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Aliases for TTC39A Gene

Aliases for TTC39A Gene

  • Tetratricopeptide Repeat Domain 39A 2 3 5
  • Differentially Expressed In MCF7 With Estradiol Protein 6 3 4
  • TPR Repeat Protein 39A 3 4
  • C1orf34 3 4
  • DEME-6 3 4
  • Tetratricopeptide Repeat Protein 39A 3
  • Chromosome 1 Open Reading Frame 34 2
  • Testicular Tissue Protein Li 213 3
  • KIAA0452 4

External Ids for TTC39A Gene

Previous HGNC Symbols for TTC39A Gene

  • C1orf34

Previous GeneCards Identifiers for TTC39A Gene

  • GC01M051526
  • GC01M051752
  • GC01M049870

Summaries for TTC39A Gene

GeneCards Summary for TTC39A Gene

TTC39A (Tetratricopeptide Repeat Domain 39A) is a Protein Coding gene. An important paralog of this gene is TTC39B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC39A Gene

Genomics for TTC39A Gene

Regulatory Elements for TTC39A Gene

Enhancers for TTC39A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F051303 1.5 FANTOM5 Ensembl ENCODE 11.4 +41.3 41335 1.6 ARNT ZNF2 RAD21 YY1 GLIS2 SCRT2 SMARCA5 ZNF362 ZNF654 REST TTC39A ENSG00000236434 RNU6-877P EPS15 GC01P051297 GC01P051316
GH01F051429 1.2 Ensembl ENCODE 11 -85.2 -85154 1.4 HDGF PKNOX1 ATF1 ARNT ZNF121 GATA2 NCOA1 MBD2 SMARCA4 ZSCAN16 ENSG00000227070 EPS15 ENSG00000238140 RNU6-877P TTC39A ENSG00000272100 GC01M051448 GC01M051449 GC01P051412
GH01F051422 1.1 Ensembl ENCODE 10.8 -78.0 -78042 1.7 HDAC1 ATF1 TBL1XR1 RFX5 CHAMP1 GATA2 FOS USF2 CEBPB ZEB2 ENSG00000238140 EPS15 RNU6-877P ENSG00000227070 TTC39A GC01P051412 GC01M051448 GC01M051449
GH01F051304 1 Ensembl ENCODE 11.4 +39.8 39816 1.4 BCOR GATAD2A SMARCA5 TFAP4 HMG20B MAZ ZMYM3 ZNF644 YY1 HNF1A TTC39A ENSG00000236434 RNU6-877P GC01P051297 GC01P051316
GH01F051541 1.1 Ensembl ENCODE 10.2 -196.4 -196422 0.9 INSM2 ZEB1 ZNF366 SCRT2 CREM EGR2 CEBPB TSHZ1 ZEB2 ZNF843 ENSG00000227070 EPS15 OSBPL9 RNU6-877P ENSG00000238140 TTC39A GC01P051545 RNU6-1281P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTC39A on UCSC Golden Path with GeneCards custom track

Promoters for TTC39A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001744828 116 401 CTCF CCNT2 ZBTB33 ZBTB7A EZH2

Genomic Location for TTC39A Gene

Chromosome:
1
Start:
51,287,258 bp from pter
End:
51,345,116 bp from pter
Size:
57,859 bases
Orientation:
Minus strand

Genomic View for TTC39A Gene

Genes around TTC39A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC39A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC39A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC39A Gene

Proteins for TTC39A Gene

  • Protein details for TTC39A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SRH9-TT39A_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 39A
    Protein Accession:
    Q5SRH9
    Secondary Accessions:
    • B7Z782
    • E7EQY9
    • G3XAF8
    • O43417
    • O75040
    • Q5SRH5
    • Q5SRH6
    • Q5SRH7
    • Q5SRH8
    • Q5SRI0
    • Q5SRI1
    • Q5SRI2
    • Q5T7S1
    • Q6PIU8
    • Q9BT24

    Protein attributes for TTC39A Gene

    Size:
    613 amino acids
    Molecular mass:
    69778 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH28374.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA32297.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA32297.1; Type=Frameshift; Positions=373; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC39A Gene

neXtProt entry for TTC39A Gene

Post-translational modifications for TTC39A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC39A Gene

Domains & Families for TTC39A Gene

Gene Families for TTC39A Gene

Protein Domains for TTC39A Gene

Suggested Antigen Peptide Sequences for TTC39A Gene

Graphical View of Domain Structure for InterPro Entry

Q5SRH9

UniProtKB/Swiss-Prot:

