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Aliases for TTC39C Gene

Aliases for TTC39C Gene

  • Tetratricopeptide Repeat Domain 39C 2 3
  • TPR Repeat Protein 39C 3 4
  • C18orf17 3 4
  • Chromosome 18 Open Reading Frame 17 2
  • HsT2697 3

External Ids for TTC39C Gene

Previous HGNC Symbols for TTC39C Gene

  • C18orf17

Previous GeneCards Identifiers for TTC39C Gene

  • GC18P019827
  • GC18P021572
  • GC18P018428

Summaries for TTC39C Gene

GeneCards Summary for TTC39C Gene

TTC39C (Tetratricopeptide Repeat Domain 39C) is a Protein Coding gene. An important paralog of this gene is TTC39A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC39C Gene

Genomics for TTC39C Gene

Regulatory Elements for TTC39C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TTC39C Gene

23,992,773 bp from pter
24,135,610 bp from pter
142,838 bases
Plus strand

Genomic View for TTC39C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTC39C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC39C Gene

Proteins for TTC39C Gene

  • Protein details for TTC39C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tetratricopeptide repeat protein 39C
    Protein Accession:
    Secondary Accessions:
    • B7WP63
    • J3QRR1
    • Q0VAJ2
    • Q8N284

    Protein attributes for TTC39C Gene

    583 amino acids
    Molecular mass:
    65870 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH32684.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC39C Gene


neXtProt entry for TTC39C Gene

Proteomics data for TTC39C Gene at MOPED

Post-translational modifications for TTC39C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC39C Gene

Domains & Families for TTC39C Gene

Gene Families for TTC39C Gene

Protein Domains for TTC39C Gene

Suggested Antigen Peptide Sequences for TTC39C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TTC39 family.
  • Contains 3 TPR repeats.
  • Belongs to the TTC39 family.
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with TTC39C: view

Function for TTC39C Gene

genes like me logo Genes that share phenotypes with TTC39C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTC39C

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC39C Gene

Localization for TTC39C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TTC39C Gene

Pathways & Interactions for TTC39C Gene

SuperPathways for TTC39C Gene

No Data Available

Interacting Proteins for TTC39C Gene

Gene Ontology (GO) - Biological Process for TTC39C Gene


No data available for Pathways by source and SIGNOR curated interactions for TTC39C Gene

Drugs & Compounds for TTC39C Gene

No Compound Related Data Available

Transcripts for TTC39C Gene

Unigene Clusters for TTC39C Gene

Tetratricopeptide repeat domain 39C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTC39C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC39C Gene

No ASD Table

Relevant External Links for TTC39C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTC39C Gene

mRNA expression in normal human tissues for TTC39C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC39C Gene

This gene is overexpressed in Liver (x10.2).

Protein differential expression in normal tissues from HIPED for TTC39C Gene

This gene is overexpressed in Spinal cord (12.9), Lung (9.5), NK cells (7.2), CD8 Tcells (7.0), and CD4 Tcells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTC39C Gene

SOURCE GeneReport for Unigene cluster for TTC39C Gene Hs.128576

genes like me logo Genes that share expression patterns with TTC39C: view

Protein tissue co-expression partners for TTC39C Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TTC39C Gene

Orthologs for TTC39C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTC39C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TTC39C 35
  • 93.66 (n)
  • 98.1 (a)
TTC39C 36
  • 98 (a)
(Canis familiaris)
Mammalia TTC39C 35
  • 93.55 (n)
  • 98.08 (a)
TTC39C 36
  • 98 (a)
(Mus musculus)
Mammalia Ttc39c 35
  • 89.31 (n)
  • 94.31 (a)
Ttc39c 16
Ttc39c 36
  • 94 (a)
(Pan troglodytes)
Mammalia LOC100614628 35
  • 99.31 (n)
  • 99.31 (a)
TTC39C 36
  • 100 (a)
(Rattus norvegicus)
Mammalia MGC125239 35
  • 88.76 (n)
  • 94.25 (a)
(Monodelphis domestica)
Mammalia TTC39C 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia TTC39C 36
  • 94 (a)
(Gallus gallus)
Aves TTC39C 35
  • 83.97 (n)
  • 90.28 (a)
TTC39C 36
  • 90 (a)
(Anolis carolinensis)
Reptilia TTC39C 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17945 35
ttc39c 35
  • 80.69 (n)
  • 88.99 (a)
(Danio rerio)
Actinopterygii ttc39c 35
  • 68.73 (n)
  • 75.41 (a)
ttc39c 36
  • 73 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001215 35
  • 48.67 (n)
  • 39.79 (a)
(Caenorhabditis elegans)
Secernentea C32D5.6 36
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 38
Species with no ortholog for TTC39C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC39C Gene

Gene Tree for TTC39C (if available)
Gene Tree for TTC39C (if available)

Paralogs for TTC39C Gene

Paralogs for TTC39C Gene Pseudogenes for TTC39C Gene

genes like me logo Genes that share paralogs with TTC39C: view

Variants for TTC39C Gene

Sequence variations from dbSNP and Humsavar for TTC39C Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs10052 -- 24,020,079(+) GACGA(C/T)AGGAG intron-variant, utr-variant-3-prime
rs185825 -- 24,095,519(+) catgg(C/G/T)gaaac intron-variant
rs185826 -- 24,096,326(+) AATGT(A/G)TAATA intron-variant
rs185827 -- 24,071,737(+) GAGAT(A/T)GAATA intron-variant
rs188177 -- 24,124,722(+) CAGTA(G/T)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC39C Gene

Variant ID Type Subtype PubMed ID
nsv909459 CNV Gain 21882294
esv259739 OTHER Complex 20981092
nsv828189 CNV Gain 20364138
esv2678806 CNV Deletion 23128226
esv2641358 CNV Deletion 19546169
nsv909460 CNV Gain 21882294

Variation tolerance for TTC39C Gene

Residual Variation Intolerance Score: 24.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC39C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC39C Gene

Disorders for TTC39C Gene

Relevant External Links for TTC39C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TTC39C: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC39C Gene

Publications for TTC39C Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 67
  2. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 67
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 67
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 67
  5. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C. … Lander E.S. (Nature 2005) 67

Products for TTC39C Gene

Sources for TTC39C Gene

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