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TTF1 Gene

protein-coding   GIFtS: 58
GCID: GC09M135250

Transcription Termination Factor, RNA Polymerase I

  See TTF1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transcription Termination Factor, RNA Polymerase I1 2
TTF-12 3
TTF-I2 3
Transcription Termination Factor 12
RNA Polymerase I Termination Factor3
Transcription Termination Factor I3

External Ids:    HGNC: 123971   Entrez Gene: 72702   Ensembl: ENSG000001254827   OMIM: 6007775   UniProtKB: Q153613   

Export aliases for TTF1 gene to outside databases

Previous GC identifers: GC09M126276 GC09M126808 GC09M128604 GC09M130526 GC09M132280 GC09M134240 GC09M104744


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TTF1 Gene:
This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role
in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription
by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript
variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1'
with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the
regulation of thyroid-specific gene expression. (provided by RefSeq, Apr 2011)

GeneCards Summary for TTF1 Gene:
TTF1 (transcription termination factor, RNA polymerase I) is a protein-coding gene. Diseases associated with TTF1 include neuroendocrine cell hyperplasia of infancy, and goiter, familial, due to ttf-1 defect. GO annotations related to this gene include chromatin binding. An important paralog of this gene is DMTF1.

UniProtKB/Swiss-Prot: TTF1_HUMAN, Q15361
Function: Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication
fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation,
being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers
DNA-binding activity

Gene Wiki entry for TTF1 (Transcription termination factor, RNA polymerase I) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TTF1 gene promoter:
         POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   GATA-1   C/EBPalpha   CHOP-10   FOXJ2 (long isoform)   Cart-1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTF1 promoter sequence
   Search Chromatin IP Primers for TTF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.13   Ensembl cytogenetic band:  9q34.13   HGNC cytogenetic band: 9q34.3

TTF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTF1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M135250:  view genomic region     (about GC identifiers)

Start:
135,250,935 bp from pter      End:
135,282,238 bp from pter
Size:
31,304 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TTF1_HUMAN, Q15361 (See protein sequence)
Recommended Name: Transcription termination factor 1  
Size: 905 amino acids; 103051 Da
Subunit: Oligomer. The oligomeric structure enables to interact simultaneously with two separate DNA fragments.
Interacts with BAZ2A/TIP5
Sequence caution: Sequence=AAH62692.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAI04640.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAI27670.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of
unknown origin in the N-terminal part; Sequence=AAI27671.1; Type=Miscellaneous discrepancy; Note=Contaminating
sequence. Sequence of unknown origin in the N-terminal part; Sequence=AAI43049.1; Type=Miscellaneous discrepancy;
Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part; Sequence=AAI43050.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part;
Sequence=CAA58807.1; Type=Frameshift; Positions=875; Sequence=CAA58807.1; Type=Miscellaneous discrepancy;
Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part;
Secondary accessions: A1L160 Q4VXF3 Q58EY2 Q6P5T5

Explore the universe of human proteins at neXtProt for TTF1: NX_Q15361

Explore proteomics data for TTF1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys765
  • Modification sites at PhosphoSitePlus

  • See TTF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001192225.1  NP_031370.2  

    ENSEMBL proteins: 
     ENSP00000333920  
    Reactome Protein details: Q15361

    TTF1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001005 SANT/Myb
     IPR017877 Myb-like_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q15361

    ProtoNet protein and cluster: Q15361

    UniProtKB/Swiss-Prot: TTF1_HUMAN, Q15361
    Domain: The N-terminal region (NRD) inhibits DNA-binding via its interaction with the C-terminal region (By
    similarity)
    Similarity: Contains 2 Myb-like domains


    Find genes that share domains with TTF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTF1_HUMAN, Q15361
    Function: Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication
    fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation,
    being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers
    DNA-binding activity

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TTF1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TTF1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TTF1
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    miRTarBase miRNAs that target TTF1:
    hsa-mir-155-5p (MIRT020919)

