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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TTF2 Gene

protein-coding   GIFtS: 60
GCID: GC01P117602

Transcription Termination Factor, RNA Polymerase II

Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transcription Termination Factor, RNA Polymerase II1 2     Human Factor 22
Lodestar Homolog2 3     Lodestar Protein2
Transcription Release Factor 22 3     Transcription Termination Factor 22
F22 3     EC 3.6.4.-3
HuF22 3     EC 3.6.18
RNA Polymerase II Termination Factor2 3     

External Ids:    HGNC: 123981   Entrez Gene: 84582   Ensembl: ENSG000001168307   OMIM: 6047185   UniProtKB: Q9UNY43   

Export aliases for TTF2 gene to outside databases

Previous GC identifers: GC01P118062 GC01P116441 GC01P116750 GC01P116949 GC01P117314 GC01P117404 GC01P115461


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TTF2 Gene:
This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA
interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II
termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing
complexes, and plays a role in pre-mRNA splicing. (provided by RefSeq, Jul 2008)

GeneCards Summary for TTF2 Gene: 
TTF2 (transcription termination factor, RNA polymerase II) is a protein-coding gene. Diseases associated with TTF2 include personality disorder, and narcissistic personality disorder, and among its related super-pathways are Insulin secretion. GO annotations related to this gene include DNA-dependent ATPase activity and ATP-dependent helicase activity. An important paralog of this gene is HLTF.

UniProtKB/Swiss-Prot: TTF2_HUMAN, Q9UNY4
Function: DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with
removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also
be involved in pre-mRNA splicing

Gene Wiki entry for TTF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TTF2 gene promoter:
         AML1a   E2F-2   Arnt   GATA-2   AREB6   PPAR-alpha   E2F-1   E2F   RSRFC4   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TTF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22   Ensembl cytogenetic band:  1p13.1   HGNC cytogenetic band: 1p13.1

TTF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTF2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P117602:  view genomic region     (about GC identifiers)

Start:
117,602,925 bp from pter      End:
117,645,492 bp from pter
Size:
42,568 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TTF2_HUMAN, Q9UNY4 (See protein sequence)
Recommended Name: Transcription termination factor 2  
Size: 1162 amino acids; 129588 Da
Subunit: Interacts with CDC5L. Part of the spliceosome
Subcellular location: Cytoplasm. Nucleus. Note=Cytoplasmic during interphase. Relocates to the nucleus as cells
enter mitosis
Secondary accessions: A8K4Q2 O75921 Q5T2K7 Q5VVU8 Q8N6I8
Alternative splicing: 2 isoforms:  Q9UNY4-1   Q9UNY4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TTF2: NX_Q9UNY4

Explore proteomics data for TTF2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UNY4

  • 4 DME Specific Peptides for TTF2 (Q9UNY4)
     GGVGLNL  MGLGKTL  HQKQALAW  LADDMGLGKT 

    TTF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TTF2 Protein Expression
    REFSEQ proteins: NP_003585.3  
    ENSEMBL proteins: 
     ENSP00000358478   ENSP00000408111  

    Human Recombinant Protein Products for TTF2: 
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    Cloud-Clone Corp. Proteins for TTF2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005681spliceosomal complex IEA--
    GO:0005737cytoplasm IDA--
    GO:0008023transcription elongation factor complex TAS9748214

    TTF2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR027417 P-loop_NTPase
     IPR010666 Znf_GRF
     IPR000330 SNF2_N
     IPR002464 DNA/RNA_helicase_DEAH_CS
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry Q9UNY4

    ProtoNet protein and cluster: Q9UNY4

    2 Blocks protein domains:
    IPB000330 SNF2 related domain
    IPB002464 ATP-dependent helicase


    UniProtKB/Swiss-Prot: TTF2_HUMAN, Q9UNY4
    Similarity: Belongs to the SNF2/RAD54 helicase family
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    TTF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTF2_HUMAN, Q9UNY4
    Function: DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with
    removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also
    be involved in pre-mRNA splicing

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.-1

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0004386helicase activity ----
    GO:0005515protein binding IPI17577209
    GO:0005524ATP binding IEA--
         
    TTF2 for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidTTF2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TTF2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Insulin secretion
    Thyroid hormone synthesis0.36
    2TSH signaling pathway
    TSH signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TTF2
        TSH signaling pathway


