TTC4 Gene
protein-coding GIFtS: 47
GCID: GC01P055181
|
|
tetratricopeptide repeat domain 4
| |
Aliases
for TTC4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tetratricopeptide Repeat Domain 41 2 | | TPR Repeat Protein 42 3 | | FLJ419301 | | MGC50971 | | Tetratricopeptide Repeat Protein 42 |
Export aliases for TTC4 gene to outside databasesPrevious GC identifers: GC01P055018 GC01P054008 GC01P054466 GC01P054551 GC01P054893 GC01P053295 |
Summaries
for TTC4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TTC4:
This gene encodes a protein that contains tetratricopeptide (TPR) repeats. The 34-amino acid tetratricopeptide repeatmotifs are found in a variety of proteins and may mediate protein-protein interactions and chaperoneactivity.(provided by RefSeq, Jun 2011)
Gene Wiki entry for TTC4
|
Genomic Views
for TTC4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TTC4 gene promoter:
Bach2 Pax-2 Lmo2 Pax-2a GATA-1 Evi-1 FAC1 POU2F1 POU2F1a SEF-1 (1)
Other transcription factors
Search SABiosciences Chromatin IP Primers for TTC4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p32.3 Ensembl cytogenetic band: 1p32.3 HGNC cytogenetic band: 1p32TTC4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P055181: view genomic region
(about GC identifiers)
Start:
|
55,181,495 bp from pter |
End:
|
55,208,330 bp from pter |
Size:
|
26,836 bases |
Orientation:
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plus strand |
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Proteins
for TTC4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TTC4_HUMAN, O95801 (See
protein sequence)Recommended Name: Tetratricopeptide repeat protein 4 Size: 387 amino acids; 44679 Da
Sequence caution: Sequence=AAD19853.1; Type=Frameshift; Positions=322;
Secondary accessions: Q53Y95 Q5TA96 Q9H3I2Explore the universe of human proteins at neXtProt for TTC4: NX_O95801
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95801
TTC4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004614.3
ENSEMBL proteins: ENSP00000360329 ENSP00000360332
Human Recombinant Protein Products:
TTC4 Antibody Products:
Assay Products for TTC4: |
Protein
Domains /
Families
for TTC4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TTC4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95801ProtoNet protein and cluster: O95801 UniProtKB/Swiss-Prot: TTC4_HUMAN, O95801Similarity: Belongs to the TTC4 familySimilarity: Contains 3 TPR repeats |
Function
for TTC4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for TTC4:tetratricopeptide-repeat containing gene isoform 4,ubiquitously expressed,localized within critical region,deleted insporadic breast cancer
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TTC4 (NM_004623) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC4 |
3 GenomeRNAi human phenotypes for TTC4:
|
Pathways & Interactions
for TTC4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTC4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
5/15 Interacting proteins for TTC4 (O958013 ENSP000003603294) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
|
Drugs & Compounds
for TTC4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TTC4
Search CenterWatch for drugs/clinical trials and news about TTC4
|
Transcripts
for TTC4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TTC4 gene: NM_004623.4 Unigene Cluster for TTC4: Tetratricopeptide repeat domain 4 Hs.729029 [show with all ESTs]Unigene Representative Sequence: AK0255244 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000371281(uc001cxx.4 uc001cxv.3) ENST00000486621 ENST00000371284
ENST00000486091
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TTC4 (NM_004623) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC4 |
Additional cDNA sequence: AF063602.1 AF073887.1 AK025524.1 AK090964.1 AK222562.1 AK292426.1 BC001276.1 BT006817.1 12 DOTS entries: DT.100646459 DT.410073 DT.97777237 DT.121396761 DT.95297805 DT.121396793 DT.100658495 DT.92435701 DT.91650177 DT.95374113 DT.101984908 DT.121120788 24/214 AceView cDNA sequences (see all 214): AX746706 BM673384 AL043872 AL117640 BX281957 AI038486 AK127008 CD244242 AW027531 CR612462 AL045710 AA382618 BM719805 BX116560 CR599311 BX443464 AL096749 CR616622 AA382617 CR606917 CR607810 BC029191 Z39270 CR620756
GeneLoc Exon Structure
|
Expression
for TTC4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TTC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGGTTGTT
About this image
