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Aliases for TTF2 Gene

Aliases for TTF2 Gene

  • Transcription Termination Factor 2 2 3 5
  • Transcription Release Factor 2 2 3 4
  • Transcription Termination Factor, RNA Polymerase II 2 3
  • RNA Polymerase II Termination Factor 3 4
  • Zinc Finger, GRF-Type Containing 6 2 3
  • Lodestar Homolog 3 4
  • HuF2 3 4
  • F2 3 4
  • Lodestar Protein 3
  • Human Factor 2 3
  • EC 3.6.4.- 4
  • EC 3.6.1 58
  • ZGRF6 3

External Ids for TTF2 Gene

Previous GeneCards Identifiers for TTF2 Gene

  • GC01P118062
  • GC01P116441
  • GC01P116750
  • GC01P116949
  • GC01P117314
  • GC01P117404
  • GC01P117602
  • GC01P115461

Summaries for TTF2 Gene

Entrez Gene Summary for TTF2 Gene

  • This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008]

GeneCards Summary for TTF2 Gene

TTF2 (Transcription Termination Factor 2) is a Protein Coding gene. Diseases associated with TTF2 include Sexual Sadism and Narcissistic Personality Disorder. Among its related pathways are Insulin secretion and Human Thyroid Stimulating Hormone (TSH) signaling pathway. GO annotations related to this gene include hydrolase activity and DNA-dependent ATPase activity. An important paralog of this gene is HLTF.

UniProtKB/Swiss-Prot for TTF2 Gene

  • DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.

Gene Wiki entry for TTF2 Gene

Additional gene information for TTF2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTF2 Gene

Genomics for TTF2 Gene

Regulatory Elements for TTF2 Gene

Enhancers for TTF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H117058 1.1 ENCODE 27.4 +0.4 376 4.4 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 WDR3 TTF2 GDAP2 MAN1A2 ATP1A1-AS1 LOC101929099 CD101 MIR942
GH01H116736 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.8 -321.2 -321233 4.6 ARNT BMI1 BATF RAD21 RFX5 ZNF121 ZNF143 ATF7 ETV6 RUNX3 TTF2 LOC101929099 CD101 IGSF3 ATP1A1 CD2 GC01M116740 GAPDHP64
GH01H117076 1.1 FANTOM5 ENCODE 12.8 +17.0 17026 1.8 ZBTB21 JUN ZSCAN4 INSM2 CEBPG RFX5 FOSL1 HIC1 ZNF366 NFYB TTF2 TRIM45 CD101 MIR942
GH01H117091 1.2 Ensembl ENCODE 6.8 +33.4 33394 3.6 HDAC1 TBP PKNOX1 ATF1 FEZF1 RAD21 TCF12 ATF7 FOS CREM TRIM45 TTF2 MIR942
GH01H116721 0.7 ENCODE 11.1 -337.7 -337746 1.3 PKNOX1 ARNT MAFG ZEB2 DPF2 ZBTB40 ZNF316 ZNF184 PBX2 NR2C1 C1orf137 LOC101929099 TTF2 CD2 MIR320B1 IGSF3 CD101 GAPDHP64 GC01M116740
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTF2 on UCSC Golden Path with GeneCards custom track

Promoters for TTF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000012051 -188 2201 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143

Genomic Locations for TTF2 Gene

Genomic Locations for TTF2 Gene
chr1:117,060,288-117,107,453
(GRCh38/hg38)
Size:
47,166 bases
Orientation:
Plus strand
chr1:117,602,925-117,650,075
(GRCh37/hg19)

Genomic View for TTF2 Gene

Genes around TTF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTF2 Gene

Proteins for TTF2 Gene

  • Protein details for TTF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNY4-TTF2_HUMAN
    Recommended name:
    Transcription termination factor 2
    Protein Accession:
    Q9UNY4
    Secondary Accessions:
    • A8K4Q2
    • O75921
    • Q5T2K7
    • Q5VVU8
    • Q8N6I8

    Protein attributes for TTF2 Gene

    Size:
    1162 amino acids
    Molecular mass:
    129588 Da
    Quaternary structure:
    • Interacts with CDC5L. Part of the spliceosome.

    Alternative splice isoforms for TTF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTF2 Gene

Selected DME Specific Peptides for TTF2 Gene

Q9UNY4:
  • LADDMGLGKT
  • GGVGLNL
  • MGLGKTL
  • HQKQALAW

Post-translational modifications for TTF2 Gene

  • Ubiquitination at posLast=567567, posLast=814814, and posLast=11091109
  • Modification sites at PhosphoSitePlus

Domains & Families for TTF2 Gene

Gene Families for TTF2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TTF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UNY4

UniProtKB/Swiss-Prot:

TTF2_HUMAN :
  • Belongs to the SNF2/RAD54 helicase family.
Family:
  • Belongs to the SNF2/RAD54 helicase family.
genes like me logo Genes that share domains with TTF2: view

Function for TTF2 Gene

Molecular function for TTF2 Gene

UniProtKB/Swiss-Prot Function:
DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.

