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Aliases for TTC4 Gene

Aliases for TTC4 Gene

  • Tetratricopeptide Repeat Domain 4 2 3 5
  • TPR Repeat Protein 4 4

External Ids for TTC4 Gene

Previous GeneCards Identifiers for TTC4 Gene

  • GC01P055018
  • GC01P054008
  • GC01P054466
  • GC01P054551
  • GC01P054893
  • GC01P055181
  • GC01P053295

Summaries for TTC4 Gene

Entrez Gene Summary for TTC4 Gene

  • This gene encodes a protein that contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions and chaperone activity. The encoded protein interacts with heat shock proteins 70 and 90. Alternative splicing results in multiple transcript variants. Naturally-occuring readthrough transcription occurs from upstream gene MROH (maestro heat-like repeat family member 7) to this gene. [provided by RefSeq, Apr 2014]

GeneCards Summary for TTC4 Gene

TTC4 (Tetratricopeptide Repeat Domain 4) is a Protein Coding gene. Diseases associated with TTC4 include sporadic breast cancer.

Gene Wiki entry for TTC4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC4 Gene

Genomics for TTC4 Gene

Regulatory Elements for TTC4 Gene

Enhancers for TTC4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TTC4 on UCSC Golden Path with GeneCards custom track

Promoters for TTC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TTC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTC4 Gene

Chromosome:
1
Start:
54,715,822 bp from pter
End:
54,742,657 bp from pter
Size:
26,836 bases
Orientation:
Plus strand

Genomic View for TTC4 Gene

Genes around TTC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC4 Gene

Proteins for TTC4 Gene

  • Protein details for TTC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95801-TTC4_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 4
    Protein Accession:
    O95801
    Secondary Accessions:
    • Q53Y95
    • Q5TA96
    • Q9H3I2

    Protein attributes for TTC4 Gene

    Size:
    387 amino acids
    Molecular mass:
    44679 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD19853.1; Type=Frameshift; Positions=322; Evidence={ECO:0000305};

neXtProt entry for TTC4 Gene

Proteomics data for TTC4 Gene at MOPED

Post-translational modifications for TTC4 Gene

  • Ubiquitination at Lys 227
  • Modification sites at PhosphoSitePlus

Other Protein References for TTC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTC4 Gene

Domains & Families for TTC4 Gene

Gene Families for TTC4 Gene

Protein Domains for TTC4 Gene

Suggested Antigen Peptide Sequences for TTC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95801

UniProtKB/Swiss-Prot:

TTC4_HUMAN :
  • Belongs to the TTC4 family.
  • Contains 3 TPR repeats.
Family:
  • Belongs to the TTC4 family.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with TTC4: view

Function for TTC4 Gene

Molecular function for TTC4 Gene

GENATLAS Biochemistry:
tetratricopeptide-repeat containing gene isoform 4,ubiquitously expressed,localized within critical region,deleted in sporadic breast cancer
genes like me logo Genes that share phenotypes with TTC4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC4 Gene

Localization for TTC4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC4 Gene COMPARTMENTS Subcellular localization image for TTC4 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 2
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC4 Gene

Pathways & Interactions for TTC4 Gene

SuperPathways for TTC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC4 Gene

Drugs & Compounds for TTC4 Gene

No Compound Related Data Available

Transcripts for TTC4 Gene

Unigene Clusters for TTC4 Gene

Tetratricopeptide repeat domain 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC4 Gene

No ASD Table

Relevant External Links for TTC4 Gene

GeneLoc Exon Structure for
TTC4
ECgene alternative splicing isoforms for
TTC4

Expression for TTC4 Gene

mRNA expression in normal human tissues for TTC4 Gene

Protein differential expression in normal tissues from HIPED for TTC4 Gene

This gene is overexpressed in Testis (26.8), Peripheral blood mononuclear cells (14.5), Lymph node (6.6), and Fetal ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTC4 Gene



SOURCE GeneReport for Unigene cluster for TTC4 Gene Hs.729029

genes like me logo Genes that share expression patterns with TTC4: view

Protein tissue co-expression partners for TTC4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTC4 Gene

Orthologs for TTC4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTC4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TTC4 35
  • 88.54 (n)
  • 86.56 (a)
TTC4 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc4 35
  • 84.59 (n)
  • 82.6 (a)
Ttc4 16
Ttc4 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TTC4 35
  • 99.05 (n)
  • 98.19 (a)
TTC4 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TTC4 36
  • 86 (a)
OneToOne
TTC4 35
  • 88.29 (n)
  • 86.3 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia TTC4 36
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC4 35
  • 64.36 (n)
  • 62.6 (a)
TTC4 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC4 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc4 35
  • 64.37 (n)
  • 62.6 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19066 35
zebrafish
(Danio rerio)
Actinopterygii ttc4 35
  • 62.52 (n)
  • 59.84 (a)
zgc56411 35
ttc4 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dpit47 37
  • 35 (a)
Dpit47 35
  • 44.63 (n)
  • 33.33 (a)
Dpit47 36
  • 29 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012044 35
  • 44.35 (n)
  • 32.78 (a)
worm
(Caenorhabditis elegans)
Secernentea C17G10.2 37
  • 34 (a)
C17G10.2 35
  • 46.84 (n)
  • 35.41 (a)
C17G10.2 36
  • 29 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL268C 35
  • 42.97 (n)
  • 29.82 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B09966g 35
  • 44.69 (n)
  • 32.18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNS1 36
  • 24 (a)
OneToOne
CNS1 38
CNS1 35
  • 43.12 (n)
  • 31.16 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06340 35
  • 44.29 (n)
  • 35.27 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cns1 35
  • 44.68 (n)
  • 32.99 (a)
Species with no ortholog for TTC4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC4 Gene

ENSEMBL:
Gene Tree for TTC4 (if available)
TreeFam:
Gene Tree for TTC4 (if available)

Paralogs for TTC4 Gene

Pseudogenes.org Pseudogenes for TTC4 Gene

genes like me logo Genes that share paralogs with TTC4: view

No data available for Paralogs for TTC4 Gene

Variants for TTC4 Gene

Sequence variations from dbSNP and Humsavar for TTC4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_031713 -
rs147253229 -- 54,715,608(+) AGAGC(-/TAAG)TAAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TTC4 Gene

Variant ID Type Subtype PubMed ID
nsv461561 CNV Gain 19166990
nsv829904 CNV Loss 17160897
nsv817614 CNV Gain 22305530
nsv461594 CNV Gain 19166990
dgv229n71 CNV Gain 21882294
esv259647 OTHER Complex 20981092
esv259828 OTHER Complex 20981092

Variation tolerance for TTC4 Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC4 Gene

HapMap Linkage Disequilibrium report
TTC4
Human Gene Mutation Database (HGMD)
TTC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC4 Gene

Disorders for TTC4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TTC4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
sporadic breast cancer
  • sporadic breast carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search TTC4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TTC4

Genetic Association Database (GAD)
TTC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC4
genes like me logo Genes that share disorders with TTC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTC4 Gene

Publications for TTC4 Gene

  1. TTC4, a novel human gene containing the tetratricopeptide repeat and mapping to the region of chromosome 1p31 that is frequently deleted in sporadic breast cancer. (PMID: 9933562) Su G. … Cowell J.K. (Genomics 1999) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. Two distinct nuclear localization signals in mammalian MSL1 regulate its function. (PMID: 24913909) Dmitriev R.I. … Okkelman I.A. (J. Cell. Biochem. 2014) 3

Products for TTC4 Gene

Sources for TTC4 Gene

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