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TTI1 Gene

protein-coding   GIFtS: 52
GCID: GC20M036612

TELO2 Interacting Protein 1

(Previous names: KIAA0406, Tel2 interacting protein 1 homolog (S. pombe))
(Previous symbol: KIAA0406)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TELO2 Interacting Protein 11 2     Tel Two Interacting Protein 12
KIAA04061 2 3 5     Tel2 Interacting Protein 1 Homolog2
Nonsense Mediated MRNA Decay Factor (C. Elegans)1     TEL2-Interacting Protein 1 Homolog2
Smg-10 Homolog1     TELO2-Interacting Protein 1 Homolog2
Tel2 Interacting Protein 1 Homolog (S. Pombe)1     SMG103
smg-102     Protein SMG103
Smg-10 Homolog, Nonsense Mediated MRNA Decay Factor2     

External Ids:    HGNC: 290291   Entrez Gene: 96752   Ensembl: ENSG000001014077   OMIM: 6144255   UniProtKB: O431563   

Export aliases for TTI1 gene to outside databases

Previous GC identifer: GC20M033347


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TTI1 Gene:
TTI1 (TELO2 interacting protein 1) is a protein-coding gene. Diseases associated with TTI1 include multiple myeloma, and myeloma.

UniProtKB/Swiss-Prot: TTI1_HUMAN, O43156
Function: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize
protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT
complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet
(UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of
newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes,
which regulate cell growth and survival in response to nutrient and hormonal signals




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TTI1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTI1 promoter sequence
   Search Chromatin IP Primers for TTI1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.23

TTI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTI1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M036612:  view genomic region     (about GC identifiers)

Start:
36,611,409 bp from pter      End:
36,661,870 bp from pter
Size:
50,462 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TTI1_HUMAN, O43156 (See protein sequence)
Recommended Name: TELO2-interacting protein 1 homolog  
Size: 1089 amino acids; 122069 Da
Subunit: Component of the TTT complex composed of TELO2, TTI1 and TTI2. Interacts with ATM, ATR, MTOR, PRKDC,
SMG1, TELO2, TRRAP AND TTI2. Component of the mTORC1 and mTORC2 complexes
Sequence caution: Sequence=BAA23702.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q5JX67 Q96A38 Q9BR47 Q9H4K0

Explore the universe of human proteins at neXtProt for TTI1: NX_O43156

Explore proteomics data for TTI1 at MOPED

Post-translational modifications: 

  • Phosphorylated at Ser-828 by CK2 following growth factor deprivation, leading to its subsequent ubiquitination by
    the SCF(FBXO9) complex. Phosphorylation by CK2 only takes place when TELO2 is bound to mTORC1, not mTORC2;
    leading to selective ubiquitination of mTORC1-associated protein1
  • Ubiquitinated by the SCF(FBXO9) complex following phosphorylation by CK2 in response to growth factor deprivation,
    leading to its degradation by the proteasome. Only mTORC1-associated protein is ubiquitinated and degraded,
    leading to selective inactivation of mTORC1 to restrain cell growth and protein translation, while mTORC2 is
    activated due to the relief of feedback inhibition by mTORC11
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TTI1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055472.1  
    ENSEMBL proteins: 
     ENSP00000362547   ENSP00000362546   ENSP00000407270  

    TTI1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for TTI1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold
     IPR016441 UCP005250

    Graphical View of Domain Structure for InterPro Entry O43156

    ProtoNet protein and cluster: O43156

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: TTI1_HUMAN, O43156
    Similarity: Belongs to the tti1 family


    TTI1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTI1_HUMAN, O43156
    Function: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize
    protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT
    complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet
    (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of
    newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes,
    which regulate cell growth and survival in response to nutrient and hormonal signals

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI--
         
    TTI1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TTI1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TTI1
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    miRNA
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    miRTarBase miRNAs that target TTI1:
    hsa-mir-98-5p (MIRT027488)

