Aliases for TTF1 Gene
External Ids for TTF1 Gene
Previous GeneCards Identifiers for TTF1 Gene
This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011]
GeneCards Summary for TTF1 Gene
TTF1 (Transcription Termination Factor 1) is a Protein Coding gene. Diseases associated with TTF1 include Neuroendocrine Cell Hyperplasia Of Infancy and Pulmonary Surfactant Metabolism Dysfunction. Among its related pathways are Surfactant metabolism and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include chromatin binding. An important paralog of this gene is DMTF1.
UniProtKB/Swiss-Prot for TTF1 Gene
Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.