Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TTC33 Gene

Aliases for TTC33 Gene

  • Tetratricopeptide Repeat Domain 33 2 3 5
  • Osmosis Responsive Factor 2 3
  • Osmosis-Responsive Factor 3 4
  • TPR Repeat Protein 33 3 4
  • OSRF 3

External Ids for TTC33 Gene

Previous GeneCards Identifiers for TTC33 Gene

  • GC05M040751
  • GC05M040663
  • GC05M040713

Summaries for TTC33 Gene

GeneCards Summary for TTC33 Gene

TTC33 (Tetratricopeptide Repeat Domain 33) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC33 Gene

Genomics for TTC33 Gene

Regulatory Elements for TTC33 Gene

Promoters for TTC33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TTC33 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTC33 Gene

40,711,576 bp from pter
40,755,975 bp from pter
44,400 bases
Minus strand

Genomic View for TTC33 Gene

Genes around TTC33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC33 Gene

Proteins for TTC33 Gene

  • Protein details for TTC33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tetratricopeptide repeat protein 33
    Protein Accession:
    Secondary Accessions:
    • B2R6G0
    • O95105

    Protein attributes for TTC33 Gene

    262 amino acids
    Molecular mass:
    29411 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TTC33 Gene

Proteomics data for TTC33 Gene at MOPED

Post-translational modifications for TTC33 Gene

  • Ubiquitination at Lys 179
  • Modification sites at PhosphoSitePlus

Other Protein References for TTC33 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTC33 Gene

Domains & Families for TTC33 Gene

Gene Families for TTC33 Gene

Protein Domains for TTC33 Gene

Suggested Antigen Peptide Sequences for TTC33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 TPR repeats.
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with TTC33: view

Function for TTC33 Gene

genes like me logo Genes that share phenotypes with TTC33: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC33 Gene

Localization for TTC33 Gene

Subcellular locations from

Jensen Localization Image for TTC33 Gene COMPARTMENTS Subcellular localization image for TTC33 gene
Compartment Confidence
cytosol 3
nucleus 3
golgi apparatus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC33 Gene

Pathways & Interactions for TTC33 Gene

SuperPathways for TTC33 Gene

No Data Available

Interacting Proteins for TTC33 Gene

Gene Ontology (GO) - Biological Process for TTC33 Gene


No data available for Pathways by source and SIGNOR curated interactions for TTC33 Gene

Drugs & Compounds for TTC33 Gene

No Compound Related Data Available

Transcripts for TTC33 Gene

mRNA/cDNA for TTC33 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TTC33 Gene

Tetratricopeptide repeat domain 33:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC33 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP3: - -
SP4: - - -

Relevant External Links for TTC33 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTC33 Gene

mRNA expression in normal human tissues for TTC33 Gene

Protein differential expression in normal tissues from HIPED for TTC33 Gene

This gene is overexpressed in Platelet (32.6), Pancreas (19.8), and Retina (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTC33 Gene

SOURCE GeneReport for Unigene cluster for TTC33 Gene Hs.348915

genes like me logo Genes that share expression patterns with TTC33: view

Protein tissue co-expression partners for TTC33 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTC33 Gene

Orthologs for TTC33 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC33 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TTC33 35
  • 99.87 (n)
  • 99.62 (a)
TTC33 36
  • 100 (a)
(Bos Taurus)
Mammalia TTC33 36
  • 94 (a)
TTC33 35
  • 91.98 (n)
  • 93.89 (a)
(Canis familiaris)
Mammalia TTC33 35
  • 91.98 (n)
  • 93.89 (a)
TTC33 36
  • 94 (a)
(Mus musculus)
Mammalia Ttc33 16
Ttc33 36
  • 82 (a)
Ttc33 35
  • 81.81 (n)
  • 82.06 (a)
(Monodelphis domestica)
Mammalia TTC33 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia TTC33 36
  • 61 (a)
(Rattus norvegicus)
Mammalia Ttc33 35
  • 83.46 (n)
  • 83.21 (a)
(Gallus gallus)
Aves TTC33 36
  • 76 (a)
TTC33 35
  • 78.16 (n)
  • 76.63 (a)
(Anolis carolinensis)
Reptilia TTC33 36
  • 72 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14643 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc33 35
  • 63.32 (n)
  • 59.46 (a)
(Danio rerio)
Actinopterygii ttc33 36
  • 53 (a)
ttc33 35
  • 60.15 (n)
  • 55.56 (a)
Species with no ortholog for TTC33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC33 Gene

Gene Tree for TTC33 (if available)
Gene Tree for TTC33 (if available)

Paralogs for TTC33 Gene

No data available for Paralogs for TTC33 Gene

Variants for TTC33 Gene

Sequence variations from dbSNP and Humsavar for TTC33 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs837105 - 40,746,814(+) AGCCA(A/T)ACTGG reference, missense
rs29742 -- 40,756,406(+) CAGCC(A/T)GAACG upstream-variant-2KB
rs249422 -- 40,742,440(-) ctgca(A/G)aaaat intron-variant
rs249423 -- 40,743,852(-) ATTAC(A/G)TTTTT intron-variant
rs249424 -- 40,753,315(-) gcaat(C/T)tcggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC33 Gene

Variant ID Type Subtype PubMed ID
nsv880539 CNV Loss 21882294
esv2668589 CNV Deletion 23128226
esv2730119 CNV Deletion 23290073
dgv6040n71 CNV Loss 21882294
nsv880438 CNV Loss 21882294

Variation tolerance for TTC33 Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC33 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC33 Gene

Disorders for TTC33 Gene

Relevant External Links for TTC33

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TTC33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC33 Gene

Publications for TTC33 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3

Products for TTC33 Gene

Sources for TTC33 Gene

Back to Top