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TTC37 Gene

protein-coding   GIFtS: 55
GCID: GC05M094826

Tetratricopeptide Repeat Domain 37

(Previous name: KIAA0372)
(Previous symbol: KIAA0372)
  See TTC37-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tetratricopeptide Repeat Domain 371 2     TPR Repeat Protein 372 3
KIAA03721 2 3 5     Tetratricopeptide Repeat Protein 372
Tricho-Hepatic-Enteric Syndrome Protein2 3     thespin2
Ski32 3     Thespin3
SKI3 Homolog2 3     

External Ids:    HGNC: 236391   Entrez Gene: 96522   Ensembl: ENSG000001986777   OMIM: 6145895   UniProtKB: Q6PGP73   

Export aliases for TTC37 gene to outside databases

Previous GC identifer: GC05M089989


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TTC37 Gene:
This gene encodes a protein with twenty tetratricopeptide (TPR) repeats. Tetratricopeptide repeat containing
motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity.
Mutations in this gene are associated with trichohepatoenteric syndrome. (provided by RefSeq, Jul 2010)

GeneCards Summary for TTC37 Gene:
TTC37 (tetratricopeptide repeat domain 37) is a protein-coding gene. Diseases associated with TTC37 include trichohepatoenteric syndrome 1, and early onset absence epilepsy.

UniProtKB/Swiss-Prot: TTC37_HUMAN, Q6PGP7
Function: Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and
associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the TTC37 gene promoter:
         E2F-5   GATA-3   Nkx5-1   GATA-1   GATA-2   POU2F1   POU2F1a   POU2F1b   POU2F1c   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTC37 promoter sequence
   Search Chromatin IP Primers for TTC37

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTC37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q15   Ensembl cytogenetic band:  5q15   HGNC cytogenetic band: 5q15

TTC37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTC37 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M094826:  view genomic region     (about GC identifiers)

Start:
94,799,599 bp from pter      End:
94,890,711 bp from pter
Size:
91,113 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TTC37_HUMAN, Q6PGP7 (See protein sequence)
Recommended Name: Tetratricopeptide repeat protein 37  
Size: 1564 amino acids; 175486 Da
Subunit: Component of the SKI complex which consists of WDR61, SKIV2L and TTC37. Interacts with PAF1
Sequence caution: Sequence=BAA20827.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: O15077 Q6PJI3

Explore the universe of human proteins at neXtProt for TTC37: NX_Q6PGP7

Explore proteomics data for TTC37 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys619, Lys1516
  • Modification sites at PhosphoSitePlus

  • See TTC37 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055454.1  
    ENSEMBL proteins: 
     ENSP00000351596   ENSP00000422749   ENSP00000423141   ENSP00000423742   ENSP00000425403  

    TTC37 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TTC37

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    5 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR006597 Sel1-like
     IPR001440 TPR_1
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry Q6PGP7

    ProtoNet protein and cluster: Q6PGP7

    UniProtKB/Swiss-Prot: TTC37_HUMAN, Q6PGP7
    Similarity: Contains 20 TPR repeats


    Find genes that share domains with TTC37           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTC37_HUMAN, Q6PGP7
    Function: Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and
    associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16024656
         
    Find genes that share ontologies with TTC37           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TTC37
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TTC37

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    miRNA
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    hsa-mir-92a-3p (MIRT049507), hsa-mir-186-3p (MIRT038611), hsa-mir-155-5p (MIRT020839), hsa-mir-1 (MIRT023848), hsa-mir-421 (MIRT016132)

    Block miRNA regulation of human, mouse, rat TTC37 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TTC37:
    hsa-miR-448 hsa-miR-4310
    SwitchGear 3'UTR luciferase reporter plasmidTTC37 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TTC37 (NM_014639)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC37


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TTC37_HUMAN, Q6PGP7: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion2
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0035327transcriptionally active chromatin IDA16024656
    GO:0055087Ski complex IDA16024656

    Find genes that share ontologies with TTC37           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TTC37 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    RNA degradation0.48


    Find genes that share SuperPaths with TTC37           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for TTC37):
        RNA degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TTC37
    Interactions:

