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Aliases for TTF2 Gene

Aliases for TTF2 Gene

  • Transcription Termination Factor, RNA Polymerase II 2 3
  • RNA Polymerase II Termination Factor 3 4
  • Transcription Release Factor 2 3 4
  • Lodestar Homolog 3 4
  • HuF2 3 4
  • F2 3 4
  • Transcription Termination Factor 2 3
  • Zinc Finger, GRF-Type Containing 6 3
  • GRF-Type Containing 6 2
  • Lodestar Protein 3
  • Human Factor 2 3
  • Zinc Finger 2
  • EC 3.6.4.- 4
  • EC 3.6.1 64
  • ZGRF6 3

External Ids for TTF2 Gene

Summaries for TTF2 Gene

Entrez Gene Summary for TTF2 Gene

  • This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008]

GeneCards Summary for TTF2 Gene

TTF2 (Transcription Termination Factor, RNA Polymerase II) is a Protein Coding gene. Diseases associated with TTF2 include myospherulosis and narcissistic personality disorder. Among its related pathways are Signaling by GPCR and Regulation of actin cytoskeleton. GO annotations related to this gene include ATP-dependent helicase activity and DNA-dependent ATPase activity.

UniProtKB/Swiss-Prot for TTF2 Gene

  • DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.

Gene Wiki entry for TTF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTF2 Gene

Genomics for TTF2 Gene

Genomic Location for TTF2 Gene

Start:
117,060,288 bp from pter
End:
117,107,453 bp from pter
Size:
47,166 bases
Orientation:
Plus strand

Genomic View for TTF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTF2 Gene

Regulatory Elements for TTF2 Gene

Proteins for TTF2 Gene

  • Protein details for TTF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNY4-TTF2_HUMAN
    Recommended name:
    Transcription termination factor 2
    Protein Accession:
    Q9UNY4
    Secondary Accessions:
    • A8K4Q2
    • O75921
    • Q5T2K7
    • Q5VVU8
    • Q8N6I8

    Protein attributes for TTF2 Gene

    Size:
    1162 amino acids
    Molecular mass:
    129588 Da
    Quaternary structure:
    • Interacts with CDC5L. Part of the spliceosome.

    Alternative splice isoforms for TTF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTF2 Gene

Proteomics data for TTF2 Gene at MOPED

Selected DME Specific Peptides for TTF2 Gene

Post-translational modifications for TTF2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys567, Lys814, and Lys1109

Other Protein References for TTF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for TTF2 Gene

UniProtKB/Swiss-Prot:

TTF2_HUMAN
Domain:
  • Contains 1 helicase ATP-binding domain.:
    • Q9UNY4
  • Contains 1 helicase C-terminal domain.:
    • Q9UNY4
Family:
  • Belongs to the SNF2/RAD54 helicase family.:
    • Q9UNY4
genes like me logo Genes that share domains with TTF2: view

No data available for Gene Families for TTF2 Gene

Function for TTF2 Gene

Molecular function for TTF2 Gene

UniProtKB/Swiss-Prot Function: DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.

Enzyme Numbers (IUBMB) for TTF2 Gene

Gene Ontology (GO) - Molecular Function for TTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 17577209
GO:0005524 ATP binding IEA --
GO:0008026 ATP-dependent helicase activity IEA --
GO:0008094 DNA-dependent ATPase activity TAS 9748214
genes like me logo Genes that share ontologies with TTF2: view

miRNA for TTF2 Gene

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TTF2 Gene

Localization for TTF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTF2 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTF2 Gene COMPARTMENTS Subcellular localization image for TTF2 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for TTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005681 spliceosomal complex IEA --
GO:0005737 cytoplasm IEA --
GO:0008023 transcription elongation factor complex TAS 9748214
genes like me logo Genes that share ontologies with TTF2: view

Pathways for TTF2 Gene

genes like me logo Genes that share pathways with TTF2: view

Gene Ontology (GO) - Biological Process for TTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006353 DNA-templated transcription, termination TAS 9748214
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006369 termination of RNA polymerase II transcription TAS 9748214
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with TTF2: view

Compounds for TTF2 Gene

(54) Novoseek inferred chemical compound relationships for TTF2 Gene

Compound -log(P) Hits PubMed IDs
fluorometholone 35.2 1
p00001 7.95 1
diclofenac 5.39 1
vegf 5.23 1
hydrogen 4.43 3
genes like me logo Genes that share compounds with TTF2: view

