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Aliases for TTC36 Gene

Aliases for TTC36 Gene

  • Tetratricopeptide Repeat Domain 36 2 3
  • HSP70 Binding Protein 21 2 3
  • HSP70-Binding Protein 21 3 4
  • TPR Repeat Protein 36 3 4
  • HBP21 3 4

External Ids for TTC36 Gene

Previous GeneCards Identifiers for TTC36 Gene

  • GC11P117904
  • GC11P118398
  • GC11P114334

Summaries for TTC36 Gene

GeneCards Summary for TTC36 Gene

TTC36 (Tetratricopeptide Repeat Domain 36) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC36 Gene

Genomics for TTC36 Gene

Regulatory Elements for TTC36 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TTC36 Gene

Chromosome:
11
Start:
118,527,472 bp from pter
End:
118,531,197 bp from pter
Size:
3,726 bases
Orientation:
Plus strand

Genomic View for TTC36 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for TTC36 Gene

Proteins for TTC36 Gene

  • Protein details for TTC36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NLP5-TTC36_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 36
    Protein Accession:
    A6NLP5
    Secondary Accessions:
    • B7ZW72
    • B9EJD8

    Protein attributes for TTC36 Gene

    Size:
    189 amino acids
    Molecular mass:
    20896 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC36 Gene

Proteomics data for TTC36 Gene at MOPED

Post-translational modifications for TTC36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC36 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTC36 Gene

Domains & Families for TTC36 Gene

Gene Families for TTC36 Gene

Protein Domains for TTC36 Gene

Suggested Antigen Peptide Sequences for TTC36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NLP5

UniProtKB/Swiss-Prot:

TTC36_HUMAN :
  • Belongs to the TTC36 family.
  • Contains 3 TPR repeats.
Family:
  • Belongs to the TTC36 family.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with TTC36: view

Function for TTC36 Gene

Gene Ontology (GO) - Molecular Function for TTC36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TTC36: view

Animal Model Products

CRISPR Products

miRNA for TTC36 Gene

miRTarBase miRNAs that target TTC36

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTC36

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC36 Gene

Localization for TTC36 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TTC36 Gene

Pathways & Interactions for TTC36 Gene

SuperPathways for TTC36 Gene

No Data Available

Interacting Proteins for TTC36 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000307640%0d%0a9606.ENSP00000289004%0d%0a9606.ENSP00000335060%0d%0a
Selected Interacting proteins: A6NLP5-TTC36_HUMAN ENSP00000307640 for TTC36 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for TTC36 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC36 Gene

Drugs & Compounds for TTC36 Gene

No Compound Related Data Available

Transcripts for TTC36 Gene

mRNA/cDNA for TTC36 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TTC36 Gene

Tetratricopeptide repeat domain 36:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTC36

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC36 Gene

No ASD Table

Relevant External Links for TTC36 Gene

GeneLoc Exon Structure for
TTC36
ECgene alternative splicing isoforms for
TTC36

Expression for TTC36 Gene

mRNA expression in normal human tissues for TTC36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC36 Gene

This gene is overexpressed in Liver (x39.5) and Kidney - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for TTC36 Gene

This gene is overexpressed in Liver, secretome (31.6), Gallbladder (18.3), and Serum (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TTC36 Gene



SOURCE GeneReport for Unigene cluster for TTC36 Gene Hs.653449

genes like me logo Genes that share expression patterns with TTC36: view

Protein tissue co-expression partners for TTC36 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TTC36 Gene

Orthologs for TTC36 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC36 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TTC36 35
  • 89.72 (n)
  • 91.49 (a)
TTC36 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTC36 35
  • 88.71 (n)
  • 88.89 (a)
TTC36 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc36 35
  • 86.74 (n)
  • 89.25 (a)
Ttc36 16
Ttc36 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttc36 35
  • 86.02 (n)
  • 88.71 (a)
oppossum
(Monodelphis domestica)
Mammalia TTC36 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC36 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TTC36 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC36 35
  • 72.34 (n)
  • 69.23 (a)
TTC36 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc36 35
  • 60.61 (n)
  • 60.96 (a)
zebrafish
(Danio rerio)
Actinopterygii ttc36 35
  • 61.78 (n)
  • 60.87 (a)
ttc36 36
  • 59 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.267 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010928 35
  • 48.19 (n)
  • 41.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14105 35
  • 48.48 (n)
  • 43.75 (a)
CG14105 36
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F52H3.5 35
  • 47.08 (n)
  • 46.33 (a)
F52H3.5 36
  • 46 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for TTC36:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC36 Gene

ENSEMBL:
Gene Tree for TTC36 (if available)
TreeFam:
Gene Tree for TTC36 (if available)

Paralogs for TTC36 Gene

No data available for Paralogs for TTC36 Gene

Variants for TTC36 Gene

Sequence variations from dbSNP and Humsavar for TTC36 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_042972 -

Structural Variations from Database of Genomic Variants (DGV) for TTC36 Gene

Variant ID Type Subtype PubMed ID
dgv1319n71 CNV Loss 21882294

Variation tolerance for TTC36 Gene

Residual Variation Intolerance Score: 72.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC36 Gene

HapMap Linkage Disequilibrium report
TTC36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC36 Gene

Disorders for TTC36 Gene

Relevant External Links for TTC36

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC36
genes like me logo Genes that share disorders with TTC36: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC36 Gene

Publications for TTC36 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  2. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 67
  3. HBP21: a novel member of TPR motif family, as a potential chaperone of heat shock protein 70 in proliferative vitreoretinopathy (PVR) and breast cancer. (PMID: 18587674) Liu Q. … Li J. (Mol. Biotechnol. 2008) 67
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for TTC36 Gene

Sources for TTC36 Gene

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