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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TTK Gene

protein-coding GIFtS: 65
GCID: GC06P080771

TTK protein kinase

Explore 17 diseases affiliated with
TTK via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
TTK Protein Kinase¹ ²		ESK²
MPS1L1¹ ² ³ ⁵		Cancer/Testis Antigen 96²
MPS1¹ ² ³		Dual Specificity Protein Kinase TTK²
PYT² ³ ⁵		Monopolar Spindle 1-Like 1²
CT96¹ ²		Phosphotyrosine Picked Threonine Kinase²
MPH1¹ ²		EC 2.7.12.1³
Phosphotyrosine Picked Threonine-Protein Kinase² ³

External Ids:	HGNC: 12401¹	Entrez Gene: 7272²	Ensembl: ENSG00000112742⁷	OMIM: 604092⁵	UniProtKB: P33981³

Export aliases for TTK gene to outside databases

Previous GC identifers: GC06P080657 GC06P080709 GC06P077937

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TTK:

This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine.

Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during

mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for

accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and

produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple

transcript variants. (provided by RefSeq, Nov 2009)

UniProtKB/Swiss-Prot: TTK_HUMAN, P33981

Function: Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation.

Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere,

and for the mitotic checkpoint

Gene Wiki entry for TTK

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007299.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TTK gene promoter:
NF-YA Nkx2-5 CBF-C FOXL1 CBF-A CBF-B CP1A CP1C NF-Y CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TTK promoter sequence

Search SABiosciences Chromatin IP Primers for TTK

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTK

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q13-q21 Ensembl cytogenetic band: 6q14.1 HGNC cytogenetic band: 6q13-q21

TTK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTK gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P080771: view genomic region (about GC identifiers)

Start:	80,713,604 bp from pter	End:	80,752,244 bp from pter
Size:	38,641 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TTK_HUMAN, P33981 (See protein sequence)

Recommended Name: Dual specificity protein kinase TTK

Size: 857 amino acids; 97072 Da

Sequence caution: Sequence=AAA61239.1; Type=Erroneous initiation; Sequence=CAB87580.1; Type=Erroneous initiation;

6/13 PDB 3D structures from and Proteopedia for TTK (see all 13):

2X9E (3D)

2ZMC (3D)

2ZMD (3D)

3CEK (3D)

3DBQ (3D)

3GFW (3D)

Secondary accessions: A8K8U5 B2RDW2 E1P543 Q15272 Q5TCS0 Q9BW51 Q9NTM0

Alternative splicing: 2 isoforms: P33981-1 P33981-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TTK: NX_P33981

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P33981

TTK Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001160163.1 NP_003309.2

ENSEMBL proteins:

ENSP00000422936 ENSP00000230510 ENSP00000358813 ENSP00000421406 ENSP00000424851

ENSP00000421636 ENSP00000427483

Human Recombinant Protein Products for TTK:

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	Novus Biologicals TTK Proteins Novus Biologicals TTK Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TTK

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005819	spindle	TAS	10366450

TTK for ontologies About GeneDecksing

TTK Antibody Products:

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Assay Products for TTK:

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	Uscn ELISAs and CLIAs for TTK

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TTK for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR017441 Protein_kinase_ATP_BS

IPR027084 Dual_sp_prot_kinse_Ttk

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

Graphical View of Domain Structure for InterPro Entry P33981

ProtoNet protein and cluster: P33981

UniProtKB/Swiss-Prot: TTK_HUMAN, P33981

Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TTK_HUMAN, P33981

Function: Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation.

Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere,

and for the mitotic checkpoint

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Inhibited by the ATP-competitive kinase inhibitor, SP600125

Genatlas biochemistry entry for TTK:

TTK serine/threonine kinase,expressed in testis and thymus,yeast Mps1and CDC20/Slp1 homolog,functioning at the mitotic

spindle checkpoint

Enzyme Number (IUBMB): EC 2.7.12.1¹

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0004712	protein serine/threonine/tyrosine kinase activity	IEA	--
GO:0004713	protein tyrosine kinase activity	IEA	--
GO:0005515	protein binding	IPI	19273613
GO:0005524	ATP binding	IEA	--

TTK for ontologies About GeneDecksing

Phenotypes:
7 GenomeRNAi human phenotypes for TTK:

Decreased focal adhesion (FA)	Decreased number of cells in m	Decreased substrate adherent c	Decreased viability
Increased cell death HMECs cel	Increased viability with 4OH t	Upregulation of Wnt/beta-caten

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ttk):

cellular

reproductive system

TTK for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TTK

miRNA Products:		miRTarBase miRNAs that target TTK: hsa-mir-376a (MIRT001746)

		OriGene 3'-UTR Clone: TTK Browse MicroRNA Expression Plasmids
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		5 QIAGEN miScript miRNA Assays for microRNAs that regulate TTK:
		hsa-miR-140-5p hsa-miR-582-5p hsa-miR-212 hsa-miR-132 hsa-miR-3692
		SwitchGear 3'UTR luciferase reporter plasmid: TTK 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTK (see all 7) OriGene shRNA RFP: TTK OriGene siRNA: TTK
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		Sirion Biotech Custom design and validation of potent shRNA sequences against TTK

