Aliases for TTF2 Gene
External Ids for TTF2 Gene
Previous GeneCards Identifiers for TTF2 Gene
This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008]
GeneCards Summary for TTF2 Gene
TTF2 (Transcription Termination Factor 2) is a Protein Coding gene. Diseases associated with TTF2 include Thyroid Cancer, Nonmedullary, 4 and Bamforth-Lazarus Syndrome. Among its related pathways are Insulin secretion and TSH signaling pathway. GO annotations related to this gene include hydrolase activity and DNA-dependent ATPase activity. An important paralog of this gene is HLTF.
UniProtKB/Swiss-Prot for TTF2 Gene
DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.