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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TTC34 Gene

protein-coding   GIFtS: 34
GCID: GC01M002567

Tetratricopeptide Repeat Domain 34

  Search for TTC34
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tetratricopeptide Repeat Domain 341 2
TPR Repeat Protein 342 3
Tetratricopeptide Repeat Protein 342
TPR Repeat-Containing Protein ENSP000003838732

External Ids:    HGNC: 342971   Entrez Gene: 1002878982   Ensembl: ENSG000002159127   UniProtKB: A8MYJ73   

Export aliases for TTC34 gene to outside databases

Previous GC identifers: GC01M002689 GC01M001993


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TTC34 Gene: 
TTC34 (tetratricopeptide repeat domain 34) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004350.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TTC34
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TTC34

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.32   Ensembl cytogenetic band:  1p36.32   HGNC cytogenetic band: 1p36.32

TTC34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTC34 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M002567:  view genomic region     (about GC identifiers)

Start:
2,567,415 bp from pter      End:
2,718,286 bp from pter
Size:
150,872 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TTC34_HUMAN, A8MYJ7 (See protein sequence)
Recommended Name: Tetratricopeptide repeat protein 34  
Size: 566 amino acids; 60903 Da
Secondary accessions: A8MXL8

Explore the universe of human proteins at neXtProt for TTC34: NX_A8MYJ7

Explore proteomics data for TTC34 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A8MYJ7

  • TTC34 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TTC34 Protein Expression
    REFSEQ proteins: NP_001229601.1  
    ENSEMBL proteins: 
     ENSP00000387700   ENSP00000458658   ENSP00000383873  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TTC: Tetratricopeptide (TTC) repeat domain containing

    5 InterPro protein domains:
     IPR001440 TPR-1
     IPR011990 TPR-like_helical
     IPR013105 TPR_2
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry A8MYJ7

    ProtoNet protein and cluster: A8MYJ7

    UniProtKB/Swiss-Prot: TTC34_HUMAN, A8MYJ7
    Similarity: Contains 8 TPR repeats


    TTC34 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    TTC34 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TTC34:
     Elongated cells 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTC34

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TTC34 (A8MYJ73 ENSP000003838734) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP4CP605103, ENSP000002793874I2D: score=1 STRING: ENSP00000279387
    KNCNENSP000003796074STRING: ENSP00000379607
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TTC34

    Search CenterWatch for drugs/clinical trials and news about TTC34

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TTC34 gene: 
    NM_001242672.1  

    Unigene Cluster for TTC34:

    Tetratricopeptide repeat domain 34
    Hs.632363  [show with all ESTs]
    Unigene Representative Sequence: NM_001242672
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000579787 ENST00000401094 ENST00000574621 ENST00000401095(uc021oey.1)

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    1 DOTS entry:

    DT.121402725 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TTC34 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TTC34 Expression
    About this image


    See TTC34 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.632363
        SABiosciences Custom PCR Arrays for TTC34
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC34

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TTC34 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttc341 , 5 tetratricopeptide repeat domain 341, 5 74.5(n)1
    69.62(a)1
      4 (85.47 cM)5
    2428001  NM_172878.31  NP_766466.31 
     1548562005 
    chicken
    (Gallus gallus)
    Aves TTC346
    Uncharacterized protein
    46(a)
    1 ↔ 1
    21(1367915-1378596)
    lizard
    (Anolis carolinensis)
    Reptilia TTC346
    Uncharacterized protein
    33(a)
    1 ↔ 1
    GL343880.1(114532-125396)
    zebrafish
    (Danio rerio)
    Actinopterygii TTC346
    tetratricopeptide repeat domain 34
    40(a)
    1 ↔ 1
    23(21084297-21089394)


    ENSEMBL Gene Tree for TTC34 (if available)
    TreeFam Gene Tree for TTC34 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TTC34 gene

    TTC34 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TTC34
    PGOHUM00000248019 PGOHUM00000246177


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3351 SNPs in TTC34 are shown (see all 3351)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1874769411,2
    --2572312(+) GGGACA/CAGGTT 1 -- ds50010--------
    rs1929881841,2
    --2572413(+) AGGCTG/TGCTGT 1 -- ds50010--------
    rs1840479631,2
    --2572643(+) TGTGGG/TGAGGG 1 -- ds50010--------
    rs1887941581,2
    --2573093(+) GCAGGA/CGACCC 2 R L mis10--------
    rs46486621,2
    C,F,H--2573199(+) CTGCAG/ACTCGG 2 /L syn116Minor allele frequency- A:0.09NS NA CSA WA EA 1324
    rs1925804941,2
    --2573266(+) GACAGC/TGAACA 2 S syn10--------
    rs1447567721,2
    --2573436(+) TGCTGG/TCTCCC 1 -- int10--------
    rs1844257881,2
    --2573480(+) TGCCCA/GCTGCT 1 -- int10--------
    rs46486631,2
    C--2573727(+) CCTTGC/ACTGGG 1 -- int111Minor allele frequency- A:0.09NA WA CSA EA 258
    rs1160446281,2
    F--2573777(+) GTCACC/TTCTCC 1 -- int11Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for TTC34 (2567415 - 2718286 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/84 variations for TTC34 (see all 84):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv9e201CNV Deletion23290073
    esv1134902CNV Deletion17803354
    esv993173CNV Deletion20482838
    dgv5e199CNV Deletion23128226
    esv2721695CNV Deletion23290073
    esv2661153CNV Deletion23128226
    esv997173CNV Deletion20482838
    esv2720917CNV Deletion23290073
    esv1460747CNV Deletion17803354
    esv1366162CNV Deletion17803354

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TTC34 for disorders           About MalaCards

    TTC34 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TTC34

    Export disorders for TTC34 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TTC34 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TTC34)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100287898 HGNC: 34297 Ensembl:ENSG00000215912 euGenes: HUgn100287898 ECgene: TTC34
    H-InvDB: TTC34

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TTC34 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TTC34 gene:
    Search GeneIP for patents involving TTC34

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Proteins for TTC34
     Antibodies for TTC34
     ELISAs for TTC34
     CLIAs for TTC34
     Search LifeMap BioReagents cell lines for TTC34
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC34
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TTC34
     Browse SwitchGear Promoter luciferase reporter plasmids for TTC34
     Search ThermoFisher Antibodies for TTC34
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TTC34
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TTC34
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TTC34
    Customized:
     lentivirus for stable overexpression of TTC34
     lentivirus expression plasmids for stable overexpression of TTC34
     adenovirus for overexpression of TTC34
     Search LSBio for Antibodies for TTC34
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    transforming growth factor, beta 1
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