TTC39C Gene
protein-coding GIFtS: 37
GCID: GC18P021572
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tetratricopeptide repeat domain 39C(Previous name: chromosome 18 open reading frame 17 )
(Previous symbol: C18orf17)
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Aliases
for TTC39C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tetratricopeptide Repeat Domain 39C1 2 | | FLJ337611 | | C18orf171 2 3 | | Chromosome 18 Open Reading Frame 171 | | HsT26971 2 | | Tetratricopeptide Repeat Protein 39C2 | | TPR Repeat Protein 39C2 3 | | |
Export aliases for TTC39C gene to outside databasesPrevious GC identifers: GC18P019827 GC18P018428 |
Summaries
for TTC39C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TTC39C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010966.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TTC39C gene promoter:
Sp1 POU6F1 (c2) HNF-4alpha1 PPAR-gamma1 ARP-1 Cart-1 PPAR-gamma2 RSRFC4 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TTC39C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC39C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q11.2 Ensembl cytogenetic band: 18q11.2 HGNC cytogenetic band: 18q11.2TTC39C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P021572: view genomic region
(about GC identifiers)
Start:
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21,572,737 bp from pter |
End:
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21,715,574 bp from pter |
Size:
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142,838 bases |
Orientation:
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plus strand |
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Proteins
for TTC39C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TT39C_HUMAN, Q8N584 (See
protein sequence)Recommended Name: Tetratricopeptide repeat protein 39C Size: 583 amino acids; 65870 Da
Sequence caution: Sequence=AAH32684.1; Type=Erroneous initiation;
Secondary accessions: B7WP63 J3QRR1 Q0VAJ2 Q8N284Alternative splicing: 3 isoforms: Q8N584-1 Q8N584-2 Q8N584-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TTC39C: NX_Q8N584
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N584
TTC39C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001129465.1 NP_001230354.1 NP_694943.2
ENSEMBL proteins: ENSP00000306598 ENSP00000464344 ENSP00000323645 ENSP00000463610 ENSP00000443016 ENSP00000463283
Human Recombinant Protein Products for TTC39C:
TTC39C Antibody Products:
Assay Products for TTC39C: |
Protein
Domains /
Families
for TTC39C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TTC39C for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N584ProtoNet protein and cluster: Q8N584 UniProtKB/Swiss-Prot: TT39C_HUMAN, Q8N584Similarity: Belongs to the TTC39 familySimilarity: Contains 3 TPR repeats |
Function
for TTC39C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 GenomeRNAi human phenotype for TTC39C:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC39C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC39C (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TTC39C (NM_001135993) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC39C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC39C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC39C |
|
Pathways & Interactions
for TTC39C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTC39C
|
Drugs & Compounds
for TTC39C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TTC39C
Search CenterWatch for drugs/clinical trials and news about TTC39C / TT39C
|
Transcripts
for TTC39C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TTC39C gene (3 alternative transcripts): NM_001135993.1 NM_001243425.1 NM_153211.3 Unigene Cluster for TTC39C: Tetratricopeptide repeat domain 39C Hs.128576 [show with all ESTs]Unigene Representative Sequence: NM_00113599310 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000304621(uc002kuu.3) ENST00000584250(uc002kuv.3) ENST00000317571(uc002kuw.3)
ENST00000578150 ENST00000577185 ENST00000540918 ENST00000579214 ENST00000581394
ENST00000584424 ENST00000584095
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC39C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC39C (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TTC39C (NM_001135993) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC39C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC39C |
Additional cDNA sequence: AK074875.1 AK091080.1 AK296442.1 BC016833.2 BC032684.1 BC121034.2 BC121035.2 15 DOTS entries: DT.91740648 DT.107022 DT.101959208 DT.101972171 DT.311452 DT.121085433 DT.206922 DT.86847378 DT.40288740 DT.40293855 DT.91740649 DT.91748924 DT.97773016 DT.92415293 DT.95233852 24/79 AceView cDNA sequences (see all 79): AL702550 CA430785 AI700034 AW976358 BM454447 BG171503 BX478505 BM683843 F10632 F10548 BX956159 BX280051 AA806102 BM798138 BU623171 CB123396 BC016833 BM930384 AA004250 AX746769 BG674566 F13040 BQ015255 AV684984
GeneLoc Exon Structure
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Expression
for TTC39C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TTC39C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAATGGGT
About this image
See TTC39C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TTC39C
SOURCE GeneReport for Unigene cluster: Hs.128576
SABiosciences Custom PCR Arrays for TTC39C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC39C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TTC39C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC39C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC39C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC39C |
Orthologs
for TTC39C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for TTC39C gene from 6/20 species (see all 20) About this table
ENSEMBL Gene Tree for TTC39C (if available)
TreeFam Gene Tree for TTC39C (if available) |
Paralogs
for TTC39C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TTC39C gene
- TTC39B2 TTC39A2
TTC39C for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TTC39C
PGOHUM00000245667
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Genomic Variants
for TTC39C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TTC39C (21572737 - 21715574 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TTC39C: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC39C |
|
Disorders
/ Diseases
for TTC39C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TTC39C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TTC39C gene integrated from 9 sources:
(articles sorted by number of sources associating them with TTC39C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
- DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)1, 2 Nusbaum C.... Lander E.S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TTC39C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TTC39C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TTC39C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TTC39C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TTC39C | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TTC39C gene:
Search GeneIP for patents involving TTC39C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TTC39C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TTC39C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTC39C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC39C | | | OriGene Protein Over-expression Lysate for TTC39C | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TTC39C | | OriGene 3'-UTR Clone for TTC39C | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC39C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC39C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TTC39C | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TTC39C | | OriGene Custom Protein Services for TTC39C | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TTC39C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC39C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC39C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTC39C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC39C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC39C |
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 |  |  |  | |
| | | | Search Tocris compounds for TTC39C |
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 | | | TTC39C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC39C |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TTC39C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC39C |
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