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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TTF1 Gene

protein-coding   GIFtS: 55
GCID: GC09M135250

transcription termination factor, RNA polymerase I

 Explore 14 diseases affiliated with
TTF1 via our new
 Human Malady Compendium 
Biological research products
for TTF1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Transcription Termination Factor, RNA Polymerase I1 2
TTF-12 3
TTF-I2 3
Transcription Termination Factor 12
RNA Polymerase I Termination Factor3
Transcription Termination Factor I3

External Ids:    HGNC: 123971   Entrez Gene: 72702   Ensembl: ENSG000001254827   OMIM: 6007775   UniProtKB: Q153613   

Export aliases for TTF1 gene to outside databases

Previous GC identifers: GC09M126276 GC09M126808 GC09M128604 GC09M130526 GC09M132280 GC09M134240 GC09M104744


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TTF1:
This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in
ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by
binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript
variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with
another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of
thyroid-specific gene expression. (provided by RefSeq, Apr 2011)

UniProtKB/Swiss-Prot: TTF1_HUMAN, Q15361
Function: Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork
arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved
in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity

Gene Wiki entry for TTF1 (Transcription termination factor, RNA polymerase I)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_035014.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TTF1 gene promoter:
         POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   GATA-1   C/EBPalpha   CHOP-10   FOXJ2 (long isoform)   Cart-1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TTF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.13   Ensembl cytogenetic band:  9q34.13   HGNC cytogenetic band: 9q34.3

TTF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTF1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M135250:  view genomic region     (about GC identifiers)

Start:
135,250,935 bp from pter      End:
135,282,221 bp from pter
Size:
31,287 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TTF1_HUMAN, Q15361 (See protein sequence)
Recommended Name: Transcription termination factor 1  
Size: 905 amino acids; 103051 Da
Subunit: Oligomer. The oligomeric structure enables to interact simultaneously with two separate DNA fragments.
Interacts with BAZ2A/TIP5
Subcellular location: Nucleus. Nucleus, nucleolus (By similarity)
Sequence caution: Sequence=AAH62692.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence; Sequence=AAI04640.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=AAI27670.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the
N-terminal part; Sequence=AAI27671.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown
origin in the N-terminal part; Sequence=AAI43049.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.
Sequence of unknown origin in the N-terminal part; Sequence=AAI43050.1; Type=Miscellaneous discrepancy;
Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part; Sequence=CAA58807.1; Type=Frameshift;
Positions=875; Sequence=CAA58807.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown
origin in the C-terminal part;
Secondary accessions: A1L160 Q4VXF3 Q58EY2 Q6P5T5

Explore the universe of human proteins at neXtProt for TTF1: NX_Q15361

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15361

  • TTF1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001192225.1  NP_031370.2  

    ENSEMBL proteins: 
     ENSP00000333920  
    Reactome Protein details: Q15361
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TTF1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS7597036
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IEA--


    TTF1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TTF1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TTF1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017877 Myb-like_dom
     IPR001005 SANT/Myb
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q15361

    ProtoNet protein and cluster: Q15361

    UniProtKB/Swiss-Prot: TTF1_HUMAN, Q15361
    Domain: The N-terminal region (NRD) inhibits DNA-binding via its interaction with the C-terminal region (By similarity)
    Similarity: Contains 2 Myb-like domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TTF1_HUMAN, Q15361
    Function: Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork
    arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved
    in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity

    miRNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTF1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding ----


    TTF1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TTF1:
     Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1RNA Polymerase I Chain Elongation
    RNA Polymerase I Transcription Termination0.90
    RNA Polymerase I Transcription0.79
    2Transcription
    Transcription1.00
    3TSH signaling pathway
    TSH signaling pathway1.00
    4RNA Polymerase III Transcription Initiation
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.59
    5Generic Transcription Pathway
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for TTF1 
        TSH signaling pathway

    5        Reactome Pathways for TTF1
        RNA Polymerase I Transcription
    Transcription
    RNA Polymerase I Transcription Termination
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
    Gene Expression



    TTF1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/10 Interacting proteins for TTF1 (Q153612, 3 ENSP000003339204) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD1Q157972, 3MINT-62007 I2D: score=3 
    SMAD7O151052, 3MINT-61821 I2D: score=3 
    PTRFQ6NZI23, ENSP000003495414I2D: score=3 STRING: ENSP00000349541
    BAZ2AQ9UIF93, ENSP000003687544I2D: score=2 STRING: ENSP00000368754
    NFATC3Q129683, ENSP000003006594I2D: score=1 STRING: ENSP00000300659
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006338chromatin remodeling IEA--
    GO:0006353DNA-dependent transcription, termination NAS7597036
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006360transcription from RNA polymerase I promoter TAS--
    GO:0006361transcription initiation from RNA polymerase I promoter IEA--


    TTF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TTF1
    Search CenterWatch for drugs/clinical trials and news about TTF1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TTF1 gene (2 alternative transcripts): 
    NM_001205296.1  NM_007344.3  

    Unigene Clusters for TTF1:

    Transcription termination factor, RNA polymerase I
    Hs.54780  [show with all ESTs], Hs.732733  [show with all ESTs]
    Unigene Representative Sequences: NM_007344, BU940778
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334270(uc004cbl.3 uc004cbm.3 uc011mcp.2) ENST00000461970


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    Additional cDNA sequence: 

