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Aliases for TTC4 Gene

Aliases for TTC4 Gene

  • Tetratricopeptide Repeat Domain 4 2 3
  • TPR Repeat Protein 4 4

External Ids for TTC4 Gene

Previous GeneCards Identifiers for TTC4 Gene

  • GC01P055018
  • GC01P054008
  • GC01P054466
  • GC01P054551
  • GC01P054893
  • GC01P055181
  • GC01P053295

Summaries for TTC4 Gene

Entrez Gene Summary for TTC4 Gene

  • This gene encodes a protein that contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions and chaperone activity. The encoded protein interacts with heat shock proteins 70 and 90. Alternative splicing results in multiple transcript variants. Naturally-occuring readthrough transcription occurs from upstream gene MROH (maestro heat-like repeat family member 7) to this gene. [provided by RefSeq, Apr 2014]

GeneCards Summary for TTC4 Gene

TTC4 (Tetratricopeptide Repeat Domain 4) is a Protein Coding gene.

Gene Wiki entry for TTC4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC4 Gene

Genomics for TTC4 Gene

Regulatory Elements for TTC4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TTC4 Gene

54,715,822 bp from pter
54,742,657 bp from pter
26,836 bases
Plus strand

Genomic View for TTC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC4 Gene

Proteins for TTC4 Gene

  • Protein details for TTC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tetratricopeptide repeat protein 4
    Protein Accession:
    Secondary Accessions:
    • Q53Y95
    • Q5TA96
    • Q9H3I2

    Protein attributes for TTC4 Gene

    387 amino acids
    Molecular mass:
    44679 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD19853.1; Type=Frameshift; Positions=322; Evidence={ECO:0000305};

neXtProt entry for TTC4 Gene

Proteomics data for TTC4 Gene at MOPED

Post-translational modifications for TTC4 Gene

  • Ubiquitination at Lys227
  • Modification sites at PhosphoSitePlus

Other Protein References for TTC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TTC4 Gene

Domains for TTC4 Gene

Gene Families for TTC4 Gene

  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for TTC4 Gene

Suggested Antigen Peptide Sequences for TTC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O95801
  • Belongs to the TTC4 family.
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with TTC4: view

Function for TTC4 Gene

Molecular function for TTC4 Gene

GENATLAS Biochemistry:
tetratricopeptide-repeat containing gene isoform 4,ubiquitously expressed,localized within critical region,deleted in sporadic breast cancer

Gene Ontology (GO) - Molecular Function for TTC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TTC4: view
genes like me logo Genes that share phenotypes with TTC4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TTC4 Gene

Localization for TTC4 Gene

Subcellular locations from

Jensen Localization Image for TTC4 Gene COMPARTMENTS Subcellular localization image for TTC4 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC4 Gene

Pathways for TTC4 Gene

SuperPathways for TTC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC4 Gene


No data available for Pathways by source for TTC4 Gene

Transcripts for TTC4 Gene

Unigene Clusters for TTC4 Gene

Tetratricopeptide repeat domain 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTC4

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC4 Gene

No ASD Table

Relevant External Links for TTC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTC4 Gene

mRNA expression in normal human tissues for TTC4 Gene

Protein differential expression in normal tissues for TTC4 Gene

This gene is overexpressed in Testis (26.8), Peripheral blood mononuclear cells (14.5), Lymph node (6.6), and Fetal ovary (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTC4 Gene

SOURCE GeneReport for Unigene cluster for TTC4 Gene Hs.729029

genes like me logo Genes that share expressions with TTC4: view

Expression partners for TTC4 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTC4 Gene

Orthologs for TTC4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TTC4 35
  • 88.29 (n)
  • 86.3 (a)
TTC4 36
  • 86 (a)
(Canis familiaris)
Mammalia TTC4 35
  • 88.54 (n)
  • 86.56 (a)
TTC4 36
  • 86 (a)
(Mus musculus)
Mammalia Ttc4 35
  • 84.59 (n)
  • 82.6 (a)
Ttc4 16
Ttc4 36
  • 82 (a)
(Pan troglodytes)
Mammalia TTC4 35
  • 99.05 (n)
  • 98.19 (a)
TTC4 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia TTC4 36
  • 44 (a)
(Gallus gallus)
Aves TTC4 35
  • 64.36 (n)
  • 62.6 (a)
TTC4 36
  • 60 (a)
(Anolis carolinensis)
Reptilia TTC4 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc4 35
  • 64.37 (n)
  • 62.6 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19066 35
(Danio rerio)
Actinopterygii ttc4 35
  • 62.52 (n)
  • 59.84 (a)
zgc56411 35
ttc4 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dpit47 37
  • 35 (a)
Dpit47 35
  • 44.63 (n)
  • 33.33 (a)
Dpit47 36
  • 29 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012044 35
  • 44.35 (n)
  • 32.78 (a)
(Caenorhabditis elegans)
Secernentea C17G10.2 37
  • 34 (a)
C17G10.2 35
  • 46.84 (n)
  • 35.41 (a)
C17G10.2 36
  • 29 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL268C 35
  • 42.97 (n)
  • 29.82 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B09966g 35
  • 44.69 (n)
  • 32.18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNS1 35
  • 43.12 (n)
  • 31.16 (a)
CNS1 36
  • 24 (a)
CNS1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU06340 35
  • 44.29 (n)
  • 35.27 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cns1 35
  • 44.68 (n)
  • 32.99 (a)
Species with no ortholog for TTC4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC4 Gene

Gene Tree for TTC4 (if available)
Gene Tree for TTC4 (if available)

Paralogs for TTC4 Gene Pseudogenes for TTC4 Gene

genes like me logo Genes that share paralogs with TTC4: view

No data available for Paralogs for TTC4 Gene

Variants for TTC4 Gene

Sequence variations from dbSNP and Humsavar for TTC4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs147253229 -- 54,715,608(+) AGAGC(-/TAAG)TAAGT upstream-variant-2KB
VAR_031713 -

Structural Variations from Database of Genomic Variants (DGV) for TTC4 Gene

Variant ID Type Subtype PubMed ID
nsv461561 CNV Gain 19166990
nsv829904 CNV Loss 17160897
nsv817614 CNV Gain 22305530
nsv461594 CNV Gain 19166990
dgv229n71 CNV Gain 21882294
esv259647 OTHER Complex 20981092
esv259828 OTHER Complex 20981092

Relevant External Links for TTC4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC4 Gene

Disorders for TTC4 Gene

Relevant External Links for TTC4

Genetic Association Database (GAD)

No disorders were found for TTC4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TTC4 Gene

Publications for TTC4 Gene

  1. TTC4, a novel human gene containing the tetratricopeptide repeat and mapping to the region of chromosome 1p31 that is frequently deleted in sporadic breast cancer. (PMID: 9933562) Su G. … Cowell J.K. (Genomics 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3

Products for TTC4 Gene

Sources for TTC4 Gene

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