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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TTF2 Gene

protein-coding   GIFtS: 57
GCID: GC01P117602

transcription termination factor, RNA polymerase II
 Explore 119 diseases affiliated with
TTF2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TTF2    

Aliases
for TTF2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transcription Termination Factor, RNA Polymerase II1 2     Human Factor 22
HuF21 2 3     Lodestar Protein2
Lodestar Homolog2 3     Transcription Termination Factor 22
Transcription Release Factor 22 3     EC 3.6.4.-3
F22 3     EC 3.6.18
RNA Polymerase II Termination Factor2 3     

External Ids:    HGNC: 123981   Entrez Gene: 84582   Ensembl: ENSG000001168307   OMIM: 6047185   UniProtKB: Q9UNY43   

Export aliases for TTF2 gene to outside databases

Previous GC identifers: GC01P118062 GC01P116441 GC01P116750 GC01P116949 GC01P117314 GC01P117404 GC01P115461


Summaries
for TTF2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TTF2:
This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA
interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II
termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing
complexes, and plays a role in pre-mRNA splicing. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TTF2_HUMAN, Q9UNY4
Function: DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with
removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be
involved in pre-mRNA splicing

Gene Wiki entry for TTF2


Genomic Views
for TTF2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TTF2 gene promoter:
         AML1a   E2F-2   Arnt   GATA-2   AREB6   PPAR-alpha   E2F-1   E2F   RSRFC4   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TTF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TTF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22   Ensembl cytogenetic band:  1p13.1   HGNC cytogenetic band: 1p13.1

TTF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTF2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P117602:  view genomic region     (about GC identifiers)

Start:
 117,602,925 bp from pter      End:
 117,645,492 bp from pter
Size:
 42,568 bases      Orientation:
 plus strand

Proteins
for TTF2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TTF2_HUMAN, Q9UNY4 (See protein sequence)
Recommended Name: Transcription termination factor 2  
Size: 1162 amino acids; 129588 Da
Subunit: Interacts with CDC5L. Part of the spliceosome
Subcellular location: Cytoplasm. Nucleus. Note=Cytoplasmic during interphase. Relocates to the nucleus as cells enter
mitosis
Secondary accessions: A8K4Q2 O75921 Q5T2K7 Q5VVU8 Q8N6I8
Alternative splicing: 2 isoforms:  Q9UNY4-1   Q9UNY4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TTF2: NX_Q9UNY4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UNY4

    • 4 DME Specific Peptides for TTF2 (Q9UNY4)
     GGVGLNL  MGLGKTL  HQKQALAW  LADDMGLGKT 

    TTF2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003585.3  
    ENSEMBL proteins: 
     ENSP00000358478   ENSP00000408111  

    Human Recombinant Protein Products: 
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    Novus Biologicals TTF2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TTF2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005681spliceosomal complex IEA--
    GO:0005737cytoplasm IDA--
    GO:0008023transcription elongation factor complex TAS9748214


    TTF2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TTF2

    Protein Domains /
    Families
    for TTF2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TTF2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR010666 Znf_GRF
     IPR000330 SNF2_N
     IPR002464 DNA/RNA_helicase_DEAH_CS
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry Q9UNY4

    ProtoNet protein and cluster: Q9UNY4

    2 Blocks protein families:
    IPB000330 SNF2 related domain
    IPB002464 ATP-dependent helicase


    UniProtKB/Swiss-Prot: TTF2_HUMAN, Q9UNY4
    Similarity: Belongs to the SNF2/RAD54 helicase family
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Function
    for TTF2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TTF2_HUMAN, Q9UNY4
    Function: DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with
    removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be
    involved in pre-mRNA splicing

    Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.-1

    miRNA
    Products:            		miRTarBase miRNAs that target TTF2:
    hsa-mir-16 (MIRT001484)

    OriGene 3'-UTR Clone: TTF2
    Browse MicroRNA Expression Plasmids
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate TTF2:
    hsa-miR-1233 hsa-miR-187* hsa-miR-1283
    SwitchGear 3'UTR luciferase reporter plasmid: TTF2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTF2 (see all 7)
    OriGene shRNA RFP: TTF2
    OriGene siRNA: TTF2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTF2

    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTF2 

    Cell Line
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    Search LifeMap BioReagents cell lines for TTF2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTF2

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI17577209
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
    GO:0008094DNA-dependent ATPase activity TAS9748214


    TTF2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for TTF2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TSH signaling pathway
    		TSH signaling pathway1.00


    1 BioSystems Pathway for TTF2 
        TSH signaling pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TTF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/55 Interacting proteins for TTF2 (Q9UNY42, 3 ENSP000003584784) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKILP127572, 3MINT-61651 I2D: score=3 
    SMAD1Q157972, 3MINT-61994 I2D: score=3 
    SMAD7O151052, 3MINT-61814 I2D: score=3 
    DRAP1Q149193, ENSP000003078504I2D: score=4 STRING: ENSP00000307850
    PRDX4Q131623, ENSP000003686464I2D: score=4 STRING: ENSP00000368646
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006353DNA-dependent transcription, termination TAS9748214
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006369termination of RNA polymerase II transcription TAS9748214
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--


