TTC38 Gene
protein-coding GIFtS: 41
GCID: GC22P046663
|
|
tetratricopeptide repeat domain 38
| |
Aliases
for TTC38 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tetratricopeptide Repeat Domain 381 2 | | TPR Repeat Protein 382 3 | | FLJ206991 | | Tetratricopeptide Repeat Protein 382 |
Export aliases for TTC38 gene to outside databasesPrevious GC identifers: GC22P045042 GC22P029607 |
Summaries
for TTC38 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TTC38 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TTC38 gene promoter:
ER-alpha AML1a HOXA5 IRF-7A SEF-1 (1) CUTL1 LCR-F1 Evi-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TTC38
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC38 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13 Ensembl cytogenetic band: 22q13.31 HGNC cytogenetic band: 22q13TTC38 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P046663: view genomic region
(about GC identifiers)
Start:
|
46,663,858 bp from pter |
End:
|
46,689,905 bp from pter |
Size:
|
26,048 bases |
Orientation:
|
plus strand |
|
Proteins
for TTC38 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TTC38_HUMAN, Q5R3I4 (See
protein sequence)Recommended Name: Tetratricopeptide repeat protein 38 Size: 469 amino acids; 52787 Da
Sequence caution: Sequence=BAA91331.1; Type=Frameshift; Positions=311;
Secondary accessions: Q8WV27 Q9NWP8Explore the universe of human proteins at neXtProt for TTC38: NX_Q5R3I4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5R3I4
TTC38 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060401.2
ENSEMBL proteins: ENSP00000391236 ENSP00000370419 ENSP00000410095 ENSP00000406604 ENSP00000393531 ENSP00000393960
Human Recombinant Protein Products:
TTC38 Antibody Products:
Assay Products for TTC38: |
Protein
Domains /
Families
for TTC38 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TTC38 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5R3I4ProtoNet protein and cluster: Q5R3I4 UniProtKB/Swiss-Prot: TTC38_HUMAN, Q5R3I4Similarity: Belongs to the TTC38 familySimilarity: Contains 3 TPR repeats |
Function
for TTC38 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC38 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC38 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TTC38 (NM_017931) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC38 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC38 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC38 |
|
Pathways & Interactions
for TTC38 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTC38
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
4 Interacting proteins for TTC38 (Q5R3I42, 3 ENSP000003704194) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TTC38 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TTC38
Search CenterWatch for drugs/clinical trials and news about TTC38
|
Transcripts
for TTC38 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TTC38 gene: NM_017931.2 Unigene Cluster for TTC38: Tetratricopeptide repeat domain 38 Hs.435832 [show with all ESTs]Unigene Representative Sequence: AK1279287 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000417709 ENST00000381031(uc003bhi.3 uc011aqx.2) ENST00000475467
ENST00000421359 ENST00000422713 ENST00000451998 ENST00000445282
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC38 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC38 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TTC38 (NM_017931) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC38 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC38 |
Additional cDNA sequence: AK000706.1 AK025188.1 AK074347.1 AK127928.1 AK300606.1 BC018918.2 15 DOTS entries: DT.445971 DT.91735808 DT.97762535 DT.100709257 DT.120663538 DT.75151222 DT.100810235 DT.87016101 DT.97845183 DT.100810237 DT.100653663 DT.100810238 DT.75144051 DT.95204473 DT.91974741 24/281 AceView cDNA sequences (see all 281): BX119890 BU931326 BU543232 AA232693 BU542797 CR595565 AA301977 AW614146 BM704585 BI821827 BF434581 AI380367 BC018918 BM803866 AA553795 AW970444 AI207233 AW473855 AI089914 BF593741 BM977719 BU948243 CB049246 AW663679
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TTC38 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TTC38
|
Expression
for TTC38 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TTC38 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGTGAGCCA
About this image
See TTC38 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TTC38
SOURCE GeneReport for Unigene cluster: Hs.435832
SABiosciences Custom PCR Arrays for TTC38
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC38
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TTC38 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC38 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC38 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC38 |
Orthologs
for TTC38 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TTC38 gene from 8/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ttc381 , 5 |
tetratricopeptide repeat domain 381, 5 |
84.81(n)1
87.69(a)1 |
|
15 (40.42 cM)5
2395701 NM_001033337.41 NP_001028509.21
858323065 |
chicken
(Gallus gallus) |
Aves |
LOC4265991 |
tetratricopeptide repeat protein 38-like |
68.98(n)
69.7(a) |
|
426599 XM_424236.3 XP_424236.3 |
lizard
(Anolis carolinensis) |
Reptilia |
TTC386 |
-- |
68(a) |
1 ↔ 1 |
5(83402241-83424521) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.119912 |
Transcribed sequence with weak similarity to protein more |
74.79(n) |
|
CF524511.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.273582 |
Transcribed sequence with weak similarity to protein more |
71.83(n) |
|
57044509 |
worm
(Caenorhabditis elegans) |
Secernentea |
CELE_Y54G11A.71 |
Protein Y54G11A.7 |
50.11(n)
38.9(a) |
|
175084 NM_064575.4 NP_496976.2 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G271506AT1G271106 |
StaR-like protein domain-containing protein |
21(a)20(a) |
many → 1many → 1 |
1(9429047-9432274) 1(9412820-9417504) |
rice
(Oryza sativa) |
Liliopsida |
-- |
expressed protein |
22(a) |
1 ↔ 1 |
3(27539164-27543130) |
ENSEMBL Gene Tree for TTC38 (if available)
TreeFam Gene Tree for TTC38 (if available) |
Paralogs
for TTC38 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TTC38 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TTC38 (46663858 - 46689905 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TTC38
2 CNVs: 4133 10627 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC38 |
|
Disorders
/ Diseases
for TTC38 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TTC38 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TTC38 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TTC38) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)
|
External Searches for TTC38 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TTC38 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TTC38 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TTC38 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TTC38 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TTC38 gene:
Search GeneIP for patents involving TTC38
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TTC38 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TTC38 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTC38 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC38 | | | OriGene Protein Over-expression Lysate for TTC38 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TTC38 | | OriGene 3'-UTR Clone for TTC38 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC38 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC38 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TTC38 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| |  |  |  |  | | | | |
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 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC38 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC38 |
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