Transcripts for TTF2 Gene

Unigene Clusters for TTF2 Gene

Transcription termination factor, RNA polymerase II:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTF2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1: -
SP2: -
SP3: -

Relevant External Links for TTF2 Gene

GeneLoc Exon Structure for
TTF2
ECgene alternative splicing isoforms for
TTF2

Expression for TTF2 Gene

mRNA expression in normal human tissues for TTF2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTF2 Gene

SOURCE GeneReport for Unigene cluster for TTF2 Gene Hs.486818

genes like me logo Genes that share expressions with TTF2: view

Orthologs for TTF2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTF2 36
  • 99.54 (n)
  • 99.14 (a)
TTF2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TTF2 36
  • 83.94 (n)
  • 77.46 (a)
TTF2 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTF2 36
  • 80.98 (n)
  • 73.79 (a)
TTF2 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttf2 36
  • 78.07 (n)
  • 72.22 (a)
Ttf2 16
Ttf2 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTF2 37
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTF2 37
  • 41 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttf2 36
  • 78.03 (n)
  • 71.7 (a)
chicken
(Gallus gallus)
Aves TTF2 36
  • 61.06 (n)
  • 56.71 (a)
TTF2 37
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTF2 37
  • 49 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16195 36
zebrafish
(Danio rerio)
Actinopterygii Dr.29408 36
si:ch1073-303l5.1 36
  • 58.57 (n)
  • 52.87 (a)
TTF2 37
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10445 37
  • 24 (a)
OneToMany
lds 37
  • 32 (a)
OneToMany
CG10445 38
  • 31 (a)
lds 38
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea F54E12.2 36
  • 48.06 (n)
  • 41.87 (a)
F54E12.2 37
  • 28 (a)
OneToMany
F59A7.8 37
  • 31 (a)
OneToMany
T23H2.3 37
  • 31 (a)
OneToMany
F59A7.8 38
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD16 37
  • 27 (a)
OneToMany
ULS1 37
  • 15 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10555 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 37 (a)
OneToOne
Species with no ortholog for TTF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TTF2 Gene

ENSEMBL:
Gene Tree for TTF2 (if available)
TreeFam:
Gene Tree for TTF2 (if available)

Paralogs for TTF2 Gene

No data available for Paralogs for TTF2 Gene

Variants for TTF2 Gene

Sequence variations from dbSNP and Humsavar for TTF2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3965 -- 117,103,012(-) GGGCC(A/G)CCTAG downstream-variant-500B
rs998532 - 117,075,083(+) AAAAG(A/G)AAGAA reference, missense
rs1061441 -- 117,101,712(+) AATTA(G/T)TTAAC utr-variant-3-prime, downstream-variant-500B, intron-variant
rs1064124 -- 117,077,959(+) ATCAC(A/G)AGTGA reference, synonymous-codon
rs1289663 -- 117,100,860(-) GCTCC(A/G)AAGCA intron-variant

Relevant External Links for TTF2 Gene

HapMap Linkage Disequilibrium report
TTF2
Human Gene Mutation Database (HGMD)
TTF2

No data available for Structural Variations from Database of Genomic Variants (DGV) for TTF2 Gene

Disorders for TTF2 Gene

(89) Novoseek inferred disease relationships for TTF2 Gene

Disease -log(P) Hits PubMed IDs
antisocial personality disorder 58.4 2
racing thoughts 44.5 2
sadism 44.3 1
personality disorders 40.1 3
narcissistic personality disorder 36.4 1

Relevant External Links for TTF2

Genetic Association Database (GAD)
TTF2
Human Genome Epidemiology (HuGE) Navigator
TTF2
genes like me logo Genes that share disorders with TTF2: view

No data available for UniProtKB/Swiss-Prot for TTF2 Gene

Publications for TTF2 Gene

  1. A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member. (PMID: 9748214) Liu M. … Price D.H. (J. Biol. Chem. 1998) 2 3 4 23
  2. Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer. (PMID: 10455150) Hara R. … Sancar A. (J. Biol. Chem. 1999) 3 4 23
  3. Involvement of transcription termination factor 2 in mitotic repression of transcription elongation. (PMID: 15125840) Jiang Y. … Price D.H. (Mol. Cell 2004) 3 4 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for TTF2 Gene

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