Enzyme Numbers (IUBMB) for TTF2 Gene

Phenotypes From GWAS Catalog for TTF2 Gene

Gene Ontology (GO) - Molecular Function for TTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 12927788
GO:0005524 ATP binding IEA --
GO:0008094 DNA-dependent ATPase activity TAS 9748214
genes like me logo Genes that share ontologies with TTF2: view
genes like me logo Genes that share phenotypes with TTF2: view

miRNA for TTF2 Gene

miRTarBase miRNAs that target TTF2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTF2 Gene

Localization for TTF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTF2 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTF2 gene
Compartment Confidence
nucleus 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005681 spliceosomal complex IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0008023 transcription elongation factor complex TAS 9748214
genes like me logo Genes that share ontologies with TTF2: view

Pathways & Interactions for TTF2 Gene

genes like me logo Genes that share pathways with TTF2: view

Pathways by source for TTF2 Gene

1 KEGG pathway for TTF2 Gene

Gene Ontology (GO) - Biological Process for TTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006353 DNA-templated transcription, termination TAS 9748214
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006369 termination of RNA polymerase II transcription TAS 9748214
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with TTF2: view

No data available for SIGNOR curated interactions for TTF2 Gene

Drugs & Compounds for TTF2 Gene

(35) Drugs for TTF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(19) Additional Compounds for TTF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TTF2: view

Transcripts for TTF2 Gene

Unigene Clusters for TTF2 Gene

Transcription termination factor, RNA polymerase II:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTF2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1: -
SP2: -
SP3: -

Relevant External Links for TTF2 Gene

GeneLoc Exon Structure for
TTF2
ECgene alternative splicing isoforms for
TTF2

Expression for TTF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTF2 Gene

Protein differential expression in normal tissues from HIPED for TTF2 Gene

This gene is overexpressed in Plasma (42.3), Monocytes (16.2), and Peripheral blood mononuclear cells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTF2 Gene



Protein tissue co-expression partners for TTF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TTF2 Gene:

TTF2

SOURCE GeneReport for Unigene cluster for TTF2 Gene:

Hs.486818

Evidence on tissue expression from TISSUES for TTF2 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TTF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTF2 Gene

Orthologs for TTF2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTF2 33 34
  • 99.54 (n)
cow
(Bos Taurus)
Mammalia TTF2 33 34
  • 83.94 (n)
dog
(Canis familiaris)
Mammalia TTF2 33 34
  • 80.98 (n)
mouse
(Mus musculus)
Mammalia Ttf2 33 16 34
  • 78.07 (n)
rat
(Rattus norvegicus)
Mammalia Ttf2 33
  • 78.03 (n)
oppossum
(Monodelphis domestica)
Mammalia TTF2 34
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTF2 34
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTF2 33 34
  • 61.06 (n)
lizard
(Anolis carolinensis)
Reptilia TTF2 34
  • 49 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16195 33
zebrafish
(Danio rerio)
Actinopterygii si:ch1073-303l5.1 33
  • 58.57 (n)
TTF2 34
  • 50 (a)
OneToOne
Dr.29408 33
fruit fly
(Drosophila melanogaster)
Insecta lds 34 35
  • 32 (a)
OneToMany
CG10445 35 34
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea F54E12.2 33 34
  • 48.06 (n)
F59A7.8 34 35
  • 31 (a)
OneToMany
T23H2.3 34
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD16 34
  • 27 (a)
OneToMany
ULS1 34
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10555 33
Species where no ortholog for TTF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TTF2 Gene

ENSEMBL:
Gene Tree for TTF2 (if available)
TreeFam:
Gene Tree for TTF2 (if available)

Paralogs for TTF2 Gene

Paralogs for TTF2 Gene

genes like me logo Genes that share paralogs with TTF2: view

Variants for TTF2 Gene

Sequence variations from dbSNP and Humsavar for TTF2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000032946 -- 117,106,272(+) AGATA(C/T)GAAAA nc-transcript-variant, utr-variant-3-prime
rs1000039347 -- 117,067,351(+) TCATG(A/G)TGAAA intron-variant
rs1000284773 -- 117,087,376(+) AACCT(C/G)TGCAT intron-variant
rs1000405612 -- 117,106,530(+) AAAAG(C/T)AAGCA nc-transcript-variant, utr-variant-3-prime
rs1000467403 -- 117,081,370(+) AAATG(C/T)TCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTF2 Gene

Variant ID Type Subtype PubMed ID
nsv1127019 CNV deletion 24896259
nsv1009706 CNV gain 25217958

Variation tolerance for TTF2 Gene

Residual Variation Intolerance Score: 73.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.24; 62.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTF2 Gene

Human Gene Mutation Database (HGMD)
TTF2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTF2 Gene

Disorders for TTF2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TTF2 Gene - From: HGMD, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sexual sadism
  • sadism
narcissistic personality disorder
brunner syndrome
  • antisocial behavior
axenfeld-rieger syndrome
  • anomaly, rieger's
- elite association - COSMIC cancer census association via MalaCards
Search TTF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TTF2

Genetic Association Database (GAD)
TTF2
Human Genome Epidemiology (HuGE) Navigator
TTF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTF2
genes like me logo Genes that share disorders with TTF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTF2 Gene

Publications for TTF2 Gene

  1. Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer. (PMID: 10455150) Hara R … Sancar A (The Journal of biological chemistry 1999) 2 3 4 22 60
  2. A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member. (PMID: 9748214) Liu M … Price DH (The Journal of biological chemistry 1998) 2 3 4 22 60
  3. Involvement of transcription termination factor 2 in mitotic repression of transcription elongation. (PMID: 15125840) Jiang Y … Price DH (Molecular cell 2004) 3 4 22 60
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for TTF2 Gene

Sources for TTF2 Gene

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