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Aliases for TTC32 Gene

Aliases for TTC32 Gene

  • Tetratricopeptide Repeat Domain 32 2 3 5
  • TPR Repeat Protein 32 4

External Ids for TTC32 Gene

Previous GeneCards Identifiers for TTC32 Gene

  • GC02M019959
  • GC02M020096

Summaries for TTC32 Gene

GeneCards Summary for TTC32 Gene

TTC32 (Tetratricopeptide Repeat Domain 32) is a Protein Coding gene. GO annotations related to this gene include identical protein binding.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC32 Gene

Genomics for TTC32 Gene

Regulatory Elements for TTC32 Gene

Enhancers for TTC32 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G020065 1.5 Ensembl ENCODE dbSUPER 53.9 -164.0 -164000 1.9 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF48 FOS SP5 REST ZNF662 TTC32 MATN3 LINC01376 ENSG00000234378 LOC105373463 GC02M020086
GH02G019899 1.4 ENCODE dbSUPER 44.3 +0.4 375 3.6 CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 SSRP1 ZNF610 TTC32 MATN3 WDR35 LINC00954
GH02G020166 1.5 Ensembl ENCODE dbSUPER 32.2 -264.6 -264647 2.0 HDGF FOXA2 ARNT ZNF493 WRNIP1 ZNF133 YBX1 TCF12 CBX5 ZNF548 TTC32 MATN3 SDC1 LINC01376 GC02M020159 GC02P020178
GH02G019971 0.9 FANTOM5 ENCODE 43.2 -69.9 -69935 1.4 SOX13 JUN NRF1 THRB ZSCAN9 YY1 FOXA1 ZGPAT HNF1A GATA2 TTC32 MATN3 RNU7-113P RNFT1P1 GC02P019954
GH02G019988 1.1 ENCODE 34.1 -88.0 -88048 2.2 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 PAF1 ZNF263 TTC32 MATN3 WDR35 RNFT1P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTC32 on UCSC Golden Path with GeneCards custom track

Promoters for TTC32 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000113704 486 2601 CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 SSRP1 ZNF610

Genomic Location for TTC32 Gene

Chromosome:
2
Start:
19,896,643 bp from pter
End:
19,901,986 bp from pter
Size:
5,344 bases
Orientation:
Minus strand

Genomic View for TTC32 Gene

Genes around TTC32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC32 Gene

Proteins for TTC32 Gene

  • Protein details for TTC32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5I0X7-TTC32_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 32
    Protein Accession:
    Q5I0X7

    Protein attributes for TTC32 Gene

    Size:
    151 amino acids
    Molecular mass:
    17296 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TTC32 Gene

Post-translational modifications for TTC32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC32 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTC32 Gene

Domains & Families for TTC32 Gene

Gene Families for TTC32 Gene

Protein Domains for TTC32 Gene

Suggested Antigen Peptide Sequences for TTC32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TTC32: view

No data available for UniProtKB/Swiss-Prot for TTC32 Gene

Function for TTC32 Gene

Gene Ontology (GO) - Molecular Function for TTC32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TTC32: view
genes like me logo Genes that share phenotypes with TTC32: view

Animal Model Products

CRISPR Products

miRNA for TTC32 Gene

miRTarBase miRNAs that target TTC32

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC32 Gene

Localization for TTC32 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC32 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC32 Gene

Pathways & Interactions for TTC32 Gene

SuperPathways for TTC32 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC32 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC32 Gene

Drugs & Compounds for TTC32 Gene

No Compound Related Data Available

Transcripts for TTC32 Gene

mRNA/cDNA for TTC32 Gene

Unigene Clusters for TTC32 Gene

Tetratricopeptide repeat domain 32:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC32 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - - -
SP2: - -
SP3: -
SP4: - - -
SP5:

Relevant External Links for TTC32 Gene

GeneLoc Exon Structure for
TTC32
ECgene alternative splicing isoforms for
TTC32

Expression for TTC32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTC32 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTC32 Gene



NURSA nuclear receptor signaling pathways regulating expression of TTC32 Gene:

TTC32

SOURCE GeneReport for Unigene cluster for TTC32 Gene:

Hs.591547

Evidence on tissue expression from TISSUES for TTC32 Gene

  • Eye(4.8)
  • Skin(3.4)
genes like me logo Genes that share expression patterns with TTC32: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC32 Gene

Orthologs for TTC32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC32 34 35
  • 99.56 (n)
cow
(Bos Taurus)
Mammalia TTC32 34 35
  • 89.27 (n)
dog
(Canis familiaris)
Mammalia TTC32 34 35
  • 89.14 (n)
mouse
(Mus musculus)
Mammalia Ttc32 34 16 35
  • 82.85 (n)
rat
(Rattus norvegicus)
Mammalia Ttc32 34
  • 81.56 (n)
oppossum
(Monodelphis domestica)
Mammalia TTC32 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC32 34 35
  • 63.98 (n)
lizard
(Anolis carolinensis)
Reptilia TTC32 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc32 34
  • 63.8 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33815 34
zebrafish
(Danio rerio)
Actinopterygii ttc32 34 35
  • 63.25 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2870 34
Species where no ortholog for TTC32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC32 Gene

ENSEMBL:
Gene Tree for TTC32 (if available)
TreeFam:
Gene Tree for TTC32 (if available)

Paralogs for TTC32 Gene

No data available for Paralogs for TTC32 Gene

Variants for TTC32 Gene

Sequence variations from dbSNP and Humsavar for TTC32 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000167483 -- 19,897,584(+) AACAT(C/G)TGAAT intron-variant
rs1000486709 -- 19,903,745(+) GAGCC(A/G)CCGCA upstream-variant-2KB
rs1000732187 -- 19,903,447(+) CTAGG(C/T)GGGCA upstream-variant-2KB
rs1000994132 -- 19,901,927(+) AAAGC(C/T)ACTTC utr-variant-5-prime
rs1001222310 -- 19,902,163(+) CGAGA(C/T)ACTAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TTC32 Gene

Variant ID Type Subtype PubMed ID
esv29979 CNV loss 17803354
nsv521619 CNV loss 19592680
nsv522640 CNV loss 19592680

Variation tolerance for TTC32 Gene

Residual Variation Intolerance Score: 48.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC32 Gene

Disorders for TTC32 Gene

Relevant External Links for TTC32

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC32

No disorders were found for TTC32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC32 Gene

Publications for TTC32 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  3. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3 64
  4. Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. (PMID: 22751097) Lu X. … Gu D. (Nat. Genet. 2012) 3 64
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3 64

Products for TTC32 Gene

Sources for TTC32 Gene

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