TT39A_HUMAN :
  • Belongs to the TTC39 family.
  • Contains 3 TPR repeats.
Family:
  • Belongs to the TTC39 family.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with TTC39A: view

Function for TTC39A Gene

Gene Ontology (GO) - Molecular Function for TTC39A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TTC39A: view

Phenotypes for TTC39A Gene

GenomeRNAi human phenotypes for TTC39A:
genes like me logo Genes that share phenotypes with TTC39A: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC39A Gene

Localization for TTC39A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC39A gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for TTC39A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with TTC39A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TTC39A Gene

Pathways & Interactions for TTC39A Gene

SuperPathways for TTC39A Gene

No Data Available

Interacting Proteins for TTC39A Gene

Gene Ontology (GO) - Biological Process for TTC39A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TTC39A: view

No data available for Pathways by source and SIGNOR curated interactions for TTC39A Gene

Transcripts for TTC39A Gene

Unigene Clusters for TTC39A Gene

Tetratricopeptide repeat domain 39A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC39A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - -

ExUns: 22a · 22b · 22c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for TTC39A Gene

GeneLoc Exon Structure for
TTC39A
ECgene alternative splicing isoforms for
TTC39A

Expression for TTC39A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTC39A Gene

mRNA differential expression in normal tissues according to GTEx for TTC39A Gene

This gene is overexpressed in Testis (x7.9) and Kidney - Cortex (x5.8).

Protein differential expression in normal tissues from HIPED for TTC39A Gene

This gene is overexpressed in Stomach (20.5), Lung (18.8), and Islet of Langerhans (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTC39A Gene



NURSA nuclear receptor signaling pathways regulating expression of TTC39A Gene:

TTC39A

SOURCE GeneReport for Unigene cluster for TTC39A Gene:

Hs.112949
genes like me logo Genes that share expression patterns with TTC39A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TTC39A Gene

Orthologs for TTC39A Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC39A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC39A 34 35
  • 99.06 (n)
cow
(Bos Taurus)
Mammalia TTC39A 34 35
  • 92.15 (n)
rat
(Rattus norvegicus)
Mammalia LOC100910316 34
  • 89.26 (n)
mouse
(Mus musculus)
Mammalia Ttc39a 34 16 35
  • 89.24 (n)
dog
(Canis familiaris)
Mammalia TTC39A 34 35
  • 88.68 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TTC39A 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTC39A 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC39A 34 35
  • 71.44 (n)
lizard
(Anolis carolinensis)
Reptilia TTC39A 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc39a 34
  • 70.64 (n)
Str.9518 34
zebrafish
(Danio rerio)
Actinopterygii TTC39A (2 of 2) 35
  • 79 (a)
OneToMany
ttc39a 34 35
  • 68.31 (n)
worm
(Caenorhabditis elegans)
Secernentea C32D5.6 35
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
Species where no ortholog for TTC39A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC39A Gene

ENSEMBL:
Gene Tree for TTC39A (if available)
TreeFam:
Gene Tree for TTC39A (if available)

Paralogs for TTC39A Gene

Paralogs for TTC39A Gene

(1) SIMAP similar genes for TTC39A Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with TTC39A: view

Variants for TTC39A Gene

Sequence variations from dbSNP and Humsavar for TTC39A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10082117 -- 51,332,856(+) tttct(C/G)atggt intron-variant, upstream-variant-2KB
rs10082157 -- 51,334,636(+) ggtaa(C/T)agagt intron-variant
rs111314879 -- 51,315,116(+) ACCTG(C/T)CCAGC intron-variant
rs111486009 -- 51,317,902(+) TAGGA(C/T)GAGGG intron-variant
rs111521308 -- 51,334,655(+) GTCTC(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC39A Gene

Variant ID Type Subtype PubMed ID
esv3586033 CNV loss 21293372

Variation tolerance for TTC39A Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC39A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC39A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC39A Gene

Disorders for TTC39A Gene

Relevant External Links for TTC39A

Genetic Association Database (GAD)
TTC39A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC39A

No disorders were found for TTC39A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC39A Gene

Publications for TTC39A Gene

  1. Differential screening and suppression subtractive hybridization identified genes differentially expressed in an estrogen receptor- positive breast carcinoma cell line. (PMID: 9461476) Kuang W.W. … Weigel R.J. (Nucleic Acids Res. 1998) 2 3 4 64
  2. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for TTC39A Gene

Sources for TTC39A Gene

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