    AK225119.1 BC062692.1 BC104639.1 

    7 DOTS entries:

    DT.414183  DT.100815079  DT.95129574  DT.100037867  DT.121156628  DT.100742372  DT.100815078 

    24/116 AceView cDNA sequences (see all 116):

    AI372017 AA687863 BF196544 AU098541 AU185722 AA456512 NM_007344 AA312422 
    BM564590 AI656571 AW207477 AA283043 BG758250 BX457598 AI768885 AW613598 
    BX331126 AL547840 CF128740 BM264466 AI091430 BU674009 AI420968 BU507081 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TTF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTGAAGGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TTF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TTF1

    SOURCE GeneReport for Unigene clusters: Hs.54780 Hs.732733
        SABiosciences Custom PCR Arrays for TTF1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TTF1 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttf11 , 5 transcription termination factor, RNA polymerase I1, 5 63.05(n)1
    52.86(a)1
      2 (19.38 cM)5
    221301  NM_009442.21  NP_033468.21 
     290602625 
    chicken
    (Gallus gallus)
    Aves TTF11 transcription termination factor, RNA polymerase I 61.52(n)
    51.83(a)
      417169  XM_415452.3  XP_415452.3 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003329921 transcription termination factor 1-like 55.65(n)
    41.74(a)
      100332992  XM_002662174.1  XP_002662220.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G410201 myb family transcription factor 42.31(n)
    25.13(a)
      834104  NM_123467.2  NP_198918.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g03037001 hypothetical protein   --   4340836  NM_001063997.2  NP_001057462.2 


    ENSEMBL Gene Tree for TTF1 (if available)
    TreeFam Gene Tree for TTF1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TTF1 gene
    DMTF12  

    TTF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/769 NCBI SNPs in TTF1 are shown (see all 769    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs779361391,2
    --104777020(+) CAACTC/TTGCAA 1 -- us2k10--------
    rs1412323381,2
    --135250438(+) TAGACA/GTGAGC 2 -- ds50010--------
    rs70302331,2
    C,F,A,H,--135250473(+) TTTCTA/GCAAGC 2 -- ds500127Minor allele frequency- G:0.24NS EA NA WA CSA 2772
    rs1450446601,2
    --135250503(+) TTTTGC/TTTGTT 2 -- ds50010--------
    rs743722341,2
    C,F,--135250517(+) AGTTAA/CATACC 2 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1932184071,2
    --135250524(+) TACCAC/GGTAAG 2 -- ds50010--------
    rs1844312161,2
    --135250601(+) CTCAGA/GAAGTT 2 -- ds50010--------
    rs1388884721,2
    --135250635(+) ACAAGA/GGAAAG 2 -- ds50010--------
    rs1417328661,2
    --135250646(+) AGACCA/GGTTTG 2 -- ds50010--------
    rs1505728711,2
    --135250655(+) TGAGAC/GAACAG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for TTF1 (135250935 - 135282221 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TTF1: --

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for TTF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TTF1 for disorders           About GeneDecksing

    OMIM gene information: 600777    OMIM disorders: --

    14 diseases for TTF1:    About MalaCards
    sex cord-gonadal stromal tumor    desmoplastic small round cell tumor    thyroiditis    pulmonary large cell neuroendocrine carcinoma
    small cell carcinoma    blastoma    ovarian small cell carcinoma    pulmonary blastoma
    hirschsprung's disease    neuroendocrine carcinoma    hepatocellular carcinoma    carcinoma
    lung cancer    adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for TTF1:
    Ovarian small cell carcinoma
    Genetic Association Database (GAD): TTF1
    Human Genome Epidemiology (HuGE) Navigator: TTF1 (12 documents)

    Export disorders for TTF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TTF1 gene, integrated from 9 sources (see all 67):
    (articles sorted by number of sources associating them with TTF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular evolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-1. (PubMed id 7597036)1, 2, 3 Evers R. and Grummt I. (1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The mitotically phosphorylated form of the transcription termination factor TTF-1 is associated with the repressed rDNA transcription machinery. (PubMed id 10504331)1, 9 Sirri V....Hernandez-Verdun D. (1999)
    4. The cellular abundance of the essential transcription termination factor TTF-I regulates ribosome biogenesis and is determined by MDM2 ubiquitinylation. (PubMed id 22383580)1 Lessard F....Moss T. (2012)
    5. Expression of thyroid transcription factor-1 in normal endometrium is associated with risk of endometrial cancer development. (PubMed id 22460811)1 Sullivan P.S....Dorigo O. (2012)
    6. High incidence of EGFR mutations in Korean men smokers with no intratumoral heterogeneity of lung adenocarcinomas: correlation with hi stologic subtypes, EGFR/TTF-1 expressions, and clinical features. (PubMed id 22237264)1 Sun P.L....Chung J.H. (2012)
    7. MYBPH, a transcriptional target of TTF-1, inhibits ROC K1, and reduces cell motility and metastasis. (PubMed id 22085929)1 Hosono Y....Takahashi T. (2012)
    8. Diagnostic utility of PAX8, TTF-1 and napsin A for dis criminating metastatic carcinoma from primary adenocarcinoma of the lung. (PubMed id 21838611)1 Ye J....Xu H. (2012)
    9. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    10. TTF-1 in embryonal tumors: an immunohistochemical stu dy of 117 cases. (PubMed id 21836486)1 Galliani C.A....Rosai J. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7270 HGNC: 12397 AceView: TTF1 Ensembl:ENSG00000125482 euGenes: HUgn7270
    ECgene: TTF1 H-InvDB: TTF1

    (According to HUGE)
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