Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TTK Gene

protein-coding   GIFtS: 68
GCID: GC06P080713

TTK Protein Kinase

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
TTK Protein Kinase1 2     ESK2
MPS1L12 3 5     MPH12
PYT2 3 5     Dual Specificity Protein Kinase TTK2
Cancer/Testis Antigen 961 2     Monopolar Spindle 1-Like 12
Phosphotyrosine Picked Threonine-Protein Kinase2 3     Phosphotyrosine Picked Threonine Kinase2
MPS12 3     EC 2.7.12.13
CT962     

External Ids:    HGNC: 124011   Entrez Gene: 72722   Ensembl: ENSG000001127427   OMIM: 6040925   UniProtKB: P339813   

Export aliases for TTK gene to outside databases

Previous GC identifers: GC06P080657 GC06P080709 GC06P080771 GC06P077937


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TTK Gene:
This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and
threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the
centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic
checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this
protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Nov 2009)

GeneCards Summary for TTK Gene:
TTK (TTK protein kinase) is a protein-coding gene. GO annotations related to this gene include protein tyrosine kinase activity and identical protein binding. An important paralog of this gene is TLK2.

UniProtKB/Swiss-Prot: TTK_HUMAN, P33981
Function: Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation.
Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the
centromere, and for the mitotic checkpoint

Gene Wiki entry for TTK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TTK gene promoter:
         NF-YA   Nkx2-5   CBF-C   FOXL1   CBF-A   CBF-B   CP1A   CP1C   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TTK promoter sequence
   Search Chromatin IP Primers for TTK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q13-q21   Ensembl cytogenetic band:  6q14.1   HGNC cytogenetic band: 6q13-q21

TTK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTK gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P080713:  view genomic region     (about GC identifiers)

Start:
80,713,604 bp from pter      End:
80,752,244 bp from pter
Size:
38,641 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TTK_HUMAN, P33981 (See protein sequence)
Recommended Name: Dual specificity protein kinase TTK  
Size: 857 amino acids; 97072 Da
Subunit: Interacts with TPR; the interactions occurs in a microtubule-independent manner
Sequence caution: Sequence=AAA61239.1; Type=Erroneous initiation; Sequence=CAB87580.1; Type=Erroneous initiation;
Selected PDB 3D structures from and Proteopedia for TTK (see all 25):
2X9E (3D)        2ZMC (3D)        2ZMD (3D)        3CEK (3D)        3DBQ (3D)        3GFW (3D)    
Secondary accessions: A8K8U5 B2RDW2 E1P543 Q15272 Q5TCS0 Q9BW51 Q9NTM0
Alternative splicing: 2 isoforms:  P33981-1   P33981-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TTK: NX_P33981

Explore proteomics data for TTK at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys19, Lys86, Lys434, Lys452, Lys538, Lys810, Lys830
  • Modification sites at PhosphoSitePlus

  • See TTK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001160163.1  NP_003309.2  

    ENSEMBL proteins: 
     ENSP00000422936   ENSP00000230510   ENSP00000358813   ENSP00000421406   ENSP00000424851  
     ENSP00000421636   ENSP00000427483  

    TTK Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TTK
    OriGene Protein Over-expression Lysate for TTK
    OriGene MassSpec for TTK
    OriGene Custom Protein Services for TTK
    GenScript Custom Purified and Recombinant Proteins Services for TTK
    Novus Biologicals TTK Proteins
    Novus Biologicals TTK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TTK

     
    Search eBioscience for Proteins for TTK 

    TTK Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TTK
    R&D Systems Antibodies for TTK
    Cell Signaling Technology (CST) Antibodies for TTK 
    OriGene Antibodies for TTK
    OriGene Custom Antibody Services for TTK
    Novus Biologicals TTK Antibodies
    Abcam antibodies for TTK
    Cloud-Clone Corp. Antibodies for TTK
    ThermoFisher Antibody for TTK
    LSBio Antibodies in human, mouse, rat for TTK

    TTK Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TTK
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TTK
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TTK
    Cloud-Clone Corp. CLIAs for TTK
    Search eBioscience for ELISAs for TTK 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: TTK protein kinase
    TTK family

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR027084 Dual_sp_prot_kinse_Ttk
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry P33981

    ProtoNet protein and cluster: P33981

    UniProtKB/Swiss-Prot: TTK_HUMAN, P33981
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with TTK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTK_HUMAN, P33981
    Function: Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation.
    Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the
    centromere, and for the mitotic checkpoint
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by the ATP-competitive kinase inhibitor, SP600125