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    GenScript: all cDNA clones in your preferred vector (see all 2): TTF1 (NM_007344)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TTF1_HUMAN, Q15361: Nucleus. Nucleus, nucleolus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS7597036
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with TTF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TTF1 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
    RNA Polymerase I Promoter Clearance0.78
    2RNA Polymerase I Promoter Escape
    RNA Polymerase I Transcription Termination0.88
    RNA Polymerase I Transcription Initiation0.55
    3Gene Expression
    Gene Expression0.40
    4Insulin secretion
    Thyroid hormone synthesis0.36
    5TSH signaling pathway
    TSH signaling pathway


    Find genes that share SuperPaths with TTF1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TTF1
        TSH signaling pathway

    3 Reactome Pathways for TTF1
        NoRC negatively regulates rRNA expression
    RNA Polymerase I Transcription Termination
    RNA Polymerase I Transcription Initiation


    1 Kegg Pathway  (Kegg details for TTF1):
        Thyroid hormone synthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TTF1
    Interactions:

        Search GeneGlobe Interaction Network for TTF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TTF1 (Q153612, 3 ENSP000003339204) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD1Q157972, 3MINT-62007 I2D: score=3 
    SMAD7O151052, 3MINT-61821 I2D: score=3 
    PTRFQ6NZI23, ENSP000003495414I2D: score=3 STRING: ENSP00000349541
    BAZ2AQ9UIF93, ENSP000003687544I2D: score=2 STRING: ENSP00000368754
    NFATC3Q129683, ENSP000003006594I2D: score=1 STRING: ENSP00000300659
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006338chromatin remodeling IEA--
    GO:0006353DNA-templated transcription, termination NAS7597036
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006360transcription from RNA polymerase I promoter TAS--
    GO:0006361transcription initiation from RNA polymerase I promoter IEA--

    Find genes that share ontologies with TTF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TTF1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TTF1 gene (2 alternative transcripts): 
    NM_001205296.1  NM_007344.3  

    Unigene Cluster for TTF1:

    Transcription termination factor, RNA polymerase I
    Hs.54780  [show with all ESTs]
    Unigene Representative Sequence: NM_007344
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334270(uc004cbl.3 uc004cbm.3 uc011mcp.2) ENST00000461970

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    Primer
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    Additional mRNA sequence: 

    AK302902.1 BC050734.1 BC127669.1 BC127670.1 BC143048.1 BC143049.1 BC143821.1 

    7 DOTS entries:

    DT.100815079  DT.414183  DT.95129574  DT.100037867  DT.121156628  DT.100815078  DT.100742372 

    Selected AceView cDNA sequences (see all 116):

    NM_007344 AA687863 AI656571 BM564590 AA312422 AU098541 AU185722 AI372017 
    BF196544 AA456512 AI420968 BQ187221 BG104454 AI554945 AL547865 BE551758 
    AU128079 AW183893 AL547840 BM827593 AI338717 CB122369 BM796734 CF128740 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TTF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGAAGGAT
    TTF1 Expression
    About this image

    TTF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TTF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.54780
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TTF1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttf15 transcription termination factor, RNA polymerase I   --   2 (19.38 cM) 29060262 
    chicken
    (Gallus gallus)
    Aves TTF16
    transcription termination factor, RNA polymerase I...
    51(a)
    1 ↔ 1
    17(6520528-6527682)
    zebrafish
    (Danio rerio)
    Actinopterygii TTF1 (2 of 6)6
    TTF1 (6 of 6)6
    (see all 6)
    transcription termination factor, RNA polymerase I...
    transcription termination factor, RNA polymerase I...
    (see all 6)
    34(a)
    31(a)
    (see all 6)
    many → 1
    many → 1
    (see all 6)
    5(66502486-66519328) ENSDARG00000092508
    5(66488425-66494803) ENSDARG00000094107


    ENSEMBL Gene Tree for TTF1 (if available)
    TreeFam Gene Tree for TTF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TTF1 gene
    DMTF12  