    1         Kegg Pathway  (Kegg details for TTF2):
        Thyroid hormone synthesis


    TTF2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TTF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/61 Interacting proteins for TTF2 (Q9UNY42, 3 ENSP000003584784) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKILP127572, 3MINT-61651 I2D: score=3 
    SMAD1Q157972, 3MINT-61994 I2D: score=3 
    SMAD7O151052, 3MINT-61814 I2D: score=3 
    ENSG00000206454Q018603I2D: score=2 
    ENSG00000229094Q018603I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006353DNA-dependent transcription, termination TAS9748214
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006369termination of RNA polymerase II transcription TAS9748214
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--

    TTF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TTF2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TTF2

    10/54 Novoseek inferred chemical compound relationships for TTF2 gene (see all 54)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fluorometholone 35.2 1 11231772 (1)
    p00001 7.95 1 12574560 (1)
    diclofenac 5.39 1 11231772 (1)
    vegf 5.23 1 10719731 (1)
    hydrogen 4.43 4 10772027 (1), 8003984 (1), 17573366 (1)
    lead 4.26 2 11675273 (1)
    ethanol 3.94 2 11448083 (1), 18767820 (1)
    oxygen 3.43 4 11401875 (1), 12439804 (1), 7483052 (1)
    carbon 3.39 1 19534558 (1)
    creatinine 2.94 4 10402440 (2), 9782673 (1), 16041606 (1)

    Search CenterWatch for drugs/clinical trials and news about TTF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TTF2 gene: 
    NM_003594.3  

    Unigene Cluster for TTF2:

    Transcription termination factor, RNA polymerase II
    Hs.486818  [show with all ESTs]
    Unigene Representative Sequence: AB209845
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369466(uc001egy.3) ENST00000470935 ENST00000469638 ENST00000492682
    ENST00000463696 ENST00000427271 ENST00000480701
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate TTF2:
    hsa-miR-1233 hsa-miR-187* hsa-miR-1283
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    Additional mRNA sequence: 

    AB209845.1 AF073771.1 AF080255.1 AK291017.1 BC015341.1 BC030058.1 

    9 DOTS entries:

    DT.422600  DT.100021292  DT.100725339  DT.92428856  DT.100741902  DT.40305064  DT.92428854  DT.92428855 
    DT.95268938 

    24/125 AceView cDNA sequences (see all 125):

    BE079391 CA430266 AL110457 AA278371 AA327454 BE894873 BU072168 W95689 
    AL039234 BU618360 AI282428 AA227424 CA942532 NM_003594 BE079359 AL555072 
    BE326897 W95668 BX281340 BE273891 CR614106 AI282709 BQ070871 AA887513 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TTF2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
    SP1:                                                                    -                                                                                       
    SP2:                                                                    -                                                                                       
    SP3:                                                                                            -                                                               


    ECgene alternative splicing isoforms for TTF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TTF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACAGATGCT
    TTF2 Expression
    About this image


    See TTF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TTF2

    SOURCE GeneReport for Unigene cluster: Hs.486818
        SABiosciences Custom PCR Arrays for TTF2
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TTF2 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttf21 , 5 transcription termination factor, RNA polymerase II less1, 5 78.19(n)1
    72.4(a)1
      3 (43.86 cM)5
    740441  NM_001013026.21  NP_001013044.21 
     1009388605 
    chicken
    (Gallus gallus)
    Aves TTF21 transcription termination factor, RNA polymerase II less 60.99(n)
    56.26(a)
      418376  XM_416595.3  XP_416595.2 
    lizard
    (Anolis carolinensis)
    Reptilia TTF26
    transcription termination factor, RNA polymerase I...
    48(a)
    1 ↔ 1
    3(175028680-175056390)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.161952 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_003585.1 (H.sapiens) transcription termination factor, RNA polymerase II; lodestar protein [Homo sapiens] less 73.29(n)    BU900083.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.294082 Danio rerio, clone IMAGE5914216, mRNA 72.22(n)    BC049476.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta lds1 , 3 transcription termination DNA dependent
    adenosinetriphosphatase less3
    lodestar1
    36(a)
    (best of 2)3
    47.03(n)1
    38.96(a)1
      3 84E53
    458941  NM_080111.21  NP_524850.21 
    worm
    (Caenorhabditis elegans)
    Secernentea F59A7.83
    CELE_F59A7.81
    helicase3
    Protein F59A7.81
    52(a)3
    52.47(n)1
    49.41(a)1
      V(2008710-2011198)3
    1786811  NM_071147.31  NP_503548.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAD56
    DNA helicase proposed to promote replication fork ...
    18(a)
    1 → many
    XII(204991-208500)


