Aliases for TTF2 Gene
External Ids for TTF2 Gene
Previous GeneCards Identifiers for TTF2 Gene
This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008]
GeneCards Summary for TTF2 Gene
TTF2 (Transcription Termination Factor, RNA Polymerase II) is a Protein Coding gene. Diseases associated with TTF2 include bamforth-lazarus syndrome and thyroid cancer, nonmedullary, 4. Among its related pathways are Signaling by GPCR and Regulation of actin cytoskeleton. GO annotations related to this gene include hydrolase activity and DNA-dependent ATPase activity.
UniProtKB/Swiss-Prot for TTF2 Gene
DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.