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TTC36 Gene

protein-coding   GIFtS: 41
GCID: GC11P118398

Tetratricopeptide Repeat Domain 36

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tetratricopeptide Repeat Domain 361 2
HSP70 Binding Protein 211 2
HBP212 3
HSP70-Binding Protein 212 3
TPR Repeat Protein 362 3
Tetratricopeptide Repeat Protein 362

External Ids:    HGNC: 337081   Entrez Gene: 1439412   Ensembl: ENSG000001724257   UniProtKB: A6NLP53   

Export aliases for TTC36 gene to outside databases

Previous GC identifers: GC11P117904 GC11P114334


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TTC36 Gene:
TTC36 (tetratricopeptide repeat domain 36) is a protein-coding gene. Diseases associated with TTC36 include proliferative vitreoretinopathy, and malaria.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the TTC36 gene promoter:
         STAT5B   HOXA9   HOXA9B   Sp1   CUTL1   Meis-1b   C/EBPalpha   Chx10   Pax-4a   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TTC36

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTC36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

TTC36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTC36 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P118398:  view genomic region     (about GC identifiers)

Start:
118,398,187 bp from pter      End:
118,401,912 bp from pter
Size:
3,726 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TTC36_HUMAN, A6NLP5 (See protein sequence)
Recommended Name: Tetratricopeptide repeat protein 36  
Size: 189 amino acids; 20896 Da
Secondary accessions: B9EJD8

Explore the universe of human proteins at neXtProt for TTC36: NX_A6NLP5

Explore proteomics data for TTC36 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TTC36 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073910.1  
    ENSEMBL proteins: 
     ENSP00000307640   ENSP00000436858   ENSP00000437178   ENSP00000442513  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    4 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR013105 TPR_2
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry A6NLP5

    ProtoNet protein and cluster: A6NLP5

    UniProtKB/Swiss-Prot: TTC36_HUMAN, A6NLP5
    Similarity: Belongs to the TTC36 family
    Similarity: Contains 3 TPR repeats


    TTC36 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    TTC36 for ontologies           About GeneDecksing


    Animal Models:
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    hsa-mir-484 (MIRT042389)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TTC36
    Interactions:

        Search GeneGlobe Interaction Network for TTC36

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TTC36 (A6NLP53 ENSP000003076404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HPDP327543, ENSP000002890044I2D: score=4 STRING: ENSP00000289004
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TTC36



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TTC36 gene: 
    NM_001080441.1  

    Unigene Cluster for TTC36:

    Tetratricopeptide repeat domain 36
    Hs.653449  [show with all ESTs]
    Unigene Representative Sequence: BC171913
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302783(uc001ptg.1) ENST00000533501(uc010ryc.1) ENST00000528570
    ENST00000539546(uc010ryb.1)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TTC36
      QuantiFast Probe-based Assays in human, mouse, rat TTC36

    Additional mRNA sequence: 

    BC146916.1 BC146921.1 BC171906.1 BC171913.1 EU489483.1 

    4 DOTS entries:

    DT.92416599  DT.86840728  DT.95106475  DT.65285882 

    20 AceView cDNA sequences:

    BF224415 AW269161 CB164226 AW027968 BX106396 CB164093 AI640368 AI016050 
    AW270894 AI253088 AW275376 AI307378 AW269171 BE048453 W25058 AW780033 
    AW300427 AA937148 BF197564 N92830 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TTC36 expression in normal human tissues (normalized intensities)      TTC36 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGGGCAGC
    TTC36 Expression
    About this image


    TTC36 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Loop of Henle Cells Loop of Henle
             Proximal Tubule
     
     Epithelial Cells
             Loop of Henle Cells Loop of Henle
     
     Liver (Hepatobiliary System)
    TTC36 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TTC36 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.653449
        Custom PCR Arrays for TTC36
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC36

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TTC36 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttc361 , 5 tetratricopeptide repeat domain 361, 5 86.74(n)1
    89.25(a)1
      9 (24.84 cM)5
    1926531  NM_138951.11  NP_620401.11 
     447994005 
    chicken
    (Gallus gallus)
    Aves TTC361 tetratricopeptide repeat domain 36 72.34(n)
    69.23(a)
      419757  NM_001278062.1  NP_001264991.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ttc361 tetratricopeptide repeat domain 36 60.61(n)
    60.96(a)
      548489  NM_001015772.1  NP_001015772.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ttc361 tetratricopeptide repeat domain 36 61.78(n)
    60.87(a)
      492516  NM_001007388.1  NP_001007389.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG141051 CG14105 48.48(n)
    43.75(a)
      39507  NM_140387.2  NP_648644.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F52H3.51 F52H3.5 47.08(n)
    46.33(a)
      174562  NM_063767.3  NP_496168.1 


    ENSEMBL Gene Tree for TTC36 (if available)
    TreeFam Gene Tree for TTC36 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TTC36 (see all 43)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1404172611,2
    --118398072(+) CAGCCA/GTGGAC 1 -- us2k10--------
    rs1449415101,2
    --118398073(+) AGCCAG/TGGACA 1 -- us2k10--------
    rs2012453161,2
    --118398195(+) GGATTC/TTGGAG 1 -- us2k10--------
    rs2004871861,2
    --118398310(+) AGAAAA/CGGAAG 2 K T mis10--------
    rs1387440021,2
    C--118398347(+) TGGAGC/TGTAGC 1 -- int10--------
    rs1493724871,2
    C--118398349(+) GAGTGC/TAGCTC 1 -- int10--------
    rs1995614251,2
    --118398364(+) CATAGG/TCTGGC 1 -- int10--------
    rs747649571,2
    F--118398600(+) ACTGCC/TAGGTG 1 -- int11Minor allele frequency- T:0.01EA 120
    rs1850532331,2
    --118398703(+) GTTCCA/GATATA 1 -- int10--------
    rs1437235631,2
    --118398828(+) TCCTTC/TGTTTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for TTC36 (118398187 - 118401912 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TTC36:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1319n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TTC36
    DNA2.0 Custom Variant and Variant Library Synthesis for TTC36

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for TTC36:    About MalaCards
    proliferative vitreoretinopathy    malaria    breast cancer


    TTC36 for disorders           About GeneDecksing


    Export disorders for TTC36 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TTC36 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TTC36)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    2. HBP21: a novel member of TPR motif family, as a potential chaperone of heat shock protein 70 in proliferative vitreoretinopathy (PVR) and breast cancer. (PubMed id 18587674)1 Liu Q....Li J. (Mol. Biotechnol. 2008)
    3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 143941 HGNC: 33708 AceView: LOC143941 Ensembl:ENSG00000172425 euGenes: HUgn143941
    ECgene: TTC36 H-InvDB: TTC36

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TTC36 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TTC36 gene:
    Search GeneIP for patents involving TTC36

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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