         Genatlas biochemistry entry for TTK:
    TTK serine/threonine kinase,expressed in testis and thymus,yeast Mps1and CDC20/Slp1 homolog,functioning at the
    mitotic spindle checkpoint

         Enzyme Number (IUBMB): EC 2.7.12.11

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI19273613
         
    Find genes that share ontologies with TTK           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for TTK:
     Decreased focal adhesion (FA)   Decreased number of cells in m  Decreased substrate adherent c  Decreased viability 
     Increased cell death HMECs cel  Increased viability with 4OH t  Upregulation of Wnt/beta-caten 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ttk):
     cellular  reproductive system 

    Find genes that share phenotypes with TTK           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TTK
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TTK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TTK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TTK

    miRNA
    Products:
        
    miRTarBase miRNAs that target TTK:
    hsa-mir-192-5p (MIRT026393), hsa-mir-215-5p (MIRT024895), hsa-mir-376a-3p (MIRT019665), hsa-mir-376a-5p (MIRT001746)

    Block miRNA regulation of human, mouse, rat TTK using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TTK:
    hsa-miR-140-5p hsa-miR-582-5p hsa-miR-212 hsa-miR-132 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidTTK 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TTK
    Predesigned siRNA for gene silencing in human, mouse, rat TTK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TTK

    Clone
    Products:
         
    OriGene clones in human, mouse for TTK (see all 14)
    OriGene ORF clones in mouse, rat for TTK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TTK (NM_003318)
    Sino Biological Human cDNA Clone for TTK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TTK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTK
    Addgene plasmids for TTK 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TTK
    Browse ESI BIO Cell Lines and PureStem Progenitors for TTK 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTK

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10367) for TTK 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol2
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005819spindle TAS10366450

    Find genes that share ontologies with TTK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TTK About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    DNA Damage0.32
    2Cell cycle
    Cell cycle0.59
    3RB in Cancer
    RB in Cancer


    Find genes that share SuperPaths with TTK           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for TTK
        Cell Cycle / Checkpoint Control
    DNA Damage

    1 BioSystems Pathway for TTK
        RB in Cancer



    1 Kegg Pathway  (Kegg details for TTK):
        Cell cycle

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TTK
    Interactions:

        GeneGlobe Interaction Network for TTK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TTK (P339812, 3 ENSP000002305104) via UniProtKB, MINT, STRING, and/or I2D (see all 675)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000232575P074372, 3, ENSP000004100714MINT-7945693 MINT-50598 I2D: score=2 STRING: ENSP00000410071
    ENSG00000183311P074372, 3MINT-7945693 MINT-50598 I2D: score=2 
    ENSG00000224156P074372, 3MINT-7945693 MINT-50598 I2D: score=2 
    ENSG00000227739P074372, 3MINT-7945693 MINT-50598 I2D: score=2 
    ENSG00000229684P074372, 3MINT-7945693 MINT-50598 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007051spindle organization TAS10366450
    GO:0007052mitotic spindle organization TAS7737118
    GO:0007094mitotic spindle assembly checkpoint TAS10366450
    GO:0008284positive regulation of cell proliferation TAS1639825

    Find genes that share ontologies with TTK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TTK

    1 DrugBank Compound for TTK    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One-- --target--10592235

    3 Novoseek inferred chemical compound relationships for TTK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 29.6 5 8254211 (2), 17981789 (1), 11393570 (1), 1639825 (1)
    threonine 25.9 5 1639825 (2), 8254211 (2)
    serine 10.8 5 1639825 (2), 8254211 (2)



    Find genes that share compounds with TTK           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TTK gene (2 alternative transcripts): 
    NM_001166691.1  NM_003318.4  

    Unigene Cluster for TTK:

    TTK protein kinase
    Hs.169840  [show with all ESTs]
    Unigene Representative Sequence: NM_001166691
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509894 ENST00000230510(uc003pjb.4) ENST00000369798(uc003pjc.3)
    ENST00000509313 ENST00000502580 ENST00000511260 ENST00000504040 ENST00000430061
    ENST00000515751 ENST00000504590
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TTK using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TTK:
    hsa-miR-140-5p hsa-miR-582-5p hsa-miR-212 hsa-miR-132 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidTTK 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TTK
    Predesigned siRNA for gene silencing in human, mouse, rat TTK
    Clone
    Products:
         
    OriGene clones in human, mouse for TTK (see all 14)
    OriGene ORF clones in mouse, rat for TTK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TTK (NM_003318)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TTK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTK
    Addgene plasmids for TTK 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TTK
    OriGene qSTAR qPCR primer pairs in human, mouse for TTK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TTK
      QuantiTect SYBR Green Assays in human, mouse, rat TTK
      QuantiFast Probe-based Assays in human, mouse, rat TTK
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10367) for TTK 