    Find genes that share paralogs with TTF1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TTF1 (see all 924)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1412323381,2
    --135250438(+) TAGACA/GTGAGC 2 -- ds50010--------
    rs70302331,2
    C,F,A,H--135250473(+) TTTCTA/GCAAGC 2 -- ds500127Minor allele frequency- G:0.24NS EA NA WA CSA 2772
    rs1450446601,2
    --135250503(+) TTTTGC/TTTGTT 2 -- ds50010--------
    rs743722341,2
    C,F--135250517(+) AGTTAA/CATACC 2 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1932184071,2
    --135250524(+) TACCAC/GGTAAG 2 -- ds50010--------
    rs1844312161,2
    --135250601(+) CTCAGA/GAAGTT 2 -- ds50010--------
    rs1388884721,2
    --135250635(+) ACAAGA/GGAAAG 2 -- ds50010--------
    rs1417328661,2
    C--135250646(+) AGACCA/GGTTTG 2 -- ds50010--------
    rs1505728711,2
    --135250655(+) TGAGAC/GAACAG 2 -- ds50010--------
    rs778031231,2
    F--135250685(+) TAACAC/TGAATG 2 -- ds50011Minor allele frequency- T:0.06WA 118

    HapMap Linkage Disequilibrium report for TTF1 (135250935 - 135282238 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TTF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739130CNV Deletion23290073
    esv2739129CNV Deletion23290073
    esv2739127CNV Deletion23290073
    esv2678054CNV Deletion23128226
    nsv6741CNV Loss18451855
    nsv894021CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600777    OMIM disorders: --

    8 diseases for TTF1:    
    About MalaCards
    neuroendocrine cell hyperplasia of infancy    goiter, familial, due to ttf-1 defect    brain lung thyroid syndrome    benign hereditary chorea
    ovarian small cell carcinoma    pulmonary blastoma    small cell carcinoma    blastoma

    1 disease from the University of Copenhagen DISEASES database for TTF1:
    Ovarian small cell carcinoma

    Find genes that share disorders with TTF1           About GenesLikeMe

    Genetic Association Database (GAD): TTF1
    Human Genome Epidemiology (HuGE) Navigator: TTF1 (12 documents)

    Export disorders for TTF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TTF1 gene, integrated from 10 sources (see all 75):
    (articles sorted by number of sources associating them with TTF1)
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    1. Molecular evolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-1. (PubMed id 7597036)1, 2, 3 Evers R. and Grummt I. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    2. A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias. (PubMed id 19464057)1, 4 Kreil S....Chase A. (Leuk. Res. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The mitotically phosphorylated form of the transcription termination factor TTF-1 is associated with the repressed rDNA transcription machinery. (PubMed id 10504331)1, 9 Sirri V....Hernandez-Verdun D. (J. Cell. Sci. 1999)
    5. Neural lineage-specific homeoprotein BRN2 is directly involved in TTF1 expression in small-cell lung cancer. (PubMed id 23358112)1 Sakaeda M....Yazawa T. ( a journal of technical methods and pathology 2013)
    6. A mutation in TTF1/NKX2.1 is associated with familial neuroendocrine cell hyperplasia of infancy. (PubMed id 23787483)1 Young L.R....Nogee L.M. (Chest 2013)
    7. EGFR and TTF-1 gene amplification in surgically resected lung adenocarcinomas: clinicopathologic significance and effect on response to EGFR-tyrosine kinase inhibitors in recurred cases. (PubMed id 23525704)1 Lee J.S....Shim H.S. (Ann. Surg. Oncol. 2013)
    8. Expression of focal TTF-1 expression in a case of CK7/CK20-positive Merkel cell carcinoma. (PubMed id 23330966)1 Reddi D.M. and Puri P.K. (J. Cutan. Pathol. 2013)
    9. The cellular abundance of the essential transcription termination factor TTF-I regulates ribosome biogenesis and is determined by MDM2 ubiquitinylation. (PubMed id 22383580)1 Lessard F....Moss T. (Nucleic Acids Res. 2012)
    10. Thyroid transcription factor 1 represses the expression of Ki-67 and induces apoptosis in non-small cell lung cancer. (PubMed id 22940844)1 Zu Y.F....Guo J. (Oncol. Rep. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7270 HGNC: 12397 AceView: TTF1 Ensembl:ENSG00000125482 euGenes: HUgn7270
    ECgene: TTF1 Kegg: 7270 H-InvDB: TTF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TTF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TTF1 gene:
    Search GeneIP for patents involving TTF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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