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Aliases for TTK Gene

Aliases for TTK Gene

  • TTK Protein Kinase 2 3
  • MPS1L1 3 4 6
  • PYT 3 4 6
  • Phosphotyrosine Picked Threonine-Protein Kinase 3 4
  • Monopolar Spindle 1 Kinase 2 3
  • Cancer/Testis Antigen 96 2 3
  • MPS1 3 4
  • Phosphotyrosine Picked Threonine Kinase 3
  • Dual Specificity Protein Kinase TTK 3
  • Monopolar Spindle 1-Like 1 3
  • EC 2.7.12.1 4
  • CT96 3
  • MPH1 3
  • ESK 3

External Ids for TTK Gene

Previous GeneCards Identifiers for TTK Gene

  • GC06P080657
  • GC06P080709
  • GC06P080771
  • GC06P077937
  • GC06P080713

Summaries for TTK Gene

Entrez Gene Summary for TTK Gene

  • This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

GeneCards Summary for TTK Gene

TTK (TTK Protein Kinase) is a Protein Coding gene. Among its related pathways are Cell Cycle / Checkpoint Control and RB in Cancer. GO annotations related to this gene include identical protein binding and protein tyrosine kinase activity. An important paralog of this gene is TLK1.

UniProtKB/Swiss-Prot for TTK Gene

  • Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.

Gene Wiki entry for TTK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTK Gene

Genomics for TTK Gene

Regulatory Elements for TTK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TTK Gene

Start:
80,003,887 bp from pter
End:
80,042,527 bp from pter
Size:
38,641 bases
Orientation:
Plus strand

Genomic View for TTK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTK Gene

Proteins for TTK Gene

  • Protein details for TTK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33981-TTK_HUMAN
    Recommended name:
    Dual specificity protein kinase TTK
    Protein Accession:
    P33981
    Secondary Accessions:
    • A8K8U5
    • B2RDW2
    • E1P543
    • Q15272
    • Q5TCS0
    • Q9BW51
    • Q9NTM0

    Protein attributes for TTK Gene

    Size:
    857 amino acids
    Molecular mass:
    97072 Da
    Quaternary structure:
    • Interacts with TPR; the interactions occurs in a microtubule-independent manner.
    SequenceCaution:
    • Sequence=AAA61239.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB87580.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TTK Gene

    Alternative splice isoforms for TTK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTK Gene

Proteomics data for TTK Gene at MOPED

Post-translational modifications for TTK Gene

  • Ubiquitination at Lys19, Lys86, Lys434, Lys452, Lys538, Lys810, and Lys830
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TTK (TTK)

No data available for DME Specific Peptides for TTK Gene

Domains for TTK Gene

Gene Families for TTK Gene

Graphical View of Domain Structure for InterPro Entry

P33981

UniProtKB/Swiss-Prot:

TTK_HUMAN :
  • P33981
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with TTK: view

Function for TTK Gene

Molecular function for TTK Gene

GENATLAS Biochemistry: TTK serine/threonine kinase,expressed in testis and thymus,yeast Mps1and CDC20/Slp1 homolog,functioning at the mitotic spindle checkpoint
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by the ATP-competitive kinase inhibitor, SP600125
UniProtKB/Swiss-Prot Function: Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.

Enzyme Numbers (IUBMB) for TTK Gene

Gene Ontology (GO) - Molecular Function for TTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0005515 protein binding IPI 19273613
genes like me logo Genes that share ontologies with TTK: view
genes like me logo Genes that share phenotypes with TTK: view

Animal Model Products

CRISPR Products

miRNA for TTK Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTK

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TTK Gene

Localization for TTK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTK Gene COMPARTMENTS Subcellular localization image for TTK gene
Compartment Confidence
cytoskeleton 4
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for TTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005819 spindle TAS 10366450
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with TTK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TTK Gene

Pathways for TTK Gene

genes like me logo Genes that share pathways with TTK: view

Pathways by source for TTK Gene

2 Cell Signaling Technology pathways for TTK Gene
1 BioSystems pathway for TTK Gene
1 KEGG pathway for TTK Gene

Gene Ontology (GO) - Biological Process for TTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0007051 spindle organization TAS 10366450
GO:0007052 mitotic spindle organization TAS 7737118
GO:0007093 mitotic cell cycle checkpoint --
GO:0007094 mitotic spindle assembly checkpoint TAS 10366450
genes like me logo Genes that share ontologies with TTK: view

Compounds for TTK Gene

(1) Drugbank Compounds for TTK Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One
target

(3) Novoseek inferred chemical compound relationships for TTK Gene

Compound -log(P) Hits PubMed IDs
tyrosine 29.6 5
threonine 25.9 4
serine 10.8 4
genes like me logo Genes that share compounds with TTK: view

