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Aliases for TTC38 Gene

Aliases for TTC38 Gene

  • Tetratricopeptide Repeat Domain 38 2 3 5
  • TPR Repeat Protein 38 3 4
  • Tetratricopeptide Repeat Protein 38 3
  • LL22NC03-5H6.5 3

External Ids for TTC38 Gene

Previous GeneCards Identifiers for TTC38 Gene

  • GC22P045042
  • GC22P046663
  • GC22P029607

Summaries for TTC38 Gene

GeneCards Summary for TTC38 Gene

TTC38 (Tetratricopeptide Repeat Domain 38) is a Protein Coding gene.

Additional gene information for TTC38 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC38 Gene

Genomics for TTC38 Gene

Regulatory Elements for TTC38 Gene

Enhancers for TTC38 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H046287 1.3 Ensembl ENCODE dbSUPER 52.9 +21.4 21354 4 HDGF ZNF143 ZNF207 ATF7 ETV6 RUNX3 CREM IKZF2 PAF1 HCFC1 TTC38 PKDREJ CDPF1 TRMU PIR50586 GC22P046269
GH22H046294 1.1 ENCODE 52.8 +28.4 28431 3 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 TTC38 PKDREJ CDPF1 TRMU GTSE1-AS1 GTSE1
GH22H046292 0.9 Ensembl ENCODE dbSUPER 52.9 +25.4 25438 1 SCRT2 TTC38 PKDREJ CDPF1 TRMU PIR50586 GC22P046269
GH22H046279 1.3 FANTOM5 ENCODE dbSUPER 34.2 +13.2 13205 2 SMARCA5 ZNF687 NR2F1 BACH1 DPF2 FOXK2 IKZF1 NBN ATF7 ZNF24 TTC38 PKDREJ CDPF1 PPARA CERK TBC1D22A PIR50586 GC22P046269
GH22H046239 1.3 Ensembl ENCODE dbSUPER 20.6 -27.1 -27078 3 TAL1 MAX RAD21 RARA YY1 TCF12 GATA2 POLR2A NCOR1 HNF4G PKDREJ TTC38 PPARA GC22P046242 PIR44878
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTC38 on UCSC Golden Path with GeneCards custom track

Promoters for TTC38 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000147358 139 1401 HDGF ARID4B FEZF1 DMAP1 ZNF2 YY1 SP3 SP5 NFYC REST

Genomic Location for TTC38 Gene

Chromosome:
22
Start:
46,267,961 bp from pter
End:
46,294,008 bp from pter
Size:
26,048 bases
Orientation:
Plus strand

Genomic View for TTC38 Gene

Genes around TTC38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC38 Gene

Proteins for TTC38 Gene

  • Protein details for TTC38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5R3I4-TTC38_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 38
    Protein Accession:
    Q5R3I4
    Secondary Accessions:
    • Q8WV27
    • Q9NWP8

    Protein attributes for TTC38 Gene

    Size:
    469 amino acids
    Molecular mass:
    52787 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91331.1; Type=Frameshift; Positions=311; Evidence={ECO:0000305};

neXtProt entry for TTC38 Gene

Post-translational modifications for TTC38 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC38 Gene

Domains & Families for TTC38 Gene

Gene Families for TTC38 Gene

Protein Domains for TTC38 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TTC38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5R3I4

UniProtKB/Swiss-Prot:

TTC38_HUMAN :
  • Belongs to the TTC38 family.
Family:
  • Belongs to the TTC38 family.
genes like me logo Genes that share domains with TTC38: view

Function for TTC38 Gene

Phenotypes From GWAS Catalog for TTC38 Gene

Phenotypes for TTC38 Gene

genes like me logo Genes that share phenotypes with TTC38: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TTC38
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC38 Gene

Localization for TTC38 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC38 gene
Compartment Confidence
extracellular 5
cytosol 4
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TTC38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with TTC38: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TTC38 Gene

Pathways & Interactions for TTC38 Gene

SuperPathways for TTC38 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC38 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC38 Gene

