TTC9C Gene
protein-coding GIFtS: 44
GCID: GC11P062495
|
|
tetratricopeptide repeat domain 9C
| |
Aliases
for TTC9C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tetratricopeptide Repeat Domain 9C1 2 | | TPR Repeat Protein 9C2 3 | | MGC296491 | | Tetratricopeptide Repeat Protein 9C2 |
Export aliases for TTC9C gene to outside databasesPrevious GC identifers: GC11P062254 GC11P058825 |
Summaries
for TTC9C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TTC9C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TTC9C gene promoter:
GR E2F-4 E2F-3a E2F-5 E2F-2 GATA-1 Max E2F E2F-1 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for TTC9C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC9C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q12.3 Ensembl cytogenetic band: 11q12.3 HGNC cytogenetic band: 11q12.3TTC9C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P062495: view genomic region
(about GC identifiers)
Start:
|
62,495,541 bp from pter |
End:
|
62,507,756 bp from pter |
Size:
|
12,216 bases |
Orientation:
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plus strand |
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Proteins
for TTC9C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TTC9C_HUMAN, Q8N5M4 (See
protein sequence)Recommended Name: Tetratricopeptide repeat protein 9C Size: 171 amino acids; 20013 DaExplore the universe of human proteins at neXtProt for TTC9C: NX_Q8N5M4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N5M4
TTC9C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_776171.1
ENSEMBL proteins: ENSP00000435282 ENSP00000294161 ENSP00000325266 ENSP00000434340 ENSP00000434137 ENSP00000444031
Human Recombinant Protein Products for TTC9C:
TTC9C Antibody Products:
Assay Products for TTC9C: |
Protein
Domains /
Families
for TTC9C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TTC9C for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N5M4ProtoNet protein and cluster: Q8N5M4 UniProtKB/Swiss-Prot: TTC9C_HUMAN, Q8N5M4Similarity: Belongs to the TTC9 familySimilarity: Contains 3 TPR repeats |
Function
for TTC9C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 GenomeRNAi human phenotype for TTC9C:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC9C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC9C
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TTC9C (NM_173810) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC9C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC9C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC9C |
|
Pathways & Interactions
for TTC9C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTC9C
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for TTC9C (Q8N5M43 ENSP000003252664) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TTC9C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TTC9C
Search CenterWatch for drugs/clinical trials and news about TTC9C
|
Transcripts
for TTC9C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TTC9C gene: NM_173810.3 Unigene Cluster for TTC9C: Tetratricopeptide repeat domain 9C Hs.31704 [show with all ESTs]Unigene Representative Sequence: AF2896056 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000530625 ENST00000294161 ENST00000316461(uc001nuy.3) ENST00000532583
ENST00000532276 ENST00000513247(uc001nux.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC9C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC9C
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TTC9C (NM_173810) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC9C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC9C |
Additional cDNA sequence: AF289605.1 AF451992.1 AF451993.1 BC032123.2 BC053665.1 8 DOTS entries: DT.215251 DT.92422260 DT.99955640 DT.101982061 DT.92422263 DT.102841759 DT.102841780 DT.95368600 24/136 AceView cDNA sequences (see all 136): AV709319 AI424641 N74876 CF127456 AA687870 NM_173810 AW407918 BM833166 W93931 AI471553 BM713659 BM845514 AA677016 BC032123 AF451993 BG720745 BU553286 AI911567 AA724597 BQ050575 W19289 BE296078 AF451992 BU844888
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TTC9C (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for TTC9C
|
Expression
for TTC9C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TTC9C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTATTGTTGC
About this image
See TTC9C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TTC9C
SOURCE GeneReport for Unigene cluster: Hs.31704
SABiosciences Custom PCR Arrays for TTC9C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC9C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TTC9C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC9C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC9C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC9C |
Orthologs
for TTC9C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TTC9C gene from 2/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
TTC9C6 |
-- |
65(a) |
1 ↔ 1 |
GL343928.1(67128-76309) |
zebrafish
(Danio rerio) |
Actinopterygii |
ttc9c1 |
tetratricopeptide repeat domain 9C |
58.43(n)
51.76(a) |
|
393235 NM_200265.1 NP_956559.1 |
ENSEMBL Gene Tree for TTC9C (if available)
TreeFam Gene Tree for TTC9C (if available) |
Paralogs
for TTC9C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TTC9C gene
- TTC9B2 TTC92
2 SIMAP similar genes for TTC9C using alignment to 5 protein entries: TTC9C_HUMAN (see all proteins):TTC9B TTC9
TTC9C for paralogs About GeneDecksing
|
Genomic Variants
for TTC9C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TTC9C (62495541 - 62507756 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TTC9C: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC9C |
|
Disorders
/ Diseases
for TTC9C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TTC9C for disorders About GeneDecksing
1  disease for TTC9C: About MalaCardsschizophrenia
Export disorders for TTC9C gene to outside databases
|
Publications
for TTC9C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TTC9C gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TTC9C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Identification of FBXO25-interacting proteins using an integrated proteomics approach. (PubMed id 20473970)1 Teixeira F.R.... Gomes M.D. (2010)
- Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. (PubMed id 19165527)1 Martins-de-Souza D....Turck C.W. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TTC9C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TTC9C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TTC9C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TTC9C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TTC9C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TTC9C gene:
Search GeneIP for patents involving TTC9C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TTC9C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TTC9C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTC9C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC9C | | | OriGene Protein Over-expression Lysate for TTC9C | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TTC9C | | OriGene 3'-UTR Clone for TTC9C | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC9C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC9C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TTC9C | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TTC9C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC9C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC9C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTC9C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC9C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC9C |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TTC9C |
| |  |  |  |  | | | | |
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 |
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 | | | TTC9C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC9C |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TTC9C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC9C |
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