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Aliases for TTC39A Gene

Aliases for TTC39A Gene

  • Tetratricopeptide Repeat Domain 39A 2 3 5
  • Differentially Expressed In MCF7 With Estradiol Protein 6 3 4
  • TPR Repeat Protein 39A 3 4
  • C1orf34 3 4
  • DEME-6 3 4
  • Chromosome 1 Open Reading Frame 34 2
  • Testicular Tissue Protein Li 213 3
  • KIAA0452 4

External Ids for TTC39A Gene

Previous HGNC Symbols for TTC39A Gene

  • C1orf34

Previous GeneCards Identifiers for TTC39A Gene

  • GC01M051526
  • GC01M051752
  • GC01M049870

Summaries for TTC39A Gene

GeneCards Summary for TTC39A Gene

TTC39A (Tetratricopeptide Repeat Domain 39A) is a Protein Coding gene. An important paralog of this gene is TTC39C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC39A Gene

Genomics for TTC39A Gene

Regulatory Elements for TTC39A Gene

Genomic Location for TTC39A Gene

Chromosome:
1
Start:
51,287,258 bp from pter
End:
51,345,116 bp from pter
Size:
57,859 bases
Orientation:
Minus strand

Genomic View for TTC39A Gene

Genes around TTC39A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC39A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC39A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC39A Gene

Proteins for TTC39A Gene

  • Protein details for TTC39A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SRH9-TT39A_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 39A
    Protein Accession:
    Q5SRH9
    Secondary Accessions:
    • B7Z782
    • E7EQY9
    • G3XAF8
    • O43417
    • O75040
    • Q5SRH5
    • Q5SRH6
    • Q5SRH7
    • Q5SRH8
    • Q5SRI0
    • Q5SRI1
    • Q5SRI2
    • Q5T7S1
    • Q6PIU8
    • Q9BT24

    Protein attributes for TTC39A Gene

    Size:
    613 amino acids
    Molecular mass:
    69778 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH28374.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA32297.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA32297.1; Type=Frameshift; Positions=373; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC39A Gene

neXtProt entry for TTC39A Gene

Proteomics data for TTC39A Gene at MOPED

Post-translational modifications for TTC39A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC39A Gene

Domains & Families for TTC39A Gene

Gene Families for TTC39A Gene

Protein Domains for TTC39A Gene

Suggested Antigen Peptide Sequences for TTC39A Gene

Graphical View of Domain Structure for InterPro Entry

Q5SRH9

UniProtKB/Swiss-Prot:

TT39A_HUMAN :
  • Belongs to the TTC39 family.
  • Contains 3 TPR repeats.
Family:
  • Belongs to the TTC39 family.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with TTC39A: view

Function for TTC39A Gene

Phenotypes for TTC39A Gene

GenomeRNAi human phenotypes for TTC39A:
genes like me logo Genes that share phenotypes with TTC39A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC39A Gene

Localization for TTC39A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC39A Gene COMPARTMENTS Subcellular localization image for TTC39A gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC39A Gene

Pathways & Interactions for TTC39A Gene

SuperPathways for TTC39A Gene

No Data Available

Interacting Proteins for TTC39A Gene

Gene Ontology (GO) - Biological Process for TTC39A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC39A Gene

Drugs & Compounds for TTC39A Gene

No Compound Related Data Available

Transcripts for TTC39A Gene

Unigene Clusters for TTC39A Gene

Tetratricopeptide repeat domain 39A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC39A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - -

ExUns: 22a · 22b · 22c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for TTC39A Gene

GeneLoc Exon Structure for
TTC39A
ECgene alternative splicing isoforms for
TTC39A

Expression for TTC39A Gene

mRNA expression in normal human tissues for TTC39A Gene

mRNA differential expression in normal tissues according to GTEx for TTC39A Gene

This gene is overexpressed in Testis (x7.9) and Kidney - Cortex (x5.8).

Protein differential expression in normal tissues from HIPED for TTC39A Gene

This gene is overexpressed in Stomach (20.5), Lung (18.8), and Islet of Langerhans (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTC39A Gene



SOURCE GeneReport for Unigene cluster for TTC39A Gene Hs.112949

genes like me logo Genes that share expression patterns with TTC39A: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TTC39A Gene

Orthologs for TTC39A Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC39A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC39A 36
  • 99 (a)
OneToOne
TTC39A 35
  • 99.06 (n)
  • 99.25 (a)
cow
(Bos Taurus)
Mammalia TTC39A 36
  • 93 (a)
OneToOne
TTC39A 35
  • 92.15 (n)
  • 93.98 (a)
dog
(Canis familiaris)
Mammalia TTC39A 35
  • 88.68 (n)
  • 89.77 (a)
TTC39A 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc39a 16
Ttc39a 35
  • 89.24 (n)
  • 93.65 (a)
Ttc39a 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTC39A 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC39A 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910316 35
  • 89.26 (n)
  • 93.98 (a)
chicken
(Gallus gallus)
Aves TTC39A 35
  • 71.44 (n)
  • 77.72 (a)
TTC39A 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC39A 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9518 35
ttc39a 35
  • 70.64 (n)
  • 75.27 (a)
zebrafish
(Danio rerio)
Actinopterygii ttc39a 36
  • 60 (a)
OneToMany
TTC39A (2 of 2) 36
  • 79 (a)
OneToMany
ttc39a 35
  • 68.31 (n)
  • 70.13 (a)
worm
(Caenorhabditis elegans)
Secernentea C32D5.6 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for TTC39A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC39A Gene

ENSEMBL:
Gene Tree for TTC39A (if available)
TreeFam:
Gene Tree for TTC39A (if available)

Paralogs for TTC39A Gene

Paralogs for TTC39A Gene

(1) SIMAP similar genes for TTC39A Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with TTC39A: view

Variants for TTC39A Gene

Sequence variations from dbSNP and Humsavar for TTC39A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs635590 -- 51,288,140(+) AGCCC(A/G)GAACT utr-variant-3-prime
rs944230 -- 51,298,515(+) CACAG(A/G)CAGCT intron-variant, upstream-variant-2KB
rs2297182 -- 51,295,930(+) GACAC(G/T)CAGGG intron-variant, utr-variant-3-prime
rs2185592 -- 51,346,258(-) cctga(C/T)ttcac upstream-variant-2KB
rs3068549 -- 51,306,865(+) CCCCC(-/C)GCCCC intron-variant

Variation tolerance for TTC39A Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC39A Gene

HapMap Linkage Disequilibrium report
TTC39A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TTC39A Gene

Disorders for TTC39A Gene

Relevant External Links for TTC39A

Genetic Association Database (GAD)
TTC39A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC39A

No disorders were found for TTC39A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC39A Gene

Publications for TTC39A Gene

  1. Differential screening and suppression subtractive hybridization identified genes differentially expressed in an estrogen receptor- positive breast carcinoma cell line. (PMID: 9461476) Kuang W.W. … Weigel R.J. (Nucleic Acids Res. 1998) 2 3 4 67
  2. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TTC39A Gene

Sources for TTC39A Gene

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