    TTF2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TTF2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TTF2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TTF2
    10/54 Novoseek chemical compound relationships for TTF2 gene (see all 54)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fluorometholone 35.2 1 11231772 (1)
    p00001 7.95 1 12574560 (1)
    diclofenac 5.39 1 11231772 (1)
    vegf 5.23 1 10719731 (1)
    hydrogen 4.43 4 10772027 (1), 8003984 (1), 17573366 (1)
    lead 4.26 2 11675273 (1)
    ethanol 3.94 2 11448083 (1), 18767820 (1)
    oxygen 3.43 4 11401875 (1), 12439804 (1), 7483052 (1)
    carbon 3.39 1 19534558 (1)
    creatinine 2.94 4 10402440 (2), 9782673 (1), 16041606 (1)

    Search CenterWatch for drugs/clinical trials and news about TTF2 

    Transcripts
    for TTF2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TTF2 gene: 
    NM_003594.3  

    Unigene Cluster for TTF2:

    Transcription termination factor, RNA polymerase II
    Hs.486818  [show with all ESTs]
    Unigene Representative Sequence: AB209845
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369466(uc001egy.3) ENST00000464062(uc001egx.1) ENST00000470935
    ENST00000469638 ENST00000492682 ENST00000463696 ENST00000427271 ENST00000480701


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TTF2
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate TTF2:
    hsa-miR-1233 hsa-miR-187* hsa-miR-1283
    SwitchGear 3'UTR luciferase reporter plasmid: TTF2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTF2 (see all 7)
    OriGene shRNA RFP: TTF2
    OriGene siRNA: TTF2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTF2
    Clone
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    GenScript: all cDNA clones in your preferred vector: TTF2 (NM_003594)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTF2 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TTF2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTF2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTF2

    Additional cDNA sequence: 

    AB209845.1 AF073771.1 AF080255.1 AK291017.1 BC015341.1 BC030058.1 

    9 DOTS entries:

    DT.422600  DT.100021292  DT.100725339  DT.100741902  DT.40305064  DT.92428854  DT.92428855  DT.92428856 
    DT.95268938 

    24/125 AceView cDNA sequences (see all 125):

    CA942532 BE079359 BQ070871 AI282709 BX281340 AL039234 BE273891 AL110457 
    AL555072 W95668 BE079391 AA227424 BU072168 AA278371 CA430266 AI282428 
    BE894873 NM_003594 AA327454 BE326897 CR614106 W95689 BU618360 BG433222 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TTF2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
    SP1:                                                                    -                                                                                       
    SP2:                                                                    -                                                                                       
    SP3:                                                                                            -                                                               


    ECgene alternative splicing isoforms for TTF2

    Expression
    for TTF2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TTF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACAGATGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See TTF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TTF2

    SOURCE GeneReport for Unigene cluster: Hs.486818
        SABiosciences Custom PCR Arrays for TTF2
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    In Situ
    Assay Products:     
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    Orthologs
    for TTF2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TTF2 gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TTF21 transcription termination factor, RNA polymerase II less 60.99(n)
    56.26(a)    		   418376  XM_416595.3  XP_416595.2 
    lizard
    (Anolis carolinensis)    		 Reptilia TTF26
    		 --
    		 50(a)
    		 1 ↔ 1
    		 3(175030273-175056195)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.161952 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_003585.1 (H.sapiens) transcription termination factor, RNA polymerase II; lodestar protein [Homo sapiens] less 73.29(n)    BU900083.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.294082 Danio rerio, clone IMAGE5914216, mRNA 72.22(n)    BC049476.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta lds1 , 3 transcription termination DNA dependent
    adenosinetriphosphatase less3
    lodestar1    		 36(a)
    (best of 2)3
    47.03(n)1
    38.96(a)1    		   3 84E53
    458941  NM_080111.21  NP_524850.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea F59A7.83
    CELE_F59A7.81    		 helicase3
    Protein F59A7.81    		 52(a)3
    52.47(n)1
    49.41(a)1    		   V(2008710-2011198)3
    1786811  NM_071147.31  NP_503548.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G166006
    AT3G200106
    (see all 5)    		 SNF2 and helicase domain-containing protein
    (see all 5)    		 24(a)
    19(a)
    (see all 5)    		 1 ↔ many
    1 ↔ many
    (see all 5)    		 3(5652839-5655670)
    3(6971352-6976595)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 DNA repair protein rhp16, putative, expressed
    SNF2 family N-terminal domain containing protein, ...
    (see all 4)    		 24(a)
    19(a)
    (see all 4)    		 possible ortholog
    1 ↔ many
    (see all 4)    		 7(19540488-19544813)
    4(31824369-31831300)


