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Aliases for TTC39C Gene

Aliases for TTC39C Gene

  • Tetratricopeptide Repeat Domain 39C 2 3 5
  • TPR Repeat Protein 39C 3 4
  • C18orf17 3 4
  • Tetratricopeptide Repeat Protein 39C 3
  • Chromosome 18 Open Reading Frame 17 2
  • HsT2697 3

External Ids for TTC39C Gene

Previous HGNC Symbols for TTC39C Gene

  • C18orf17

Previous GeneCards Identifiers for TTC39C Gene

  • GC18P019827
  • GC18P021572
  • GC18P018428

Summaries for TTC39C Gene

GeneCards Summary for TTC39C Gene

TTC39C (Tetratricopeptide Repeat Domain 39C) is a Protein Coding gene. An important paralog of this gene is TTC39B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC39C Gene

Genomics for TTC39C Gene

Regulatory Elements for TTC39C Gene

Enhancers for TTC39C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F023998 1.3 FANTOM5 Ensembl ENCODE 43.8 +8.9 8871 6.7 SOX13 KLF1 MXI1 TFAP4 MAX CEBPG ZIC2 RAD21 ZKSCAN1 CTBP1 TTC39C TTC39C-AS1 LAMA3 CABYR ANKRD29 C18orf8
GH18F023969 1.2 Ensembl ENCODE 12.9 -22.1 -22098 1.9 ATF1 MLX ARID4B DMAP1 ZSCAN9 YY1 RARA ZNF121 GATA4 CREM TTC39C LAMA3 LOC105372023 ENSG00000265752
GH18F024112 1.2 Ensembl ENCODE 10.9 +120.4 120413 2.2 ATF1 MLX ARID4B DMAP1 YY1 FOS NFYC MXD4 PPARG SMARCB1 TTC39C ANKRD29 CABYR ENSG00000264924 ENSG00000265204
GH18F024033 1 Ensembl ENCODE 13 +41.1 41122 1.8 SOX13 BRD4 BCOR PKNOX1 ZNF384 TEAD3 ZNF121 ADNP SCRT2 CHD1 TTC39C PIR46321 ENSG00000265204
GH18F023972 1 FANTOM5 ENCODE 12.3 -20.1 -20136 0.7 STAT1 PKNOX1 IKZF1 EED JUNB FOS KDM1A CREM YY1 TTC39C ANKRD29 C18orf8 LOC105372023 ENSG00000265752
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTC39C on UCSC Golden Path with GeneCards custom track

Genomic Location for TTC39C Gene

Chromosome:
18
Start:
23,992,773 bp from pter
End:
24,135,610 bp from pter
Size:
142,838 bases
Orientation:
Plus strand

Genomic View for TTC39C Gene

Genes around TTC39C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC39C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC39C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC39C Gene

Proteins for TTC39C Gene

  • Protein details for TTC39C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N584-TT39C_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 39C
    Protein Accession:
    Q8N584
    Secondary Accessions:
    • B7WP63
    • J3QRR1
    • Q0VAJ2
    • Q8N284

    Protein attributes for TTC39C Gene

    Size:
    583 amino acids
    Molecular mass:
    65870 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH32684.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC39C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC39C Gene

Post-translational modifications for TTC39C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC39C Gene

Domains & Families for TTC39C Gene

Gene Families for TTC39C Gene

Protein Domains for TTC39C Gene

Suggested Antigen Peptide Sequences for TTC39C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N584

UniProtKB/Swiss-Prot:

TT39C_HUMAN :
  • Belongs to the TTC39 family.
  • Contains 3 TPR repeats.
Family:
  • Belongs to the TTC39 family.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with TTC39C: view

Function for TTC39C Gene

genes like me logo Genes that share phenotypes with TTC39C: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC39C Gene

Localization for TTC39C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC39C gene
Compartment Confidence
cytosol 2
peroxisome 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC39C Gene

Pathways & Interactions for TTC39C Gene

SuperPathways for TTC39C Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC39C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC39C Gene

Transcripts for TTC39C Gene

Unigene Clusters for TTC39C Gene

Tetratricopeptide repeat domain 39C:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC39C Gene

No ASD Table

Relevant External Links for TTC39C Gene

GeneLoc Exon Structure for
TTC39C
ECgene alternative splicing isoforms for
TTC39C

Expression for TTC39C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTC39C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC39C Gene

This gene is overexpressed in Liver (x10.2).

