Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TTC39B Gene

protein-coding GIFtS: 48
GCID: GC09M015170

tetratricopeptide repeat domain 39B

(Previous name: chromosome 9 open reading frame 52 )
(Previous symbol: C9orf52)

Explore 3 diseases affiliated with
TTC39B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tetratricopeptide Repeat Domain 39B¹ ²
C9orf52¹ ² ³
TPR Repeat Protein 39B² ³
FLJ33868¹
Chromosome 9 Open Reading Frame 52¹
Tetratricopeptide Repeat Protein 39B²

External Ids:	HGNC: 23704¹	Entrez Gene: 158219²	Ensembl: ENSG00000155158⁷	OMIM: 613574⁵	UniProtKB: Q5VTQ0³

Export aliases for TTC39B gene to outside databases

Previous GC identifer: GC09M015162

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008413.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TTC39B gene promoter:
c-Fos C/EBPbeta AP-1 FOXF2 Bach2 POU6F1 (c2) YY1 IRF-7A c-Jun Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TTC39B promoter sequence

Search SABiosciences Chromatin IP Primers for TTC39B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC39B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22.3 Ensembl cytogenetic band: 9p22.3 HGNC cytogenetic band: 9p22.2

TTC39B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTC39B gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M015170: view genomic region (about GC identifiers)

Start:	15,170,842 bp from pter	End:	15,307,358 bp from pter
Size:	136,517 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TT39B_HUMAN, Q5VTQ0 (See protein sequence)

Recommended Name: Tetratricopeptide repeat protein 39B

Size: 682 amino acids; 76956 Da

Sequence caution: Sequence=AAH42417.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Sequence=AAI42986.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC03603.1;

Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG60772.1; Type=Erroneous initiation;

Note=Translation N-terminally extended; Sequence=CAH71481.1; Type=Erroneous initiation; Note=Translation N-terminally

extended;

Secondary accessions: A5PLN1 B4DQ10 B4DQX4 B4DW93 Q8IVR7 Q8IXZ6 Q8N267

Alternative splicing: 7 isoforms: Q5VTQ0-1 Q5VTQ0-2 Q5VTQ0-3 Q5VTQ0-4 Q5VTQ0-5 Q5VTQ0-6 Q5VTQ0-7 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TTC39B: NX_Q5VTQ0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5VTQ0

TTC39B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001161811.1 NP_001161812.1 NP_001161813.1 NP_001161814.1 NP_689787.2

ENSEMBL proteins:

ENSP00000422496 ENSP00000421923 ENSP00000426539 ENSP00000423392 ENSP00000427314

ENSP00000370231 ENSP00000297615 ENSP00000347920 ENSP00000442880

Human Recombinant Protein Products for TTC39B:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): TTC39B OriGene Protein Over-expression Lysate: TTC39B OriGene Custom Protein Services for TTC39B
	GenScript Custom Purified and Recombinant Proteins Services for TTC39B
	Novus Biologicals TTC39B Protein Novus Biologicals TTC39B Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TTC39B

TTC39B Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for TTC39B
	GenScript Custom Superior Antibodies Services for TTC39B
	Novus Biologicals TTC39B Antibodies
	Abcam antibodies for TTC39B
	Uscn Antibodies for TTC39B
	ThermoFisher Antibodies for TTC39B

Assay Products for TTC39B:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TTC39B
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TTC39B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TTC39B for domains About GeneDecksing

3 InterPro domains/families:

IPR011990 TPR-like_helical

IPR019412 OMP_IML2_mit/TPR_39

IPR019734 TPR_repeat

Graphical View of Domain Structure for InterPro Entry Q5VTQ0

ProtoNet protein and cluster: Q5VTQ0

UniProtKB/Swiss-Prot: TT39B_HUMAN, Q5VTQ0

Similarity: Belongs to the TTC39 family

Similarity: Contains 2 TPR repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Phenotypes:
1 GenomeRNAi human phenotype for TTC39B:

Decreased POU5F1-GFP protein e

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Ttc39b):

growth/size

TTC39B for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TTC39B

miRNA Products:		OriGene 3'-UTR Clone: TTC39B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TTC39B
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate TTC39B (see all 13):
		hsa-miR-16-2* hsa-miR-181c hsa-miR-374b hsa-miR-128 hsa-miR-3681* hsa-miR-374a hsa-miR-181a hsa-miR-181d

