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Aliases for TTC4 Gene

Aliases for TTC4 Gene

  • Tetratricopeptide Repeat Domain 4 2 3 5
  • TPR Repeat Protein 4 4

External Ids for TTC4 Gene

Previous GeneCards Identifiers for TTC4 Gene

  • GC01P055018
  • GC01P054008
  • GC01P054466
  • GC01P054551
  • GC01P054893
  • GC01P055181
  • GC01P053295

Summaries for TTC4 Gene

Entrez Gene Summary for TTC4 Gene

  • This gene encodes a protein that contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions and chaperone activity. The encoded protein interacts with heat shock proteins 70 and 90. Alternative splicing results in multiple transcript variants. Naturally-occuring readthrough transcription occurs from upstream gene MROH (maestro heat-like repeat family member 7) to this gene. [provided by RefSeq, Apr 2014]

GeneCards Summary for TTC4 Gene

TTC4 (Tetratricopeptide Repeat Domain 4) is a Protein Coding gene. Diseases associated with TTC4 include Sporadic Breast Cancer.

Gene Wiki entry for TTC4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC4 Gene

Genomics for TTC4 Gene

Regulatory Elements for TTC4 Gene

Enhancers for TTC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G054715 1.2 ENCODE 31.7 +0.3 333 2.2 HDGF PKNOX1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 CBX5 TTC4 TTC22 ENSG00000237453 HSPB11 MROH7 PIR47125
GH01G054792 1.4 Ensembl ENCODE dbSUPER 10.3 +81.7 81701 9.5 HDGF ATF1 CREB3L1 ARID4B DMAP1 YY1 ZNF143 FOS SP5 JUNB LEXM PARS2 TTC4 DHCR24 ENSG00000242396 ENSG00000233203 TTC22 PIR51709 ENSG00000237453
GH01G054587 0.8 dbSUPER 14.9 -127.4 -127385 1.5 SOX13 TFAP4 THRB YY1 KAT2B RARA HNF4G NR2F6 CREM GATAD2A MROH7 TTC4 FAM151A ACOT11
GH01G053835 1.2 ENCODE 9.7 -878.7 -878692 4.1 MLX CREB3L1 AGO1 DMAP1 YBX1 YY1 ZNF143 ZNF263 SP3 TBX21 HSPB11 LRRC42 C1orf123 SSBP3-AS1 TTC4 TCEANC2 TMEM59 ENSG00000237453 TTC22 YIPF1
GH01G055631 1 Ensembl ENCODE 10 +916.8 916832 1.9 PKNOX1 JUN ZNF140 CEBPB JUNB FEZF1 EP300 JUND MAFF POLR3A TTC4 ENSG00000234810 GC01P055807
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTC4 on UCSC Golden Path with GeneCards custom track

Promoters for TTC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000006680 278 1401 ZFP64 FEZF1 DMAP1 ZNF143 SP3 NFYC ZNF610 GLIS1 NBN NR2C1

Genomic Location for TTC4 Gene

Chromosome:
1
Start:
54,715,822 bp from pter
End:
54,742,657 bp from pter
Size:
26,836 bases
Orientation:
Plus strand

Genomic View for TTC4 Gene

Genes around TTC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC4 Gene

Proteins for TTC4 Gene

  • Protein details for TTC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95801-TTC4_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 4
    Protein Accession:
    O95801
    Secondary Accessions:
    • Q53Y95
    • Q5TA96
    • Q9H3I2

    Protein attributes for TTC4 Gene

    Size:
    387 amino acids
    Molecular mass:
    44679 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD19853.1; Type=Frameshift; Positions=322; Evidence={ECO:0000305};

neXtProt entry for TTC4 Gene

Post-translational modifications for TTC4 Gene

  • Ubiquitination at isoforms=227
  • Modification sites at PhosphoSitePlus

Other Protein References for TTC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTC4 Gene

Domains & Families for TTC4 Gene

Gene Families for TTC4 Gene

Protein Domains for TTC4 Gene

Suggested Antigen Peptide Sequences for TTC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95801

UniProtKB/Swiss-Prot:

TTC4_HUMAN :
  • Belongs to the TTC4 family.
Family:
  • Belongs to the TTC4 family.
genes like me logo Genes that share domains with TTC4: view

Function for TTC4 Gene

Molecular function for TTC4 Gene

GENATLAS Biochemistry:
tetratricopeptide-repeat containing gene isoform 4,ubiquitously expressed,localized within critical region,deleted in sporadic breast cancer
genes like me logo Genes that share phenotypes with TTC4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TTC4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC4 Gene

