Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TTK Gene

Aliases for TTK Gene

  • TTK Protein Kinase 2 3 5
  • Phosphotyrosine Picked Threonine-Protein Kinase 3 4
  • Monopolar Spindle 1 Kinase 2 3
  • Cancer/Testis Antigen 96 2 3
  • MPS1L1 3 4
  • MPS1 3 4
  • PYT 3 4
  • Phosphotyrosine Picked Threonine Kinase 3
  • Dual Specificity Protein Kinase TTK 3
  • Monopolar Spindle 1-Like 1 3
  • EC 2.7.12.1 4
  • CT96 3
  • MPH1 3
  • ESK 3

External Ids for TTK Gene

Previous GeneCards Identifiers for TTK Gene

  • GC06P080657
  • GC06P080709
  • GC06P080771
  • GC06P077937
  • GC06P080713

Summaries for TTK Gene

Entrez Gene Summary for TTK Gene

  • This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

GeneCards Summary for TTK Gene

TTK (TTK Protein Kinase) is a Protein Coding gene. Diseases associated with TTK include Chronic Polyneuropathy. Among its related pathways are DNA Damage and Retinoblastoma (RB) in Cancer. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TLK1.

UniProtKB/Swiss-Prot for TTK Gene

  • Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.

Tocris Summary for TTK Gene

  • Monopolar spindle 1 (Mps1) kinase, also known as TTK protein kinase, is a mitotic kinase that is critical in the regulation of cell division, as it is involved in controlling the progression of cells through mitosis. It is widely found, but is not ubiquitous, in eukaryotes.

Gene Wiki entry for TTK Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTK Gene

Genomics for TTK Gene

Regulatory Elements for TTK Gene

Enhancers for TTK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G079964 0.8 ENCODE dbSUPER 10.8 -38.7 -38739 2.1 GATA3 ATF2 ZNF652 FOXA1 TTK BCKDHB ELOVL4 RPL35AP18 PIR47691
GH06G079980 0.7 dbSUPER 12.3 -20.4 -20350 6.8 CTCF ZNF140 ELF4 RAD21 ATF2 ZBTB40 FOXA1 OSR2 HNF1A ZNF316 ELOVL4 TTK ENSG00000272129 BCKDHB GC06P080080 PIR53632 PIR39637
GH06G080437 0.9 Ensembl ENCODE 5.3 +435.6 435644 4.4 CTCF ELK4 SOX13 MTA2 JUN CEBPB RAD21 EP300 ATF2 JUND ENSG00000233967 ENSG00000260645 TTK ENSG00000279022 RPL17P25
GH06G080002 1.3 ENCODE dbSUPER 0.7 +0.4 404 3.1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS KLF13 SP3 ELOVL4 ENSG00000272129 BCKDHB TTK LOC643562
GH06G079992 0.6 ENCODE dbSUPER 0.4 -10.5 -10538 0.9 ZBTB7B ELOVL4 ENSG00000272129 GC06P080091 PIR50421 TTK
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTK on UCSC Golden Path with GeneCards custom track

Promoters for TTK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000199227 813 1801 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS KLF13 SP3 MXD4

Genomic Location for TTK Gene

Chromosome:
6
Start:
80,003,887 bp from pter
End:
80,042,527 bp from pter
Size:
38,641 bases
Orientation:
Plus strand

Genomic View for TTK Gene

Genes around TTK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTK Gene

Proteins for TTK Gene

  • Protein details for TTK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33981-TTK_HUMAN
    Recommended name:
    Dual specificity protein kinase TTK
    Protein Accession:
    P33981
    Secondary Accessions:
    • A8K8U5
    • B2RDW2
    • E1P543
    • Q15272
    • Q5TCS0
    • Q9BW51
    • Q9NTM0

    Protein attributes for TTK Gene

    Size:
    857 amino acids
    Molecular mass:
    97072 Da
    Quaternary structure:
    • Interacts with TPR; the interactions occurs in a microtubule-independent manner.
    SequenceCaution:
    • Sequence=AAA61239.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB87580.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TTK Gene

    Alternative splice isoforms for TTK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTK Gene

