Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TTF1 Gene

Aliases for TTF1 Gene

  • Transcription Termination Factor, RNA Polymerase I 2 3
  • TTF-1 3 4
  • TTF-I 3 4
  • RNA Polymerase I Termination Factor 4
  • Transcription Termination Factor I 4

External Ids for TTF1 Gene

Previous GeneCards Identifiers for TTF1 Gene

  • GC09M126276
  • GC09M126808
  • GC09M128604
  • GC09M130526
  • GC09M132280
  • GC09M134240
  • GC09M135250
  • GC09M104744

Summaries for TTF1 Gene

Entrez Gene Summary for TTF1 Gene

  • This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011]

GeneCards Summary for TTF1 Gene

TTF1 (Transcription Termination Factor, RNA Polymerase I) is a Protein Coding gene. Diseases associated with TTF1 include thyroid cancer, monmedullary, 1 and chorea, hereditary benign. Among its related pathways are Infectious disease and Transport to the Golgi and subsequent modification. GO annotations related to this gene include chromatin binding. An important paralog of this gene is DMTF1.

UniProtKB/Swiss-Prot for TTF1 Gene

  • Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.

Gene Wiki entry for TTF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTF1 Gene

Genomics for TTF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TTF1 Gene

Chromosome:
9
Start:
132,375,548 bp from pter
End:
132,406,871 bp from pter
Size:
31,324 bases
Orientation:
Minus strand

Genomic View for TTF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTF1 Gene

Proteins for TTF1 Gene

  • Protein details for TTF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15361-TTF1_HUMAN
    Recommended name:
    Transcription termination factor 1
    Protein Accession:
    Q15361
    Secondary Accessions:
    • A1L160
    • Q4VXF3
    • Q58EY2
    • Q6P5T5

    Protein attributes for TTF1 Gene

    Size:
    905 amino acids
    Molecular mass:
    103051 Da
    Quaternary structure:
    • Oligomer. The oligomeric structure enables to interact simultaneously with two separate DNA fragments. Interacts with BAZ2A/TIP5
    SequenceCaution:
    • Sequence=AAH62692.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI04640.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI27670.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAI27671.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAI43049.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAI43050.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=CAA58807.1; Type=Frameshift; Positions=875; Evidence={ECO:0000305}; Sequence=CAA58807.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305};

neXtProt entry for TTF1 Gene

Proteomics data for TTF1 Gene at MOPED

Post-translational modifications for TTF1 Gene

  • Ubiquitination at Lys 765
  • Modification sites at PhosphoSitePlus

Other Protein References for TTF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TTF1 Gene

Domains & Families for TTF1 Gene

Gene Families for TTF1 Gene

Protein Domains for TTF1 Gene

Suggested Antigen Peptide Sequences for TTF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15361

UniProtKB/Swiss-Prot:

TTF1_HUMAN :
  • The N-terminal region (NRD) inhibits DNA-binding via its interaction with the C-terminal region.
Domain:
  • The N-terminal region (NRD) inhibits DNA-binding via its interaction with the C-terminal region.
  • Contains 2 Myb-like domains.
genes like me logo Genes that share domains with TTF1: view

Function for TTF1 Gene

Molecular function for TTF1 Gene

UniProtKB/Swiss-Prot Function:
Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.

Gene Ontology (GO) - Molecular Function for TTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TTF1: view
genes like me logo Genes that share phenotypes with TTF1: view

Animal Model Products

miRNA for TTF1 Gene

miRTarBase miRNAs that target TTF1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TTF1 Gene

Localization for TTF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTF1 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTF1 Gene COMPARTMENTS Subcellular localization image for TTF1 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 7597036
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with TTF1: view

Pathways & Interactions for TTF1 Gene

genes like me logo Genes that share pathways with TTF1: view

Pathways by source for TTF1 Gene

SIGNOR curated interactions for TTF1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling IEA --
GO:0006353 DNA-templated transcription, termination NAS 7597036
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006360 transcription from RNA polymerase I promoter TAS --
GO:0006361 transcription initiation from RNA polymerase I promoter IEA --
genes like me logo Genes that share ontologies with TTF1: view

Drugs & Compounds for TTF1 Gene

No Compound Related Data Available

Transcripts for TTF1 Gene

Unigene Clusters for TTF1 Gene

Transcription termination factor, RNA polymerase I:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTF1 Gene

No ASD Table

Relevant External Links for TTF1 Gene

GeneLoc Exon Structure for
TTF1
ECgene alternative splicing isoforms for
TTF1

Expression for TTF1 Gene

mRNA expression in normal human tissues for TTF1 Gene

Protein differential expression in normal tissues from HIPED for TTF1 Gene

This gene is overexpressed in Lung (50.1), Blymphocyte (8.3), and Adipocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTF1 Gene