        Search GeneGlobe Interaction Network for TTC37

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TTC37 (Q6PGP71, 2, 3 ENSP000003515964) via UniProtKB, MINT, STRING, and/or I2D (see all 156)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD9O151982, 3MINT-62099 I2D: score=3 
    ENSG00000223493Q154773, ENSP000004123104I2D: score=5 STRING: ENSP00000412310
    ENSG00000225737Q154773, ENSP000003944004I2D: score=5 STRING: ENSP00000394400
    ENSG00000232616Q154773, ENSP000004006264I2D: score=5 STRING: ENSP00000400626
    SKIV2LQ154773, ENSP000003645434I2D: score=5 STRING: ENSP00000364543
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TTC37



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TTC37 gene: 
    NM_014639.3  

    Unigene Cluster for TTC37:

    Tetratricopeptide repeat domain 37
    Hs.482868  [show with all ESTs]
    Unigene Representative Sequence: NM_014639
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358746(uc003klb.3 uc010jbf.2) ENST00000502768 ENST00000508181
    ENST00000512026 ENST00000515176 ENST00000507805 ENST00000506007 ENST00000513232
    ENST00000505578 ENST00000514952 ENST00000504421 ENST00000503279 ENST00000515207
    ENST00000513823 ENST00000510228
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate TTC37:
    hsa-miR-448 hsa-miR-4310
    SwitchGear 3'UTR luciferase reporter plasmidTTC37 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TTC37
    Predesigned siRNA for gene silencing in human, mouse, rat TTC37
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TTC37 (NM_014639)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TTC37
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC37
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TTC37
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TTC37
      QuantiTect SYBR Green Assays in human, mouse, rat TTC37
      QuantiFast Probe-based Assays in human, mouse, rat TTC37

    Additional mRNA sequence: 

    AB002370.1 AK307531.1 BC009767.1 BC015163.2 BC030966.1 BC056893.1 

    19 DOTS entries:

    DT.453607  DT.92433999  DT.40209180  DT.120880323  DT.97775644  DT.92434001  DT.95178392  DT.95178427 
    DT.100793201  DT.120880304  DT.120880335  DT.95178389  DT.97825721  DT.100704646  DT.120880293  DT.75103583 
    DT.91664181  DT.70102937  DT.99956562 

    Selected AceView cDNA sequences (see all 273):

    BU633306 AI636382 BC056893 BQ228132 BU633347 AW627536 BM788918 BU618232 
    BM263400 AW157222 AI658888 BU189359 BM721897 BQ776645 F05241 CD105462 
    BU679091 BU178607 AA761500 CK902246 BP870775 AI936011 AU141186 BG912748 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TTC37 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
    SP1:                                                                    -                 -                                                                     
    SP2:                                                                                                              -                             -               
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^
    SP1:                    -     -                                   -     -                                                                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                              -     -                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 42 ^ 43 ^ 44
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for TTC37

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TTC37 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATTCCTTC
    TTC37 Expression
    About this image

    TTC37 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TTC37 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.482868

    UniProtKB/Swiss-Prot: TTC37_HUMAN, Q6PGP7
    Tissue specificity: Widely expressed with the highest levels observed in vascular tissues, lymph node, pituitary,
    lung and intestine. Not expressed in the liver

        Custom PCR Arrays for TTC37
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC37

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TTC37 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttc371 , 5 tetratricopeptide repeat domain 371, 5 85.03(n)1
    84.71(a)1
      13 (40.95 cM)5
    2183431  NM_001081352.11  NP_001074821.11 
     760987345 
    chicken
    (Gallus gallus)
    Aves TTC371 tetratricopeptide repeat domain 37 70.96(n)
    67.18(a)
      427114  XM_004949386.1  XP_004949443.1 
    lizard
    (Anolis carolinensis)
    Reptilia TTC376
    tetratricopeptide repeat domain 37
    68(a)
    1 ↔ 1
    2(25831152-25872904)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.290762 Xenopus laevis transcribed sequence with weak similarity more 73.03(n)    CF287296.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd11f082 Transcribed sequence with moderate similarity to protein more 76.36(n)    AL915419.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG87771 CG8777 40.82(n)
    28.6(a)
      35921  NM_136608.4  NP_610452.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SKI3(YPR189W)4 Ski complex component and TPR protein, mediates 3'-5' more   --   16(912664-916962) 856319  NP_015515.1 