		SwitchGear 3'UTR luciferase reporter plasmid: TTC39B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTC39B (see all 4) OriGene shRNA RFP: TTC39B Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTC39B
		Sirion Biotech Custom design and validation of potent shRNA sequences against TTC39B

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TTC39B
			Sirion Biotech Customized adenovirus for overexpression of TTC39B Sirion Biotech Customized adenovirus for potent knockdown of TTC39B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC39B (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC39B (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): TTC39B (NM_001168339)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TTC39B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC39B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TTC39B
		Search LifeMap BioReagents cell lines for TTC39B
		Sirion Biotech Customized stable knockdown cell line services for TTC39B Sirion Biotech Customized inducible knockdown cell line services for TTC39B Sirion Biotech Customized stable overexpressing cell line services for TTC39B Sirion Biotech Customized inducible overexpressing cell line services for TTC39B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC39B

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TTC39B

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for TTC39B (Q5VTQ0³ ENSP00000347920⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TTC39B
Search CenterWatch for drugs/clinical trials and news about TTC39B / TT39B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TTC39B gene (5 alternative transcripts):

NM_001168339.1 NM_001168340.1 NM_001168341.1 NM_001168342.1 NM_152574.2

Unigene Cluster for TTC39B:

Tetratricopeptide repeat domain 39B

Hs.563630 [show with all ESTs]

Unigene Representative Sequence: NM_152574

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000512701 ENST00000380853 ENST00000463391 ENST00000507285(uc003zls.1)

ENST00000507993 ENST00000505732(uc010mig.1 uc010mif.2 uc011lms.2)

ENST00000582994 ENST00000506891 ENST00000380850(uc011lmq.2) ENST00000297615(uc003zlp.2 uc011lmr.2)

ENST00000355694(uc003zlq.2 uc011lmp.2 uc003zlr.2 uc010mie.2)

ENST00000541445

miRNA Products:		OriGene 3'-UTR Clone: TTC39B Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TTC39B
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate TTC39B (see all 13):
		hsa-miR-16-2* hsa-miR-181c hsa-miR-374b hsa-miR-128 hsa-miR-3681* hsa-miR-374a hsa-miR-181a hsa-miR-181d

		SwitchGear 3'UTR luciferase reporter plasmid: TTC39B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTC39B (see all 4) OriGene shRNA RFP: TTC39B Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTC39B
		Sirion Biotech Custom design and validation of potent shRNA sequences against TTC39B

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC39B (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC39B (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): TTC39B (NM_001168339)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TTC39B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC39B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC39B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TTC39B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC39B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC39B

Additional cDNA sequence:

AK091187.1 AK093459.1 AK298581.1 AK298998.1 AK301185.1 AK301427.1 AK310271.1 AK310482.1

BC038592.1 BC042417.1 BC070139.1 BC142985.1

10 DOTS entries:

DT.100021251 DT.430828 DT.451955 DT.95257732 DT.75135318 DT.100744909 DT.121197788 DT.92324704

DT.121197757 DT.92036076

24/70 AceView cDNA sequences (see all 70):

CA311808 CA310821 AA292721 CB160540 AA485589 CB121022 BC042417 AI418767

AA485425 BQ576125 AI270597 BX115990 AI242326 AK091187 CK904345 CD637887

AX746836 AK093996 CA438701 AA036820 BI909163 AI672546 CB528632 AA398910

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for TTC39B About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^
SP1:							-		-		-		-		-
SP2:															-
SP3:
SP4:
SP5:

ExUns:	24a	·	24b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for TTC39B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TTC39B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATTATTTTT

About this image

TTC39B expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Zeugopod Growth Plate

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

See TTC39B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TTC39B

SOURCE GeneReport for Unigene cluster: Hs.563630

SABiosciences Custom PCR Arrays for TTC39B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC39B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TTC39B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC39B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC39B