See TTC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TTC4
SOURCE GeneReport for Unigene cluster: Hs.729029
SABiosciences Custom PCR Arrays for TTC4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TTC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC4 |
Orthologs
for TTC4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TTC4 gene from 10/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ttc41 , 5 |
tetratricopeptide repeat domain 41, 5 |
84.59(n)1
82.6(a)1 |
|
4 (49.68 cM)5
723541 NM_028209.21 NP_082485.11
1066622565 |
chicken
(Gallus gallus) |
Aves |
TTC41 |
tetratricopeptide repeat domain 4 |
64.36(n)
62.6(a) |
|
429109 XM_426665.3 XP_426665.3 |
lizard
(Anolis carolinensis) |
Reptilia |
TTC46 |
-- |
65(a) |
1 ↔ 1 |
4(104501578-104513739) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.190662 |
Xenopus laevis transcribed sequence with weak similarity more |
76.22(n) |
|
AW644008.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc564112 |
similar to tetratricopeptide repeat domain 4 |
75.03(n) |
|
393981 BC049428.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Dpit471 , 3 |
DNA polymerase interacting tpr containing protein of more1 |
35(a)3
44.72(n)1
33.33(a)1 |
|
42C33
355651 NM_080367.21 NP_525106.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
C17G10.21 , 3 |
TPR domain3
Protein C17G10.21 |
34(a)3
47.48(n)1
35.9(a)1 |
|
II(5594708-5596310)3
1739461 NM_062686.21 NP_495087.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
CNS1(YBR155W)4
CNS11 |
TPR-containing co-chaperone; binds both Hsp82p (Hsp9 more4
Cns1p1 |
43.09(n)1
30.49(a)1 |
|
2(549771-550928)4
8524521, 4 NP_009713.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G041301 |
tetratricopeptide repeat-containing protein |
44.98(n)
31.62(a) |
|
839276 NM_100294.2 NP_563702.1 |
rice
(Oryza sativa) |
Liliopsida |
Os03g07501001 |
hypothetical protein |
40.89(n)
28.87(a) |
|
4334120 NM_001057816.2 NP_001051281.2 |
ENSEMBL Gene Tree for TTC4 (if available)
TreeFam Gene Tree for TTC4 (if available) |
Paralogs
for TTC4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TTC4 gene
TTC4 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TTC4
PGOHUM00000232681
|
Genomic Variants
for TTC4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TTC4 (55181495 - 55208330 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TTC4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC4 |
|
Disorders
/ Diseases
for TTC4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TTC4 for disorders About GeneDecksing
OMIM gene information: 606753
OMIM disorders: --
4  diseases for TTC4: About MalaCardssporadic breast cancer hepatitis c breast cancer hepatitis
Export disorders for TTC4 gene to outside databases
|
Publications
for TTC4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TTC4 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with TTC4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TTC4, a novel human gene containing the tetratricopeptide repeat and mapping to the region of chromosome 1p31 that is frequently deleted in sporadic breast cancer. (PubMed id 9933562)1, 2, 3 Su G.... Cowell J.K. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for TTC4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TTC4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TTC4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TTC4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TTC4 gene:
Search GeneIP for patents involving TTC4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TTC4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TTC4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTC4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC4 | | | OriGene Protein Over-expression Lysate for TTC4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TTC4 | | OriGene 3'-UTR Clone for TTC4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TTC4 | | OriGene Custom Protein Services for TTC4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TTC4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC4 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TTC4 |
| |  |  |  |  | | | | |
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 |
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 | | | TTC4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC4 |
|  |  |  | | | | ThermoFisher Antibody for TTC4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC4 |
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