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Aliases for TTC7B Gene

Aliases for TTC7B Gene

  • Tetratricopeptide Repeat Domain 7B 2 3
  • Tetratricopeptide Repeat Protein 7-Like-1 3 4
  • Tetratricopeptide Repeat Domain 7 Like 1 2 3
  • TPR Repeat Protein 7-Like-1 3 4
  • TPR Repeat Protein 7B 3 4
  • TTC7L1 3 4
  • Tetratricopeptide Repeat Protein 7B 3
  • C14_5685 3

External Ids for TTC7B Gene

Previous HGNC Symbols for TTC7B Gene

  • TTC7L1

Previous GeneCards Identifiers for TTC7B Gene

  • GC14M088997
  • GC14M090076
  • GC14M091006
  • GC14M071182

Summaries for TTC7B Gene

GeneCards Summary for TTC7B Gene

TTC7B (Tetratricopeptide Repeat Domain 7B) is a Protein Coding gene. An important paralog of this gene is TTC7A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC7B Gene

Genomics for TTC7B Gene

Regulatory Elements for TTC7B Gene

Genomic Location for TTC7B Gene

Start:
90,524,564 bp from pter
End:
90,816,479 bp from pter
Size:
291,916 bases
Orientation:
Minus strand

Genomic View for TTC7B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTC7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC7B Gene

Proteins for TTC7B Gene

  • Protein details for TTC7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TV6-TTC7B_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 7B
    Protein Accession:
    Q86TV6
    Secondary Accessions:
    • Q86U24
    • Q86VT3

    Protein attributes for TTC7B Gene

    Size:
    843 amino acids
    Molecular mass:
    94179 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI46128.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI46128.1; Type=Frameshift; Positions=718; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC7B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC7B Gene

Proteomics data for TTC7B Gene at MOPED

Post-translational modifications for TTC7B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC7B Gene

Domains for TTC7B Gene

Gene Families for TTC7B Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for TTC7B Gene

Suggested Antigen Peptide Sequences for TTC7B Gene

Graphical View of Domain Structure for InterPro Entry

Q86TV6

UniProtKB/Swiss-Prot:

TTC7B_HUMAN :
  • Q86TV6
Similarity:
  • Contains 11 TPR repeats.
genes like me logo Genes that share domains with TTC7B: view

Function for TTC7B Gene

Gene Ontology (GO) - Molecular Function for TTC7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TTC7B: view

Phenotypes for TTC7B Gene

GenomeRNAi human phenotypes for TTC7B:
genes like me logo Genes that share phenotypes with TTC7B: view

Animal Model Products

CRISPR Products

miRNA for TTC7B Gene

miRTarBase miRNAs that target TTC7B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TTC7B Gene

Localization for TTC7B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC7B Gene COMPARTMENTS Subcellular localization image for TTC7B gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC7B Gene

Pathways for TTC7B Gene

SuperPathways for TTC7B Gene

No Data Available

Interacting Proteins for TTC7B Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000336127%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000458238%0d%0a9606.ENSP00000384081%0d%0a
Selected Interacting proteins: ENSP00000336127 Q86TV6-TTC7B_HUMAN for TTC7B Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TTC7B Gene

None

No data available for Pathways by source for TTC7B Gene

Transcripts for TTC7B Gene

Unigene Clusters for TTC7B Gene

Tetratricopeptide repeat domain 7B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTC7B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TTC7B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC7B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c
SP1: -
SP2: - -
SP3: - - - -
SP4:

Relevant External Links for TTC7B Gene

GeneLoc Exon Structure for
TTC7B
ECgene alternative splicing isoforms for
TTC7B

Expression for TTC7B Gene

mRNA expression in normal human tissues for TTC7B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTC7B Gene

SOURCE GeneReport for Unigene cluster for TTC7B Gene Hs.655697

genes like me logo Genes that share expressions with TTC7B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTC7B Gene

Orthologs for TTC7B Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC7B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC7B 35
  • 99.37 (n)
  • 99.53 (a)
TTC7B 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TTC7B 35
  • 90.6 (n)
  • 95.63 (a)
TTC7B 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTC7B 35
  • 92.26 (n)
  • 98 (a)
TTC7B 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc7b 35
  • 90.19 (n)
  • 97.15 (a)
Ttc7b 16
Ttc7b 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TTC7B 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC7B 35
  • 80.98 (n)
  • 93.7 (a)
TTC7B 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC7B 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3921 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc7b 35
  • 77.03 (n)
  • 89.32 (a)
zebrafish
(Danio rerio)
Actinopterygii ttc7b 35
  • 74.02 (n)
  • 83.39 (a)
ttc7b 36
  • 83 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010587 35
  • 47.79 (n)
  • 39.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)k14710 35
  • 47.57 (n)
  • 37.38 (a)
l(2)k14710 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y39A3CR.3 35
  • 42.78 (n)
  • 31.04 (a)
Y39A3CR.3 36
  • 24 (a)
OneToMany
Species with no ortholog for TTC7B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC7B Gene

ENSEMBL:
Gene Tree for TTC7B (if available)
TreeFam:
Gene Tree for TTC7B (if available)

Paralogs for TTC7B Gene

Paralogs for TTC7B Gene

Selected SIMAP similar genes for TTC7B Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for TTC7B Gene

genes like me logo Genes that share paralogs with TTC7B: view

Variants for TTC7B Gene

Sequence variations from dbSNP and Humsavar for TTC7B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2343 -- 90,628,156(-) TTCCA(A/G)AGGCA intron-variant
rs714489 -- 90,559,918(+) CGCGC(A/G)CTCCC intron-variant
rs720925 -- 90,772,891(+) gggag(A/G)cagag intron-variant
rs727350 -- 90,797,437(-) tctgt(C/T)gccca intron-variant
rs730043 -- 90,743,271(-) GAGAG(G/T)TGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC7B Gene

Variant ID Type Subtype PubMed ID
nsv470654 CNV Loss 18288195
nsv520068 CNV Loss 19592680
nsv456392 CNV Loss 19166990
dgv1973n71 CNV Loss 21882294
esv2749010 CNV Deletion 23290073
esv2657236 CNV Deletion 23128226
esv2660016 CNV Deletion 23128226
nsv84673 CNV Loss 16902084
esv1131124 CNV Insertion 17803354
esv270875 CNV Insertion 20981092
esv272559 CNV Insertion 20981092
esv1610604 CNV Insertion 17803354
nsv832855 CNV Loss 17160897
esv2659108 CNV Deletion 23128226
nsv516108 CNV Loss 19592680
nsv817641 CNV Loss 17921354

Relevant External Links for TTC7B Gene

HapMap Linkage Disequilibrium report
TTC7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC7B Gene

Disorders for TTC7B Gene

Relevant External Links for TTC7B

Genetic Association Database (GAD)
TTC7B
genes like me logo Genes that share disorders with TTC7B: view

No data available for UniProtKB/Swiss-Prot for TTC7B Gene

Publications for TTC7B Gene

  1. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genome-wide association study does not reveal major genetic determinants for anti-cytomegalovirus antibody response. (PMID: 21993531) Kuparinen T. … Hurme M. (Genes Immun. 2012) 3 48
  4. TTC7B emerges as a novel risk factor for ischemic stroke through the convergence of several genome-wide approaches. (PMID: 22453632) Krug T. … Oliveira S.A. (J. Cereb. Blood Flow Metab. 2012) 3
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for TTC7B Gene

Sources for TTC7B Gene

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