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Aliases for TTC31 Gene

Aliases for TTC31 Gene

  • Tetratricopeptide Repeat Domain 31 2 3
  • TPR Repeat Protein 31 4

External Ids for TTC31 Gene

Previous GeneCards Identifiers for TTC31 Gene

  • GC02P074564
  • GC02P074710
  • GC02P074446

Summaries for TTC31 Gene

GeneCards Summary for TTC31 Gene

TTC31 (Tetratricopeptide Repeat Domain 31) is a Protein Coding gene. An important paralog of this gene is STIP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC31 Gene

Genomics for TTC31 Gene

Regulatory Elements for TTC31 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TTC31 Gene

74,483,032 bp from pter
74,494,886 bp from pter
11,855 bases
Plus strand

Genomic View for TTC31 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTC31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC31 Gene

Proteins for TTC31 Gene

  • Protein details for TTC31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tetratricopeptide repeat protein 31
    Protein Accession:
    Secondary Accessions:
    • Q4KN40
    • Q53FD4
    • Q9H9F7

    Protein attributes for TTC31 Gene

    519 amino acids
    Molecular mass:
    57105 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC31 Gene


neXtProt entry for TTC31 Gene

Proteomics data for TTC31 Gene at MOPED

Post-translational modifications for TTC31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC31 Gene

No data available for DME Specific Peptides for TTC31 Gene

Domains & Families for TTC31 Gene

Gene Families for TTC31 Gene

Protein Domains for TTC31 Gene

Suggested Antigen Peptide Sequences for TTC31 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 TPR repeats.
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with TTC31: view

Function for TTC31 Gene

Gene Ontology (GO) - Molecular Function for TTC31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TTC31: view
genes like me logo Genes that share phenotypes with TTC31: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTC31

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC31 Gene

Localization for TTC31 Gene

Subcellular locations from

Jensen Localization Image for TTC31 Gene COMPARTMENTS Subcellular localization image for TTC31 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC31 Gene

Pathways & Interactions for TTC31 Gene

SuperPathways for TTC31 Gene

No Data Available

Interacting Proteins for TTC31 Gene

Gene Ontology (GO) - Biological Process for TTC31 Gene


No data available for Pathways by source and SIGNOR curated interactions for TTC31 Gene

Drugs & Compounds for TTC31 Gene

No Compound Related Data Available

Transcripts for TTC31 Gene

Unigene Clusters for TTC31 Gene

Tetratricopeptide repeat domain 31:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTC31

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC31 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: - - - -
SP7: - - -
SP8: - -
SP9: - - -
SP10: -
SP11: - - - -
SP12: - - -
SP13: - - - - - - - - - - - - - - - -

ExUns: 14a · 14b · 14c · 14d · 14e

Relevant External Links for TTC31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTC31 Gene

mRNA expression in normal human tissues for TTC31 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTC31 Gene

SOURCE GeneReport for Unigene cluster for TTC31 Gene Hs.557709

genes like me logo Genes that share expression patterns with TTC31: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TTC31 Gene

Orthologs for TTC31 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTC31 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TTC31 35
  • 82 (n)
  • 77.71 (a)
TTC31 36
  • 68 (a)
(Pan troglodytes)
Mammalia TTC31 35
  • 99.49 (n)
  • 98.84 (a)
TTC31 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia TTC31 36
  • 56 (a)
(Gallus gallus)
Aves TTC31 36
  • 21 (a)
(Anolis carolinensis)
Reptilia TTC31 36
  • 39 (a)
(Danio rerio)
Actinopterygii TTC31 36
  • 19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STI1 36
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 14 (a)
Species with no ortholog for TTC31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC31 Gene

Gene Tree for TTC31 (if available)
Gene Tree for TTC31 (if available)

Paralogs for TTC31 Gene

Paralogs for TTC31 Gene

(1) SIMAP similar genes for TTC31 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TTC31: view

Variants for TTC31 Gene

Sequence variations from dbSNP and Humsavar for TTC31 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1045583 -- 74,494,390(+) GGGTC(A/C)CCTTG utr-variant-3-prime, nc-transcript-variant
rs1128487 -- 74,494,413(+) aacat(C/T)taagc utr-variant-3-prime, nc-transcript-variant
rs2276691 -- 74,490,396(+) CCTCT(A/G)CCTCT missense, reference, nc-transcript-variant, utr-variant-5-prime
rs2301984 -- 74,493,928(-) GCAGC(C/T)TGGGC utr-variant-3-prime, nc-transcript-variant
rs3755445 -- 74,495,043(+) ctgca(A/G)tgacc downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TTC31 Gene

Variant ID Type Subtype PubMed ID
dgv1199e1 CNV Complex 17122850
nsv458185 CNV Loss 19166990
nsv515851 CNV Loss 19592680
dgv4166n71 CNV Loss 21882294

Variation tolerance for TTC31 Gene

Residual Variation Intolerance Score: 86.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.45; 54.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC31 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC31 Gene

Disorders for TTC31 Gene

Relevant External Links for TTC31

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TTC31: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC31 Gene

Publications for TTC31 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. [Novel bidirectional promoter from human genome]. (PMID: 21790010) Orekhova A.S. … Rubtsov P.M. (Mol. Biol. (Mosk.) 2011) 67
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 67
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 67

Products for TTC31 Gene

Sources for TTC31 Gene

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