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Aliases for TTC31 Gene

Aliases for TTC31 Gene

  • Tetratricopeptide Repeat Domain 31 2 3 5
  • TPR Repeat Protein 31 4

External Ids for TTC31 Gene

Previous GeneCards Identifiers for TTC31 Gene

  • GC02P074564
  • GC02P074710
  • GC02P074446

Summaries for TTC31 Gene

GeneCards Summary for TTC31 Gene

TTC31 (Tetratricopeptide Repeat Domain 31) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC31 Gene

Genomics for TTC31 Gene

Regulatory Elements for TTC31 Gene

Enhancers for TTC31 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G074575 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +94.1 94057 3.4 CTCF PKNOX1 MAX CEBPG ZBTB40 EED SMC3 ETV6 CREM ZNF639 DOK1 LOXL3 AUP1 HTRA2 DQX1 TLX2 PCGF1 LBX2 TTC31 CCDC142
GH02G074583 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +100.9 100921 1.6 PKNOX1 BACH1 ZNF316 CBX5 FOS NFE2 MAFK CREM NFE2L2 MTA2 LOXL3 DOK1 HTRA2 AUP1 TLX2 PCGF1 CCDC142 TTC31 DQX1 LBX2
GH02G074528 1.2 ENCODE 11.3 +47.3 47294 4.4 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 LBX2 WBP1 CCDC142 PCGF1 DUSP11 MOGS MTHFD2 ENSG00000273245 TTC31 LOXL3
GH02G074585 1.2 Ensembl dbSUPER 11.3 +102.6 102569 0.4 ELF3 FOXA2 NFIB MLX ARID4B THRB ZNF48 RAD21 RARA SLC30A9 DOK1 LOXL3 HTRA2 AUP1 TLX2 PCGF1 TTC31 CCDC142 DQX1 LBX2
GH02G074587 1.1 Ensembl ENCODE 11.1 +104.8 104769 0.4 HDGF RB1 TBL1XR1 WRNIP1 ARID4B ZNF2 RAD21 ZNF143 THAP11 ZNF654 LBX2 DOK1 MRPL53 AUP1 HTRA2 PCGF1 DQX1 LOXL3 CCDC142 TTC31
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTC31 on UCSC Golden Path with GeneCards custom track

Promoters for TTC31 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000119170 -132 1801 PKNOX1 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for TTC31 Gene

Chromosome:
2
Start:
74,483,032 bp from pter
End:
74,494,886 bp from pter
Size:
11,855 bases
Orientation:
Plus strand

Genomic View for TTC31 Gene

Genes around TTC31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC31 Gene

Proteins for TTC31 Gene

  • Protein details for TTC31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49AM3-TTC31_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 31
    Protein Accession:
    Q49AM3
    Secondary Accessions:
    • Q4KN40
    • Q53FD4
    • Q9H9F7

    Protein attributes for TTC31 Gene

    Size:
    519 amino acids
    Molecular mass:
    57105 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC31 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC31 Gene

Post-translational modifications for TTC31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC31 Gene

Domains & Families for TTC31 Gene

Gene Families for TTC31 Gene

Protein Domains for TTC31 Gene

Suggested Antigen Peptide Sequences for TTC31 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TTC31: view

No data available for UniProtKB/Swiss-Prot for TTC31 Gene

Function for TTC31 Gene

genes like me logo Genes that share phenotypes with TTC31: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC31 Gene

Localization for TTC31 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC31 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC31 Gene

Pathways & Interactions for TTC31 Gene

SuperPathways for TTC31 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC31 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC31 Gene

Transcripts for TTC31 Gene

Unigene Clusters for TTC31 Gene

Tetratricopeptide repeat domain 31:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC31 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: - - - -
SP7: - - -
SP8: - -
SP9: - - -
SP10: -
SP11: - - - -
SP12: - - -
SP13: - - - - - - - - - - - - - - - -
SP14:
SP15:
SP16:

ExUns: 14a · 14b · 14c · 14d · 14e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for TTC31 Gene

GeneLoc Exon Structure for
TTC31
ECgene alternative splicing isoforms for
TTC31

Expression for TTC31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTC31 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTC31 Gene



NURSA nuclear receptor signaling pathways regulating expression of TTC31 Gene:

TTC31

SOURCE GeneReport for Unigene cluster for TTC31 Gene:

Hs.557709
genes like me logo Genes that share expression patterns with TTC31: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC31 Gene

Orthologs for TTC31 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTC31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC31 34 35
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia TTC31 34 35
  • 82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TTC31 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC31 35
  • 21 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC31 35
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TTC31 35
  • 19 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STI1 35
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 14 (a)
OneToOne
Species where no ortholog for TTC31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC31 Gene

ENSEMBL:
Gene Tree for TTC31 (if available)
TreeFam:
Gene Tree for TTC31 (if available)

Paralogs for TTC31 Gene

(1) SIMAP similar genes for TTC31 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TTC31: view

No data available for Paralogs for TTC31 Gene

Variants for TTC31 Gene

Sequence variations from dbSNP and Humsavar for TTC31 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000074070 -- 74,485,979(+) GTCTA(C/T)ACTCA intron-variant
rs1000914543 -- 74,485,835(+) CAGAC(C/T)TCAGG intron-variant
rs1001077083 -- 74,487,599(+) ATACA(A/G)TATAT intron-variant, upstream-variant-2KB
rs1001245829 -- 74,494,562(+) CAACT(A/G)TCCTA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1001365143 -- 74,481,282(+) GAGGA(A/G)GAAAG upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TTC31 Gene

Variant ID Type Subtype PubMed ID
esv2759061 CNV loss 17122850
nsv458185 CNV loss 19166990
nsv472055 CNV novel sequence insertion 20440878
nsv515851 CNV loss 19592680
nsv582214 CNV loss 21841781

Variation tolerance for TTC31 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.45; 54.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC31 Gene

Disorders for TTC31 Gene

Relevant External Links for TTC31

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC31

No disorders were found for TTC31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC31 Gene

Publications for TTC31 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for TTC31 Gene

Sources for TTC31 Gene

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