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Aliases for TTC9C Gene

Aliases for TTC9C Gene

  • Tetratricopeptide Repeat Domain 9C 2 3 5
  • TPR Repeat Protein 9C 4

External Ids for TTC9C Gene

Previous GeneCards Identifiers for TTC9C Gene

  • GC11P062254
  • GC11P062495
  • GC11P058825

Summaries for TTC9C Gene

GeneCards Summary for TTC9C Gene

TTC9C (Tetratricopeptide Repeat Domain 9C) is a Protein Coding gene. An important paralog of this gene is TTC9.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC9C Gene

Genomics for TTC9C Gene

Regulatory Elements for TTC9C Gene

Promoters for TTC9C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TTC9C on UCSC Golden Path with GeneCards custom track

Genomic Location for TTC9C Gene

Chromosome:
11
Start:
62,728,069 bp from pter
End:
62,740,293 bp from pter
Size:
12,225 bases
Orientation:
Plus strand

Genomic View for TTC9C Gene

Genes around TTC9C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC9C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC9C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC9C Gene

Proteins for TTC9C Gene

  • Protein details for TTC9C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5M4-TTC9C_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 9C
    Protein Accession:
    Q8N5M4
    Secondary Accessions:
    • Q8WYY7

    Protein attributes for TTC9C Gene

    Size:
    171 amino acids
    Molecular mass:
    20013 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC9C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC9C Gene

Proteomics data for TTC9C Gene at MOPED

Post-translational modifications for TTC9C Gene

  • Ubiquitination at Lys 12
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TTC9C Gene

Domains & Families for TTC9C Gene

Gene Families for TTC9C Gene

Protein Domains for TTC9C Gene

Suggested Antigen Peptide Sequences for TTC9C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5M4

UniProtKB/Swiss-Prot:

TTC9C_HUMAN :
  • Belongs to the TTC9 family.
  • Contains 3 TPR repeats.
Family:
  • Belongs to the TTC9 family.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with TTC9C: view

Function for TTC9C Gene

Gene Ontology (GO) - Molecular Function for TTC9C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 25416956
genes like me logo Genes that share ontologies with TTC9C: view
genes like me logo Genes that share phenotypes with TTC9C: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC9C Gene

Localization for TTC9C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC9C Gene COMPARTMENTS Subcellular localization image for TTC9C gene
Compartment Confidence
endoplasmic reticulum 3
nucleus 3
cytosol 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC9C Gene

Pathways & Interactions for TTC9C Gene

SuperPathways for TTC9C Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC9C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IBA --
genes like me logo Genes that share ontologies with TTC9C: view

No data available for Pathways by source and SIGNOR curated interactions for TTC9C Gene

Drugs & Compounds for TTC9C Gene

No Compound Related Data Available

Transcripts for TTC9C Gene

Unigene Clusters for TTC9C Gene

Tetratricopeptide repeat domain 9C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC9C Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1:
SP2: - -
SP3: -
SP4: - - - - - -
SP5: -
SP6:

Relevant External Links for TTC9C Gene

GeneLoc Exon Structure for
TTC9C
ECgene alternative splicing isoforms for
TTC9C

Expression for TTC9C Gene

mRNA expression in normal human tissues for TTC9C Gene

Protein differential expression in normal tissues from HIPED for TTC9C Gene

This gene is overexpressed in Bone (28.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTC9C Gene



SOURCE GeneReport for Unigene cluster for TTC9C Gene Hs.31704

genes like me logo Genes that share expression patterns with TTC9C: view

Protein tissue co-expression partners for TTC9C Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTC9C Gene

Orthologs for TTC9C Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC9C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC9C 35
  • 99.42 (n)
  • 100 (a)
TTC9C 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
TTC9C 36
  • 94 (a)
OneToMany
TTC9C 35
  • 90.64 (n)
  • 94.15 (a)
dog
(Canis familiaris)
Mammalia TTC9C 35
  • 89.86 (n)
  • 94.74 (a)
TTC9C 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc9c 16
Ttc9c 36
  • 96 (a)
OneToOne
Ttc9c 35
  • 88.3 (n)
  • 95.91 (a)
oppossum
(Monodelphis domestica)
Mammalia TTC9C 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttc9c 35
  • 89.28 (n)
  • 97.08 (a)
lizard
(Anolis carolinensis)
Reptilia TTC9C 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc9c 35
  • 57.12 (n)
  • 54.97 (a)
zebrafish
(Danio rerio)
Actinopterygii ttc9c 35
  • 58.43 (n)
  • 51.76 (a)
ttc9c 36
  • 40 (a)
OneToOne
Species with no ortholog for TTC9C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC9C Gene

ENSEMBL:
Gene Tree for TTC9C (if available)
TreeFam:
Gene Tree for TTC9C (if available)

Paralogs for TTC9C Gene

Paralogs for TTC9C Gene

(2) SIMAP similar genes for TTC9C Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TTC9C: view

Variants for TTC9C Gene

Sequence variations from dbSNP and Humsavar for TTC9C Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2861 -- 62,738,525(-) AAGTA(A/G)TGAAG utr-variant-3-prime
rs514401 -- 62,733,032(-) CCTGT(A/G)CTGAT intron-variant
rs646194 -- 62,730,625(-) TTGCA(C/T)TCCAG intron-variant
rs2510539 -- 62,732,626(+) aaaaa(A/T)TTAAT intron-variant
rs3110101 -- 62,732,086(-) cccag(A/G)aggca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC9C Gene

Variant ID Type Subtype PubMed ID
nsv897623 CNV Loss 21882294
nsv348 CNV Loss 18451855

Variation tolerance for TTC9C Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.84; 58.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC9C Gene

HapMap Linkage Disequilibrium report
TTC9C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC9C Gene

Disorders for TTC9C Gene

Relevant External Links for TTC9C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC9C

No disorders were found for TTC9C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC9C Gene

Publications for TTC9C Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 67
  2. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PMID: 22623428) Byron A. … Humphries M.J. (Proteomics 2012) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for TTC9C Gene

Sources for TTC9C Gene

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