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Aliases for TTF2 Gene

Aliases for TTF2 Gene

  • Transcription Termination Factor, RNA Polymerase II 2 3 5
  • RNA Polymerase II Termination Factor 3 4
  • Transcription Release Factor 2 3 4
  • Lodestar Homolog 3 4
  • HuF2 3 4
  • F2 3 4
  • Zinc Finger, GRF-Type Containing 6 3
  • GRF-Type Containing 6 2
  • Lodestar Protein 3
  • Human Factor 2 3
  • Zinc Finger 2
  • EC 3.6.4.- 4
  • EC 3.6.1 63
  • ZGRF6 3

External Ids for TTF2 Gene

Previous GeneCards Identifiers for TTF2 Gene

  • GC01P118062
  • GC01P116441
  • GC01P116750
  • GC01P116949
  • GC01P117314
  • GC01P117404
  • GC01P117602
  • GC01P115461

Summaries for TTF2 Gene

Entrez Gene Summary for TTF2 Gene

  • This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008]

GeneCards Summary for TTF2 Gene

TTF2 (Transcription Termination Factor, RNA Polymerase II) is a Protein Coding gene. Diseases associated with TTF2 include thyroid cancer, nonmedullary, 4 and bamforth-lazarus syndrome. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include hydrolase activity and DNA-dependent ATPase activity.

UniProtKB/Swiss-Prot for TTF2 Gene

  • DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.

Gene Wiki entry for TTF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTF2 Gene

Genomics for TTF2 Gene

Regulatory Elements for TTF2 Gene

Promoters for TTF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TTF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTF2 Gene

Chromosome:
1
Start:
117,060,288 bp from pter
End:
117,107,453 bp from pter
Size:
47,166 bases
Orientation:
Plus strand

Genomic View for TTF2 Gene

Genes around TTF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTF2 Gene

Proteins for TTF2 Gene

  • Protein details for TTF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNY4-TTF2_HUMAN
    Recommended name:
    Transcription termination factor 2
    Protein Accession:
    Q9UNY4
    Secondary Accessions:
    • A8K4Q2
    • O75921
    • Q5T2K7
    • Q5VVU8
    • Q8N6I8

    Protein attributes for TTF2 Gene

    Size:
    1162 amino acids
    Molecular mass:
    129588 Da
    Quaternary structure:
    • Interacts with CDC5L. Part of the spliceosome.

    Alternative splice isoforms for TTF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTF2 Gene

Proteomics data for TTF2 Gene at MOPED

Selected DME Specific Peptides for TTF2 Gene

Post-translational modifications for TTF2 Gene

  • Ubiquitination at Lys 567, Lys 814, and Lys 1109
  • Modification sites at PhosphoSitePlus

Other Protein References for TTF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TTF2 Gene

Gene Families for TTF2 Gene

Suggested Antigen Peptide Sequences for TTF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UNY4

UniProtKB/Swiss-Prot:

TTF2_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the SNF2/RAD54 helicase family.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the SNF2/RAD54 helicase family.
genes like me logo Genes that share domains with TTF2: view

Function for TTF2 Gene

Molecular function for TTF2 Gene

UniProtKB/Swiss-Prot Function:
DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.

Enzyme Numbers (IUBMB) for TTF2 Gene

Gene Ontology (GO) - Molecular Function for TTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008094 DNA-dependent ATPase activity TAS 9748214
genes like me logo Genes that share ontologies with TTF2: view
genes like me logo Genes that share phenotypes with TTF2: view

Animal Model Products

miRNA for TTF2 Gene

miRTarBase miRNAs that target TTF2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTF2 Gene

Localization for TTF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTF2 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTF2 Gene COMPARTMENTS Subcellular localization image for TTF2 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for TTF2 Gene

Pathways & Interactions for TTF2 Gene

genes like me logo Genes that share pathways with TTF2: view

Gene Ontology (GO) - Biological Process for TTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TTF2: view

No data available for SIGNOR curated interactions for TTF2 Gene

Drugs & Compounds for TTF2 Gene

(31) Drugs for TTF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(23) Additional Compounds for TTF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TTF2: view

Transcripts for TTF2 Gene

Unigene Clusters for TTF2 Gene

Transcription termination factor, RNA polymerase II:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTF2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1: -
SP2: -
SP3: -

