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Aliases for TTC34 Gene

Aliases for TTC34 Gene

  • Tetratricopeptide Repeat Domain 34 2 3 5
  • TPR Repeat Protein 34 4

External Ids for TTC34 Gene

Previous GeneCards Identifiers for TTC34 Gene

  • GC01M002689
  • GC01M002567
  • GC01M001993

Summaries for TTC34 Gene

GeneCards Summary for TTC34 Gene

TTC34 (Tetratricopeptide Repeat Domain 34) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC34 Gene

Genomics for TTC34 Gene

Genomic Location for TTC34 Gene

2,635,976 bp from pter
2,789,755 bp from pter
153,780 bases
Minus strand

Genomic View for TTC34 Gene

Genes around TTC34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC34 Gene

No data available for Regulatory Elements for TTC34 Gene

Proteins for TTC34 Gene

  • Protein details for TTC34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tetratricopeptide repeat protein 34
    Protein Accession:
    Secondary Accessions:
    • A8MXL8

    Protein attributes for TTC34 Gene

    566 amino acids
    Molecular mass:
    60903 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TTC34 Gene

Proteomics data for TTC34 Gene at MOPED

Post-translational modifications for TTC34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTC34 Gene

Domains & Families for TTC34 Gene

Gene Families for TTC34 Gene

Protein Domains for TTC34 Gene

Suggested Antigen Peptide Sequences for TTC34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 8 TPR repeats.
  • Contains 8 TPR repeats.
genes like me logo Genes that share domains with TTC34: view

Function for TTC34 Gene

genes like me logo Genes that share phenotypes with TTC34: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TTC34 Gene

Localization for TTC34 Gene

Subcellular locations from

Jensen Localization Image for TTC34 Gene COMPARTMENTS Subcellular localization image for TTC34 gene
Compartment Confidence
cytosol 2
mitochondrion 2
endoplasmic reticulum 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC34 Gene

Pathways & Interactions for TTC34 Gene

SuperPathways for TTC34 Gene

No Data Available

Interacting Proteins for TTC34 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: A8MYJ7-TTC34_HUMAN ENSP00000383873 for TTC34 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for TTC34 Gene


No data available for Pathways by source and SIGNOR curated interactions for TTC34 Gene

Drugs & Compounds for TTC34 Gene

No Compound Related Data Available

Transcripts for TTC34 Gene

mRNA/cDNA for TTC34 Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TTC34 Gene

Tetratricopeptide repeat domain 34:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC34 Gene

No ASD Table

Relevant External Links for TTC34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTC34 Gene

mRNA expression in normal human tissues for TTC34 Gene

mRNA differential expression in normal tissues according to GTEx for TTC34 Gene

This gene is overexpressed in Testis (x12.2).

SOURCE GeneReport for Unigene cluster for TTC34 Gene Hs.632363

genes like me logo Genes that share expression patterns with TTC34: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TTC34 Gene

Orthologs for TTC34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC34 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TTC34 35
  • 79.88 (n)
  • 75.75 (a)
TTC34 36
  • 74 (a)
(Canis familiaris)
Mammalia TTC34 35
  • 81.57 (n)
  • 75.8 (a)
TTC34 36
  • 75 (a)
(Mus musculus)
Mammalia Ttc34 35
  • 74.49 (n)
  • 69.49 (a)
Ttc34 16
Ttc34 36
  • 69 (a)
(Rattus norvegicus)
Mammalia Ttc34 35
  • 75.27 (n)
  • 70.58 (a)
(Monodelphis domestica)
Mammalia TTC34 36
  • 31 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
-- 36
  • 44 (a)
(Pan troglodytes)
Mammalia TTC34 36
  • 98 (a)
(Gallus gallus)
Aves TTC34 36
  • 46 (a)
(Anolis carolinensis)
Reptilia TTC34 36
  • 33 (a)
(Danio rerio)
Actinopterygii TTC34 36
  • 41 (a)
Species with no ortholog for TTC34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC34 Gene

Gene Tree for TTC34 (if available)
Gene Tree for TTC34 (if available)

Paralogs for TTC34 Gene Pseudogenes for TTC34 Gene

genes like me logo Genes that share paralogs with TTC34: view

No data available for Paralogs for TTC34 Gene

Variants for TTC34 Gene

Sequence variations from dbSNP and Humsavar for TTC34 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1456462 -- 2,785,251(-) GGAAC(C/G)CGGCC intron-variant
rs1456463 -- 2,785,234(-) TTAGT(A/G)AGCAC intron-variant
rs4074340 -- 2,645,098(-) CTCCT(C/T)TGCTT intron-variant
rs4074927 -- 2,687,365(-) TGGGG(G/T)TGGGG intron-variant
rs4075560 -- 2,643,657(+) CGGGG(C/G)GGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC34 Gene

