Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TTC30B Gene

Aliases for TTC30B Gene

  • Tetratricopeptide Repeat Domain 30B 2 3
  • TPR Repeat Protein 30B 3 4
  • Tetratricopeptide Repeat Protein 30B 3
  • IFT70 3
  • Fleer 3

External Ids for TTC30B Gene

Summaries for TTC30B Gene

GeneCards Summary for TTC30B Gene

TTC30B (Tetratricopeptide Repeat Domain 30B) is a Protein Coding gene. An important paralog of this gene is TTC30A.

UniProtKB/Swiss-Prot for TTC30B Gene

  • Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC30B Gene

Genomics for TTC30B Gene

Genomic Location for TTC30B Gene

Start:
177,548,998 bp from pter
End:
177,553,014 bp from pter
Size:
4,017 bases
Orientation:
Minus strand

Genomic View for TTC30B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTC30B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC30B Gene

Regulatory Elements for TTC30B Gene

Proteins for TTC30B Gene

  • Protein details for TTC30B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4P2-TT30B_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 30B
    Protein Accession:
    Q8N4P2
    Secondary Accessions:
    • Q63HQ1
    • Q96NE6

    Protein attributes for TTC30B Gene

    Size:
    665 amino acids
    Molecular mass:
    76099 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TTC30B Gene

Proteomics data for TTC30B Gene at MOPED

Post-translational modifications for TTC30B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys123

Other Protein References for TTC30B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTC30B Gene

Domains for TTC30B Gene

Gene Families for TTC30B Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing
  • IFT :Intraflagellar transport homologs

Protein Domains for TTC30B Gene

UniProtKB/Swiss-Prot:

TT30B_HUMAN
Family:
  • Belongs to the TTC30/dfy-1/fleer family.:
    • Q8N4P2
Similarity:
  • Contains 8 TPR repeats.:
    • Q8N4P2
genes like me logo Genes that share domains with TTC30B: view

Function for TTC30B Gene

Molecular function for TTC30B Gene

UniProtKB/Swiss-Prot Function: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.

Gene Ontology (GO) - Molecular Function for TTC30B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21602787
genes like me logo Genes that share ontologies with TTC30B: view

miRNA for TTC30B Gene

miRTarBase miRNAs that target TTC30B

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TTC30B Gene

Localization for TTC30B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTC30B Gene

Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC30B Gene COMPARTMENTS Subcellular localization image for TTC30B gene
Compartment Confidence
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TTC30B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IBA --
GO:0030992 intraciliary transport particle B IBA --
GO:0072372 primary cilium TAS --
GO:0097542 ciliary tip TAS --
genes like me logo Genes that share ontologies with TTC30B: view

Pathways for TTC30B Gene

SuperPathways for TTC30B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC30B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0042073 intraciliary transport IBA --
GO:0042384 cilium assembly IBA --
genes like me logo Genes that share ontologies with TTC30B: view

No data available for Pathways by source for TTC30B Gene

Transcripts for TTC30B Gene

mRNA/cDNA for TTC30B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TTC30B Gene

Tetratricopeptide repeat domain 30B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC30B Gene

No ASD Table

Relevant External Links for TTC30B Gene

GeneLoc Exon Structure for
TTC30B
ECgene alternative splicing isoforms for
TTC30B

Expression for TTC30B Gene

mRNA expression in normal human tissues for TTC30B Gene

mRNA differential expression in normal tissues according to GTEx for TTC30B Gene

This gene is overexpressed in Testis (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TTC30B Gene

SOURCE GeneReport for Unigene cluster for TTC30B Gene Hs.447659

genes like me logo Genes that share expressions with TTC30B: view

Orthologs for TTC30B Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC30B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC30B 36
  • 99.55 (n)
  • 98.95 (a)
TTC30B 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TTC30A 36
  • 89.86 (n)
  • 93.67 (a)
TTC30A 37
  • 94 (a)
ManyToMany
TTC30B 37
  • 93 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 94 (a)
ManyToMany
-- 37
  • 91 (a)
ManyToMany
TTC30B 36
  • 89.31 (n)
  • 93.83 (a)
mouse
(Mus musculus)
Mammalia Ttc30a1 37
  • 90 (a)
ManyToMany
Ttc30a2 37
  • 92 (a)
ManyToMany
Ttc30b 36
  • 87.3 (n)
  • 92.62 (a)
Ttc30b 16
Ttc30b 37
  • 93 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 94 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ttc30b 36
  • 86.95 (n)
  • 92.32 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 78 (a)
OneToMany
TTC30A 36
  • 74.23 (n)
  • 77.91 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 76 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc30a 36
  • 73.17 (n)
  • 81.72 (a)
zebrafish
(Danio rerio)
Actinopterygii flr 36
  • 71.11 (n)
  • 78.29 (a)
flr 37
  • 78 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta TTC30_ANOGA 36
  • 53.67 (n)
  • 51.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5142 36
  • 53.62 (n)
  • 47.8 (a)
CG5142 37
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dyf-1 36
  • 55.05 (n)
  • 50.24 (a)
dyf-1 37
  • 48 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8524 36
Species with no ortholog for TTC30B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC30B Gene

ENSEMBL:
Gene Tree for TTC30B (if available)
TreeFam:
Gene Tree for TTC30B (if available)

Paralogs for TTC30B Gene

Paralogs for TTC30B Gene

Selected SIMAP similar genes for TTC30B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TTC30B: view

Variants for TTC30B Gene

Sequence variations from dbSNP and Humsavar for TTC30B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1046370 -- 177,550,713(-) GCATC(A/G)CTTTA utr-variant-3-prime
rs1348850 -- 177,553,847(+) TTTCC(A/G)GATTC upstream-variant-2KB
rs1348851 -- 177,553,949(+) GCTGT(A/G)GATTC upstream-variant-2KB
rs1348852 -- 177,554,061(+) TATAT(C/T)TAATC upstream-variant-2KB
rs1852530 -- 177,549,913(-) CTGGC(A/G)CAAAT downstream-variant-500B

Relevant External Links for TTC30B Gene

HapMap Linkage Disequilibrium report
TTC30B

No data available for Structural Variations from Database of Genomic Variants (DGV) for TTC30B Gene

Disorders for TTC30B Gene

No disorders were found for TTC30B Gene.

No data available for UniProtKB/Swiss-Prot for TTC30B Gene

Publications for TTC30B Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos. (PMID: 21602787) Zhao C. … Malicki J. (EMBO J. 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for TTC30B Gene

Sources for TTC30B Gene

Back to Top

Content