    ENSEMBL Gene Tree for TTF2 (if available)
    TreeFam Gene Tree for TTF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TTF2 gene
    HLTF2  

    TTF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/928 SNPs in TTF2 are shown (see all 928)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1411023731,2
    --117601231(+) CATCAC/TTTGCA 1 -- us2k10--------
    rs24777211,2
    C,F,H--117601238(-) TTATTC/TTTGCA 1 -- us2k1 tfbs316Minor allele frequency- T:0.04NS EA NA 2102
    rs37541091,2
    C,F,H--117601619(-) ACAAAC/TCTGAG 1 -- us2k121Minor allele frequency- T:0.12NS EA NA WA CSA 2348
    rs1906769231,2
    --117601631(+) TCCCTC/TCCTCC 1 -- us2k10--------
    rs1819314491,2
    --117601756(+) ATATGA/GTCCTC 1 -- us2k10--------
    rs1870529661,2
    --117601803(+) ATCTAA/GTATCT 1 -- us2k10--------
    rs1914460151,2
    --117601847(+) ACTTCA/GAATTT 1 -- us2k10--------
    rs10049861,2
    C,F,A,H--117601896(+) CCCTTC/TCTTCT 1 -- us2k1 tfbs3 trp321Minor allele frequency- T:0.29NS EA WA NA CSA 2338
    rs763286531,2
    C--117601955(+) AAAAAA/GTTTGA 1 -- us2k10--------
    rs802831171,2
    C--117601956(+) AAAAGG/TTTGAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TTF2 (117602925 - 117645492 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TTF2: --

    Human Gene Mutation Database (HGMD): TTF2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TTF2
    DNA2.0 Custom Variant and Variant Library Synthesis for TTF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604718    OMIM disorders: --

    20/107 diseases for TTF2 (see all 107):    About MalaCards
    personality disorder    narcissistic personality disorder    myospherulosis    chronic venous leg ulcers
    alexithymia    cystoid macular edema    thyroid agenesis    antisocial personality disorder
    conduct disorder    borderline personality disorder    warfarin resistance    somatoform disorder
    chronic pain    resting heart rate    portal vein thrombosis    gilles de la tourette syndrome
    head injury    back pain    hiv/aids    peters anomaly


    TTF2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/89 Novoseek inferred disease relationships for TTF2 gene (see all 89)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    antisocial personality disorder 58.4 2 14593834 (1), 9573521 (1)
    racing thoughts 44.5 2 12524632 (2)
    sadism 44.3 1 10212024 (1)
    personality disorders 40.1 4 15723027 (1), 15614323 (1), 19290767 (1)
    narcissistic personality disorder 36.4 1 18243885 (1)
    neuroticism 33.5 6 16118990 (1), 16150005 (1), 18480502 (1), 9800522 (1) (see all 6)
    antisocial behavior 30.5 2 16333809 (1), 17658978 (1)
    obsessive-compulsive personality 26 1 15614323 (1)
    anxiety depression 20.9 2 14509074 (1)
    psychological distress 17.9 1 8121696 (1)

    Genetic Association Database (GAD): TTF2
    Human Genome Epidemiology (HuGE) Navigator: TTF2 (24 documents)

    Export disorders for TTF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TTF2 gene, integrated from 9 sources (see all 481):
    (articles sorted by number of sources associating them with TTF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member. (PubMed id 9748214)1, 2, 3, 9 Liu M.... Price D.H. (1998)
    2. Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer. (PubMed id 10455150)1, 2, 9 Hara R.... Sancar A. (1999)
    3. Involvement of transcription termination factor 2 in mitotic repression of transcription elongation. (PubMed id 15125840)1, 2, 9 Jiang Y.... Price D.H. (2004)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Genetic analysis of TTF-2 gene in children with congenital hypothyroidism and cleft palate, congenital hypothyroidism, or isolated cleft palate. (PubMed id 15320969)1, 4 Tonacchera M....Pinchera A. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing. (PubMed id 12927788)1, 2 Leonard D.... Legerski R.J. (2003)
    8. A novel loss-of-function mutation in TTF-2 is associated with congenital hypothyroidism, thyroid agenesis and cleft palate. (PubMed id 12165566)1, 4 Castanet M.... Polak M. (2002)
    9. The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (2013)
    10. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8458 HGNC: 12398 AceView: TTF2 Ensembl:ENSG00000116830 euGenes: HUgn8458
    ECgene: TTF2 Kegg: 8458 H-InvDB: TTF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TTF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TTF2 gene:
    Search GeneIP for patents involving TTF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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