Post-translational modifications for TTK Gene

  • Ubiquitination at Lys19, Lys86, Lys452, posLast=538538, posLast=810810, and Lys830
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TTK Gene

Domains & Families for TTK Gene

Gene Families for TTK Gene

Graphical View of Domain Structure for InterPro Entry

P33981

UniProtKB/Swiss-Prot:

TTK_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with TTK: view

Function for TTK Gene

Molecular function for TTK Gene

GENATLAS Biochemistry:
TTK serine/threonine kinase,expressed in testis and thymus,yeast Mps1and CDC20/Slp1 homolog,functioning at the mitotic spindle checkpoint
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the ATP-competitive kinase inhibitor, SP600125.
UniProtKB/Swiss-Prot Function:
Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.

Enzyme Numbers (IUBMB) for TTK Gene

Gene Ontology (GO) - Molecular Function for TTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS,IEA --
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity TAS,IEA --
GO:0005515 protein binding IPI 19273613
genes like me logo Genes that share ontologies with TTK: view
genes like me logo Genes that share phenotypes with TTK: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TTK

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TTK

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTK Gene

Localization for TTK Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTK gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for TTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0005737 cytoplasm IDA 25468996
GO:0005819 spindle TAS 10366450
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with TTK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TTK Gene

Pathways & Interactions for TTK Gene

genes like me logo Genes that share pathways with TTK: view

Pathways by source for TTK Gene

1 Cell Signaling Technology pathway for TTK Gene
1 BioSystems pathway for TTK Gene
1 KEGG pathway for TTK Gene

SIGNOR curated interactions for TTK Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for TTK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007051 spindle organization TAS 10366450
GO:0007052 mitotic spindle organization TAS 7737118
GO:0007093 mitotic cell cycle checkpoint IEA --
GO:0007094 mitotic spindle assembly checkpoint TAS 10366450
genes like me logo Genes that share ontologies with TTK: view

Drugs & Compounds for TTK Gene

(13) Drugs for TTK Gene - From: DrugBank, ClinicalTrials, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One Experimental Pharma Target 0
Adjuvants, Immunologic Pharma 2554
Freund's Adjuvant Pharma 105
Vaccines Pharma 6611
AZ3146 Pharma Mps1 inhibitor,potent and selective, Potent and selective Mps1 kinase inhibitor 0

(2) Additional Compounds for TTK Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Mps BAY 2a
1382477-96-4
Mps1-IN-1 dihydrochloride

(2) Tocris Compounds for TTK Gene

Compound Action Cas Number
Mps BAY 2a Potent and selective Mps1 kinase inhibitor 1382477-96-4
Mps1-IN-1 dihydrochloride Selective Mps1 kinase inhibitor

(6) ApexBio Compounds for TTK Gene

Compound Action Cas Number
AZ3146 Mps1 inhibitor,potent and selective 1124329-14-1
MPI-0479605 Mps1 inhibitor,selective and ATP competitive 1246529-32-7
Mps1-IN-1 1125593-20-5
Mps1-IN-2 Mps1 kinase inhibitor 1228817-38-6
Mps1-IN-3 1609584-72-6
NMS-P715 MPS1 kinase inhibitor 1202055-34-2
genes like me logo Genes that share compounds with TTK: view

Drug Products

Transcripts for TTK Gene

Unigene Clusters for TTK Gene

TTK protein kinase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TTK

Alternative Splicing Database (ASD) splice patterns (SP) for TTK Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^
SP1: - - -
SP2: -
SP3: -
SP4: - -
SP5: - -
SP6: -
SP7:

ExUns: 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24
SP1: -
SP2:
SP3: - -
SP4:
SP5:
SP6:
SP7:

Relevant External Links for TTK Gene

GeneLoc Exon Structure for
TTK
ECgene alternative splicing isoforms for
TTK

Expression for TTK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTK Gene

mRNA differential expression in normal tissues according to GTEx for TTK Gene

This gene is overexpressed in Testis (x13.1).