Relevant External Links for TTF2 Gene

GeneLoc Exon Structure for
TTF2
ECgene alternative splicing isoforms for
TTF2

Expression for TTF2 Gene

mRNA expression in normal human tissues for TTF2 Gene

Protein differential expression in normal tissues from HIPED for TTF2 Gene

This gene is overexpressed in Plasma (42.3), Monocytes (16.2), and Peripheral blood mononuclear cells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTF2 Gene



SOURCE GeneReport for Unigene cluster for TTF2 Gene Hs.486818

genes like me logo Genes that share expression patterns with TTF2: view

Protein tissue co-expression partners for TTF2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTF2 Gene

Orthologs for TTF2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TTF2 35
  • 83.94 (n)
  • 77.46 (a)
TTF2 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTF2 35
  • 80.98 (n)
  • 73.79 (a)
TTF2 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttf2 35
  • 78.07 (n)
  • 72.22 (a)
Ttf2 16
Ttf2 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TTF2 35
  • 99.54 (n)
  • 99.14 (a)
TTF2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttf2 35
  • 78.03 (n)
  • 71.7 (a)
oppossum
(Monodelphis domestica)
Mammalia TTF2 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTF2 36
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTF2 35
  • 61.06 (n)
  • 56.71 (a)
TTF2 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTF2 36
  • 49 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16195 35
zebrafish
(Danio rerio)
Actinopterygii Dr.29408 35
si:ch1073-303l5.1 35
  • 58.57 (n)
  • 52.87 (a)
TTF2 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10445 37
  • 31 (a)
lds 37
  • 36 (a)
CG10445 36
  • 24 (a)
OneToMany
lds 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F59A7.8 37
  • 52 (a)
F54E12.2 35
  • 48.06 (n)
  • 41.87 (a)
F54E12.2 36
  • 28 (a)
OneToMany
F59A7.8 36
  • 31 (a)
OneToMany
T23H2.3 36
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD16 36
  • 27 (a)
OneToMany
ULS1 36
  • 15 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10555 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for TTF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TTF2 Gene

ENSEMBL:
Gene Tree for TTF2 (if available)
TreeFam:
Gene Tree for TTF2 (if available)

Paralogs for TTF2 Gene

No data available for Paralogs for TTF2 Gene

Variants for TTF2 Gene

Sequence variations from dbSNP and Humsavar for TTF2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs998532 - 117,075,083(+) AAAAG(A/G)AAGAA nc-transcript-variant, reference, missense
rs7535524 - 117,075,222(+) ACACA(A/G)AAGAG nc-transcript-variant, reference, missense
rs34334470 - 117,075,351(+) GAGAG(A/G)AAAGG nc-transcript-variant, reference, missense
rs41276572 - 117,101,436(+) AAAGA(A/G)AGATT reference, missense
rs34236116 - 117,101,498(+) TGGCT(A/C/G)ACCTC reference, missense

Variation tolerance for TTF2 Gene

Residual Variation Intolerance Score: 73.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.24; 62.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTF2 Gene

HapMap Linkage Disequilibrium report
TTF2
Human Gene Mutation Database (HGMD)
TTF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TTF2 Gene

Disorders for TTF2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TTF2 Gene - From: OMIM and Novoseek

Disorder Aliases PubMed IDs
thyroid cancer, nonmedullary, 4
  • thyroid cancer, non-medullary, 4
bamforth-lazarus syndrome
  • hypothyroidism, athyroidal, with spiky hair and cleft palate
sexual sadism
  • sadism
narcissistic personality disorder
- elite association - COSMIC cancer census association via MalaCards
Search TTF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TTF2

Genetic Association Database (GAD)
TTF2
Human Genome Epidemiology (HuGE) Navigator
TTF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTF2
genes like me logo Genes that share disorders with TTF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTF2 Gene

Publications for TTF2 Gene

  1. A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member. (PMID: 9748214) Liu M. … Price D.H. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Involvement of transcription termination factor 2 in mitotic repression of transcription elongation. (PMID: 15125840) Jiang Y. … Price D.H. (Mol. Cell 2004) 3 23
  3. Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer. (PMID: 10455150) Hara R. … Sancar A. (J. Biol. Chem. 1999) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for TTF2 Gene

Sources for TTF2 Gene

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