Drugs & Compounds for TTC38 Gene

No Compound Related Data Available

Transcripts for TTC38 Gene

Unigene Clusters for TTC38 Gene

Tetratricopeptide repeat domain 38:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TTC38
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TTC38 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17
SP1: - - - - - - -
SP2: -
SP3: -
SP4: - - - - -
SP5: - -
SP6:
SP7: -

Relevant External Links for TTC38 Gene

GeneLoc Exon Structure for
TTC38
ECgene alternative splicing isoforms for
TTC38

Expression for TTC38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTC38 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC38 Gene

This gene is overexpressed in Liver (x9.8).

Protein differential expression in normal tissues from HIPED for TTC38 Gene

This gene is overexpressed in Nasal epithelium (14.6) and Liver, secretome (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTC38 Gene



Protein tissue co-expression partners for TTC38 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TTC38 Gene:

TTC38

SOURCE GeneReport for Unigene cluster for TTC38 Gene:

Hs.435832

Evidence on tissue expression from TISSUES for TTC38 Gene

  • Liver(4.4)
  • Intestine(4.3)
  • Nervous system(4.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with TTC38: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC38 Gene

Orthologs for TTC38 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC38 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC38 33 34
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia TTC38 33 34
  • 87.28 (n)
rat
(Rattus norvegicus)
Mammalia Ttc38 33
  • 85.14 (n)
mouse
(Mus musculus)
Mammalia Ttc38 33 16 34
  • 84.81 (n)
cow
(Bos Taurus)
Mammalia TTC38 34
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC38 34
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTC38 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC426599 33
  • 68.98 (n)
-- 34
  • 68 (a)
OneToMany
-- 34
  • 68 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia TTC38 34
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc38 33
  • 65.13 (n)
Str.11991 33
zebrafish
(Danio rerio)
Actinopterygii ttc38 33 34
  • 63.45 (n)
Dr.27358 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4540 33
worm
(Caenorhabditis elegans)
Secernentea CELE_Y54G11A.7 33
  • 49.96 (n)
Y54G11A.7 34
  • 37 (a)
OneToMany
Y54G11A.4 34
  • 36 (a)
OneToMany
Species where no ortholog for TTC38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC38 Gene

ENSEMBL:
Gene Tree for TTC38 (if available)
TreeFam:
Gene Tree for TTC38 (if available)

Paralogs for TTC38 Gene

No data available for Paralogs for TTC38 Gene

Variants for TTC38 Gene

Sequence variations from dbSNP and Humsavar for TTC38 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000008768 -- 46,272,963(+) CGTGG(C/T)GCGGC intron-variant
rs1000078050 -- 46,279,491(+) GAGCC(A/G)GATTC intron-variant
rs1000140505 -- 46,292,487(+) CATTC(A/G)GTCCA intron-variant, downstream-variant-500B
rs1000271083 -- 46,278,626(+) AAACC(A/G)ACTTC nc-transcript-variant, reference, missense
rs1000299299 -- 46,267,584(+) CTGGG(A/G)CTGGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TTC38 Gene

Variant ID Type Subtype PubMed ID
dgv2469n106 OTHER inversion 24896259
esv2758844 CNV gain+loss 17122850
nsv1152661 OTHER inversion 26484159
nsv428393 CNV gain 18775914
nsv471214 CNV loss 18288195
nsv589136 CNV gain 21841781
nsv818001 CNV loss 17921354
nsv829281 CNV gain 20364138
nsv829293 CNV gain 20364138
nsv829294 CNV loss 20364138

Variation tolerance for TTC38 Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.86; 67.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC38

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC38 Gene

Disorders for TTC38 Gene

Relevant External Links for TTC38

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC38

No disorders were found for TTC38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC38 Gene

Publications for TTC38 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 60
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 60
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3 60
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard TR … Colinge J (BMC systems biology 2011) 4 60

Products for TTC38 Gene

Sources for TTC38 Gene

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