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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TTC32 Gene

protein-coding   GIFtS: 43
GCID: GC02M020096

Tetratricopeptide Repeat Domain 32

  Search for TTC32
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tetratricopeptide Repeat Domain 321 2
TPR Repeat Protein 322 3
Tetratricopeptide Repeat Protein 322

External Ids:    HGNC: 329541   Entrez Gene: 1305022   Ensembl: ENSG000001838917   UniProtKB: Q5I0X73   

Export aliases for TTC32 gene to outside databases

Previous GC identifers: GC02M019959 GC02M019853


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TTC32 Gene: 
TTC32 (tetratricopeptide repeat domain 32) is a protein-coding gene. GO annotations related to this gene include identical protein binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_015926.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TTC32 gene promoter:
         MEF-2A   C/EBPbeta   HTF   c-Myb   aMEF-2   CUTL1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTC32 promoter sequence
   Search SABiosciences Chromatin IP Primers for TTC32

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC32


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24.1   Ensembl cytogenetic band:  2p24.1   HGNC cytogenetic band: 2p24.1

TTC32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTC32 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M020096:  view genomic region     (about GC identifiers)

Start:
20,096,404 bp from pter      End:
20,101,747 bp from pter
Size:
5,344 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TTC32_HUMAN, Q5I0X7 (See protein sequence)
Recommended Name: Tetratricopeptide repeat protein 32  
Size: 151 amino acids; 17296 Da

Explore the universe of human proteins at neXtProt for TTC32: NX_Q5I0X7

Explore proteomics data for TTC32 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5I0X7

  • TTC32 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TTC32 Protein Expression
    REFSEQ proteins: NP_001008238.1  
    ENSEMBL proteins: 
     ENSP00000385708   ENSP00000333018   ENSP00000412874  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TTC: Tetratricopeptide (TTC) repeat domain containing

    4 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR011717 TPR-4
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry Q5I0X7

    ProtoNet protein and cluster: Q5I0X7

    UniProtKB/Swiss-Prot: TTC32_HUMAN, Q5I0X7
    Similarity: Contains 3 TPR repeats


    TTC32 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042802identical protein binding IEA--
         
    TTC32 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTC32

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for TTC32 (Q5I0X73 ENSP000003330184) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYOGP151733I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TTC32

    Search CenterWatch for drugs/clinical trials and news about TTC32

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TTC32 gene: 
    NM_001008237.1  

    Unigene Cluster for TTC32:

    Tetratricopeptide repeat domain 32
    Hs.591547  [show with all ESTs]
    Unigene Representative Sequence: BC050088
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000402414 ENST00000333610(uc002rdg.3) ENST00000495698 ENST00000431392

    miRNA
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    hsa-miR-551b*
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TTC32 (NM_001008237)
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                         Customized lentivirus expression plasmids for stable overexpression of TTC32 
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    Additional mRNA sequence: 

    BC050088.1 BC057850.1 BC070381.1 

    5 DOTS entries:

    DT.92420878  DT.99986560  DT.448381  DT.92420877  DT.121645424 

    24/76 AceView cDNA sequences (see all 76):

    AI492364 AW151698 BG116043 AI253103 AW293658 AA576733 BC050088 BX951044 
    BU729749 CA450143 BU617722 AW271392 AI479584 BE465877 BG149801 BE501080 
    AW519289 AI373045 AW204623 C00008 AI492498 BM982020 AI693068 AI016706 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TTC32    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:              -     -     -     -                                 
    SP2:                          -     -                                 
    SP3:                                -                                 
    SP4:              -     -     -                                       
    SP5:                                                                  


    ECgene alternative splicing isoforms for TTC32

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TTC32 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCTTACAT
    TTC32 Expression
    About this image


    See TTC32 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TTC32

    SOURCE GeneReport for Unigene cluster: Hs.591547
        SABiosciences Custom PCR Arrays for TTC32
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC32

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TTC32 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttc321 , 5 tetratricopeptide repeat domain 321, 5 82.85(n)1
    80.43(a)1
      12 (3.98 cM)5
    755161  NM_029321.21  NP_083597.11 
     90299975 
    chicken
    (Gallus gallus)
    Aves TTC321 tetratricopeptide repeat domain 32 65.57(n)
    67.21(a)
      769943  XM_001233259.2  XP_001233260.1 
    lizard
    (Anolis carolinensis)
    Reptilia TTC326
    Uncharacterized protein
    63(a)
    1 ↔ 1
    1(154731307-154737823)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.338152 Xenopus laevis transcribed sequence with weak similarity more 76.31(n)    AW636824.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ttc321 tetratricopeptide repeat domain 32 63.23(n)
    61.11(a)
      100004012  NM_001025520.1  NP_001020691.1 


    ENSEMBL Gene Tree for TTC32 (if available)
    TreeFam Gene Tree for TTC32 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/167 SNPs in TTC32 are shown (see all 167)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1394536651,2
    C--20096096(+) GAACT-/GAGA  
            
    GAAAC
    1 -- int10--------
    rs1392033801,2
    C--20096509(+) CCACAC/TATTCC 1 -- int10--------
    rs1901520441,2
    --20096589(+) AACCCA/GTTCAA 1 -- ut310--------
    rs2021816601,2
    --20096761(+) TTTTTA/GCAACA 2 A V mis10--------
    rs1471169331,2
    C--20096767(+) CAACAT/CTTCTT 2 /N /S mis11Minor allele frequency- C:0.00NA 3968
    rs762629171,2
    C--20096779(+) TTTGTT/CTTTCT 2 /K /R mis11Minor allele frequency- C:0.00EU 1159
    rs132571,2
    C,F--20096799(+) AGAATA/GGTCTG 2 T syn13Minor allele frequency- G:0.00MN WA NA 4474
    rs1482956961,2
    F--20096818(+) TCAAAG/ATAGCA 2 /T /I mis11Minor allele frequency- A:0.00NA 4296
    rs617405651,2
    C,F--20096846(+) TAAGTC/GTAAGA 2 H D mis13Minor allele frequency- G:0.04NS WA NA 4468
    rs1150567721,2
    C,F--20096899(+) CAGAAC/TCCAAA 1 -- int11Minor allele frequency- T:0.05WA 118

    HapMap Linkage Disequilibrium report for TTC32 (20096404 - 20101747 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TTC32:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv29979CNV Loss17803354
    nsv521619CNV Loss19592680
    nsv522640CNV Loss19592680
    dgv4067n71CNV Gain21882294
    nsv873715CNV Gain21882294
    nsv873714CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TTC32 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TTC32)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    3. Genome-wide association study in Han Chinese identifie s four new susceptibility loci for coronary artery disease. (PubMed id 22751097)1 Lu X....Gu D. (2012)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 130502 HGNC: 32954 AceView: LOC130502 Ensembl:ENSG00000183891 euGenes: HUgn130502
    ECgene: TTC32 H-InvDB: TTC32

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TTC32 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TTC32 gene:
    Search GeneIP for patents involving TTC32

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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