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Aliases for TTC9 Gene

Aliases for TTC9 Gene

  • Tetratricopeptide Repeat Domain 9 2 3
  • TPR Repeat Protein 9A 3 4
  • TTC9A 3 4
  • Tetratricopeptide Repeat Protein 9A 3
  • KIAA0227 4

External Ids for TTC9 Gene

Summaries for TTC9 Gene

Entrez Gene Summary for TTC9 Gene

  • This gene encodes a protein that contains three tetratricopeptide repeats. The gene has been shown to be hormonally regulated in breast cancer cells and may play a role in cancer cell invasion and metastasis. [provided by RefSeq, Mar 2009]

GeneCards Summary for TTC9 Gene

TTC9 (Tetratricopeptide Repeat Domain 9) is a Protein Coding gene. Diseases associated with TTC9 include breast cancer. An important paralog of this gene is TTC9B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC9 Gene

Genomics for TTC9 Gene

Genomic Location for TTC9 Gene

Start:
70,641,787 bp from pter
End:
70,675,360 bp from pter
Size:
33,574 bases
Orientation:
Plus strand

Genomic View for TTC9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC9 Gene

Regulatory Elements for TTC9 Gene

Proteins for TTC9 Gene

  • Protein details for TTC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92623-TTC9A_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 9A
    Protein Accession:
    Q92623
    Secondary Accessions:
    • Q86WT2

    Protein attributes for TTC9 Gene

    Size:
    222 amino acids
    Molecular mass:
    24379 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH47950.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA13216.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TTC9 Gene

Proteomics data for TTC9 Gene at MOPED

Post-translational modifications for TTC9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTC9 Gene

Domains for TTC9 Gene

Gene Families for TTC9 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for TTC9 Gene

UniProtKB/Swiss-Prot:

TTC9A_HUMAN
Family:
  • Belongs to the TTC9 family.:
    • Q92623
Similarity:
  • Contains 3 TPR repeats.:
    • Q92623
genes like me logo Genes that share domains with TTC9: view

Function for TTC9 Gene

Gene Ontology (GO) - Molecular Function for TTC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TTC9: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TTC9 Gene

Localization for TTC9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC9 Gene COMPARTMENTS Subcellular localization image for TTC9 gene
Compartment Confidence
cytosol 2
extracellular 2
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TTC9 Gene

Pathways for TTC9 Gene

SuperPathways for TTC9 Gene

No Data Available

Interacting Proteins for TTC9 Gene

Gene Ontology (GO) - Biological Process for TTC9 Gene

None

No data available for Pathways by source for TTC9 Gene

Transcripts for TTC9 Gene

mRNA/cDNA for TTC9 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(115) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TTC9 Gene

Tetratricopeptide repeat domain 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC9 Gene

No ASD Table

Relevant External Links for TTC9 Gene

GeneLoc Exon Structure for
TTC9
ECgene alternative splicing isoforms for
TTC9

Expression for TTC9 Gene

mRNA expression in normal human tissues for TTC9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC9 Gene

This gene is overexpressed in Esophagus - Mucosa (10.9).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TTC9 Gene

SOURCE GeneReport for Unigene cluster for TTC9 Gene Hs.79170

genes like me logo Genes that share expressions with TTC9: view

Orthologs for TTC9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC9 36
  • 95.35 (n)
  • 92.34 (a)
TTC9 37
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TTC9 36
  • 92.8 (n)
  • 95.68 (a)
TTC9 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTC9 36
  • 91.48 (n)
  • 95.56 (a)
TTC9 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc9 36
  • 85.54 (n)
  • 88.13 (a)
Ttc9 16
Ttc9 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTC9 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttc9 36
  • 86.27 (n)
  • 90.05 (a)
chicken
(Gallus gallus)
Aves TTC9 36
  • 80.56 (n)
  • 85.71 (a)
TTC9 37
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20173 36
ttc9 36
  • 74.51 (n)
  • 79.41 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC560706 36
  • 69.01 (n)
  • 70.18 (a)
TTC9 37
  • 68 (a)
OneToOne
Species with no ortholog for TTC9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC9 Gene

ENSEMBL:
Gene Tree for TTC9 (if available)
TreeFam:
Gene Tree for TTC9 (if available)

Paralogs for TTC9 Gene

Paralogs for TTC9 Gene

Selected SIMAP similar genes for TTC9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TTC9: view

Variants for TTC9 Gene

Sequence variations from dbSNP and Humsavar for TTC9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs8688 -- 70,672,562(+) ACACC(G/T)TTAAT utr-variant-3-prime
rs13154 -- 70,672,714(+) atctt(A/T)acatg utr-variant-3-prime
rs13738 -- 70,672,013(+) AAAAA(A/C/G/T)AAATT utr-variant-3-prime
rs1018974 -- 70,664,375(-) TCAGC(A/G)CTACC intron-variant
rs1050651 -- 70,672,024(+) AACAG(C/G)TAGTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TTC9 Gene

Variant ID Type Subtype PubMed ID
esv2672447 CNV Deletion 23128226

Relevant External Links for TTC9 Gene

HapMap Linkage Disequilibrium report
TTC9

Disorders for TTC9 Gene

(1) MalaCards Diseases for TTC9 Gene

Search for TTC9 Gene in MalaCards »

Relevant External Links for TTC9

Genetic Association Database (GAD)
TTC9
genes like me logo Genes that share disorders with TTC9: view

No data available for UniProtKB/Swiss-Prot for TTC9 Gene

Publications for TTC9 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Identification of tetratricopeptide repeat domain 9, a hormonally regulated protein. (PMID: 16678794) Cao S. … Lin V. (Biochem. Biophys. Res. Commun. 2006) 3
  5. Tetratricopeptide repeat domain 9A is an interacting protein for tropomyosin Tm5NM-1. (PMID: 18699990) Cao S. … Lin V.C. (BMC Cancer 2008) 3

Products for TTC9 Gene

Sources for TTC9 Gene

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