Protein differential expression in normal tissues from HIPED for TTC39C Gene

This gene is overexpressed in Spinal cord (12.9), Lung (9.5), NK cells (7.2), CD8 Tcells (7.0), and CD4 Tcells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTC39C Gene



Protein tissue co-expression partners for TTC39C Gene

NURSA nuclear receptor signaling pathways regulating expression of TTC39C Gene:

TTC39C

SOURCE GeneReport for Unigene cluster for TTC39C Gene:

Hs.128576
genes like me logo Genes that share expression patterns with TTC39C: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TTC39C Gene

Orthologs for TTC39C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTC39C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC39C 35
  • 100 (a)
OneToOne
LOC100614628 34
  • 99.31 (n)
oppossum
(Monodelphis domestica)
Mammalia TTC39C 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC39C 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TTC39C 34 35
  • 93.66 (n)
dog
(Canis familiaris)
Mammalia TTC39C 34 35
  • 93.55 (n)
mouse
(Mus musculus)
Mammalia Ttc39c 34 16 35
  • 89.31 (n)
rat
(Rattus norvegicus)
Mammalia MGC125239 34
  • 88.76 (n)
chicken
(Gallus gallus)
Aves TTC39C 34 35
  • 83.97 (n)
lizard
(Anolis carolinensis)
Reptilia TTC39C 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc39c 34
  • 80.69 (n)
Str.17945 34
zebrafish
(Danio rerio)
Actinopterygii ttc39c 34 35
  • 68.73 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001215 34
  • 48.67 (n)
worm
(Caenorhabditis elegans)
Secernentea C32D5.6 35
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
Species where no ortholog for TTC39C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC39C Gene

ENSEMBL:
Gene Tree for TTC39C (if available)
TreeFam:
Gene Tree for TTC39C (if available)

Paralogs for TTC39C Gene

Paralogs for TTC39C Gene

Pseudogenes.org Pseudogenes for TTC39C Gene

genes like me logo Genes that share paralogs with TTC39C: view

Variants for TTC39C Gene

Sequence variations from dbSNP and Humsavar for TTC39C Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs10052 -- 24,020,079(+) GACGA(C/T)AGGAG intron-variant, utr-variant-3-prime, utr-variant-5-prime
rs10163625 -- 24,119,273(+) TGTAC(A/C)TTTTC intron-variant
rs10163628 -- 24,119,544(+) TGCAT(C/T)GGTCC intron-variant
rs10163724 -- 24,083,560(+) ACTGC(A/G)TTAAG intron-variant
rs10164032 -- 24,086,426(+) TTTAC(A/G)TACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC39C Gene

Variant ID Type Subtype PubMed ID
nsv828189 CNV gain 20364138
esv3641976 CNV loss 21293372
esv3641975 CNV gain 21293372
esv3302765 CNV tandem duplication 20981092
esv2678806 CNV deletion 23128226
esv2641358 CNV deletion 19546169

Variation tolerance for TTC39C Gene

Residual Variation Intolerance Score: 24.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC39C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC39C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC39C Gene

Disorders for TTC39C Gene

Relevant External Links for TTC39C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC39C

No disorders were found for TTC39C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC39C Gene

Publications for TTC39C Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 64
  2. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C. … Lander E.S. (Nature 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3 64
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64

Products for TTC39C Gene

Sources for TTC39C Gene

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