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TTK
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 2): TTK (NM_003318)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TTK
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTK

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

DNA Damage

DNA Damage

1.00

Cell Cycle / Checkpoint Control

Cell Cycle / Checkpoint Control

1.00

Cell cycle

Cell cycle

0.57

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Cell Signaling Technology (CST) Pathways for TTK

	Cell Cycle / Checkpoint Control
	DNA Damage

1 Kegg Pathway (Kegg details for TTK):

Cell cycle

TTK for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TTK

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/575 Interacting proteins for TTK (P33981^{1, 2, 3} ENSP00000230510⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 575)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TUBB	P07437²^,³	MINT-7945693 MINT-50598 I2D: score=2
CDC16	Q13042²^,³, ENSP00000348554⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000348554
MAPK6	Q16659²^,³	MINT-8262099 I2D: score=2
CDC27	P30260²^,³	MINT-7945693 I2D: score=1
TACC2	O95359²^,³, ENSP00000334280⁴	MINT-50599 MINT-50600 I2D: score=1 STRING: ENSP00000334280

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007051	spindle organization	TAS	10366450
GO:0007052	mitotic spindle organization	TAS	7737118
GO:0007094	mitotic cell cycle spindle assembly checkpoint	TAS	10366450
GO:0008284	positive regulation of cell proliferation	TAS	1639825
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	TAS	19018011

TTK for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TTK for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TTK

1 DrugBank Compound for TTK About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One	--	--	target	--	10592235

3 Novoseek chemical compound relationships for TTK gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	29.6	5	8254211 (2), 17981789 (1), 11393570 (1), 1639825 (1)
threonine	25.9	5	1639825 (2), 8254211 (2)
serine	10.8	5	1639825 (2), 8254211 (2)

Search CenterWatch for drugs/clinical trials and news about TTK

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TTK gene (2 alternative transcripts):

NM_001166691.1 NM_003318.4

Unigene Cluster for TTK:

TTK protein kinase

Hs.169840 [show with all ESTs]

Unigene Representative Sequence: NM_001166691

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000509894 ENST00000230510(uc003pjb.4) ENST00000369798(uc003pjc.3)

ENST00000509313 ENST00000502580 ENST00000511260 ENST00000504040 ENST00000430061

ENST00000515751 ENST00000504590

miRNA Products:		OriGene 3'-UTR Clone: TTK Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TTK
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate TTK:
		hsa-miR-140-5p hsa-miR-582-5p hsa-miR-212 hsa-miR-132 hsa-miR-3692
		SwitchGear 3'UTR luciferase reporter plasmid: TTK 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AK095599.1 AK292460.1 AK315696.1 BC000633.2 BC032858.2 X70500.1

9 DOTS entries:

DT.100019275 DT.92030142 DT.212400 DT.92427570 DT.92427574 DT.100670812 DT.121322298 DT.95367140

DT.99957561

24/101 AceView cDNA sequences (see all 101):

AU132784 AA993767 AU119487 AI973225 AU124846 AK095599 BM836070 AU136576

BM905869 AU118786 AA421620 AA470077 BQ929926 CR624652 BQ420892 AA121159

BX103137 BG576948 AU132533 Z21415 BI462468 BX350316 BG724288 BE885880

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TTK (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	·	6d	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17	^	18a	·	18b	^
SP1:							-		-				-
SP2:													-
SP3:																																																			-
SP4:							-		-
SP5:									-				-

ExUns:	19a	·	19b	^	20a	·	20b	^	21a	·	21b	^	22a	·	22b	^	23	^	24
SP1:					-
SP2:
SP3:	-				-
SP4:
SP5:

ECgene alternative splicing isoforms for TTK

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TTK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATTGAATT

About this image

TTK expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

S-shaped Body

Kidney Endothelial Cells

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TTK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TTK

SOURCE GeneReport for Unigene cluster: Hs.169840

UniProtKB/Swiss-Prot: TTK_HUMAN, P33981

Tissue specificity: Present in rapidly proliferating cell lines

SABiosciences Custom PCR Arrays for TTK

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTK

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTK

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TTK gene from 8/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ttk^{1 , 5}	Ttk protein kinase^{1, 5}	81.2(n)¹ 76.27(a)¹		9 (45.61 cM)⁵ 22137¹ NM_009445.2¹ NP_033471.2¹ 83834689⁵
chicken (Gallus gallus)	Aves	TTK¹	TTK protein kinase	69.58(n) 63.95(a)		421849 XM_419867.3 XP_419867.3
lizard (Anolis carolinensis)	Reptilia	TTK⁶	--	58(a)	1 ↔ 1	1(199248894-199283663)
African clawed frog (Xenopus laevis)	Amphibia	LOC398219²	Mps1/TTK	76.05(n)		AF250290.1
zebrafish (Danio rerio)	Actinopterygii	mps1²	monopolar spindle 1	72.4(n)		317763 AF488735.1
fruit fly (Drosophila melanogaster)	Insecta	CG7643³	protein amino acid phosphorylation protein kinase	44(a)		90C1 --
thale cress (Arabidopsis thaliana)	eudicotyledons	PPK1⁶	serine/threonine-protein kinase TTK/MPS1	21(a)	1 ↔ 1	1(29210521-29214087)
rice (Oryza sativa)	Liliopsida	--	protein kinase family protein, putative, expressed...	22(a)	1 ↔ 1	3(28307325-28313013)

