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Aliases for TTC9C Gene

Aliases for TTC9C Gene

  • Tetratricopeptide Repeat Domain 9C 2 3 5
  • TPR Repeat Protein 9C 4

External Ids for TTC9C Gene

Previous GeneCards Identifiers for TTC9C Gene

  • GC11P062254
  • GC11P062495
  • GC11P058825

Summaries for TTC9C Gene

GeneCards Summary for TTC9C Gene

TTC9C (Tetratricopeptide Repeat Domain 9C) is a Protein Coding gene. An important paralog of this gene is TTC9B.

Additional gene information for TTC9C Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC9C Gene

Genomics for TTC9C Gene

Regulatory Elements for TTC9C Gene

Enhancers for TTC9C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H062571 1.6 Ensembl ENCODE dbSUPER 21.7 -152.6 -152584 7.4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 BSCL2 TTC9C EML3 MTA2 STX5 NXF1 GANAB TMEM179B INTS5 METTL12
GH11H062838 1.5 ENCODE dbSUPER 22.5 +112.8 112777 4.8 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC UBXN1 METTL12 WDR74 NXF1 SNHG1 INTS5 LOC105369332 STX5 MTA2 GANAB
GH11H062551 2.1 FANTOM5 Ensembl ENCODE dbSUPER 13.1 -170.9 -170893 12.9 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF207 EML3 TUT1 MTA2 TAF6L NXF1 LOC105369332 WDR74 STX5 INTS5 TTC9C
GH11H062878 1.4 ENCODE dbSUPER 18.1 +153.8 153764 5.9 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 SNHG1 TTC9C SLC3A2 SNORD28 ENSG00000257002 SNORD22 TAF6L METTL12 AHNAK BSCL2
GH11H063563 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.1 +837.9 837937 5.8 HDGF PKNOX1 FOXA2 ATF1 ARNT TCF12 ZNF766 GATA2 ZNF207 ATF7 RARRES3 TTC9C ENSG00000203520 PLA2G16 ENSG00000256789 OTUB1 HRASLS2 LOC105369335
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTC9C on UCSC Golden Path with GeneCards custom track

Promoters for TTC9C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040468 -669 4801 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207

Genomic Locations for TTC9C Gene

Genomic Locations for TTC9C Gene
chr11:62,728,069-62,740,293
(GRCh38/hg38)
Size:
12,225 bases
Orientation:
Plus strand
chr11:62,495,541-62,507,765
(GRCh37/hg19)

Genomic View for TTC9C Gene

Genes around TTC9C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC9C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC9C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC9C Gene

Proteins for TTC9C Gene

  • Protein details for TTC9C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5M4-TTC9C_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 9C
    Protein Accession:
    Q8N5M4
    Secondary Accessions:
    • Q8WYY7

    Protein attributes for TTC9C Gene

    Size:
    171 amino acids
    Molecular mass:
    20013 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC9C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC9C Gene

Post-translational modifications for TTC9C Gene

  • Ubiquitination at Lys12
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TTC9C Gene

Domains & Families for TTC9C Gene

Gene Families for TTC9C Gene

Protein Domains for TTC9C Gene

Suggested Antigen Peptide Sequences for TTC9C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5M4

UniProtKB/Swiss-Prot:

TTC9C_HUMAN :
  • Belongs to the TTC9 family.
Family:
  • Belongs to the TTC9 family.
genes like me logo Genes that share domains with TTC9C: view

Function for TTC9C Gene

Phenotypes From GWAS Catalog for TTC9C Gene

Gene Ontology (GO) - Molecular Function for TTC9C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TTC9C: view
genes like me logo Genes that share phenotypes with TTC9C: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC9C Gene

Localization for TTC9C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC9C gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC9C Gene

Pathways & Interactions for TTC9C Gene

SuperPathways for TTC9C Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC9C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC9C Gene

Drugs & Compounds for TTC9C Gene

No Compound Related Data Available

Transcripts for TTC9C Gene

Unigene Clusters for TTC9C Gene

Tetratricopeptide repeat domain 9C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC9C Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1:
SP2: - -
SP3: -
SP4: - - - - - -
SP5: -
SP6:

Relevant External Links for TTC9C Gene

GeneLoc Exon Structure for
TTC9C
ECgene alternative splicing isoforms for
TTC9C

Expression for TTC9C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTC9C Gene

Protein differential expression in normal tissues from HIPED for TTC9C Gene

This gene is overexpressed in Bone (28.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTC9C Gene



Protein tissue co-expression partners for TTC9C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TTC9C Gene:

TTC9C

SOURCE GeneReport for Unigene cluster for TTC9C Gene:

Hs.31704
genes like me logo Genes that share expression patterns with TTC9C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC9C Gene

Orthologs for TTC9C Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC9C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC9C 33 34
  • 99.42 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 92 (a)
OneToMany
-- 34
  • 92 (a)
OneToMany
TTC9C 33 34
  • 90.64 (n)
dog
(Canis familiaris)
Mammalia TTC9C 33 34
  • 89.86 (n)
rat
(Rattus norvegicus)
Mammalia Ttc9c 33
  • 89.28 (n)
mouse
(Mus musculus)
Mammalia Ttc9c 33 16 34
  • 88.3 (n)
oppossum
(Monodelphis domestica)
Mammalia TTC9C 34
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC9C 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc9c 33
  • 57.12 (n)
zebrafish
(Danio rerio)
Actinopterygii ttc9c 33 34
  • 58.43 (n)
Species where no ortholog for TTC9C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC9C Gene

ENSEMBL:
Gene Tree for TTC9C (if available)
TreeFam:
Gene Tree for TTC9C (if available)

Paralogs for TTC9C Gene

Paralogs for TTC9C Gene

(2) SIMAP similar genes for TTC9C Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TTC9C: view

Variants for TTC9C Gene

Sequence variations from dbSNP and Humsavar for TTC9C Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000010504 -- 62,736,362(+) CATGG(C/T)GGAAC intron-variant, downstream-variant-500B
rs1000519479 -- 62,733,000(+) CTTGG(G/T)GGGGA intron-variant
rs1000553131 -- 62,732,287(+) ACTGC(A/G)TCCAG intron-variant
rs1000707265 -- 62,727,479(+) CCTCC(C/T)GCCCT upstream-variant-2KB
rs1000826593 -- 62,727,383(+) CCAAA(A/T)CAACG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TTC9C Gene

Variant ID Type Subtype PubMed ID
nsv555174 CNV gain 21841781
nsv348 CNV deletion 18451855

Variation tolerance for TTC9C Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.84; 58.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC9C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC9C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC9C Gene

Disorders for TTC9C Gene

Relevant External Links for TTC9C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC9C

No disorders were found for TTC9C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC9C Gene

Publications for TTC9C Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  4. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M … Lindquist S (Cell 2014) 3 60
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60

Products for TTC9C Gene

Sources for TTC9C Gene

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