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Aliases for TTC36 Gene

Aliases for TTC36 Gene

  • Tetratricopeptide Repeat Domain 36 2 3 5
  • HSP70 Binding Protein 21 2 3
  • TPR Repeat Protein 36 3 4
  • HBP21 3 4
  • Tetratricopeptide Repeat Protein 36 3
  • HSP70-Binding Protein 21 4

External Ids for TTC36 Gene

Previous GeneCards Identifiers for TTC36 Gene

  • GC11P117904
  • GC11P118398
  • GC11P114334

Summaries for TTC36 Gene

Entrez Gene Summary for TTC36 Gene

  • The protein encoded by this gene has three tetratricopeptide repeats and is a chaperone for heat shock protein 70. The encoded protein may function as a tumor suppressor in hepatocellular carcinoma (HCC) since it promotes apoptosis but is downregulated in HCC. [provided by RefSeq, Sep 2016]

GeneCards Summary for TTC36 Gene

TTC36 (Tetratricopeptide Repeat Domain 36) is a Protein Coding gene. Diseases associated with TTC36 include Hepatocellular Carcinoma.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC36 Gene

Genomics for TTC36 Gene

Regulatory Elements for TTC36 Gene

Enhancers for TTC36 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F118603 1.5 FANTOM5 ENCODE 9.8 +81.2 81156 9.9 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 ZNF2 ZNF143 ZNF207 IFT46 TREHP1 LOC105369519 TREH SETP16 ENSG00000254892 ENSG00000255176 ARCN1 TTC36 LOC100130353
GH11F118398 1.1 ENCODE 10.2 -126.7 -126674 5.1 ATF1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF48 YY1 GTF3C2 ELK1 ARCN1 RNF26 ENSG00000254909 ENSG00000254428 RPL23AP64 UBE4A BCL9L ENSG00000255384 KMT2A RPS25
GH11F118174 1.1 Ensembl ENCODE 8.9 -351.8 -351794 2.2 ELF3 PKNOX1 ZFP64 RAD21 RFX5 YY1 ZNF366 JUNB CEBPB TBX21 SCN4B SCN2B CD3D CD3G CD3E TMPRSS4 FXYD6 FXYD6-FXYD2 TTC36 GC11P118174
GH11F118171 1.1 Ensembl ENCODE 8.9 -355.8 -355776 0.7 ELF3 CTCF ZNF792 TEAD4 ARID4B MAX ZNF48 ZNF2 RAD21 TEAD3 SCN2B CD3D CD3G CD3E TMPRSS4 FXYD6 FXYD6-FXYD2 TTC36 GC11P118174 SCN4B
GH11F118442 1 Ensembl ENCODE 9.7 -84.2 -84234 1.1 TBL1XR1 BMI1 RELA ZFHX2 GATA3 POLR2A EED CREM EGR2 MTA2 ATP5L ENSG00000254873 LOC101929089 TMEM25 TTC36 KMT2A GC11M118474
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTC36 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTC36 Gene

Chromosome:
11
Start:
118,527,472 bp from pter
End:
118,531,197 bp from pter
Size:
3,726 bases
Orientation:
Plus strand

Genomic View for TTC36 Gene

Genes around TTC36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC36 Gene

Proteins for TTC36 Gene

  • Protein details for TTC36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NLP5-TTC36_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 36
    Protein Accession:
    A6NLP5
    Secondary Accessions:
    • B7ZW72
    • B9EJD8

    Protein attributes for TTC36 Gene

    Size:
    189 amino acids
    Molecular mass:
    20896 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC36 Gene

Post-translational modifications for TTC36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC36 Gene

No data available for DME Specific Peptides for TTC36 Gene

Domains & Families for TTC36 Gene

Gene Families for TTC36 Gene

Protein Domains for TTC36 Gene

Suggested Antigen Peptide Sequences for TTC36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NLP5

UniProtKB/Swiss-Prot:

TTC36_HUMAN :
  • Belongs to the TTC36 family.
  • Contains 3 TPR repeats.
Family:
  • Belongs to the TTC36 family.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with TTC36: view

Function for TTC36 Gene

Phenotypes for TTC36 Gene

MGI mutant phenotypes for TTC36:
inferred from 1 alleles
GenomeRNAi human phenotypes for TTC36:
genes like me logo Genes that share phenotypes with TTC36: view