Localization for TTC4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC4 gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 2
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC4 Gene

Pathways & Interactions for TTC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC4 Gene

Drugs & Compounds for TTC4 Gene

No Compound Related Data Available

Transcripts for TTC4 Gene

Unigene Clusters for TTC4 Gene

Tetratricopeptide repeat domain 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TTC4

Alternative Splicing Database (ASD) splice patterns (SP) for TTC4 Gene

No ASD Table

Relevant External Links for TTC4 Gene

GeneLoc Exon Structure for
TTC4
ECgene alternative splicing isoforms for
TTC4

Expression for TTC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTC4 Gene

Protein differential expression in normal tissues from HIPED for TTC4 Gene

This gene is overexpressed in Testis (26.8), Peripheral blood mononuclear cells (14.5), Lymph node (6.6), and Fetal ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTC4 Gene



Protein tissue co-expression partners for TTC4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TTC4 Gene:

TTC4

SOURCE GeneReport for Unigene cluster for TTC4 Gene:

Hs.729029

Evidence on tissue expression from TISSUES for TTC4 Gene

  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with TTC4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC4 Gene

Orthologs for TTC4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC4 34 35
  • 99.05 (n)
dog
(Canis familiaris)
Mammalia TTC4 34 35
  • 88.54 (n)
cow
(Bos Taurus)
Mammalia TTC4 34 35
  • 88.29 (n)
mouse
(Mus musculus)
Mammalia Ttc4 34 16 35
  • 84.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TTC4 35
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC4 34 35
  • 64.36 (n)
lizard
(Anolis carolinensis)
Reptilia TTC4 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc4 34
  • 64.37 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19066 34
zebrafish
(Danio rerio)
Actinopterygii ttc4 34 35
  • 62.52 (n)
zgc56411 34
fruit fly
(Drosophila melanogaster)
Insecta Dpit47 36 34 35
  • 44.63 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012044 34
  • 44.35 (n)
worm
(Caenorhabditis elegans)
Secernentea C17G10.2 36 34 35
  • 46.84 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B09966g 34
  • 44.69 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNS1 34 35 37
  • 43.12 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL268C 34
  • 42.97 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cns1 34
  • 44.68 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06340 34
  • 44.29 (n)
Species where no ortholog for TTC4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC4 Gene

ENSEMBL:
Gene Tree for TTC4 (if available)
TreeFam:
Gene Tree for TTC4 (if available)

Paralogs for TTC4 Gene

Pseudogenes.org Pseudogenes for TTC4 Gene

genes like me logo Genes that share paralogs with TTC4: view

No data available for Paralogs for TTC4 Gene

Variants for TTC4 Gene

Sequence variations from dbSNP and Humsavar for TTC4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000162021 -- 54,730,026(+) GGGGT(A/G)GGTTT intron-variant
rs1000189006 -- 54,719,220(+) ACTCT(A/G)ACTGC intron-variant
rs1000235241 -- 54,732,455(+) TTTTT(G/T)GTAAT intron-variant
rs1000291350 -- 54,726,390(+) AGAGA(A/C)GTAGT intron-variant
rs1000363913 -- 54,726,040(+) GGGCA(A/C)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC4 Gene

Variant ID Type Subtype PubMed ID
dgv166n100 CNV gain 25217958
dgv38e212 CNV gain 25503493
dgv90e59 CNV tandem duplication 20981092
esv3390763 CNV duplication 20981092
nsv1000673 CNV gain 25217958
nsv1004778 CNV gain 25217958
nsv461561 CNV gain 19166990
nsv461594 CNV gain 19166990
nsv546266 CNV gain 21841781
nsv546269 CNV gain 21841781
nsv817614 CNV gain 22305530
nsv829904 CNV loss 17160897

Variation tolerance for TTC4 Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC4 Gene

Human Gene Mutation Database (HGMD)
TTC4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC4 Gene

Disorders for TTC4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TTC4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
sporadic breast cancer
  • sporadic breast carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search TTC4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TTC4

Genetic Association Database (GAD)
TTC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC4
genes like me logo Genes that share disorders with TTC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTC4 Gene

Publications for TTC4 Gene

  1. TTC4, a novel human gene containing the tetratricopeptide repeat and mapping to the region of chromosome 1p31 that is frequently deleted in sporadic breast cancer. (PMID: 9933562) Su G. … Cowell J.K. (Genomics 1999) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for TTC4 Gene

Sources for TTC4 Gene

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