    Additional mRNA sequence: 

    AK095599.1 AK292460.1 AK315696.1 BC000633.2 BC032858.2 X70500.1 

    9 DOTS entries:

    DT.100019275  DT.92030142  DT.212400  DT.92427570  DT.92427574  DT.100670812  DT.121322298  DT.95367140 
    DT.99957561 

    Selected AceView cDNA sequences (see all 101):

    BM905869 BQ420892 AU132784 AK095599 AU118786 CR624652 AI973225 AU119487 
    AA470077 AA993767 BQ929926 AU124846 AA421620 AU136576 BM836070 AA122377 
    BP350490 BU508578 BC032858 BE885880 BF965658 AU132533 AI472200 NM_003318 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TTK (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^
    SP1:                    -     -           -                                                                                                                     
    SP2:                                      -                                                                                                                     
    SP3:                                                                                                                                                        -   
    SP4:                    -     -                                                                                                                                 
    SP5:                          -           -                                                                                                                     

    ExUns: 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24
    SP1:              -                                             
    SP2:                                                            
    SP3:  -           -                                             
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for TTK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TTK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTGAATT
    TTK Expression
    About this image


    TTK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Pre-Sertoli Cells Testis Cord
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Bone (Muscoskeletal System)
             Bone Marrow
    TTK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TTK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.169840

    UniProtKB/Swiss-Prot: TTK_HUMAN, P33981
    Tissue specificity: Present in rapidly proliferating cell lines

        Custom PCR Arrays for TTK
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TTK
    OriGene qSTAR qPCR primer pairs in human, mouse for TTK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TTK
    QuantiTect SYBR Green Assays in human, mouse, rat TTK
    QuantiFast Probe-based Assays in human, mouse, rat TTK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TTK gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttk1 , 5 Ttk protein kinase1, 5 81.2(n)1
    76.27(a)1
      9 (45.61 cM)5
    221371  NM_009445.21  NP_033471.21 
     838346895 
    chicken
    (Gallus gallus)
    Aves TTK1 TTK protein kinase 70.02(n)
    64.11(a)
      421849  XM_419867.4  XP_419867.4 
    lizard
    (Anolis carolinensis)
    Reptilia TTK6
    TTK protein kinase
    58(a)
    1 ↔ 1
    1(199248885-199310737)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3982192 Mps1/TTK 76.05(n)    AF250290.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mps12 monopolar spindle 1 72.4(n)   317763  AF488735.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG76433 protein amino acid phosphorylation
    protein kinase
    44(a)   90C1   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MPS1(YDL028C)4 Dual-specificity kinase required for spindle pole body more   --   4(403291-400997) 851533  NP_010256.1 


    ENSEMBL Gene Tree for TTK (if available)
    TreeFam Gene Tree for TTK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TTK gene
    TLK22  TLK12  

    Find genes that share paralogs with TTK           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TTK
    PGOHUM00000250931


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TTK (see all 945)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2402121,2
    C,F,O,A,H--80712351(+) cttacG/Attgtt 2 -- us2k113Minor allele frequency- A:0.37MN NS EA WA NA CSA 968
    rs2402131,2
    C,F,A,H--80712416(+) AAAGAG/AAGCAA 2 -- us2k1 tfbs3 trp311Minor allele frequency- A:0.37NS EA WA NA CSA 718
    rs1902776981,2
    --80712438(+) TTAAAA/TAGTTT 2 -- us2k10--------
    rs2402141,2
    C,A,H--80712498(+) ttaatC/Aaatta 2 -- us2k1 tfbs35Minor allele frequency- A:0.45NA WA EA 362
    rs793639161,2
    C,F--80712748(+) TCAGTT/CAAGTG 2 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1408011581,2
    C--80712841(+) ACTCAA/GTCTGC 2 -- us2k10--------
    rs737479361,2
    C--80712899(+) AAAAAA/GTTTAA 2 -- us2k13Minor allele frequency- G:0.07WA EA 240
    rs2402151,2
    C,F,H--80712939(+) taaaaA/Caaaca 2 -- us2k15Minor allele frequency- C:0.10NS EA WA 532
    rs1496935051,2
    --80712959(+) AGGAAC/GATCAG 2 -- us2k10--------
    rs117543351,2
    C,F,A,H--80713014(+) tgtaaG/Atgaag 2 -- us2k18Minor allele frequency- A:0.01NS EA NA 546

    HapMap Linkage Disequilibrium report for TTK (80713604 - 80752244 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TTK:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv886306CNV Loss21882294
    dgv6931n71CNV Loss21882294
    nsv5370CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TTK
    DNA2.0 Custom Variant and Variant Library Synthesis for TTK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604092    OMIM disorders: --


