TTC7B Gene
protein-coding GIFtS: 41
GCID: GC14M091006
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tetratricopeptide repeat domain 7B(Previous name: tetratricopeptide repeat domain 7 like 1 )
(Previous symbol: TTC7L1)
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Aliases
for TTC7B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tetratricopeptide Repeat Domain 7B1 2 | | TPR Repeat Protein 7-Like-12 3 | | TTC7L11 2 3 | | TPR Repeat Protein 7B2 3 | | Tetratricopeptide Repeat Domain 7 Like 11 2 | | C14_56851 | | Tetratricopeptide Repeat Protein 7-Like-12 3 | | Tetratricopeptide Repeat Protein 7B2 |
Export aliases for TTC7B gene to outside databasesPrevious GC identifers: GC14M088997 GC14M090076 GC14M071182 |
Summaries
for TTC7B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TTC7B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TTC7B gene promoter:
TBP Bach1 USF1 TFIID FOXD3 MyoD USF-1:USF-2 Cdc5 LCR-F1 Evi-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TTC7B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC7B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.11 Ensembl cytogenetic band: 14q32.11 HGNC cytogenetic band: 14q32.12TTC7B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M091006: view genomic region
(about GC identifiers)
Start:
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91,006,932 bp from pter |
End:
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91,282,823 bp from pter |
Size:
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275,892 bases |
Orientation:
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minus strand |
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Proteins
for TTC7B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TTC7B_HUMAN, Q86TV6 (See
protein sequence)Recommended Name: Tetratricopeptide repeat protein 7B Size: 843 amino acids; 94179 Da
Sequence caution: Sequence=CAI46128.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=CAI46128.1; Type=Frameshift; Positions=718;
Secondary accessions: Q86U24 Q86VT3Alternative splicing: 2 isoforms: Q86TV6-1 Q86TV6-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TTC7B: NX_Q86TV6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86TV6
TTC7B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001010854.1
ENSEMBL proteins: ENSP00000451825 ENSP00000336127 ENSP00000451440 ENSP00000452594 ENSP00000452031 ENSP00000450520 ENSP00000451928 ENSP00000451238 ENSP00000451201 ENSP00000349564
Human Recombinant Protein Products:
TTC7B Antibody Products:
Assay Products for TTC7B: |
Protein
Domains /
Families
for TTC7B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TTC7B for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86TV6ProtoNet protein and cluster: Q86TV6 UniProtKB/Swiss-Prot: TTC7B_HUMAN, Q86TV6Similarity: Contains 11 TPR repeats |
Function
for TTC7B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC7B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC7B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TTC7B (NM_001010854) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC7B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC7B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC7B |
1 GenomeRNAi human phenotype for TTC7B:
|
Pathways & Interactions
for TTC7B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTC7B
4 Interacting proteins for TTC7B (Q86TV63) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TTC7B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TTC7B
Search CenterWatch for drugs/clinical trials and news about TTC7B
|
Transcripts
for TTC7B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TTC7B gene: NM_001010854.1 Unigene Cluster for TTC7B: Tetratricopeptide repeat domain 7B Hs.655697 [show with all ESTs]Unigene Representative Sequence: NM_00101085416 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000555005(uc010ats.3) ENST00000328459(uc001xyp.3) ENST00000553972
ENST00000554654 ENST00000555894 ENST00000557292 ENST00000556960 ENST00000557059
ENST00000555239 ENST00000556490 ENST00000556749 ENST00000554462 ENST00000557766
ENST00000553948 ENST00000557187 ENST00000357056(uc001xyo.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC7B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC7B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TTC7B (NM_001010854) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC7B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC7B |
Additional cDNA sequence: AK126571.1 AL832848.1 BC048270.2 BX247966.1 BX248275.1 8 DOTS entries: DT.101982255 DT.455650 DT.100804970 DT.100784649 DT.100728936 DT.120753851 DT.40254590 DT.95157652 24/146 AceView cDNA sequences (see all 146): BF436104 BU628337 BM718654 BI964078 BE503574 CA430758 AI022911 H88622 AW572451 AI587596 BU158411 BU623692 BX247966 BF594721 AW130805 BC035865 AL707304 CR624723 AW206083 AW207629 BX248275 BU783916 AI198357 BM127247
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TTC7B About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TTC7B
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Expression
for TTC7B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TTC7B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAAGATGAT
About this image
See TTC7B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TTC7B
SOURCE GeneReport for Unigene cluster: Hs.655697
SABiosciences Custom PCR Arrays for TTC7B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC7B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TTC7B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC7B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC7B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC7B |
Orthologs
for TTC7B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TTC7B gene from 9/22 species (see all 22) About this table
ENSEMBL Gene Tree for TTC7B (if available)
TreeFam Gene Tree for TTC7B (if available) |
Paralogs
for TTC7B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TTC7B gene
- TTC7A2
1 SIMAP similar gene for TTC7B using alignment to 8 protein entries: TTC7B_HUMAN (see all proteins):TTC7A
TTC7B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TTC7B
PGOHUM00000247849
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Genomic Variants
for TTC7B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TTC7B (91006932 - 91256932 bp, first 250kb of TTC7B)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for TTC7B
4 CNVs: 4845 49437 10450 49436
2 Indels: 11763 49438 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC7B |
|
Disorders
/ Diseases
for TTC7B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TTC7B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TTC7B gene integrated from 9 sources:
(articles sorted by number of sources associating them with TTC7B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
- Genome-wide association study does not reveal major ge netic determinants for anti-cytomegalovirus antibody response. (PubMed id 21993531)1 Kuparinen T....Hurme M. (2012)
- TTC7B emerges as a novel risk factor for ischemic stro ke through the convergence of several genome-wide approaches. (PubMed id 22453632)1 Krug T....Oliveira S.A. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TTC7B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TTC7B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TTC7B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TTC7B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TTC7B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TTC7B gene:
Search GeneIP for patents involving TTC7B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TTC7B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TTC7B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTC7B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC7B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TTC7B | | OriGene 3'-UTR Clone for TTC7B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC7B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC7B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TTC7B | | OriGene Custom Protein Services for TTC7B | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TTC7B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC7B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC7B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTC7B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC7B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC7B |
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 |  |  |  | |
| | | | Search Tocris compounds for TTC7B |
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 | | | TTC7B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC7B |
|  |  |  | | | | Search ThermoFisher Antibodies for TTC7B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC7B |
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