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Aliases for TTC9B Gene

Aliases for TTC9B Gene

  • Tetratricopeptide Repeat Domain 9B 2 3 5
  • TPR Repeat Protein 9B 4

External Ids for TTC9B Gene

Previous GeneCards Identifiers for TTC9B Gene

  • GC19M045417
  • GC19M040721
  • GC19M037156

Summaries for TTC9B Gene

GeneCards Summary for TTC9B Gene

TTC9B (Tetratricopeptide Repeat Domain 9B) is a Protein Coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and FK506 binding. An important paralog of this gene is TTC9C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC9B Gene

Genomics for TTC9B Gene

Regulatory Elements for TTC9B Gene

Genomic Location for TTC9B Gene

Chromosome:
19
Start:
40,216,058 bp from pter
End:
40,218,399 bp from pter
Size:
2,342 bases
Orientation:
Minus strand

Genomic View for TTC9B Gene

Genes around TTC9B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC9B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC9B Gene

Proteins for TTC9B Gene

  • Protein details for TTC9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6N2-TTC9B_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 9B
    Protein Accession:
    Q8N6N2
    Secondary Accessions:
    • A8K0I5
    • Q96NP9

    Protein attributes for TTC9B Gene

    Size:
    239 amino acids
    Molecular mass:
    25932 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC9B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC9B Gene

Proteomics data for TTC9B Gene at MOPED

Post-translational modifications for TTC9B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC9B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTC9B Gene

Domains & Families for TTC9B Gene

Gene Families for TTC9B Gene

Protein Domains for TTC9B Gene

Suggested Antigen Peptide Sequences for TTC9B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N6N2

UniProtKB/Swiss-Prot:

TTC9B_HUMAN :
  • Belongs to the TTC9 family.
  • Contains 2 TPR repeats.
Family:
  • Belongs to the TTC9 family.
Similarity:
  • Contains 2 TPR repeats.
genes like me logo Genes that share domains with TTC9B: view

Function for TTC9B Gene

Gene Ontology (GO) - Molecular Function for TTC9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TTC9B: view

Phenotypes for TTC9B Gene

GenomeRNAi human phenotypes for TTC9B:
genes like me logo Genes that share phenotypes with TTC9B: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TTC9B Gene

Localization for TTC9B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC9B Gene COMPARTMENTS Subcellular localization image for TTC9B gene
Compartment Confidence
endoplasmic reticulum 3
cytosol 2
mitochondrion 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC9B Gene

Pathways & Interactions for TTC9B Gene

SuperPathways for TTC9B Gene

No Data Available

Interacting Proteins for TTC9B Gene

Selected Interacting proteins: Q8N6N2-TTC9B_HUMAN for TTC9B Gene via I2D

Symbol External ID(s) Details
GRID2

Gene Ontology (GO) - Biological Process for TTC9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TTC9B: view

No data available for Pathways by source and SIGNOR curated interactions for TTC9B Gene

Drugs & Compounds for TTC9B Gene

No Compound Related Data Available

Transcripts for TTC9B Gene

mRNA/cDNA for TTC9B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(50) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TTC9B Gene

Tetratricopeptide repeat domain 9B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC9B Gene

No ASD Table

Relevant External Links for TTC9B Gene

GeneLoc Exon Structure for
TTC9B
ECgene alternative splicing isoforms for
TTC9B

Expression for TTC9B Gene

mRNA expression in normal human tissues for TTC9B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC9B Gene

This gene is overexpressed in Brain - Amygdala (x7.9), Brain - Cortex (x6.2), Brain - Anterior cingulate cortex (BA24) (x6.2), Brain - Cerebellar Hemisphere (x6.0), Brain - Cerebellum (x5.6), Brain - Frontal Cortex (BA9) (x5.3), and Brain - Hippocampus (x5.1).

Protein differential expression in normal tissues from HIPED for TTC9B Gene

This gene is overexpressed in Brain (54.5) and Frontal cortex (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TTC9B Gene



SOURCE GeneReport for Unigene cluster for TTC9B Gene Hs.631572

genes like me logo Genes that share expression patterns with TTC9B: view

Protein tissue co-expression partners for TTC9B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TTC9B Gene

Orthologs for TTC9B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC9B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC9B 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TTC9B 36
  • 94 (a)
OneToOne
TTC9B 35
  • 87.94 (n)
  • 90.64 (a)
dog
(Canis familiaris)
Mammalia TTC9B 35
  • 90.78 (n)
  • 91.06 (a)
TTC9B 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc9b 16
Ttc9b 36
  • 90 (a)
OneToOne
Ttc9b 35
  • 89.03 (n)
  • 91.98 (a)
oppossum
(Monodelphis domestica)
Mammalia TTC9B 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC9B 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttc9b 35
  • 88.47 (n)
  • 91.56 (a)
lizard
(Anolis carolinensis)
Reptilia TTC9B 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc9b 35
  • 64.47 (n)
  • 65.93 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9184 35
zebrafish
(Danio rerio)
Actinopterygii ttc9b 35
  • 68.44 (n)
  • 69.82 (a)
ttc9b 36
  • 49 (a)
OneToOne
Species with no ortholog for TTC9B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC9B Gene

ENSEMBL:
Gene Tree for TTC9B (if available)
TreeFam:
Gene Tree for TTC9B (if available)

Paralogs for TTC9B Gene

Paralogs for TTC9B Gene

(2) SIMAP similar genes for TTC9B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TTC9B: view

Variants for TTC9B Gene

Sequence variations from dbSNP and Humsavar for TTC9B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11553464 - 40,216,215(+) GCTGG(A/G/T)GGCTG reference, missense
rs17852680 -- 40,218,055(+) GGGGC(G/T)GGGGC reference, synonymous-codon
rs55710849 -- 40,217,020(+) ATGGA(C/T)GAGTG intron-variant
rs75353755 -- 40,218,348(+) GCTGA(A/G)CATCA reference, missense
rs111960706 -- 40,217,734(+) CTGAA(G/T)ACCCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC9B Gene

Variant ID Type Subtype PubMed ID
dgv1083e1 CNV Complex 17122850
dgv3865n71 CNV Loss 21882294
nsv911699 CNV Loss 21882294
dgv3866n71 CNV Loss 21882294
nsv9728 CNV Loss 18304495

Variation tolerance for TTC9B Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC9B Gene

HapMap Linkage Disequilibrium report
TTC9B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC9B Gene

Disorders for TTC9B Gene

Relevant External Links for TTC9B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC9B

No disorders were found for TTC9B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC9B Gene

Publications for TTC9B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R. … Aloy P. (J. Mol. Biol. 2015) 3
  3. Seeing the future: epigenetic biomarkers of postpartum depression. (PMID: 24317310) Kaminsky Z. … Payne J. (Neuropsychopharmacology 2014) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TTC9B Gene

Sources for TTC9B Gene

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