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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TTC36 Gene

protein-coding   GIFtS: 38
GCID: GC11P118398

tetratricopeptide repeat domain 36
 Explore 3 diseases affiliated with
TTC36 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TTC36    

Aliases
for TTC36 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tetratricopeptide Repeat Domain 361 2
HBP211 2 3
HSP70-Binding Protein 212 3
TPR Repeat Protein 362 3
HSP70 Binding Protein 212
Tetratricopeptide Repeat Protein 362

External Ids:    HGNC: 337081   Entrez Gene: 1439412   Ensembl: ENSG000001724257   UniProtKB: A6NLP53   

Export aliases for TTC36 gene to outside databases

Previous GC identifers: GC11P117904 GC11P114334


Summaries
for TTC36 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for TTC36 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TTC36 gene promoter:
         STAT5B   HOXA9   HOXA9B   Sp1   CUTL1   Meis-1b   C/EBPalpha   Chx10   Pax-4a   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TTC36

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

TTC36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTC36 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P118398:  view genomic region     (about GC identifiers)

Start:
 118,398,187 bp from pter      End:
 118,401,912 bp from pter
Size:
 3,726 bases      Orientation:
 plus strand

Proteins
for TTC36 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TTC36_HUMAN, A6NLP5 (See protein sequence)
Recommended Name: Tetratricopeptide repeat protein 36  
Size: 189 amino acids; 20896 Da
Secondary accessions: B9EJD8

Explore the universe of human proteins at neXtProt for TTC36: NX_A6NLP5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_A6NLP5

    • TTC36 Protein expression data from MOPED and PaxDb:    About this image 
    TTC36 Protein Expression
    REFSEQ proteins: NP_001073910.1  
    ENSEMBL proteins: 
     ENSP00000307640   ENSP00000436858   ENSP00000437178   ENSP00000442513  

    Human Recombinant Protein Products for TTC36: 
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    Protein Domains /
    Families
    for TTC36 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TTC36 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR011990 TPR-like_helical
     IPR013105 TPR_2
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry A6NLP5

    ProtoNet protein and cluster: A6NLP5

    UniProtKB/Swiss-Prot: TTC36_HUMAN, A6NLP5
    Similarity: Belongs to the TTC36 family
    Similarity: Contains 3 TPR repeats


    Function
    for TTC36 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TTC36 

    miRNA
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for TTC36 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTC36

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TTC36 (A6NLP53 ENSP000003076404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HPDP327543, ENSP000002890044I2D: score=4 STRING: ENSP00000289004
    About this table

    Drugs & Compounds
    for TTC36 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TTC36
    Search CenterWatch for drugs/clinical trials and news about TTC36 

    Transcripts
    for TTC36 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TTC36 gene: 
    NM_001080441.1  

    Unigene Cluster for TTC36:

    Tetratricopeptide repeat domain 36
    Hs.653449  [show with all ESTs]
    Unigene Representative Sequence: BC171913
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302783(uc001ptg.1) ENST00000533501(uc010ryc.1) ENST00000528570
    ENST00000539546(uc010ryb.1)

    miRNA
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    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTC36 (see all 4)
    OriGene shRNA RFP: TTC36
    OriGene siRNA: TTC36
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    Sirion Biotech Custom design and validation of potent shRNA sequences against TTC36 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC36 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TTC36 (NM_001080441)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC36
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC36

    Additional cDNA sequence: 

    BC146916.1 BC146921.1 BC171906.1 BC171913.1 EU489483.1 

    4 DOTS entries:

    DT.92416599  DT.86840728  DT.95106475  DT.65285882 

    20 AceView cDNA sequences:

    BF224415 AI016050 AI640368 BX106396 CB164093 AW027968 AW269161 CB164226 
    AI253088 AW275376 AW270894 AI307378 AW269171 AW780033 W25058 AW300427 
    BE048453 BF197564 AA937148 N92830 