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC39B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TTC39B gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ttc39b^{1 , 5}	tetratricopeptide repeat domain 39B^{1, 5}	84.45(n)¹ 88.42(a)¹		4 (39.41 cM)⁵ 69863¹ NM_027238.2¹ NP_081514.1¹ 83220300⁵
chicken (Gallus gallus)	Aves	TTC39B¹	tetratricopeptide repeat domain 39B	74.34(n) 72.01(a)		427354 XM_424931.3 XP_424931.3
lizard (Anolis carolinensis)	Reptilia	TTC39B⁶	--	69(a)	1 ↔ 1	2(34730274-34755220)
African clawed frog (Xenopus laevis)	Amphibia	Xl.18685²	Xenopus laevis transcribed sequence with weak similarity more	78.61(n)		CD301999.1
mosquito (Anopheles gambiae)	Insecta	AgaP_AGAP010417¹	AGAP010417-PA	50.03(n) 43.19(a)		1272630 XM_311530.4 XP_311530.4
worm (Caenorhabditis elegans)	Secernentea	C32D5.6¹	Protein C32D5.6	48.9(n) 38.61(a)		174046 NM_062872.2 NP_495273.1

ENSEMBL Gene Tree for TTC39B (if available)
TreeFam Gene Tree for TTC39B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TTC39B gene

TTC39C² TTC39A²

1 SIMAP similar gene for TTC39B using alignment to 4 protein entries: TT39B_HUMAN (see all proteins):

TTC39A

TTC39B for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for TTC39B
PGOHUM00000240625

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147734090^1,2		--	15170377(+)	`ACACTG/TCTTTC`	5	--	int¹		0	--	--	--	--
rs2761132^1,2	C	--	15170396(+)	`ACACAG/AACCAC`	5	--	int¹		12		NA WA CSA EA	374
rs193200857^1,2		--	15170471(+)	`TAATTC/TATACT`	5	--	int¹		0	--	--	--	--
rs116299453^1,2	F	--	15170487(+)	`ATAGCC/TTTTTA`	5	--	int¹		1		WA	118
rs142342486^1,2		--	15170512(+)	`CTATCA/GTATGT`	5	--	int¹		0	--	--	--	--
rs1746331^1,2	C,F,A,H	--	15170552(+)	`AATACT/CACACC`	5	--	int¹		22		NS EA NA WA CSA	2251
rs116899400^1,2		--	15170609(+)	`ACTCCG/ATGTCA`	5	--	int¹		1		NA	120
rs150185313^1,2		--	15170637(+)	`AGAGAG/TGAACT`	5	--	int¹		0	--	--	--	--
rs185072389^1,2		--	15170661(+)	`ATGTGA/GCTCCT`	5	--	int¹		0	--	--	--	--
rs2489543^1,2	C,F,A,H	--	15170740(+)	`TCATCG/AACTCA`	5	--	int¹		14		NA WA CSA EA	379

HapMap Linkage Disequilibrium report for TTC39B (15170842 - 15307358 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TTC39B
2 CNVs: 0127 22662

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC39B

DNA2.0 Custom Variant and Variant Library Synthesis for TTC39B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TTC39B for disorders           About GeneDecksing

OMIM gene information: 613574    OMIM disorders: --

3 diseases for TTC39B:    About MalaCards

fanconi's anemia parkinson's disease anemia

Human Genome Epidemiology (HuGE) Navigator: TTC39B (5 documents)

Export disorders for TTC39B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TTC39B gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with TTC39B)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population. (PubMed id 20972250)¹ Park M.H....Park H.Y. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
A genome-wide meta-analysis identifies novel loci ass ociated with schizophrenia and bipolar disorder. (PubMed id 20889312)¹ Wang K.S....Aragam N. (2010)
Genetic variants influencing circulating lipid levels and risk of coronary artery disease. (PubMed id 20864672)¹ Waterworth D.M....Sandhu M.S. (2010)
Evaluating the discriminative power of multi-trait ge netic risk scores for type 2 diabetes in a northern Swedish population. (PubMed id 20571754)¹ Fontaine-Bisson B....Franks P.W. (2010)
Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)¹ Teslovich T.M....Kathiresan S. (2010)
Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. (PubMed id 20705733)¹ O'Seaghdha C.M....KAPttgen A. (2010)
TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)¹ Vanderwerf S.M....Bagby G.C. (2009)
Common variants at 30 loci contribute to polygenic dyslipidemia. (PubMed id 19060906)¹ Kathiresan S....Cupples L.A. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 158219	HGNC: 23704	AceView: C9orf52	Ensembl:ENSG00000155158	euGenes: HUgn158219
ECgene: TTC39B	H-InvDB: TTC39B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TTC39B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TTC39B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TTC39B gene:
Search GeneIP for patents involving TTC39B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for TTC39B
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTC39B		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC39B
	OriGene Protein Over-expression Lysate for TTC39B		Browse OriGene Fluorogenic Cell Assay Kits
	Browse OriGene siRNAs		OriGene 3'-UTR Clone for TTC39B
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC39B		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC39B
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for TTC39B		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TTC39B		OriGene Custom Protein Services for TTC39B
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TTC39B
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC39B
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC39B
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTC39B
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC39B
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC39B

