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Aliases for TTC30A Gene

Aliases for TTC30A Gene

  • Tetratricopeptide Repeat Domain 30A 2 3
  • TPR Repeat Protein 30A 4

External Ids for TTC30A Gene

Summaries for TTC30A Gene

GeneCards Summary for TTC30A Gene

TTC30A (Tetratricopeptide Repeat Domain 30A) is a Protein Coding gene. An important paralog of this gene is TTC30B.

UniProtKB/Swiss-Prot for TTC30A Gene

  • Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC30A Gene

Genomics for TTC30A Gene

Genomic Location for TTC30A Gene

Start:
177,612,992 bp from pter
End:
177,618,966 bp from pter
Size:
5,975 bases
Orientation:
Minus strand

Genomic View for TTC30A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTC30A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC30A Gene

Regulatory Elements for TTC30A Gene

Proteins for TTC30A Gene

  • Protein details for TTC30A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WT1-TT30A_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 30A
    Protein Accession:
    Q86WT1
    Secondary Accessions:
    • A8K8N0
    • Q8IVP2

    Protein attributes for TTC30A Gene

    Size:
    665 amino acids
    Molecular mass:
    76136 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TTC30A Gene

Proteomics data for TTC30A Gene at MOPED

Post-translational modifications for TTC30A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys123 and Lys643

Other Protein References for TTC30A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTC30A Gene

Domains for TTC30A Gene

Gene Families for TTC30A Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for TTC30A Gene

UniProtKB/Swiss-Prot:

TT30A_HUMAN
Family:
  • Belongs to the TTC30/dfy-1/fleer family.:
    • Q86WT1
Similarity:
  • Contains 8 TPR repeats.:
    • Q86WT1
genes like me logo Genes that share domains with TTC30A: view

Function for TTC30A Gene

Molecular function for TTC30A Gene

UniProtKB/Swiss-Prot Function: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.

Gene Ontology (GO) - Molecular Function for TTC30A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TTC30A: view

Phenotypes for TTC30A Gene

GenomeRNAi human phenotypes for TTC30A:
genes like me logo Genes that share phenotypes with TTC30A: view

miRNA for TTC30A Gene

miRTarBase miRNAs that target TTC30A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TTC30A Gene

Localization for TTC30A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTC30A Gene

Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC30A Gene COMPARTMENTS Subcellular localization image for TTC30A gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TTC30A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IBA --
GO:0030992 intraciliary transport particle B IBA --
genes like me logo Genes that share ontologies with TTC30A: view

Pathways for TTC30A Gene

SuperPathways for TTC30A Gene

No Data Available

Interacting Proteins for TTC30A Gene

Selected Interacting proteins: Q86WT1-TT30A_HUMAN for TTC30A Gene via I2D

Symbol External ID(s) Details
EEF1D

Gene Ontology (GO) - Biological Process for TTC30A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042073 intraciliary transport IBA --
GO:0042384 cilium assembly IBA --
genes like me logo Genes that share ontologies with TTC30A: view

No data available for Pathways by source for TTC30A Gene

Transcripts for TTC30A Gene

mRNA/cDNA for TTC30A Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(46) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TTC30A Gene

Tetratricopeptide repeat domain 30A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC30A Gene

No ASD Table

Relevant External Links for TTC30A Gene

GeneLoc Exon Structure for
TTC30A
ECgene alternative splicing isoforms for
TTC30A

Expression for TTC30A Gene

mRNA expression in normal human tissues for TTC30A Gene

mRNA differential expression in normal tissues according to GTEx for TTC30A Gene

This gene is overexpressed in Testis (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TTC30A Gene

SOURCE GeneReport for Unigene cluster for TTC30A Gene Hs.128384

genes like me logo Genes that share expressions with TTC30A: view

Orthologs for TTC30A Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC30A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC30A 36
  • 99.45 (n)
  • 99.55 (a)
TTC30A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TTC30A 37
  • 93 (a)
ManyToMany
TTC30B 37
  • 91 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 92 (a)
ManyToMany
-- 37
  • 92 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ttc30a1 36
  • 86.53 (n)
  • 90.5 (a)
Ttc30a1 16
Ttc30a1 37
  • 90 (a)
ManyToMany
Ttc30a2 37
  • 91 (a)
ManyToMany
Ttc30b 37
  • 91 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100362431 36
  • 86.07 (n)
  • 90.05 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 75 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.7550 36
zebrafish
(Danio rerio)
Actinopterygii flr 37
  • 76 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5142 37
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dyf-1 37
  • 47 (a)
OneToMany
Species with no ortholog for TTC30A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TTC30A Gene

ENSEMBL:
Gene Tree for TTC30A (if available)
TreeFam:
Gene Tree for TTC30A (if available)

Paralogs for TTC30A Gene

Paralogs for TTC30A Gene

Selected SIMAP similar genes for TTC30A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TTC30A: view

Variants for TTC30A Gene

Sequence variations from dbSNP and Humsavar for TTC30A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2717526 -- 177,616,977(+) TTTTT(A/G)TTATA synonymous-codon, reference
rs2717527 -- 177,616,980(+) TTATT(A/G)TAAGG synonymous-codon, reference
rs2717528 -- 177,617,877(+) ATGTC(A/G)GTGAG reference, synonymous-codon
rs2953467 -- 177,617,493(-) CACAA(C/T)AGAGA reference, synonymous-codon
rs3731804 -- 177,614,751(+) AGAAC(A/G)GGGTG utr-variant-3-prime

Relevant External Links for TTC30A Gene

HapMap Linkage Disequilibrium report
TTC30A

No data available for Structural Variations from Database of Genomic Variants (DGV) for TTC30A Gene

Disorders for TTC30A Gene

Relevant External Links for TTC30A

Genetic Association Database (GAD)
TTC30A
genes like me logo Genes that share disorders with TTC30A: view

No data available for UniProtKB/Swiss-Prot for TTC30A Gene

Publications for TTC30A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3
  4. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 49
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for TTC30A Gene

Sources for TTC30A Gene

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