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Aliases for TTC5 Gene

Aliases for TTC5 Gene

  • Tetratricopeptide Repeat Domain 5 2 3 5
  • Stress-Responsive Activator Of P300 3 4
  • TPR Repeat Protein 5 3 4
  • STRAP 3 4

External Ids for TTC5 Gene

Previous GeneCards Identifiers for TTC5 Gene

  • GC14M018748
  • GC14M018749
  • GC14M019827
  • GC14M020757
  • GC14M000879

Summaries for TTC5 Gene

GeneCards Summary for TTC5 Gene

TTC5 (Tetratricopeptide Repeat Domain 5) is a Protein Coding gene. Among its related pathways are Gene Expression and p53 pathway (Pathway Interaction Database). GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for TTC5 Gene

  • Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC5 Gene

Genomics for TTC5 Gene

Regulatory Elements for TTC5 Gene

Promoters for TTC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TTC5 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTC5 Gene

Chromosome:
14
Start:
20,256,558 bp from pter
End:
20,305,994 bp from pter
Size:
49,437 bases
Orientation:
Minus strand

Genomic View for TTC5 Gene

Genes around TTC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC5 Gene

Proteins for TTC5 Gene

  • Protein details for TTC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0Z6-TTC5_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 5
    Protein Accession:
    Q8N0Z6
    Secondary Accessions:
    • A8MQ18
    • Q96HF9

    Protein attributes for TTC5 Gene

    Size:
    440 amino acids
    Molecular mass:
    48928 Da
    Quaternary structure:
    • Interacts with JMY and p300/EP300.

    Three dimensional structures from OCA and Proteopedia for TTC5 Gene

neXtProt entry for TTC5 Gene

Proteomics data for TTC5 Gene at MOPED

Post-translational modifications for TTC5 Gene

  • Phosphorylation at Ser-203 enhances protein stability, regulates nuclear accumulation and association with p300/EP300.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTC5 Gene

Domains & Families for TTC5 Gene

Gene Families for TTC5 Gene

Protein Domains for TTC5 Gene

Suggested Antigen Peptide Sequences for TTC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N0Z6

UniProtKB/Swiss-Prot:

TTC5_HUMAN :
  • Contains 6 TPR repeats.
Similarity:
  • Contains 6 TPR repeats.
genes like me logo Genes that share domains with TTC5: view

Function for TTC5 Gene

Molecular function for TTC5 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).

Gene Ontology (GO) - Molecular Function for TTC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TTC5: view

Phenotypes for TTC5 Gene

GenomeRNAi human phenotypes for TTC5:
genes like me logo Genes that share phenotypes with TTC5: view

Animal Model Products

miRNA for TTC5 Gene

miRTarBase miRNAs that target TTC5

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC5 Gene

Localization for TTC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTC5 Gene

Nucleus. Cytoplasm. Note=Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC5 Gene COMPARTMENTS Subcellular localization image for TTC5 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TTC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TTC5: view

Pathways & Interactions for TTC5 Gene

genes like me logo Genes that share pathways with TTC5: view

Pathways by source for TTC5 Gene

Gene Ontology (GO) - Biological Process for TTC5 Gene

None

No data available for SIGNOR curated interactions for TTC5 Gene

Drugs & Compounds for TTC5 Gene

No Compound Related Data Available

Transcripts for TTC5 Gene

Unigene Clusters for TTC5 Gene

Tetratricopeptide repeat domain 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2: -
SP3: - - -

Relevant External Links for TTC5 Gene

GeneLoc Exon Structure for
TTC5
ECgene alternative splicing isoforms for
TTC5

Expression for TTC5 Gene

mRNA expression in normal human tissues for TTC5 Gene

Protein differential expression in normal tissues from HIPED for TTC5 Gene

This gene is overexpressed in Heart (40.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTC5 Gene



SOURCE GeneReport for Unigene cluster for TTC5 Gene Hs.98553

genes like me logo Genes that share expression patterns with TTC5: view

Protein tissue co-expression partners for TTC5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTC5 Gene

Orthologs for TTC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TTC5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TTC5 35
  • 91.36 (n)
  • 92.73 (a)
TTC5 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTC5 35
  • 85.19 (n)
  • 89.75 (a)
TTC5 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc5 35
  • 86.59 (n)
  • 90.45 (a)
Ttc5 16
Ttc5 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TTC5 35
  • 99.77 (n)
  • 99.55 (a)
TTC5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttc5 35
  • 86.36 (n)
  • 90.23 (a)
oppossum
(Monodelphis domestica)
Mammalia TTC5 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC5 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.18743 35
ttc5 35
  • 66.28 (n)
  • 67.84 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11459 35
zebrafish
(Danio rerio)
Actinopterygii ttc5 35
  • 60.71 (n)
  • 59.16 (a)
ttc5 36
  • 55 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y37E3.1 36
  • 25 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os01g0506200 35
  • 44.73 (n)
  • 36.5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToOne
Species with no ortholog for TTC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC5 Gene

ENSEMBL:
Gene Tree for TTC5 (if available)
TreeFam:
Gene Tree for TTC5 (if available)

Paralogs for TTC5 Gene

(1) SIMAP similar genes for TTC5 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for TTC5 Gene

genes like me logo Genes that share paralogs with TTC5: view

No data available for Paralogs for TTC5 Gene

Variants for TTC5 Gene

Sequence variations from dbSNP and Humsavar for TTC5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_034131 -
rs3742945 - 20,301,877(-) TGTGC(A/G)GAAGG reference, missense
rs998040 -- 20,294,215(-) TTCTC(C/T)TTATA intron-variant
rs1000608 -- 20,294,847(+) CACTC(A/C)ATAAA intron-variant
rs945459 -- 20,299,547(+) CCTTT(C/T)TAAGT intron-variant

Variation tolerance for TTC5 Gene

Residual Variation Intolerance Score: 48.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC5 Gene

HapMap Linkage Disequilibrium report
TTC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TTC5 Gene

Disorders for TTC5 Gene

Relevant External Links for TTC5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC5

No disorders were found for TTC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC5 Gene

Publications for TTC5 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A TPR motif cofactor contributes to p300 activity in the p53 response. (PMID: 11511361) Demonacos C. … La Thangue N.B. (Mol. Cell 2001) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for TTC5 Gene

Sources for TTC5 Gene

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