Aliases for TTI1 Gene
External Ids for TTI1 Gene
Previous HGNC Symbols for TTI1 Gene
Previous GeneCards Identifiers for TTI1 Gene
GeneCards Summary for TTI1 Gene
TTI1 (TELO2 Interacting Protein 1) is a Protein Coding gene.
UniProtKB/Swiss-Prot for TTI1 Gene
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.