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TTI2 Gene

protein-coding   GIFtS: 44
GCID: GC08M033330

TELO2 Interacting Protein 2

(Previous names: chromosome 8 open reading frame 41, Tel2 interacting protein...)
(Previous symbol: C8orf41)
  See TTI2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TELO2 Interacting Protein 21 2     Tel2 Interacting Protein 2 Homolog (S. Pombe)1
C8orf411 2 3 5     Tel2 Interacting Protein 2 Homolog2
MRT392 5     TELO2-Interacting Protein 22
Chromosome 8 Open Reading Frame 411     

External Ids:    HGNC: 262621   Entrez Gene: 801852   Ensembl: ENSG000001296967   OMIM: 6144265   UniProtKB: Q6NXR43   

Export aliases for TTI2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TTI2 Gene:
This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT)
which also includes telomere length regulation protein and TELO2 interacting protein 1. The TTT complex is
involved in cellular resistance to DNA damage stresses and may act as a regulator of
phosphoinositide-3-kinase-related protein kinase (PIKK) abundance. (provided by RefSeq, May 2013)

GeneCards Summary for TTI2 Gene:
TTI2 (TELO2 interacting protein 2) is a protein-coding gene. Diseases associated with TTI2 include mental retardation, autosomal recessive 39, and temtamy preaxial brachydactyly syndrome.

UniProtKB/Swiss-Prot: TTI2_HUMAN, Q6NXR4
Function: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize
protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT
complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet
(UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of
newly synthesized PIKKs




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_167187.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TTI2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TTI2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12   Ensembl cytogenetic band:  8p12   HGNC cytogenetic band: 8p12

TTI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTI2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M033330:  view genomic region     (about GC identifiers)

Start:
33,330,904 bp from pter      End:
33,371,119 bp from pter
Size:
40,216 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TTI2_HUMAN, Q6NXR4 (See protein sequence)
Recommended Name: TELO2-interacting protein 2  
Size: 508 amino acids; 56915 Da
Subunit: Component of the TTT complex composed of TELO2, TTI1 and TTI2. Interacts with TELO2 and TTI1
Secondary accessions: D3DSV7 Q96IM2 Q9H5N4

Explore the universe of human proteins at neXtProt for TTI2: NX_Q6NXR4

Explore proteomics data for TTI2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys479, Lys488, Lys495
  • Modification sites at PhosphoSitePlus

  • See TTI2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001095871.1  NP_001252510.1  NP_079391.2  

    ENSEMBL proteins: 
     ENSP00000353971   ENSP00000411169   ENSP00000428401   ENSP00000428569  

    TTI2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TTI2

     
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    antibodies-online proteins for TTI2 (2 products) 

     
    antibodies-online peptides for TTI2

    TTI2 Antibody Products:

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    antibodies-online antibodies for TTI2 (3 products) 

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    Cloud-Clone Corp. ELISAs for TTI2
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR018870 DUF2454
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q6NXR4

    ProtoNet protein and cluster: Q6NXR4

    UniProtKB/Swiss-Prot: TTI2_HUMAN, Q6NXR4
    Similarity: Belongs to the TTI2 family


    Find genes that share domains with TTI2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTI2_HUMAN, Q6NXR4
    Function: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize
    protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT
    complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet
    (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of
    newly synthesized PIKKs

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
         
    Find genes that share ontologies with TTI2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TTI2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TTI2

    miRNA
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    miRTarBase miRNAs that target TTI2:
    hsa-mir-26b-5p (MIRT029659), hsa-mir-186-5p (MIRT045214)

    Block miRNA regulation of human, mouse, rat TTI2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TTI2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TTI2
    Interactions:

        Search GeneGlobe Interaction Network for TTI2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for TTI2 (Q6NXR43 ENSP000003539714) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKDCP785273, ENSP000003134204I2D: score=1 STRING: ENSP00000313420
    RUVBL2Q9Y2303, ENSP000002214134I2D: score=1 STRING: ENSP00000221413
    TELO2Q9Y4R83, ENSP000002623194I2D: score=1 STRING: ENSP00000262319
    TTI1O431563, ENSP000003625464I2D: score=1 STRING: ENSP00000362546
    HSP90AA1P079003, ENSP000003351534I2D: score=1 STRING: ENSP00000335153
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TTI2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TTI2 gene (3 alternative transcripts): 
    NM_001102401.2  NM_001265581.1  NM_025115.3  

    Unigene Cluster for TTI2:

    TELO2 interacting protein 2
    Hs.77135  [show with all ESTs]
    Unigene Representative Sequence: NM_025115
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000519356(uc010lvu.1) ENST00000360742(uc003xjn.1 uc003xjl.4)
    ENST00000431156(uc003xjm.4) ENST00000520636 ENST00000523305
    miRNA
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    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for TTI2
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      QuantiTect SYBR Green Assays in human, mouse, rat TTI2
      QuantiFast Probe-based Assays in human, mouse, rat TTI2