    GeneLoc Exon Structure


    Expression
    for TTC36 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TTC36 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGGGGCAGC
    TTC36 Expression
    About this image

    TTC36 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyLoop of HenleLoop of Henle CellsKidney
    KidneyProximal TubuleProximal Tubule CellsKidney
    KidneyEpithelial TubuleKidney
    KidneyLoop of HenleKidney
    KidneyProximal TubuleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TTC36 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TTC36

    SOURCE GeneReport for Unigene cluster: Hs.653449
        SABiosciences Custom PCR Arrays for TTC36
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC36
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TTC36

    Orthologs
    for TTC36 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TTC36 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ttc361 , 5 tetratricopeptide repeat domain 361, 5 86.74(n)1
    89.25(a)1    		   9 (24.84 cM)5
    1926531  NM_138951.11  NP_620401.11 
     447994005 
    chicken
    (Gallus gallus)    		 Aves TTC361 tetratricopeptide repeat domain 36 72.34(n)
    69.23(a)    		   419757  XM_417895.2  XP_417895.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ttc361 tetratricopeptide repeat domain 36 61.78(n)
    60.87(a)    		   492516  NM_001007388.1  NP_001007389.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG141051 CG14105 48.3(n)
    43.75(a)    		   39507  NM_140387.2  NP_648644.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea F52H3.51 Protein F52H3.5 46.55(n)
    45.81(a)    		   174562  NM_063767.2  NP_496168.1 


    ENSEMBL Gene Tree for TTC36 (if available)
    TreeFam Gene Tree for TTC36 (if available) 

    Paralogs
    for TTC36 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for TTC36 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/30 NCBI SNPs in TTC36 are shown (see all 30)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1404172611,2
    		--118398072(+) CAGCCA/GTGGAC 1 -- us2k10--------
    rs1449415101,2
    		--118398073(+) AGCCAG/TGGACA 1 -- us2k10--------
    rs2012453161,2
    		--118398195(+) GGATTC/TTGGAG 1 -- us2k10--------
    rs2004871861,2
    		--118398310(+) AGAAAA/CGGAAG 2 K T mis10--------
    rs1387440021,2
    		C--118398347(+) TGGAGC/TGTAGC 1 -- int10--------
    rs1493724871,2
    		C--118398349(+) GAGTGC/TAGCTC 1 -- int10--------
    rs1995614251,2
    		--118398364(+) CATAGG/TCTGGC 1 -- int10--------
    rs747649571,2
    		--118398600(+) ACTGCC/TAGGTG 1 -- int11Minor allele frequency- T:0.01EA 120
    rs1850532331,2
    		--118398703(+) GTTCCA/GATATA 1 -- int10--------
    rs1437235631,2
    		--118398828(+) TCCTTC/TGTTTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for TTC36 (118398187 - 118401912 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TTC36: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC36
    DNA2.0 Custom Variant and Variant Library Synthesis for TTC36

    Disorders / Diseases
    for TTC36 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TTC36 for disorders           About GeneDecksing

    3 diseases for TTC36:    About MalaCards
    proliferative vitreoretinopathy    vitreoretinopathy    breast cancer


    Export disorders for TTC36 gene to outside databases

    Publications
    for TTC36 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TTC36 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TTC36)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. HBP21: a novel member of TPR motif family, as a potential chaperone of heat shock protein 70 in proliferative vitreoretinopathy (PVR) and breast cancer. (PubMed id 18587674)1 Liu Q....Li J. (2008)
    2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    External Searches for TTC36 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TTC36 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 143941 HGNC: 33708 AceView: LOC143941 Ensembl:ENSG00000172425 euGenes: HUgn143941
    ECgene: TTC36 H-InvDB: TTC36

    Other Databases showing TTC36 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TTC36 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TTC36 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TTC36 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TTC36 gene:
    Search GeneIP for patents involving TTC36

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TTC36 gene

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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
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