    ENSEMBL Gene Tree for TTF2 (if available)
    TreeFam Gene Tree for TTF2 (if available) 

    Paralogs
    for TTF2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TTF2 gene
    HLTF2  SHPRH2  

    TTF2 for paralogs           About GeneDecksing



    Genomic Variants
    for TTF2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/788 NCBI SNPs in TTF2 are shown (see all 788)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1411023731,2
    		--117601231(+) CATCAC/TTTGCA 1 -- us2k10--------
    rs24777211,2
    		C,F,H,--117601238(-) TTATTC/TTTGCA 1 -- us2k1 tfbs316Minor allele frequency- T:0.04NS EA NA 2102
    rs37541091,2
    		C,F,H,--117601619(-) ACAAAC/TCTGAG 1 -- us2k121Minor allele frequency- T:0.12NS EA NA WA CSA 2348
    rs1906769231,2
    		--117601631(+) TCCCTC/TCCTCC 1 -- us2k10--------
    rs1819314491,2
    		--117601756(+) ATATGA/GTCCTC 1 -- us2k10--------
    rs1870529661,2
    		--117601803(+) ATCTAA/GTATCT 1 -- us2k10--------
    rs1914460151,2
    		--117601847(+) ACTTCA/GAATTT 1 -- us2k10--------
    rs10049861,2
    		C,F,A,H,--117601896(+) CCCTTC/TCTTCT 1 -- us2k1 tfbs3 trp321Minor allele frequency- T:0.29NS EA WA NA CSA 2338
    rs763286531,2
    		C--117601955(+) AAAAAA/GTTTGA 1 -- us2k10--------
    rs802831171,2
    		C--117601956(+) AAAAGG/TTTGAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TTF2 (117602925 - 117645492 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TTF2: --
    Human Gene Mutation Database (HGMD): TTF2

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for TTF2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TTF2 for disorders           About GeneDecksing

    OMIM gene information: 604718    OMIM disorders: --

    20/119 diseases for TTF2 (see all 119):    About MalaCards
    gilles de la tourette syndrome    narcissistic personality disorder    obsessive-compulsive disorder    charcot-marie-tooth disease
    attention deficit hyperactivity disorder    personality disorder    deep vein thrombosis    antisocial personality disorder
    borderline personality disorder    chronic venous leg ulcers    cystoid macular edema    portal vein thrombosis
    glucose intolerance    barrett's esophagus    peters anomaly    gastroesophageal reflux disease
    back pain    anxiety disorder    type 2 diabetes mellitus    coronary heart disease

    10/89 Novoseek disease relationships for TTF2 gene (see all 89)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    antisocial personality disorder 58.4 2 14593834 (1), 9573521 (1)
    racing thoughts 44.5 2 12524632 (2)
    sadism 44.3 1 10212024 (1)
    personality disorders 40.1 4 15723027 (1), 15614323 (1), 19290767 (1)
    narcissistic personality disorder 36.4 1 18243885 (1)
    neuroticism 33.5 6 16118990 (1), 16150005 (1), 18480502 (1), 9800522 (1) (see all 6)
    antisocial behavior 30.5 2 16333809 (1), 17658978 (1)
    obsessive-compulsive personality 26 1 15614323 (1)
    anxiety depression 20.9 2 14509074 (1)
    psychological distress 17.9 1 8121696 (1)

    Genetic Association Database (GAD): TTF2
    Human Genome Epidemiology (HuGE) Navigator: TTF2 (24 documents)

    Export disorders for TTF2 gene to outside databases

    Publications
    for TTF2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TTF2 gene, integrated from 9 sources (see all 475):
    (articles sorted by number of sources associating them with TTF2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member. (PubMed id 9748214)1, 2, 3, 9 Liu M.... Price D.H. (1998)
    2. Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer. (PubMed id 10455150)1, 2, 9 Hara R.... Sancar A. (1999)
    3. Involvement of transcription termination factor 2 in mitotic repression of transcription elongation. (PubMed id 15125840)1, 2, 9 Jiang Y.... Price D.H. (2004)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Genetic analysis of TTF-2 gene in children with congenital hypothyroidism and cleft palate, congenital hypothyroidism, or isolated cleft palate. (PubMed id 15320969)1, 4 Tonacchera M....Pinchera A. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing. (PubMed id 12927788)1, 2 Leonard D.... Legerski R.J. (2003)
    8. A novel loss-of-function mutation in TTF-2 is associated with congenital hypothyroidism, thyroid agenesis and cleft palate. (PubMed id 12165566)1, 4 Castanet M.... Polak M. (2002)
    9. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    External Searches for TTF2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TTF2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8458 HGNC: 12398 AceView: TTF2 Ensembl:ENSG00000116830 euGenes: HUgn8458
    ECgene: TTF2 H-InvDB: TTF2

    Other Databases showing TTF2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TTF2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TTF2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TTF2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TTF2 gene:
    Search GeneIP for patents involving TTF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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