ENSEMBL Gene Tree for TTK (if available)
TreeFam Gene Tree for TTK (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TTK gene

TLK2² TLK1²

TTK for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for TTK
PGOHUM00000250931

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs240212^1,2	C,F,O,A,H	--	80712351(+)	`CTTACG/ATTGTT`	2	--	us2k¹		13		MN NS EA WA NA CSA	968
rs240213^1,2	C,F,A,H	--	80712416(+)	`AAAGAG/AAGCAA`	2	--	us2k¹ tfbs³ trp³		11		NS EA WA NA CSA	718
rs190277698^1,2		--	80712438(+)	`TTAAAA/TAGTTT`	2	--	us2k¹		0	--	--	--	--
rs240214^1,2	C,A,H	--	80712498(+)	`TTAATC/AAATTA`	2	--	us2k¹ tfbs³		5		NA WA EA	362
rs79363916^1,2	F	--	80712748(+)	`TCAGTT/CAAGTG`	2	--	us2k¹		1		NA	120
rs140801158^1,2	C	--	80712841(+)	`ACTCAA/GTCTGC`	2	--	us2k¹		0	--	--	--	--
rs73747936^1,2	C	--	80712899(+)	`AAAAAA/GTTTAA`	2	--	us2k¹		3		WA EA	240
rs240215^1,2	C,F,H	--	80712939(+)	`taaaaA/Caaaca`	2	--	us2k¹		5		NS EA WA	532
rs149693505^1,2		--	80712959(+)	`AGGAAC/GATCAG`	2	--	us2k¹		0	--	--	--	--
rs11754335^1,2	C,F,A,H	--	80713014(+)	`TGTAAG/ATGAAG`	2	--	us2k¹		8		NS EA NA	546

HapMap Linkage Disequilibrium report for TTK (80713604 - 80752244 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TTK: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TTK for disorders           About GeneDecksing

OMIM gene information: 604092    OMIM disorders: --

17 diseases for TTK:    About MalaCards

oral submucous fibrosis skin tag mantle cell lymphoma esophageal squamous cell carcinoma

squamous cell carcinoma familial breast cancer breast cancer papillary carcinoma

esophagitis thyroid carcinoma esophageal cancer gastric cancer

carcinoma colorectal cancer thyroiditis fibrosis

melanoma

1 disease from the University of Copenhagen DISEASES database for TTK:

Skin tag

3 Novoseek disease relationships for TTK gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	28.3	6	20057968 (2), 1639825 (1), 8254211 (1), 17439397 (1) (see all 5)
breast cancer	9.46	6	17210994 (2), 17268814 (1), 16428479 (1)
tumors	0	1	17981789 (1)

Human Genome Epidemiology (HuGE) Navigator: TTK (4 documents)

Export disorders for TTK gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TTK gene, integrated from 9 sources (see all 95):
(articles sorted by number of sources associating them with TTK)

Utopia: connect your pdf to the dynamic
world of online information

Expression of TTK, a novel human protein kinase, is associated with cell proliferation. (PubMed id 1639825)^{1, 2, 3, 9} Mills G.B.... Hogg D. (1992)
Structural and mechanistic insights into Mps1 kinase activation. (PubMed id 19120698)^{1, 2} Wang W.... Liu X. (2009)
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. (PubMed id 18243099)^{1, 2} Jelluma N.... Kops G.J.P.L. (2008)
Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125. (PubMed id 18480048)^{1, 2} Chu M.L.H.... Tabernero L. (2008)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Characterization of a human protein threonine kinase isolated by screening an expression library with antibodies to phosphotyrosine. (PubMed id 7678926)^{1, 2} Lindberg R.A.... Hunter T. (1993)
Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. (PubMed id 1956325)^{1, 2} Hanks S.K. and Quinn A.M. (1991)
Mutational Analysis of TTK Gene in Gastric and Colore ctal Cancers with Microsatellite Instability. (PubMed id 20057968)^{1, 9} Ahn C.H....Lee S.H. (2009)
TTK/Mps1 controls nuclear targeting of c-Abl by 14-3-3-coupled phosphorylation in response to oxidative stress. (PubMed id 18794806)^{1, 9} Nihira K....Yoshida K. (2008)
TTK kinase is essential for the centrosomal localization of TACC2. (PubMed id 15304323)^{1, 9} Dou Z.... Yao X. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7272	HGNC: 12401	AceView: TTK	Ensembl:ENSG00000112742	euGenes: HUgn7272
ECgene: TTK	Kegg: 7272	H-InvDB: TTK

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TTK	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TTK	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TTK gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TTK gene:
Search GeneIP for patents involving TTK

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

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