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    5 qRT-PCR Assays for microRNAs that regulate TTI1:
    hsa-miR-205 hsa-miR-576-5p hsa-miR-4263 hsa-miR-369-5p hsa-miR-147
    SwitchGear 3'UTR luciferase reporter plasmidTTI1 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTI1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TTI1_HUMAN, O43156: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0031931TORC1 complex IDA--
    GO:0031932TORC2 complex IDA--

    TTI1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TTI1
    Interactions:

        Search GeneGlobe Interaction Network for TTI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TTI1 (O431561, 3 ENSP000003625464) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TELO2Q9Y4R81, 3, ENSP000002623194EBI-1055680,EBI-1043674 I2D: score=1 STRING: ENSP00000262319
    ATMQ133151, 3, ENSP000002786164EBI-1055680,EBI-495465 I2D: score=1 STRING: ENSP00000278616
    ATRQ135351, 3, ENSP000003437414EBI-1055680,EBI-968983 I2D: score=1 STRING: ENSP00000343741
    PRKDCP785273, ENSP000003134204I2D: score=1 STRING: ENSP00000313420
    PTP4A3O753653, ENSP000003322744I2D: score=1 STRING: ENSP00000332274
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032006regulation of TOR signaling IMP--

    TTI1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TTI1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TTI1 gene: 
    NM_014657.1  

    Unigene Cluster for TTI1:

    TELO2 interacting protein 1
    Hs.655481  [show with all ESTs]
    Unigene Representative Sequence: BC013121
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373448(uc002xhl.3) ENST00000373447(uc002xhm.3) ENST00000473288
    ENST00000487362 ENST00000449821
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate TTI1:
    hsa-miR-205 hsa-miR-576-5p hsa-miR-4263 hsa-miR-369-5p hsa-miR-147
    SwitchGear 3'UTR luciferase reporter plasmidTTI1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TTI1
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    GenScript: all cDNA clones in your preferred vector: TTI1 (NM_014657)
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    Primer
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    OriGene qPCR primer pairs and template standards for TTI1
    OriGene qSTAR qPCR primer pairs in human, mouse for TTI1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TTI1
      QuantiTect SYBR Green Assays in human, mouse, rat TTI1
      Search QuantiFast Probe-based Assays in human, mouse, rat TTI1

    Additional mRNA sequence: 

    AB007866.2 AK095451.1 AK308164.1 BC013121.1 BC013755.1 BC107778.1 BC131759.1 

    8 DOTS entries:

    DT.101961860  DT.100694288  DT.212821  DT.100027212  DT.91687949  DT.120818872  DT.100684749  DT.95217085 

    Selected AceView cDNA sequences (see all 140):

    CR596340 BM464983 BE883532 AL559273 AK093690 BU172334 BU170769 AI601235 
    BC013755 BC013121 CR607862 AA355808 CB125949 BQ064449 AW294732 NM_014657 
    BX482228 BU684997 AB007866 AX748262 CB164765 BU539305 AA346191 BX279765 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TTI1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                              -                 -                           
    SP2:              -     -     -     -     -     -                 -                 -                           
    SP3:                          -                                                                                 
    SP4:                                                                                                            
    SP5:              -                                                                                             


    ECgene alternative splicing isoforms for TTI1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TTI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACGTGATGG
    TTI1 Expression
    About this image

    TTI1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TTI1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655481

