Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TTC38 Gene

Aliases for TTC38 Gene

  • Tetratricopeptide Repeat Domain 38 2 3 5
  • TPR Repeat Protein 38 3 4
  • LL22NC03-5H6.5 3

External Ids for TTC38 Gene

Previous GeneCards Identifiers for TTC38 Gene

  • GC22P045042
  • GC22P046663
  • GC22P029607

Summaries for TTC38 Gene

GeneCards Summary for TTC38 Gene

TTC38 (Tetratricopeptide Repeat Domain 38) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC38 Gene

Genomics for TTC38 Gene

Regulatory Elements for TTC38 Gene

Enhancers for TTC38 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TTC38 on UCSC Golden Path with GeneCards custom track

Promoters for TTC38 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TTC38 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTC38 Gene

Chromosome:
22
Start:
46,267,961 bp from pter
End:
46,294,008 bp from pter
Size:
26,048 bases
Orientation:
Plus strand

Genomic View for TTC38 Gene

Genes around TTC38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC38 Gene

Proteins for TTC38 Gene

  • Protein details for TTC38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5R3I4-TTC38_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 38
    Protein Accession:
    Q5R3I4
    Secondary Accessions:
    • Q8WV27
    • Q9NWP8

    Protein attributes for TTC38 Gene

    Size:
    469 amino acids
    Molecular mass:
    52787 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91331.1; Type=Frameshift; Positions=311; Evidence={ECO:0000305};

neXtProt entry for TTC38 Gene

Proteomics data for TTC38 Gene at MOPED

Post-translational modifications for TTC38 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC38 Gene

No data available for DME Specific Peptides for TTC38 Gene

Domains & Families for TTC38 Gene

Gene Families for TTC38 Gene

Protein Domains for TTC38 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TTC38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5R3I4

UniProtKB/Swiss-Prot:

TTC38_HUMAN :
  • Belongs to the TTC38 family.
  • Contains 3 TPR repeats.
Family:
  • Belongs to the TTC38 family.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with TTC38: view

Function for TTC38 Gene

Phenotypes for TTC38 Gene

genes like me logo Genes that share phenotypes with TTC38: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC38 Gene

Localization for TTC38 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC38 Gene COMPARTMENTS Subcellular localization image for TTC38 gene
Compartment Confidence
extracellular 5
cytosol 4
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC38 Gene

Pathways & Interactions for TTC38 Gene

SuperPathways for TTC38 Gene

No Data Available

Interacting Proteins for TTC38 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000370419%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q5R3I4-TTC38_HUMAN ENSP00000370419 for TTC38 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for TTC38 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC38 Gene

Drugs & Compounds for TTC38 Gene

No Compound Related Data Available

Transcripts for TTC38 Gene

Unigene Clusters for TTC38 Gene

Tetratricopeptide repeat domain 38:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC38 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17
SP1: - - - - - - -
SP2: -
SP3: -
SP4: - - - - -
SP5: - -
SP6:
SP7: -

Relevant External Links for TTC38 Gene

GeneLoc Exon Structure for
TTC38
ECgene alternative splicing isoforms for
TTC38

Expression for TTC38 Gene

mRNA expression in normal human tissues for TTC38 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC38 Gene

This gene is overexpressed in Liver (x9.8).

Protein differential expression in normal tissues from HIPED for TTC38 Gene

This gene is overexpressed in Nasal epithelium (14.6) and Liver, secretome (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TTC38 Gene



SOURCE GeneReport for Unigene cluster for TTC38 Gene Hs.435832

genes like me logo Genes that share expression patterns with TTC38: view

Protein tissue co-expression partners for TTC38 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TTC38 Gene

Orthologs for TTC38 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC38 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TTC38 35
  • 87.28 (n)
  • 88.7 (a)
TTC38 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc38 35
  • 84.81 (n)
  • 87.69 (a)
Ttc38 16
Ttc38 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TTC38 35
  • 99.29 (n)
  • 98.51 (a)
TTC38 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttc38 35
  • 85.14 (n)
  • 89.39 (a)
cow
(Bos Taurus)
Mammalia TTC38 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTC38 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC38 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC426599 35
  • 68.98 (n)
  • 69.7 (a)
-- 36
  • 68 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia TTC38 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11991 35
ttc38 35
  • 65.13 (n)
  • 64.33 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.27358 35
ttc38 35
  • 63.45 (n)
  • 60.31 (a)
ttc38 36
  • 60 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4540 35
worm
(Caenorhabditis elegans)
Secernentea CELE_Y54G11A.7 35
  • 49.96 (n)
  • 38.9 (a)
Y54G11A.4 36
  • 36 (a)
OneToMany
Y54G11A.7 36
  • 37 (a)
OneToMany
Species with no ortholog for TTC38:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC38 Gene

ENSEMBL:
Gene Tree for TTC38 (if available)
TreeFam:
Gene Tree for TTC38 (if available)

Paralogs for TTC38 Gene

No data available for Paralogs for TTC38 Gene

Variants for TTC38 Gene

Sequence variations from dbSNP and Humsavar for TTC38 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs130642 - 46,281,710(-) CCAGA(A/C/G)GGTCT nc-transcript-variant, downstream-variant-500B, reference, missense
rs130641 -- 46,284,890(-) TTTTC(-/T)TTTTT intron-variant
rs130643 -- 46,277,629(-) CTCTC(-/T)TTTTT intron-variant
rs130644 -- 46,277,046(-) tgtgt(A/G)tgtat intron-variant
rs130645 -- 46,276,760(-) atttt(-/AATATATATTTAATATATATTTT)taata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC38 Gene

Variant ID Type Subtype PubMed ID
nsv829281 CNV Gain 20364138
dgv5013n71 CNV Loss 21882294
nsv829293 CNV Gain 20364138
nsv915349 CNV Loss 21882294
nsv915350 CNV Loss 21882294
dgv5014n71 CNV Loss 21882294
dgv1412e1 CNV Complex 17122850
nsv428393 CNV Gain 18775914
nsv818001 CNV Loss 17921354
nsv471214 CNV Loss 18288195
nsv829294 CNV Loss 20364138

Variation tolerance for TTC38 Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.86; 67.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TTC38 Gene

Disorders for TTC38 Gene

Relevant External Links for TTC38

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC38

No disorders were found for TTC38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC38 Gene

Publications for TTC38 Gene

  1. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 67
  2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  3. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for TTC38 Gene

Sources for TTC38 Gene

Content