Transcripts for TTK Gene

Unigene Clusters for TTK Gene

TTK protein kinase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTK

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTK Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^
SP1: - - -
SP2: -
SP3: -
SP4: - -
SP5: - -
SP6: -
SP7:

ExUns: 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24
SP1: -
SP2:
SP3: - -
SP4:
SP5:
SP6:
SP7:

Relevant External Links for TTK Gene

GeneLoc Exon Structure for
TTK
ECgene alternative splicing isoforms for
TTK

Expression for TTK Gene

mRNA expression in normal human tissues for TTK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTK Gene

This gene is overexpressed in Testis (13.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTK Gene

SOURCE GeneReport for Unigene cluster for TTK Gene Hs.169840

mRNA Expression by UniProt/SwissProt for TTK Gene

P33981-TTK_HUMAN
Tissue specificity: Present in rapidly proliferating cell lines
genes like me logo Genes that share expressions with TTK: view

In Situ Assay Products

Orthologs for TTK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTK 35
  • 99.38 (n)
  • 99.18 (a)
TTK 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TTK 35
  • 89.21 (n)
  • 86.57 (a)
TTK 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTK 35
  • 90.11 (n)
  • 87.46 (a)
TTK 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttk 35
  • 81.2 (n)
  • 76.27 (a)
Ttk 16
Ttk 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTK 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTK 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttk 35
  • 82.55 (n)
  • 78.68 (a)
chicken
(Gallus gallus)
Aves TTK 35
  • 70.02 (n)
  • 64.11 (a)
TTK 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTK 36
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398219 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ttk 35
  • 63.16 (n)
  • 56.01 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2362 35
zebrafish
(Danio rerio)
Actinopterygii mps1 35
ttk 35
  • 54.23 (n)
  • 48.48 (a)
ttk 36
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ald 36
  • 29 (a)
OneToOne
CG7643 37
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MPS1 36
  • 25 (a)
OneToMany
MPS1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToOne
Species with no ortholog for TTK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTK Gene

ENSEMBL:
Gene Tree for TTK (if available)
TreeFam:
Gene Tree for TTK (if available)

Paralogs for TTK Gene

Paralogs for TTK Gene

Pseudogenes.org Pseudogenes for TTK Gene

genes like me logo Genes that share paralogs with TTK: view

Variants for TTK Gene

Sequence variations from dbSNP and Humsavar for TTK Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs61794 -- 80,032,871(+) aatta(G/T)agttg intron-variant
rs61795 -- 80,032,914(+) ttttt(A/T)aatac intron-variant
rs61796 -- 80,033,163(+) aaggt(A/G)gtatg intron-variant
rs151587 -- 80,011,016(-) TATCC(C/T)GAATC intron-variant
rs151588 -- 80,022,887(+) TTTAC(A/C)GAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTK Gene

Variant ID Type Subtype PubMed ID
nsv5370 CNV Loss 18451855
nsv886306 CNV Loss 21882294
dgv6931n71 CNV Loss 21882294

Relevant External Links for TTK Gene

HapMap Linkage Disequilibrium report
TTK
Human Gene Mutation Database (HGMD)
TTK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTK Gene

Disorders for TTK Gene

(3) Novoseek inferred disease relationships for TTK Gene

Disease -log(P) Hits PubMed IDs
cancer 28.3 6
breast cancer 9.46 4
tumors 0 1

Relevant External Links for TTK

Genetic Association Database (GAD)
TTK
Human Genome Epidemiology (HuGE) Navigator
TTK
genes like me logo Genes that share disorders with TTK: view

No data available for UniProtKB/Swiss-Prot for TTK Gene

Publications for TTK Gene

  1. Expression of TTK, a novel human protein kinase, is associated with cell proliferation. (PMID: 1639825) Mills G.B. … Hogg D. (J. Biol. Chem. 1992) 2 3 4 23
  2. Breast cancer risk associated with genotypic polymorphism of the mitotic checkpoint genes: a multigenic study on cancer susceptibility. (PMID: 17210994) Lo Y.L. … Shen C.Y. (Carcinogenesis 2007) 3 23 48
  3. Genetic variation in the major mitotic checkpoint genes does not affect familial breast cancer risk. (PMID: 17268814) Vaclavicek A. … FAPrsti A. (Breast Cancer Res. Treat. 2007) 3 23 48
  4. Mutational analysis of TTK gene in gastric and colorectal cancers with microsatellite instability. (PMID: 20057968) Ahn C.H. … Lee S.H. (Cancer Res Treat 2009) 3 23 48
  5. Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. (PMID: 1956325) Hanks S.K. … Quinn A.M. (Methods Enzymol. 1991) 3 4

Products for TTK Gene

  • Addgene plasmids for TTK

Sources for TTK Gene

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