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Aliases for TTC31 Gene

Aliases for TTC31 Gene

  • Tetratricopeptide Repeat Domain 31 2 3 5
  • TPR Repeat Protein 31 4

External Ids for TTC31 Gene

Previous GeneCards Identifiers for TTC31 Gene

  • GC02P074564
  • GC02P074710
  • GC02P074446

Summaries for TTC31 Gene

GeneCards Summary for TTC31 Gene

TTC31 (Tetratricopeptide Repeat Domain 31) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC31 Gene

Genomics for TTC31 Gene

Regulatory Elements for TTC31 Gene

Promoters for TTC31 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TTC31 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTC31 Gene

Chromosome:
2
Start:
74,483,032 bp from pter
End:
74,494,886 bp from pter
Size:
11,855 bases
Orientation:
Plus strand

Genomic View for TTC31 Gene

Genes around TTC31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC31 Gene

Proteins for TTC31 Gene

  • Protein details for TTC31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49AM3-TTC31_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 31
    Protein Accession:
    Q49AM3
    Secondary Accessions:
    • Q4KN40
    • Q53FD4
    • Q9H9F7

    Protein attributes for TTC31 Gene

    Size:
    519 amino acids
    Molecular mass:
    57105 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC31 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC31 Gene

Proteomics data for TTC31 Gene at MOPED

Post-translational modifications for TTC31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC31 Gene

No data available for DME Specific Peptides for TTC31 Gene

Domains & Families for TTC31 Gene

Gene Families for TTC31 Gene

Protein Domains for TTC31 Gene

Suggested Antigen Peptide Sequences for TTC31 Gene

Graphical View of Domain Structure for InterPro Entry

Q49AM3

UniProtKB/Swiss-Prot:

TTC31_HUMAN :
  • Contains 3 TPR repeats.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with TTC31: view

Function for TTC31 Gene

genes like me logo Genes that share phenotypes with TTC31: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC31 Gene

Localization for TTC31 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC31 Gene COMPARTMENTS Subcellular localization image for TTC31 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC31 Gene

Pathways & Interactions for TTC31 Gene

SuperPathways for TTC31 Gene

No Data Available

Interacting Proteins for TTC31 Gene

Gene Ontology (GO) - Biological Process for TTC31 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC31 Gene

Drugs & Compounds for TTC31 Gene

No Compound Related Data Available

Transcripts for TTC31 Gene

Unigene Clusters for TTC31 Gene

Tetratricopeptide repeat domain 31:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC31 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: - - - -
SP7: - - -
SP8: - -
SP9: - - -
SP10: -
SP11: - - - -
SP12: - - -
SP13: - - - - - - - - - - - - - - - -
SP14:
SP15:
SP16:

ExUns: 14a · 14b · 14c · 14d · 14e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for TTC31 Gene

GeneLoc Exon Structure for
TTC31
ECgene alternative splicing isoforms for
TTC31

Expression for TTC31 Gene

mRNA expression in normal human tissues for TTC31 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTC31 Gene



SOURCE GeneReport for Unigene cluster for TTC31 Gene Hs.557709

genes like me logo Genes that share expression patterns with TTC31: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TTC31 Gene

Orthologs for TTC31 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTC31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC31 36
  • 99 (a)
OneToOne
TTC31 35
  • 99.49 (n)
  • 98.84 (a)
dog
(Canis familiaris)
Mammalia TTC31 35
  • 82 (n)
  • 77.71 (a)
TTC31 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC31 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC31 36
  • 21 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC31 36
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TTC31 36
  • 19 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STI1 36
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 14 (a)
OneToOne
Species with no ortholog for TTC31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC31 Gene

ENSEMBL:
Gene Tree for TTC31 (if available)
TreeFam:
Gene Tree for TTC31 (if available)

Paralogs for TTC31 Gene

(1) SIMAP similar genes for TTC31 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TTC31: view

No data available for Paralogs for TTC31 Gene

Variants for TTC31 Gene

Sequence variations from dbSNP and Humsavar for TTC31 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_047357 -
rs35852562 - 74,491,304(-) TGAGG(G/T)AGTGC nc-transcript-variant, reference, missense
rs1128487 -- 74,494,413(+) aacat(C/T)taagc nc-transcript-variant, utr-variant-3-prime
rs12469716 -- 74,490,887(+) GGGGG(G/T)TCTCT intron-variant
rs12621712 -- 74,489,013(+) ATCAT(A/G)CCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC31 Gene

Variant ID Type Subtype PubMed ID
dgv1199e1 CNV Complex 17122850
nsv458185 CNV Loss 19166990
nsv515851 CNV Loss 19592680
dgv4166n71 CNV Loss 21882294

Variation tolerance for TTC31 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.45; 54.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC31 Gene

HapMap Linkage Disequilibrium report
TTC31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC31 Gene

Disorders for TTC31 Gene

Relevant External Links for TTC31

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC31

No disorders were found for TTC31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC31 Gene

Publications for TTC31 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. [Novel bidirectional promoter from human genome]. (PMID: 21790010) Orekhova A.S. … Rubtsov P.M. (Mol. Biol. (Mosk.) 2011) 3
  5. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3

Products for TTC31 Gene

Sources for TTC31 Gene

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