    ENSEMBL Gene Tree for TTC37 (if available)
    TreeFam Gene Tree for TTC37 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TTC37 gene
    1 SIMAP similar gene for TTC37 using alignment to 5 protein entries:     TTC37_HUMAN (see all proteins):
    UTY

    Find genes that share paralogs with TTC37           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TTC37 (see all 1738)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0679584
    Trichohepatoenteric syndrome 1 (THES1)4--see VAR_0679582 D N mis40--------
    VAR_0679574
    Trichohepatoenteric syndrome 1 (THES1)4--see VAR_0679572 G R mis40--------
    VAR_0679594
    Trichohepatoenteric syndrome 1 (THES1)4--see VAR_0679592 L S mis40--------
    rs3713344851,2
    C--89990224(+) ATTAA-/TTTTTT 1 -- ut310--------
    rs1421214701,2
    C--89996598(+) TTTAT-/TCTC  
            
    TCTCA
    1 -- int10--------
    rs1455046961,2
    C--89997358(+) TCCTC-/TTTTTT 1 -- int10--------
    rs360325721,2
    C--89999178(+) CTGCAG/-TCCCA 1 -- int13Minor allele frequency- -:0.17NA CSA 6
    rs761037231,2
    C--90012982(+) CTGGAA/TGCTTC 1 -- int12Minor allele frequency- T:0.00NA CSA 3
    rs1453923561,2
    C--90044424(+) ATCAA-/TTTTTT 1 -- int10--------
    rs568868811,2
    C--94799504(+) TATGT-/AAAGAGC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TTC37 (94799599 - 94890711 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TTC37:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665441CNV Deletion23128226
    esv2667457CNV Deletion23128226
    nsv882388CNV Loss21882294

    Human Gene Mutation Database (HGMD): TTC37
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TTC37
    DNA2.0 Custom Variant and Variant Library Synthesis for TTC37

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 614589   
    OMIM disorders: 222470  
    UniProtKB/Swiss-Prot: TTC37_HUMAN, Q6PGP7
  • Trichohepatoenteric syndrome 1 (THES1) [MIM:222470]: A syndrome characterized by intrauterine growth
    retardation, severe diarrhea in infancy requiring total parenteral nutrition, facial dysmorphism,
    immunodeficiency, and hair abnormalities, mostly trichorrhexis nodosa. Hepatic involvement contributes to the
    poor prognosis of affected patients. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 2 diseases for TTC37:    
    About MalaCards
    trichohepatoenteric syndrome 1    early onset absence epilepsy

    1 disease from the University of Copenhagen DISEASES database for TTC37:
    Diarrhea

    Find genes that share disorders with TTC37           About GenesLikeMe


    Export disorders for TTC37 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for TTC37 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with TTC37)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1997)
    2. Novel mutations in TTC37 associated with Tricho-Hepato-Enteric syndrome. (PubMed id 21120949)1, 2 Fabre A.... Badens C. (Hum. Mutat. 2011)
    3. Mutations in TTC37 cause trichohepatoenteric syndrome (phenotypic diarrhea of infancy). (PubMed id 20176027)1, 2 Hartley J.L.... Maher E.R. (Gastroenterology 2010)
    4. The human PAF complex coordinates transcription with events downstream of RNA synthesis. (PubMed id 16024656)1, 2 Zhu B.... Reinberg D. (Genes Dev. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 9652 HGNC: 23639 AceView: KIAA0372 Ensembl:ENSG00000198677 euGenes: HUgn9652
    ECgene: TTC37 Kegg: 9652 H-InvDB: TTC37

    (According to HUGE)
    About This Section

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    HUGE: KIAA0372

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TTC37 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TTC37 gene:
    Search GeneIP for patents involving TTC37

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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