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Aliases for TTC6 Gene

Aliases for TTC6 Gene

  • Tetratricopeptide Repeat Domain 6 2 3
  • TPR Repeat Protein 6 3 4
  • Chromosome 14 Open Reading Frame 25 2
  • Non-Protein Coding RNA 291 2
  • NCRNA00291 3
  • C14orf25 3

External Ids for TTC6 Gene

Previous HGNC Symbols for TTC6 Gene

  • NCRNA00291
  • C14orf25

Previous GeneCards Identifiers for TTC6 Gene

  • GC14P032144
  • GC14P036231
  • GC14P037311
  • GC14P038222
  • GC14P038081
  • GC14P018186
  • GC14P038066

Summaries for TTC6 Gene

GeneCards Summary for TTC6 Gene

TTC6 (Tetratricopeptide Repeat Domain 6) is a Protein Coding gene. An important paralog of this gene is TTC13.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC6 Gene

Genomics for TTC6 Gene

Genomic Location for TTC6 Gene

37,595,199 bp from pter
38,041,442 bp from pter
446,244 bases
Plus strand

Genomic View for TTC6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC6 Gene

No data available for Regulatory Elements for TTC6 Gene

Proteins for TTC6 Gene

  • Protein details for TTC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tetratricopeptide repeat protein 6
    Protein Accession:
    Secondary Accessions:
    • Q3SY88
    • Q96CE6

    Protein attributes for TTC6 Gene

    520 amino acids
    Molecular mass:
    59379 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC6 Gene


neXtProt entry for TTC6 Gene

Proteomics data for TTC6 Gene at MOPED

Post-translational modifications for TTC6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC6 Gene

Domains & Families for TTC6 Gene

Gene Families for TTC6 Gene

Protein Domains for TTC6 Gene

Suggested Antigen Peptide Sequences for TTC6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 13 TPR repeats.
  • Contains 13 TPR repeats.
genes like me logo Genes that share domains with TTC6: view

Function for TTC6 Gene

Gene Ontology (GO) - Molecular Function for TTC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TTC6: view

Phenotypes for TTC6 Gene

GenomeRNAi human phenotypes for TTC6:
genes like me logo Genes that share phenotypes with TTC6: view

miRNA for TTC6 Gene

miRTarBase miRNAs that target TTC6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC6 Gene

Localization for TTC6 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TTC6 Gene

Pathways & Interactions for TTC6 Gene

SuperPathways for TTC6 Gene

No Data Available

Interacting Proteins for TTC6 Gene

Gene Ontology (GO) - Biological Process for TTC6 Gene


No data available for Pathways by source and SIGNOR curated interactions for TTC6 Gene

Drugs & Compounds for TTC6 Gene

No Compound Related Data Available

Transcripts for TTC6 Gene

mRNA/cDNA for TTC6 Gene

(10) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TTC6 Gene

Tetratricopeptide repeat domain 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC6 Gene

No ASD Table

Relevant External Links for TTC6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTC6 Gene

mRNA expression in normal human tissues for TTC6 Gene

mRNA differential expression in normal tissues according to GTEx for TTC6 Gene

This gene is overexpressed in Prostate (x12.7), Breast - Mammary Tissue (x8.0), Testis (x7.6), Liver (x5.1), and Stomach (x4.5).

Protein differential expression in normal tissues from HIPED for TTC6 Gene

This gene is overexpressed in Urine (61.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TTC6 Gene

SOURCE GeneReport for Unigene cluster for TTC6 Gene Hs.659936

genes like me logo Genes that share expression patterns with TTC6: view

Protein tissue co-expression partners for TTC6 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TTC6 Gene

Orthologs for TTC6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TTC6 35
  • 76.56 (n)
  • 66.61 (a)
TTC6 36
  • 83 (a)
(Canis familiaris)
Mammalia LOC490659 35
  • 72.43 (n)
  • 61.5 (a)
TTC6 36
  • 86 (a)
(Pan troglodytes)
Mammalia TTC6 35
  • 99.46 (n)
  • 98.87 (a)
TTC6 36
  • 99 (a)
(Monodelphis domestica)
Mammalia TTC6 36
  • 37 (a)
(Ornithorhynchus anatinus)
Mammalia TTC6 36
  • 53 (a)
(Gallus gallus)
Aves TTC6 36
  • 54 (a)
(Anolis carolinensis)
Reptilia TTC6 36
  • 56 (a)
(Danio rerio)
Actinopterygii ttc6 36
  • 35 (a)
Species with no ortholog for TTC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC6 Gene

Gene Tree for TTC6 (if available)
Gene Tree for TTC6 (if available)

Paralogs for TTC6 Gene

Paralogs for TTC6 Gene

genes like me logo Genes that share paralogs with TTC6: view

Variants for TTC6 Gene

Sequence variations from dbSNP and Humsavar for TTC6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs177829 -- 37,621,686(+) TTGTG(A/G)CCTTT intron-variant
rs177830 -- 37,623,510(+) TTTCT(A/G)TGTCT intron-variant
rs177831 -- 37,624,299(+) TTTCT(A/G)TGAAT intron-variant
rs177832 -- 37,625,404(+) ttagc(C/T)gggcg intron-variant
rs177833 -- 37,625,970(+) ttcat(C/T)gaagg intron-variant

Variation tolerance for TTC6 Gene

Gene Damage Index Score: 12.42; 94.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TTC6 Gene

Disorders for TTC6 Gene

Relevant External Links for TTC6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TTC6: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC6 Gene

Publications for TTC6 Gene

  1. A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. (PMID: 23817569) Hinds D.A. … Tung J.Y. (Nat. Genet. 2013) 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  3. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 67
  4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S. … Cupples L.A. (BMC Med. Genet. 2007) 67
  5. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan R.S. … Benjamin E.J. (BMC Med. Genet. 2007) 67

Products for TTC6 Gene

Sources for TTC6 Gene

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