    Find genes that share disorders with TTK           About GenesLikeMe

    3 Novoseek inferred disease relationships for TTK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 28.3 6 20057968 (2), 1639825 (1), 8254211 (1), 17439397 (1) (see all 5)
    breast cancer 9.46 6 17210994 (2), 17268814 (1), 16428479 (1)
    tumors 0 1 17981789 (1)

    Genetic Association Database (GAD): TTK
    Human Genome Epidemiology (HuGE) Navigator: TTK (4 documents)

    Export disorders for TTK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TTK gene, integrated from 10 sources (see all 110):
    (articles sorted by number of sources associating them with TTK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of TTK, a novel human protein kinase, is associated with cell proliferation. (PubMed id 1639825)1, 2, 3, 9 Mills G.B.... Hogg D. (J. Biol. Chem. 1992)
    2. Mutational analysis of TTK gene in gastric and colorectal cancers with microsatellite instability. (PubMed id 20057968)1, 4, 9 Ahn C.H....Lee S.H. (Cancer Res Treat 2009)
    3. Breast cancer risk associated with genotypic polymorphism of the mitotic checkpoint genes: a multigenic study on cancer susceptibility. (PubMed id 17210994)1, 4, 9 Lo Y.L....Shen C.Y. (Carcinogenesis 2007)
    4. Genetic variation in the major mitotic checkpoint genes does not affect familial breast cancer risk. (PubMed id 17268814)1, 4, 9 Vaclavicek A....FAPrsti A. (Breast Cancer Res. Treat. 2007)
    5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    6. Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator. (PubMed id 19273613)1, 2 Lince-Faria M.... Maiato H. (J. Cell Biol. 2009)
    7. Structural and mechanistic insights into Mps1 kinase activation. (PubMed id 19120698)1, 2 Wang W.... Liu X. (J. Cell. Mol. Med. 2009)
    8. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. (PubMed id 18243099)1, 2 Jelluma N.... Kops G.J.P.L. (Cell 2008)
    9. Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125. (PubMed id 18480048)1, 2 Chu M.L.H.... Tabernero L. (J. Biol. Chem. 2008)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7272 HGNC: 12401 AceView: TTK Ensembl:ENSG00000112742 euGenes: HUgn7272
    ECgene: TTK Kegg: 7272 H-InvDB: TTK

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TTK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TTK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TTK gene:
    Search GeneIP for patents involving TTK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of TTK
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for TTK (TTK)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TTK   OriGene RNAi products in human, mouse, rat for TTK  
     OriGene qPCR primer pairs and template standards for TTK   OriGene Protein Over-expression Lysate for TTK  
     OriGene MassSpec something-or-other for TTK   OriGene clones in human, mouse for TTK  
     OriGene qSTAR qPCR primer pairs in human, mouse for TTK   OriGene Purified Protein for TTK  
     OriGene ORF clones in mouse, rat for TTK   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TTK   OriGene Custom Protein Services for TTK  

     
     
     Block miRNA regulation of human, mouse, rat TTK using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TTK
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTK Predesigned siRNA for gene silencing in human, mouse, rat TTK
     QuantiFast Probe-based Assays in human, mouse, rat TTK QuantiTect SYBR Green Assays in human, mouse, rat TTK
     Custom PCR Arrays for TTK Search Chromatin IP Primers for TTK
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TTK  GeneGlobe Interaction Network for TTK
     Regulatory tfbs in TTK promoter
     GenScript Custom Purified and Recombinant Proteins Services for TTK GenScript cDNA clones with any tag delivered in your preferred vector for TTK
     GenScript Custom Assay Services for TTK GenScript Custom overexpressing Cell Line Services for TTK
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for TTK 

     Search Tocris compounds for TTK
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for TTK
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TTK antibodies
     TTK proteins
     TTK lysates
     Antibodies for TTK
     See all of Abcam's Antibodies, Kits and Proteins for TTK
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TTK
     Antibodies for TTK
     ELISAs for TTK
     CLIAs for TTK



     Browse ESI BIO Cell Lines and PureStem Progenitors for TTK
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTK
     SwitchGear 3'UTR luciferase reporter plasmids for TTK
     SwitchGear Promoter luciferase reporter plasmids for TTK
     ThermoFisher Antibody for TTK
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTK
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TTK
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TTK
     LSBio Antibodies in human, mouse, rat for TTK
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for TTK
      Search eBioscience for proteins for TTK
      Search eBioscience for elisas for TTK
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TTK gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4