    UniProtKB/Swiss-Prot: TTI1_HUMAN, O43156
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TTI1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tti11 , 5 TELO2 interacting protein 11, 5 85.42(n)1
    85.15(a)1
      2 (78.68 cM)5
    754251  NM_029282.11  NP_083558.11 
     1579818035 
    chicken
    (Gallus gallus)
    Aves LOC1017496341 TELO2-interacting protein 1 homolog 64.11(n)
    60.98(a)
      101749634  XM_004947276.1  XP_004947333.1 
    lizard
    (Anolis carolinensis)
    Reptilia TTI16
    TELO2 interacting protein 1
    62(a)
    1 ↔ 1
    GL343572.1(81680-117765)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tti11 TELO2 interacting protein 1 53.96(n)
    48.76(a)
      100124746  NM_001102727.1  NP_001096197.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tti11 TELO2 interacting protein 1 57.01(n)
    55.56(a)
      570077  XM_693510.6  XP_698602.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG169081 CG16908 39.49(n)
    23.31(a)
      41189  NM_141680.2  NP_649937.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TTI1(YKL033W)4 Putative protein of unknown function; subunit of the more   --   11(375456-378572) 853834  NP_012892.1 


    ENSEMBL Gene Tree for TTI1 (if available)
    TreeFam Gene Tree for TTI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TTI1 gene
    2 SIMAP similar genes for TTI1 using alignment to 1 protein entry:     TTI1_HUMAN:
    KIAA0406    Tti1

    TTI1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TTI1 (see all 1104)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs356979651,2
    C,F--33347018(+) GAGGGG/TGAGAT 1 -- int14Minor allele frequency- T:0.10NA EA 244
    rs1907760001,2
    --33347115(+) ATTTTA/TAAAAA 1 -- int10--------
    rs1816989991,2
    --33347198(+) TCCGTG/TTGTTT 1 -- ut310--------
    rs1444248861,2
    C--33347293(+) CCTCT-/TGTGTGT 1 -- ut310--------
    rs750954781,2
    C--33347298(+) TGTGTG/ATGTGT 1 -- ut312Minor allele frequency- A:0.05WA 120
    rs20361,2
    C,F,A,H--33347389(+) CTTGAA/CAACAC 1 -- ut31 ese314Minor allele frequency- C:0.25MN NA WA CSA EA 445
    rs20371,2
    C,F,A,H--33347406(+) TGAAAT/CATAAA 1 -- ut31 ese325Minor allele frequency- C:0.36MN NS EA NA WA CSA 2717
    rs559608401,2
    C,F--33347461(+) TGATCG/AATCAA 1 -- ut311Minor allele frequency- A:0.05NA 120
    rs1379967771,2
    C--33347572(+) GGGATC/TGGTGG 1 -- ut310--------
    rs1999676911,2
    C--33347599(+) GCAGGG/ATCACT 1 -- ut311Minor allele frequency- A:0.00EU 1003

    HapMap Linkage Disequilibrium report for TTI1 (36611409 - 36661870 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TTI1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669429CNV Deletion23128226
    nsv833972CNV Loss17160897
    nsv833971CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TTI1
    DNA2.0 Custom Variant and Variant Library Synthesis for TTI1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614425    OMIM disorders: --

    3 diseases for TTI1:    
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    multiple myeloma    myeloma    malaria


    TTI1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TTI1
    Human Genome Epidemiology (HuGE) Navigator: TTI1 (1 document)

    Export disorders for TTI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TTI1 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with TTI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly. (PubMed id 20427287)1, 2, 3 Kaizuka T.... Mizushima N. (J. Biol. Chem. 2010)
    2. AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay. (PubMed id 20371770)1, 2, 3 Izumi N.... Ohno S. (Sci. Signal. 2010)
    3. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1997)
    4. Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. (PubMed id 20801936)1, 2 Takai H.... Pavletich N.P. (Genes Dev. 2010)
    5. A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. (PubMed id 20810650)1, 2 Hurov K.E.... Elledge S.J. (Genes Dev. 2010)
    6. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    10. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9675 HGNC: 29029 AceView: KIAA0406 Ensembl:ENSG00000101407 euGenes: HUgn9675
    ECgene: TTI1 H-InvDB: TTI1

    (According to HUGE)
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    HUGE: KIAA0406

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TTI1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TTI1 gene:
    Search GeneIP for patents involving TTI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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