Animal Model Products

miRNA for TTC36 Gene

miRTarBase miRNAs that target TTC36

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC36 Gene

Localization for TTC36 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC36 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC36 Gene

Pathways & Interactions for TTC36 Gene

SuperPathways for TTC36 Gene

No Data Available

Interacting Proteins for TTC36 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000307640%0d%0a9606.ENSP00000289004%0d%0a9606.ENSP00000335060%0d%0a
Selected Interacting proteins: ENSP00000307640 A6NLP5-TTC36_HUMAN for TTC36 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TTC36 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC36 Gene

Transcripts for TTC36 Gene

mRNA/cDNA for TTC36 Gene

Unigene Clusters for TTC36 Gene

Tetratricopeptide repeat domain 36:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC36 Gene

No ASD Table

Relevant External Links for TTC36 Gene

GeneLoc Exon Structure for
TTC36
ECgene alternative splicing isoforms for
TTC36

Expression for TTC36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTC36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC36 Gene

This gene is overexpressed in Liver (x39.5) and Kidney - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for TTC36 Gene

This gene is overexpressed in Liver, secretome (31.6), Gallbladder (18.3), and Serum (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TTC36 Gene



Protein tissue co-expression partners for TTC36 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TTC36 Gene:

TTC36

SOURCE GeneReport for Unigene cluster for TTC36 Gene:

Hs.653449
genes like me logo Genes that share expression patterns with TTC36: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TTC36 Gene

Orthologs for TTC36 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC36 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TTC36 34 35
  • 89.72 (n)
dog
(Canis familiaris)
Mammalia TTC36 34 35
  • 88.71 (n)
mouse
(Mus musculus)
Mammalia Ttc36 34 16 35
  • 86.74 (n)
rat
(Rattus norvegicus)
Mammalia Ttc36 34
  • 86.02 (n)
oppossum
(Monodelphis domestica)
Mammalia TTC36 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC36 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC36 34 35
  • 72.34 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc36 34
  • 60.61 (n)
zebrafish
(Danio rerio)
Actinopterygii ttc36 34 35
  • 61.78 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.267 34
fruit fly
(Drosophila melanogaster)
Insecta CG14105 34 35
  • 48.48 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010928 34
  • 48.19 (n)
worm
(Caenorhabditis elegans)
Secernentea F52H3.5 34 35
  • 47.08 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToOne
Species where no ortholog for TTC36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC36 Gene

ENSEMBL:
Gene Tree for TTC36 (if available)
TreeFam:
Gene Tree for TTC36 (if available)

Paralogs for TTC36 Gene

No data available for Paralogs for TTC36 Gene

Variants for TTC36 Gene

Sequence variations from dbSNP and Humsavar for TTC36 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1064939 -- 118,525,616(+) aaaaa(A/T)aaaag intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs111477129 -- 118,528,787(+) GACGT(A/G)GCAGG intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs113565497 -- 118,528,833(+) CCACG(A/G)GAGGG intron-variant, upstream-variant-2KB
rs113835012 -- 118,529,818(+) ACCAA(A/G)GAGTA intron-variant, upstream-variant-2KB
rs115843837 -- 118,531,330(+) CACCA(A/T)CATCA intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TTC36 Gene

Variant ID Type Subtype PubMed ID
nsv1044281 CNV gain 25217958
esv3627872 CNV gain 21293372

Variation tolerance for TTC36 Gene

Residual Variation Intolerance Score: 72.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC36 Gene

Disorders for TTC36 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TTC36 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards
Search TTC36 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TTC36

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC36
genes like me logo Genes that share disorders with TTC36: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTC36 Gene

Publications for TTC36 Gene

  1. HBP21, a chaperone of heat shock protein 70, functions as a tumor suppressor in hepatocellular carcinoma. (PMID: 26246424) Jiang L. … Guan X.Y. (Carcinogenesis 2015) 3 64
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  3. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3 64
  4. HBP21: a novel member of TPR motif family, as a potential chaperone of heat shock protein 70 in proliferative vitreoretinopathy (PVR) and breast cancer. (PMID: 18587674) Liu Q. … Li J. (Mol. Biotechnol. 2008) 3 64
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64

Products for TTC36 Gene

Sources for TTC36 Gene

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