Protein differential expression in normal tissues from HIPED for TTK Gene

This gene is overexpressed in Cervix (22.7), Bone (15.5), Heart (10.2), Testis (9.9), and Placenta (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTK Gene



Protein tissue co-expression partners for TTK Gene

NURSA nuclear receptor signaling pathways regulating expression of TTK Gene:

TTK

SOURCE GeneReport for Unigene cluster for TTK Gene:

Hs.169840

mRNA Expression by UniProt/SwissProt for TTK Gene:

P33981-TTK_HUMAN
Tissue specificity: Present in rapidly proliferating cell lines.

Evidence on tissue expression from TISSUES for TTK Gene

  • Eye(4)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with TTK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTK Gene

Orthologs for TTK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTK 34 35
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia TTK 34 35
  • 90.11 (n)
cow
(Bos Taurus)
Mammalia TTK 34 35
  • 89.21 (n)
rat
(Rattus norvegicus)
Mammalia Ttk 34
  • 82.55 (n)
mouse
(Mus musculus)
Mammalia Ttk 34 16 35
  • 81.2 (n)
oppossum
(Monodelphis domestica)
Mammalia TTK 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTK 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTK 34 35
  • 70.02 (n)
lizard
(Anolis carolinensis)
Reptilia TTK 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttk 34
  • 63.16 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398219 34
zebrafish
(Danio rerio)
Actinopterygii ttk 34 35
  • 54.23 (n)
mps1 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2362 34
fruit fly
(Drosophila melanogaster)
Insecta CG7643 36
  • 44 (a)
ald 35
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MPS1 35 37
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
OneToOne
Species where no ortholog for TTK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTK Gene

ENSEMBL:
Gene Tree for TTK (if available)
TreeFam:
Gene Tree for TTK (if available)

Paralogs for TTK Gene

Paralogs for TTK Gene

Pseudogenes.org Pseudogenes for TTK Gene

genes like me logo Genes that share paralogs with TTK: view

Variants for TTK Gene

Sequence variations from dbSNP and Humsavar for TTK Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000011676 -- 80,015,438(+) ATTGG(A/G)TGTAT intron-variant
rs1000079763 -- 80,016,845(+) TAACA(A/C)AGAGC intron-variant
rs1000156218 -- 80,039,955(+) ATATA(A/G)CTGTT intron-variant
rs1000179964 -- 80,034,517(+) GAGAC(C/T)GTGTC intron-variant
rs1000313266 -- 80,041,880(+) AGTAG(C/T)TCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTK Gene

Variant ID Type Subtype PubMed ID
nsv5370 CNV deletion 18451855

Variation tolerance for TTK Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTK Gene

Human Gene Mutation Database (HGMD)
TTK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTK Gene

Disorders for TTK Gene

MalaCards: The human disease database

(1) MalaCards diseases for TTK Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chronic polyneuropathy
- elite association - COSMIC cancer census association via MalaCards
Search TTK in MalaCards View complete list of genes associated with diseases

Relevant External Links for TTK

Genetic Association Database (GAD)
TTK
Human Genome Epidemiology (HuGE) Navigator
TTK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTK
genes like me logo Genes that share disorders with TTK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTK Gene

Publications for TTK Gene

  1. Expression of TTK, a novel human protein kinase, is associated with cell proliferation. (PMID: 1639825) Mills G.B. … Hogg D. (J. Biol. Chem. 1992) 2 3 4 22 64
  2. Mutational analysis of TTK gene in gastric and colorectal cancers with microsatellite instability. (PMID: 20057968) Ahn C.H. … Lee S.H. (Cancer Res Treat 2009) 3 22 46 64
  3. Breast cancer risk associated with genotypic polymorphism of the mitotic checkpoint genes: a multigenic study on cancer susceptibility. (PMID: 17210994) Lo Y.L. … Shen C.Y. (Carcinogenesis 2007) 3 22 46 64
  4. Genetic variation in the major mitotic checkpoint genes does not affect familial breast cancer risk. (PMID: 17268814) Vaclavicek A. … FAPrsti A. (Breast Cancer Res. Treat. 2007) 3 22 46 64
  5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64

Products for TTK Gene

  • Addgene plasmids for TTK

Sources for TTK Gene

Content
Loading form....