TTI2 Gene
protein-coding GIFtS: 40
GCID: GC08M033330
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TELO2 interacting protein 2(Previous names: chromosome 8 open reading frame 41, Tel2 interacting protein...)
(Previous symbol: C8orf41)
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Aliases
for TTI2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TELO2 Interacting Protein 21 2 | | Tel2 Interacting Protein 2 Homolog (S. Pombe)1 | | C8orf411 2 3 | | Tel2 Interacting Protein 2 Homolog2 | | FLJ232631 | | TELO2-Interacting Protein 22 | | Chromosome 8 Open Reading Frame 411 | | |
Export aliases for TTI2 gene to outside databases |
Summaries
for TTI2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TTI2_HUMAN, Q6NXR4Function: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize proteinlevels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involvedin the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C(MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs
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Genomic Views
for TTI2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TTI2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TTI2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTI2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p12 Ensembl cytogenetic band: 8p12 HGNC cytogenetic band: 8p12TTI2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M033330: view genomic region
(about GC identifiers)
Start:
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33,330,904 bp from pter |
End:
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33,371,119 bp from pter |
Size:
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40,216 bases |
Orientation:
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minus strand |
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Proteins
for TTI2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TTI2_HUMAN, Q6NXR4 (See
protein sequence)Recommended Name: TELO2-interacting protein 2 Size: 508 amino acids; 56915 Da
Subunit: Component of the TTT complex composed of TELO2, TTI1 and TTI2. Interacts with TELO2 and TTI1
Secondary accessions: D3DSV7 Q96IM2 Q9H5N4Explore the universe of human proteins at neXtProt for TTI2: NX_Q6NXR4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6NXR4
TTI2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001095871.1 NP_001252510.1 NP_079391.2
ENSEMBL proteins: ENSP00000353971 ENSP00000411169 ENSP00000429257 ENSP00000428401 ENSP00000429838 ENSP00000428569
Human Recombinant Protein Products:
TTI2 Antibody Products:
Assay Products for TTI2: |
Protein
Domains /
Families
for TTI2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TTI2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6NXR4ProtoNet protein and cluster: Q6NXR4 UniProtKB/Swiss-Prot: TTI2_HUMAN, Q6NXR4Similarity: Belongs to the TTI2 family |
Function
for TTI2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TTI2_HUMAN, Q6NXR4Function: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize proteinlevels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involvedin the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C(MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTI2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTI2 |
|
Pathways & Interactions
for TTI2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTI2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/15 Interacting proteins for TTI2 (Q6NXR43 ENSP000003539714) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
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Drugs & Compounds
for TTI2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TTI2
Search CenterWatch for drugs/clinical trials and news about TTI2
|
Transcripts
for TTI2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TTI2 gene (3 alternative transcripts): NM_001102401.2 NM_001265581.1 NM_025115.3 Unigene Cluster for TTI2: TELO2 interacting protein 2 Hs.77135 [show with all ESTs]Unigene Representative Sequence: NM_0251157 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000519356(uc010lvu.1) ENST00000360742(uc003xjn.1 uc003xjl.4)
ENST00000431156(uc003xjm.4) ENST00000522668 ENST00000520636 ENST00000520397
ENST00000523305
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTI2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTI2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for TTI2 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTI2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTI2 |
Additional cDNA sequence: AK026916.1 AK308918.1 BC007387.2 BC066935.1 BX648410.1 7 DOTS entries: DT.40116397 DT.97840279 DT.121489858 DT.417148 DT.100762942 DT.100776654 DT.102831216 24/110 AceView cDNA sequences (see all 110): AA829822 CR598770 BE673408 CR609158 BU629396 AA194856 BC066935 AI914967 CD517896 AL530920 AW665777 CR613354 BX648410 CD742703 AA808673 BI914526 BM550924 BE743064 BP370362 AA235279 AA302602 CB048387 AA928069 BG772307
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TTI2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
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| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TTI2
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Expression
for TTI2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TTI2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAACATACTT
About this image
See TTI2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TTI2
SOURCE GeneReport for Unigene cluster: Hs.77135
SABiosciences Custom PCR Arrays for TTI2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTI2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TTI2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTI2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTI2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTI2 |
Orthologs
for TTI2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TTI2 gene from 3/13 species (see all 13) About this table
ENSEMBL Gene Tree for TTI2 (if available)
TreeFam Gene Tree for TTI2 (if available) |
Paralogs
for TTI2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TTI2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TTI2 (33330904 - 33371119 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TTI2: --
Human Gene Mutation Database (HGMD): TTI2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTI2 |
|
Disorders
/ Diseases
for TTI2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TTI2 for disorders About MalaCards
TTI2 for disorders About GeneDecksing
OMIM gene information: 614426
OMIM disorders: --
Export disorders for TTI2 gene to outside databases
|
Publications
for TTI2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TTI2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with TTI2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A genetic screen identifies the Triple T complex requ ired for DNA damage signaling and ATM and ATR stability. (PubMed id 20810650)1, 2, 3 Hurov K.E....Elledge S.J. (2010)
- Tel2 structure and function in the Hsp90-dependent ma turation of mTOR and ATR complexes. (PubMed id 20801936)1, 2, 3 Takai H....Pavletich N.P. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1 Jeronimo C.... Coulombe B. (2007)
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External Searches for TTI2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TTI2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TTI2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TTI2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TTI2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TTI2 gene:
Search GeneIP for patents involving TTI2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TTI2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 |  |  |  | |
| | | | Search Tocris compounds for TTI2 |
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 | | | TTI2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTI2 |
|  |  |  | | | | Search ThermoFisher Antibodies for TTI2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTI2 |
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