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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TTC6 Gene

protein-coding   GIFtS: 36
GCID: GC14P038066

Tetratricopeptide Repeat Domain 6

(Previous names: non-protein coding RNA 291, chromosome 14 open reading frame...)
(Previous symbols: NCRNA00291, C14orf25)
  Search for TTC6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 8

Aliases
Tetratricopeptide Repeat Domain 61 2     Chromosome 14 Open Reading Frame 251
C14orf251 2     Non-Protein Coding RNA 2911
NCRNA002911 2     Tetratricopeptide Repeat Protein 62
TPR Repeat Protein 62 3     

External Ids:    HGNC: 197391   Entrez Gene: 3190892   Ensembl: ENSG000001398657   UniProtKB: Q86TZ13   
ORGUL members:         
NONCODE14:n374392 n382152 n374129      

Export aliases for TTC6 gene to outside databases

Previous GC identifers: GC14P032144 GC14P036231 GC14P037311 GC14P038222 GC14P038081 GC14P018186


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TTC6 Gene: 
TTC6 (tetratricopeptide repeat domain 6) is a protein-coding gene, and is affiliated with the lncRNA class. An important paralog of this gene is TTC13.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TTC6
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTC6 promoter sequence
   Search SABiosciences Chromatin IP Primers for TTC6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21.1   Ensembl cytogenetic band:  14q21.1   HGNC cytogenetic band: 14q13.1

TTC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTC6 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P038066:  view genomic region     (about GC identifiers)

Start:
38,065,052 bp from pter      End:
38,510,647 bp from pter
Size:
445,596 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TTC6

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TTC6_HUMAN, Q86TZ1 (See protein sequence)
Recommended Name: Tetratricopeptide repeat protein 6  
Size: 520 amino acids; 59379 Da
Secondary accessions: Q96CE6

Explore the universe of human proteins at neXtProt for TTC6: NX_Q86TZ1

Explore proteomics data for TTC6 at MOPED 

TTC6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TTC6 Protein Expression

ENSEMBL proteins: 
 ENSP00000450572   ENSP00000451566   ENSP00000451131   ENSP00000417788   ENSP00000419204  
 ENSP00000450568   ENSP00000267368   ENSP00000371757  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
TTC: Tetratricopeptide (TTC) repeat domain containing

4 InterPro protein domains:
 IPR001440 TPR-1
 IPR011990 TPR-like_helical
 IPR013026 TPR-contain_dom
 IPR019734 TPR_repeat

Graphical View of Domain Structure for InterPro Entry Q86TZ1

ProtoNet protein and cluster: Q86TZ1

UniProtKB/Swiss-Prot: TTC6_HUMAN, Q86TZ1
Similarity: Contains 13 TPR repeats


TTC6 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
TTC6 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTC6

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TTC6

Search CenterWatch for drugs/clinical trials and news about TTC6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TTC6 gene: 
NM_001007795.1  

Unigene Cluster for TTC6:

Tetratricopeptide repeat domain 6
Hs.659936  [show with all ESTs]
Unigene Representative Sequence: BX161415
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000556845 ENST00000533625(uc001wug.3) ENST00000553443(uc001wuj.3)
ENST00000476979(uc001wuh.3) ENST00000478811 ENST00000554555 ENST00000555921
ENST00000553887 ENST00000267368 ENST00000382320(uc001wui.3)
miRNA
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Additional mRNA sequence: 

BC014342.2 BC103914.2 BC103915.1 BC103916.2 BX161415.1 

5 DOTS entries:

DT.75199244  DT.120785882  DT.120785833  DT.91887055  DT.120785857 

3 AceView cDNA sequences:

BI463990 BF063203 BC038110 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TTC6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TTC6 Expression
About this image


See TTC6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TTC6

SOURCE GeneReport for Unigene cluster: Hs.659936
    SABiosciences Custom PCR Arrays for TTC6
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TTC6 gene from 4/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia TTC66
tetratricopeptide repeat domain 6
86(a)
1 ↔ 1
8(16223579-16282556)
chicken
(Gallus gallus)
Aves TTC66
Uncharacterized protein
54(a)
1 ↔ 1
5(36464047-36517135)
lizard
(Anolis carolinensis)
Reptilia TTC66
Uncharacterized protein
56(a)
1 ↔ 1
1(25699060-25730723)
zebrafish
(Danio rerio)
Actinopterygii ttc66
tetratricopeptide repeat domain 6
47(a)
1 ↔ 1
17(10320824-10342552)


ENSEMBL Gene Tree for TTC6 (if available)
TreeFam Gene Tree for TTC6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TTC6 gene
TTC132  

TTC6 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1641 SNPs in TTC6 are shown (see all 1641)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0341344
----see VAR_0341342 T S mis40--------
VAR_0341324
----see VAR_0341322 I S mis40--------
VAR_0341334
----see VAR_0341332 A T mis40--------
VAR_0246774
----see VAR_0246772 T I mis40--------
rs347560831,2
C--18208730(+) AAAAAA/-GAATG 1 -- int11Minor allele frequency- -:0.00NA 2
rs358373051,2
C--18222881(+) AAAAAA/-TTAGC 1 -- int12Minor allele frequency- -:0.25NA 4
rs557757031,2
C--18234593(+) TTTTT-/T/TTTTT
T
/TTTTTTT
CCATC
1 -- int11NA 2
rs2020784521,2
C--18239017(+) TTCAGC/TTTTTT 1 -- int10--------
rs714339121,2
C,F--18239660(+) TGTGC-/GT    
   
/GTGT
GTGTG
1 -- int12NA CSA 4
rs790989851,2
--18253737(+) CTCACC/TTTTTT 1 -- int10--------

HapMap Linkage Disequilibrium report for TTC6 (38065052 - 38315052 bp, first 250kb of TTC6)

Structural Variations
      Database of Genomic Variants (DGV) variations for TTC6: --
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing TTC6
DNA2.0 Custom Variant and Variant Library Synthesis for TTC6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TTC6 for disorders           About MalaCards

TTC6 for disorders           About GeneDecksing

Genetic Association Database (GAD): TTC6
Human Genome Epidemiology (HuGE) Navigator: TTC6 (1 document)

Export disorders for TTC6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TTC6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TTC6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1 Guey L.T....Malats N. (2010)
  4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
  5. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (2007)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  7. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
  8. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 319089 HGNC: 19739 AceView: C14orf25 Ensembl:ENSG00000139865 euGenes: HUgn319089
ECgene: TTC6 H-InvDB: TTC6

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TTC6 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TTC6 gene:
Search GeneIP for patents involving TTC6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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 Search ThermoFisher Antibodies for TTC6
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TTC6
 inGenious Targeting Laboratory - Custom generated mouse model solutions for TTC6
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TTC6
Customized:
 lentivirus for stable overexpression of TTC6
 lentivirus expression plasmids for stable overexpression of TTC6
 adenovirus for overexpression of TTC6
 LSBio Antibodies in human, mouse, rat for TTC6
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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