	GenScript Custom Purified and Recombinant Proteins Services for TTC39B		GenScript cDNA clones with any tag delivered in your preferred vector for TTC39B
	GenScript Custom Assay Services for TTC39B		GenScript Custom Superior Antibodies Services for TTC39B
	GenScript Custom overexpressing Cell Line Services for TTC39B		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TTC39B promoter
	Search Chromatin IP Primers for TTC39B
	RT² qPCR Primer Assay in human, mouse, rat TTC39B
	Search GNC Networks for TTC39B
	SABiosciences Custom PCR Arrays for TTC39B

Search Tocris compounds for TTC39B

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TTC39B antibodies
	TTC39B proteins
	TTC39B lysates

	Antibodies for TTC39B
	See all of Abcam's Antibodies, Kits and Proteins for TTC39B
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

TTC39B Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TTC39B

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC39B

	SwitchGear 3'UTR luciferase reporter plasmids for TTC39B
	SwitchGear Promoter luciferase reporter plasmids for TTC39B

ThermoFisher Antibodies for TTC39B

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC39B

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TTC39B

Sirion Biotech Customized:

	stable knockdown cell line services for TTC39B
	inducible knockdown cell line services for TTC39B
	design and validation of potent shRNA sequences against TTC39B
	adenovirus for potent knockdown of TTC39B
	adenovirus for overexpression of TTC39B
	stable overexpressing cell line services for TTC39B
	inducible overexpressing cell line services for TTC39B

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TTC39B gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

TTC39B Gene

tetratricopeptide repeat domain 39B

Aliases
for TTC39B gene

Summaries
for TTC39B gene

Genomic Views
for TTC39B gene

Proteins
for TTC39B gene

Protein Domains /
Families
for TTC39B gene

Function
for TTC39B gene

Pathways & Interactions
for TTC39B gene

Drugs & Compounds
for TTC39B gene

Transcripts
for TTC39B gene

Expression
for TTC39B gene

Orthologs
for TTC39B gene

Paralogs
for TTC39B gene

Genomic Variants
for TTC39B gene

Disorders / Diseases
for TTC39B gene

Publications
for TTC39B gene

External Searches for TTC39B gene

Genome Databases showing TTC39B gene

Other Databases showing TTC39B gene

Specialized Databases showing TTC39B gene

Intellectual Property
for TTC39B gene

Products
for TTC39B gene

View Random Gene

Advanced Search

Export list of displayed genes

TTC39B Gene

tetratricopeptide repeat domain 39B

Aliasesfor TTC39B gene

Summariesfor TTC39B gene

Genomic Viewsfor TTC39B gene

Proteinsfor TTC39B gene

Protein Domains /Familiesfor TTC39B gene

Functionfor TTC39B gene

Pathways & Interactionsfor TTC39B gene

Drugs & Compoundsfor TTC39B gene

Transcriptsfor TTC39B gene

Expression for TTC39B gene

Orthologsfor TTC39B gene

Paralogsfor TTC39B gene

Genomic Variantsfor TTC39B gene

Disorders / Diseasesfor TTC39B gene

Publicationsfor TTC39B gene

External Searches for TTC39B gene

Genome Databases showing TTC39B gene

Other Databases showing TTC39B gene

Specialized Databases showing TTC39B gene

Intellectual Propertyfor TTC39B gene

Productsfor TTC39B gene

View Random Gene

Aliases
for TTC39B gene

Summaries
for TTC39B gene

Genomic Views
for TTC39B gene

Proteins
for TTC39B gene

Protein Domains /
Families
for TTC39B gene

Function
for TTC39B gene

Pathways & Interactions
for TTC39B gene

Drugs & Compounds
for TTC39B gene

Transcripts
for TTC39B gene

Expression
for TTC39B gene

Orthologs
for TTC39B gene

Paralogs
for TTC39B gene

Genomic Variants
for TTC39B gene

Disorders / Diseases
for TTC39B gene

Publications
for TTC39B gene

Intellectual Property
for TTC39B gene

Products
for TTC39B gene