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Aliases for TTC6 Gene

Aliases for TTC6 Gene

  • Tetratricopeptide Repeat Domain 6 2 3 5
  • TPR Repeat Protein 6 3 4
  • NCRNA00291 3 4
  • C14orf25 3 4
  • Chromosome 14 Open Reading Frame 25 2
  • Tetratricopeptide Repeat Protein 6 3
  • Non-Protein Coding RNA 291 2

External Ids for TTC6 Gene

Previous HGNC Symbols for TTC6 Gene

  • NCRNA00291
  • C14orf25

Previous GeneCards Identifiers for TTC6 Gene

  • GC14P032144
  • GC14P036231
  • GC14P037311
  • GC14P038222
  • GC14P038081
  • GC14P018186
  • GC14P038066

Summaries for TTC6 Gene

GeneCards Summary for TTC6 Gene

TTC6 (Tetratricopeptide Repeat Domain 6) is a Protein Coding gene. An important paralog of this gene is TTC13.

Additional gene information for TTC6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC6 Gene

Genomics for TTC6 Gene

Regulatory Elements for TTC6 Gene

Enhancers for TTC6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H037566 1.1 ENCODE dbSUPER 12.2 -28.2 -28182 0 FOXA2 ESRRA MAX ZBTB40 RAD21 YY1 CTBP1 GATA3 FOSL2 FOS TTC6 FOXA1 MIPOL1 ENSG00000259087 ENSG00000258414
GH14H037622 0.9 Ensembl ENCODE dbSUPER 11.7 +27.3 27306 0 CTBP2 EZH2 FOXA1 TTC6 PIR51609
GH14H037623 0.8 ENCODE dbSUPER 11.7 +28.6 28618 1 PKNOX1 RFX1 NFIB CREB1 FOXA1 TTC6 ENSG00000259087 PIR51609
GH14H037582 1.7 FANTOM5 ENCODE dbSUPER 0.7 -3.7 -3749 18 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B MIPOL1 SLC25A21-AS1 FOXA1 TTC6 ENSG00000259087
GH14H037580 0.9 ENCODE dbSUPER 0.4 -14.8 -14809 0 TBP JUN MAX CEBPB EP300 RFX5 JUND MAFF STAT3 FOS TTC6 ENSG00000259087
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTC6 on UCSC Golden Path with GeneCards custom track

Promoters for TTC6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000067780 -99 1801 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 ZNF207

Genomic Location for TTC6 Gene

Chromosome:
14
Start:
37,595,199 bp from pter
End:
38,041,442 bp from pter
Size:
446,244 bases
Orientation:
Plus strand

Genomic View for TTC6 Gene

Genes around TTC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC6 Gene

Proteins for TTC6 Gene

  • Protein details for TTC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TZ1-TTC6_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 6
    Protein Accession:
    Q86TZ1
    Secondary Accessions:
    • Q3SY88
    • Q96CE6

    Protein attributes for TTC6 Gene

    Size:
    520 amino acids
    Molecular mass:
    59379 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC6 Gene

Post-translational modifications for TTC6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC6 Gene

Domains & Families for TTC6 Gene

Gene Families for TTC6 Gene

Protein Domains for TTC6 Gene

Suggested Antigen Peptide Sequences for TTC6 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TTC6: view

No data available for UniProtKB/Swiss-Prot for TTC6 Gene

Function for TTC6 Gene

Phenotypes From GWAS Catalog for TTC6 Gene

Phenotypes for TTC6 Gene

genes like me logo Genes that share phenotypes with TTC6: view

Animal Model Products

CRISPR Products

miRNA for TTC6 Gene

miRTarBase miRNAs that target TTC6

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC6 Gene

Localization for TTC6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC6 gene
Compartment Confidence
cytosol 3
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC6 Gene

Pathways & Interactions for TTC6 Gene

No Data Available

Interacting Proteins for TTC6 Gene

Gene Ontology (GO) - Biological Process for TTC6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC6 Gene

Drugs & Compounds for TTC6 Gene

No Compound Related Data Available

Transcripts for TTC6 Gene

mRNA/cDNA for TTC6 Gene

(9) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TTC6 Gene

Tetratricopeptide repeat domain 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC6 Gene

No ASD Table

Relevant External Links for TTC6 Gene

GeneLoc Exon Structure for
TTC6
ECgene alternative splicing isoforms for
TTC6

Expression for TTC6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTC6 Gene

mRNA differential expression in normal tissues according to GTEx for TTC6 Gene

This gene is overexpressed in Prostate (x12.7), Breast - Mammary Tissue (x8.0), Testis (x7.6), Liver (x5.1), and Stomach (x4.5).

Protein differential expression in normal tissues from HIPED for TTC6 Gene

This gene is overexpressed in Urine (61.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TTC6 Gene



Protein tissue co-expression partners for TTC6 Gene

NURSA nuclear receptor signaling pathways regulating expression of TTC6 Gene:

TTC6

SOURCE GeneReport for Unigene cluster for TTC6 Gene:

Hs.659936
genes like me logo Genes that share expression patterns with TTC6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC6 Gene

Orthologs for TTC6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC6 33 34
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia TTC6 34
  • 86 (a)
OneToOne
LOC490659 33
  • 72.43 (n)
cow
(Bos Taurus)
Mammalia TTC6 33 34
  • 76.56 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TTC6 34
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTC6 34
  • 37 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC6 34
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC6 34
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ttc6 34
  • 35 (a)
OneToOne
Species where no ortholog for TTC6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC6 Gene

ENSEMBL:
Gene Tree for TTC6 (if available)
TreeFam:
Gene Tree for TTC6 (if available)

Paralogs for TTC6 Gene

Paralogs for TTC6 Gene

genes like me logo Genes that share paralogs with TTC6: view

Variants for TTC6 Gene

Sequence variations from dbSNP and Humsavar for TTC6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000047670 -- 37,825,856(+) TGTGT(G/T)TGCAG intron-variant
rs1000049253 -- 37,708,964(+) CATCA(-/T)TCTCA intron-variant
rs1000059489 -- 37,784,546(+) ACACA(A/G)CACAC intron-variant
rs1000086410 -- 37,628,964(+) GGTCT(A/G)TATAT intron-variant
rs1000091498 -- 37,802,727(+) GACTT(C/T)CTTTT intron-variant

Variation tolerance for TTC6 Gene

Gene Damage Index Score: 12.42; 94.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC6 Gene

Human Gene Mutation Database (HGMD)
TTC6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TTC6 Gene

Disorders for TTC6 Gene

Relevant External Links for TTC6

Genetic Association Database (GAD)
TTC6
Human Genome Epidemiology (HuGE) Navigator
TTC6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC6

No disorders were found for TTC6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC6 Gene

Publications for TTC6 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. (PMID: 23817569) Hinds DA … Tung JY (Nature genetics 2013) 3 60
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 60
  5. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S … Cupples LA (BMC medical genetics 2007) 45 60

Products for TTC6 Gene

Sources for TTC6 Gene

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