Variant ID Type Subtype PubMed ID
dgv75n71 CNV Loss 21882294
nsv470684 CNV Loss 18288195
nsv870655 CNV Loss 21882294
nsv871833 CNV Loss 21882294
dgv85n71 CNV Loss 21882294
nsv428399 CNV Gain 18775914
esv21805 CNV Gain+Loss 19812545
esv994553 CNV Insertion 20482838
nsv824586 CNV Gain 20364138
nsv161117 CNV Loss 16902084
dgv9e201 CNV Deletion 23290073
dgv1n6 CNV Loss 16902084
esv1381913 CNV Insertion 17803354
nsv820462 CNV Duplication 20802225
nsv160953 CNV Loss 16902084
nsv160689 CNV Loss 16902084
dgv10e201 CNV Deletion 23290073
esv2720917 CNV Deletion 23290073
esv2721139 CNV Deletion 23290073
esv999533 CNV Deletion 20482838
dgv86n71 CNV Loss 21882294
nsv159794 CNV Loss 16902084
nsv159997 CNV Loss 16902084
nsv160053 CNV Insertion 16902084
dgv4e199 CNV Deletion 23128226
esv8624 CNV Loss 19470904
dgv5e199 CNV Deletion 23128226
esv2721250 CNV Deletion 23290073
esv1995006 CNV Deletion 18987734
esv999575 CNV Deletion 20482838
nsv5853 CNV Insertion 18451855
esv1159004 CNV Insertion 17803354
esv1780740 CNV Deletion 17803354
esv1286791 CNV Deletion 17803354
esv1001627 CNV Deletion 20482838
esv1366162 CNV Deletion 17803354
esv1701153 CNV Deletion 17803354
esv990905 CNV Deletion 20482838
esv1348726 CNV Insertion 17803354
esv992616 CNV Deletion 20482838
esv1068112 CNV Insertion 17803354
esv1134902 CNV Deletion 17803354
esv1460747 CNV Deletion 17803354
esv1312498 CNV Deletion 17803354
esv997173 CNV Deletion 20482838
esv1162144 CNV Deletion 17803354
esv2721472 CNV Deletion 23290073
esv1394797 CNV Deletion 17803354
nsv160294 CNV Loss 16902084
esv1779754 CNV Insertion 17803354
esv2672332 CNV Deletion 23128226
esv993173 CNV Deletion 20482838
nsv159383 CNV Loss 16902084
esv989273 CNV Deletion 20482838
esv6961 CNV Loss 19470904
nsv159584 CNV Loss 16902084
esv2721583 CNV Deletion 23290073
nsv6964 CNV Insertion 18451855
nsv160877 CNV Loss 16902084
nsv7534 CNV Insertion 18451855
esv2663943 CNV Deletion 23128226
nsv160247 CNV Loss 16902084
nsv160029 CNV Loss 16902084
nsv160879 CNV Loss 16902084
nsv159137 CNV Loss 16902084
nsv160272 CNV Loss 16902084
nsv160341 CNV Loss 16902084
esv2721695 CNV Deletion 23290073
esv2721806 CNV Deletion 23290073
esv2721917 CNV Deletion 23290073
esv6481 CNV Loss 19470904
esv2722028 CNV Deletion 23290073
esv1095177 CNV Insertion 17803354
nsv160000 CNV Loss 16902084
nsv159461 CNV Loss 16902084
esv23086 CNV Gain+Loss 19812545
nsv821258 CNV Duplication 20802225
esv2722139 CNV Deletion 23290073
esv2722250 CNV Deletion 23290073
esv2722361 CNV Deletion 23290073
esv1006680 CNV Deletion 20482838
esv1125194 CNV Deletion 17803354
esv2661153 CNV Deletion 23128226
nsv871110 CNV Loss 21882294

Variation tolerance for TTC34 Gene

Gene Damage Index Score: 3.27; 52.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC34 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC34 Gene

Disorders for TTC34 Gene

Relevant External Links for TTC34

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TTC34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC34 Gene

Publications for TTC34 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for TTC34 Gene

Sources for TTC34 Gene

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