    Additional mRNA sequence: 

    AK026916.1 AK308918.1 BC007387.2 BC066935.1 BX648410.1 

    7 DOTS entries:

    DT.40116397  DT.97840279  DT.121489858  DT.417148  DT.100762942  DT.100776654  DT.102831216 

    Selected AceView cDNA sequences (see all 110):

    AI914967 AA808673 BI914526 BC066935 CD742703 AL530920 CR613354 BU629396 
    BM550924 CR598770 AA829822 AW665777 CD517896 AA194856 CR609158 BE673408 
    BX648410 BP342854 AL530199 CB048387 BI914599 BG392521 BP370362 BM821946 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TTI2    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                                            
    SP2:                                            -               
    SP3:        -                                                   
    SP4:                                                            


    ECgene alternative splicing isoforms for TTI2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TTI2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAACATACTT
    TTI2 Expression
    About this image


    TTI2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    TTI2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TTI2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.77135
        Custom PCR Arrays for TTI2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTI2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TTI2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tti21 , 5 TELO2 interacting protein 21, 5 78.66(n)1
    72.73(a)1
      8 (18.03 cM)5
    2341381  NM_144927.31  NP_659176.21 
     311503165 
    chicken
    (Gallus gallus)
    Aves TTI21 chromosome 8 open reading frame 41 62.75(n)
    60.41(a)
      426923  XM_004947575.1  XP_004947632.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tti21 TELO2 interacting protein 2 57.37(n)
    55.15(a)
      100487242  XM_002932694.2  XP_002932740.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tti21 TELO2 interacting protein 2 50.46(n)
    44.56(a)
      100334230  XM_002663205.3  XP_002663251.1 


    ENSEMBL Gene Tree for TTI2 (if available)
    TreeFam Gene Tree for TTI2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TTI2 (see all 301)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0706714
    Mental retardation, autosomal recessive 39 (MRT39)4--see VAR_0706712 I N mis40--------
    rs1885261301,2
    C--33359332(+) TTTTCA/GGCTAT 3 -- int10--------
    rs625118861,2
    F--33359337(+) AGCTAC/TGCAAG 3 -- int11Minor allele frequency- T:0.50NA 2
    rs1921639701,2
    --33359388(+) GACACC/TTACCT 3 -- int10--------
    rs572550101,2
    C--33359497(+) CGCTCC/TGTCAC 3 -- int10--------
    rs357198341,2
    C--33359504(+) TCACCC/TAGTCT 3 -- int11Minor allele frequency- T:0.50NA 2
    rs26764201,2
    C,F,A,H--33359528(+) TCCATC/TGCACC 3 -- int115Minor allele frequency- T:0.30NS EA NA WA CSA 792
    rs1124258961,2
    C,F--33359576(+) ACTGCG/TTCAGC 3 -- int11Minor allele frequency- T:0.50CSA 2
    rs1397110931,2
    C--33359609(+) GGTGCA/GCGCCA 3 -- int10--------
    rs1847130341,2
    --33359610(+) GTGCGC/TGCCAC 3 -- int10--------

    HapMap Linkage Disequilibrium report for TTI2 (33330904 - 33371119 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TTI2: --
    Human Gene Mutation Database (HGMD): TTI2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TTI2
    DNA2.0 Custom Variant and Variant Library Synthesis for TTI2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614426   
    OMIM disorders: 615541  
    UniProtKB/Swiss-Prot: TTI2_HUMAN, Q6NXR4
  • Mental retardation, autosomal recessive 39 (MRT39) [MIM:615541]: A disorder characterized by
    significantly below average general intellectual functioning associated with impairments in adaptive behavior and
    manifested during the developmental period. MRT39 affected individuals show delayed psychomotor development,
    severe speech delay, short stature, kyphoscoliosis, and dysmorphic facial features. Behavioral abnormalities
    include hyperactivity, aggression, and stereotypic movements. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 2 diseases for TTI2:    
    About MalaCards
    mental retardation, autosomal recessive 39    temtamy preaxial brachydactyly syndrome


    Find genes that share disorders with TTI2           About GenesLikeMe


    Export disorders for TTI2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TTI2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with TTI2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. (PubMed id 20810650)1, 2, 3 Hurov K.E.... Elledge S.J. (Genes Dev. 2010)
    2. Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. (PubMed id 20801936)1, 2, 3 Takai H.... Pavletich N.P. (Genes Dev. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Mutation in TTI2 reveals a role for triple T complex in human brain development. (PubMed id 23956177)2 Langouet M....Colleaux L. (Hum. Mutat. 2013)
    6. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80185 HGNC: 26262 AceView: FLJ23263 Ensembl:ENSG00000129696 euGenes: HUgn80185
    ECgene: TTI2 H-InvDB: TTI2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TTI2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TTI2 gene:
    Search GeneIP for patents involving TTI2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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