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Aliases for TTC9 Gene

Aliases for TTC9 Gene

  • Tetratricopeptide Repeat Domain 9 2 3
  • TPR Repeat Protein 9A 3 4
  • TTC9A 3 4
  • KIAA0227 4

External Ids for TTC9 Gene

Previous GeneCards Identifiers for TTC9 Gene

  • GC14P069090
  • GC14P070177
  • GC14P071110
  • GC14P051277

Summaries for TTC9 Gene

Entrez Gene Summary for TTC9 Gene

  • This gene encodes a protein that contains three tetratricopeptide repeats. The gene has been shown to be hormonally regulated in breast cancer cells and may play a role in cancer cell invasion and metastasis. [provided by RefSeq, Mar 2009]

GeneCards Summary for TTC9 Gene

TTC9 (Tetratricopeptide Repeat Domain 9) is a Protein Coding gene. An important paralog of this gene is TTC9B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC9 Gene

Genomics for TTC9 Gene

Regulatory Elements for TTC9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TTC9 Gene

Chromosome:
14
Start:
70,641,787 bp from pter
End:
70,675,360 bp from pter
Size:
33,574 bases
Orientation:
Plus strand

Genomic View for TTC9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC9 Gene

Proteins for TTC9 Gene

  • Protein details for TTC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92623-TTC9A_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 9A
    Protein Accession:
    Q92623
    Secondary Accessions:
    • Q86WT2

    Protein attributes for TTC9 Gene

    Size:
    222 amino acids
    Molecular mass:
    24379 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH47950.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA13216.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TTC9 Gene

Proteomics data for TTC9 Gene at MOPED

Post-translational modifications for TTC9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTC9 Gene

Domains & Families for TTC9 Gene

Gene Families for TTC9 Gene

Protein Domains for TTC9 Gene

Suggested Antigen Peptide Sequences for TTC9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92623

UniProtKB/Swiss-Prot:

TTC9A_HUMAN :
  • Belongs to the TTC9 family.
  • Contains 3 TPR repeats.
Family:
  • Belongs to the TTC9 family.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with TTC9: view

Function for TTC9 Gene

Gene Ontology (GO) - Molecular Function for TTC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0005515 protein binding --
GO:0005528 FK506 binding IBA --
genes like me logo Genes that share ontologies with TTC9: view

Phenotypes for TTC9 Gene

GenomeRNAi human phenotypes for TTC9:
genes like me logo Genes that share phenotypes with TTC9: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTC9

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC9 Gene

Localization for TTC9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC9 Gene COMPARTMENTS Subcellular localization image for TTC9 gene
Compartment Confidence
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for TTC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005789 endoplasmic reticulum membrane IBA --
genes like me logo Genes that share ontologies with TTC9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TTC9 Gene

Pathways & Interactions for TTC9 Gene

SuperPathways for TTC9 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for TTC9 Gene

Gene Ontology (GO) - Biological Process for TTC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IBA --
GO:0061077 chaperone-mediated protein folding IBA --
genes like me logo Genes that share ontologies with TTC9: view

No data available for Pathways by source and SIGNOR curated interactions for TTC9 Gene

Drugs & Compounds for TTC9 Gene

No Compound Related Data Available

Transcripts for TTC9 Gene

mRNA/cDNA for TTC9 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(115) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TTC9 Gene

Tetratricopeptide repeat domain 9:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTC9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC9 Gene

No ASD Table

Relevant External Links for TTC9 Gene

GeneLoc Exon Structure for
TTC9
ECgene alternative splicing isoforms for
TTC9

Expression for TTC9 Gene

mRNA expression in normal human tissues for TTC9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC9 Gene

This gene is overexpressed in Esophagus - Mucosa (x10.9).

Protein differential expression in normal tissues from HIPED for TTC9 Gene

This gene is overexpressed in Cervix (30.8), Brain (12.5), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TTC9 Gene



SOURCE GeneReport for Unigene cluster for TTC9 Gene Hs.79170

genes like me logo Genes that share expression patterns with TTC9: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TTC9 Gene

Orthologs for TTC9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TTC9 35
  • 92.8 (n)
  • 95.68 (a)
TTC9 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTC9 35
  • 91.48 (n)
  • 95.56 (a)
TTC9 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc9 35
  • 85.54 (n)
  • 88.13 (a)
Ttc9 16
Ttc9 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TTC9 35
  • 95.35 (n)
  • 92.34 (a)
TTC9 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttc9 35
  • 86.27 (n)
  • 90.05 (a)
oppossum
(Monodelphis domestica)
Mammalia TTC9 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC9 35
  • 80.56 (n)
  • 85.71 (a)
TTC9 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20173 35
ttc9 35
  • 74.51 (n)
  • 79.41 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC560706 35
  • 69.01 (n)
  • 70.18 (a)
TTC9 36
  • 68 (a)
OneToOne
Species with no ortholog for TTC9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC9 Gene

ENSEMBL:
Gene Tree for TTC9 (if available)
TreeFam:
Gene Tree for TTC9 (if available)

Paralogs for TTC9 Gene

Paralogs for TTC9 Gene

(2) SIMAP similar genes for TTC9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TTC9: view

Variants for TTC9 Gene

Sequence variations from dbSNP and Humsavar for TTC9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs8688 -- 70,672,562(+) ACACC(G/T)TTAAT utr-variant-3-prime
rs13154 -- 70,672,714(+) atctt(A/T)acatg utr-variant-3-prime
rs13738 -- 70,672,013(+) AAAAA(A/C/G/T)AAATT utr-variant-3-prime
rs1018974 -- 70,664,375(-) TCAGC(A/G)CTACC intron-variant
rs1050651 -- 70,672,024(+) AACAG(C/G)TAGTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TTC9 Gene

Variant ID Type Subtype PubMed ID
esv2672447 CNV Deletion 23128226

Variation tolerance for TTC9 Gene

Residual Variation Intolerance Score: 53.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.11; 69.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC9 Gene

HapMap Linkage Disequilibrium report
TTC9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC9 Gene

Disorders for TTC9 Gene

Relevant External Links for TTC9

Genetic Association Database (GAD)
TTC9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC9
genes like me logo Genes that share disorders with TTC9: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC9 Gene

Publications for TTC9 Gene

  1. A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. (PMID: 25217961) Al Olama A.A. … Haiman C.A. (Nat. Genet. 2014) 67
  2. Tetratricopeptide repeat domain 9A is an interacting protein for tropomyosin Tm5NM-1. (PMID: 18699990) Cao S. … Lin V.C. (BMC Cancer 2008) 67
  3. Identification of tetratricopeptide repeat domain 9, a hormonally regulated protein. (PMID: 16678794) Cao S. … Lin V. (Biochem. Biophys. Res. Commun. 2006) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 67

Products for TTC9 Gene

Sources for TTC9 Gene

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