SOURCE GeneReport for Unigene cluster for TTF1 Gene Hs.54780

genes like me logo Genes that share expression patterns with TTF1: view

Protein tissue co-expression partners for TTF1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTF1 Gene

Orthologs for TTF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TTF1 35
  • 77.49 (n)
  • 70.28 (a)
TTF1 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTF1 35
  • 77.82 (n)
  • 73.38 (a)
TTF1 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TTF1 35
  • 98.54 (n)
  • 98.22 (a)
TTF1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttf1 16
Ttf1 36
  • 52 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTF1 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTF1 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTF1 36
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ttf1 36
  • 26 (a)
OneToMany
ttf1 36
  • 29 (a)
OneToMany
TTF1 (2 of 6) 36
  • 34 (a)
OneToMany
TTF1 (3 of 6) 36
  • 29 (a)
OneToMany
TTF1 (5 of 6) 36
  • 31 (a)
OneToMany
TTF1 (6 of 6) 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
OneToMany
Species with no ortholog for TTF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTF1 Gene

ENSEMBL:
Gene Tree for TTF1 (if available)
TreeFam:
Gene Tree for TTF1 (if available)

Paralogs for TTF1 Gene

Paralogs for TTF1 Gene

genes like me logo Genes that share paralogs with TTF1: view

Variants for TTF1 Gene

Sequence variations from dbSNP and Humsavar for TTF1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs572712 -- 132,383,322(+) gacat(C/T)actgg intron-variant
rs574062 -- 132,396,083(+) CTGAA(G/T)GGAAC intron-variant
rs575019 -- 132,396,204(+) AAGTG(C/T)AGAGA intron-variant
rs579081 -- 132,389,975(+) TCTCT(A/C)TATAT intron-variant
rs693650 -- 132,399,512(+) ACCCA(A/C)TAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTF1 Gene

Variant ID Type Subtype PubMed ID
nsv894021 CNV Gain 21882294
esv2678054 CNV Deletion 23128226
esv2739127 CNV Deletion 23290073
esv2739129 CNV Deletion 23290073
esv2739130 CNV Deletion 23290073
nsv6741 CNV Loss 18451855

Variation tolerance for TTF1 Gene

Residual Variation Intolerance Score: 98.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.18; 75.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTF1 Gene

HapMap Linkage Disequilibrium report
TTF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTF1 Gene

Disorders for TTF1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TTF1 Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
thyroid cancer, monmedullary, 1
  • papillary thyroid carcinoma
chorea, hereditary benign
  • benign hereditary chorea
choreoathetosis, hypothyroidism, and neonatal respiratory distress
  • brain lung thyroid syndrome
neuroendocrine cell hyperplasia of infancy
  • nchi
pulmonary surfactant metabolism dysfunction
  • pulmonary alveolar proteinosis
- elite association
Search TTF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TTF1

Genetic Association Database (GAD)
TTF1
Human Genome Epidemiology (HuGE) Navigator
TTF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTF1
genes like me logo Genes that share disorders with TTF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTF1 Gene

Publications for TTF1 Gene

  1. The human papillomavirus type 8 E2 tethering protein targets the ribosomal DNA loci of host mitotic chromosomes. (PMID: 19004936) Poddar A. … McBride A.A. (J. Virol. 2009) 23 67
  2. c-Myc induces changes in higher order rDNA structure on stimulation of quiescent cells. (PMID: 19270725) Shiue C.N. … Wright A.P. (Oncogene 2009) 23 67
  3. In vitro expression and redistribution of nucleolar proteins following the treatment with cis-dichloro-1,2-propylenediamine-N,N,N',N'-tetraacetato ruthenium (III) (RAP). (PMID: 19718949) Delmani F.A. … GonzA!lez-VA-ltchez F. (Oncol. Res. 2009) 23 67
  4. Growth factor signaling regulates elongation of RNA polymerase I transcription in mammals via UBF phosphorylation and r-chromatin remodeling. (PMID: 16507361) Stefanovsky V. … Moss T. (Mol. Cell 2006) 23 67
  5. Combined small cell carcinoma with pulmonary blastoma and adenocarcinoma: case report and clonality analysis. (PMID: 17046168) Iezumi K. … Mitsuya T. (Pathol. Res. Pract. 2006) 23 67

Products for TTF1 Gene

Sources for TTF1 Gene

Back to Top

Content