    About MalaCards
    skin tag    oral submucous fibrosis    familial breast cancer    papillary carcinoma
    mantle cell lymphoma    esophagitis    esophageal cancer    esophageal squamous cell carcinoma
    breast cancer    thyroiditis    squamous cell carcinoma    gastric cancer
    colorectal cancer    melanoma


    TTK for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for TTK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 28.3 6 20057968 (2), 1639825 (1), 8254211 (1), 17439397 (1) (see all 5)
    breast cancer 9.46 6 17210994 (2), 17268814 (1), 16428479 (1)
    tumors 0 1 17981789 (1)

    Genetic Association Database (GAD): TTK
    Human Genome Epidemiology (HuGE) Navigator: TTK (4 documents)

    Export disorders for TTK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TTK gene, integrated from 9 sources (see all 103):
    (articles sorted by number of sources associating them with TTK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of TTK, a novel human protein kinase, is associated with cell proliferation. (PubMed id 1639825)1, 2, 3, 9 Mills G.B.... Hogg D. (1992)
    2. Mutational Analysis of TTK Gene in Gastric and Colore ctal Cancers with Microsatellite Instability. (PubMed id 20057968)1, 4, 9 Ahn C.H....Lee S.H. (2009)
    3. Breast cancer risk associated with genotypic polymorphism of the mitotic checkpoint genes: a multigenic study on cancer susceptibility. (PubMed id 17210994)1, 4, 9 Lo Y.L....Shen C.Y. (2007)
    4. Genetic variation in the major mitotic checkpoint genes does not affect familial breast cancer risk. (PubMed id 17268814)1, 4, 9 Vaclavicek A....Forsti A. (2007)
    5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    6. Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator. (PubMed id 19273613)1, 2 Lince-Faria M....Maiato H. (2009)
    7. Structural and mechanistic insights into Mps1 kinase activation. (PubMed id 19120698)1, 2 Wang W.... Liu X. (2009)
    8. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. (PubMed id 18243099)1, 2 Jelluma N.... Kops G.J.P.L. (2008)
    9. Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125. (PubMed id 18480048)1, 2 Chu M.L.H.... Tabernero L. (2008)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7272 HGNC: 12401 AceView: TTK Ensembl:ENSG00000112742 euGenes: HUgn7272
    ECgene: TTK Kegg: 7272 H-InvDB: TTK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TTK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TTK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TTK gene:
    Search GeneIP for patents involving TTK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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