TTC30A Gene
protein-coding GIFtS : 44
GCID: GC02 M178479
tetratricopeptide repeat domain 30A
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Aliasesfor TTC30A gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Tetratricopeptide Repeat Domain 30A 1 2 TPR Repeat Protein 30A2 3 FLJ139461 Tetratricopeptide Repeat Protein 30A2
Export aliases for TTC30A gene to outside databases Previous GC identifers: GC02M178187 GC02M170350
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Summariesfor TTC30A gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: TT30A_HUMAN, Q86WT1 Function : Required for polyglutamylation of axonemal tubulin (By similarity). Plays a role in anterogradeintraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity)
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Genomic Viewsfor TTC30A gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000002.11 NC_018913.1 NT_005403.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TTC30A gene promoter: E2F-4 E2F-3a E2F-5 Nkx2-5 E2F-2 Gfi-1 FOXL1 E2F E2F-1 POU2F1a Other transcription factors Search SABiosciences Chromatin IP Primers for TTC30A Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TTC30A
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2q31.2 Ensembl cytogenetic band: 2q31.2 HGNC cytogenetic band: 2q31.2 TTC30A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M178479: view genomic region
(about GC identifiers )
Start:
178,479,026 bp from pter
End:
178,483,694 bp from pter
Size:
4,669 bases
Orientation:
minus strand
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Proteinsfor TTC30A gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TT30A_HUMAN, Q86WT1 (See
protein sequence )Recommended Name: Tetratricopeptide repeat protein 30A Size : 665 amino acids; 76136 Da
Subcellular location : Cell projection, cilium (By similarity)
Secondary accessions : A8K8N0 Q8IVP2Explore the universe of human proteins at neXtProt for TTC30A: NX_Q86WT1 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q86WT1 TTC30A Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_689488.3 ENSEMBL proteins: ENSP00000347915 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005929 cilium
IEA --
TTC30A for ontologies About GeneDecksing TTC30A Antibody Products: Assay Products for TTC30A:
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Protein
Domains / Familiesfor TTC30A gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TTC30A for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q86WT1 ProtoNet protein and cluster: Q86WT1
UniProtKB/Swiss-Prot: TT30A_HUMAN, Q86WT1 Similarity : Belongs to the TTC30/dfy-1/fleer familySimilarity : Contains 8 TPR repeats
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Functionfor TTC30A gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: TT30A_HUMAN, Q86WT1 Function : Required for polyglutamylation of axonemal tubulin (By similarity). Plays a role in anterogradeintraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TTC30A (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TTC30AOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TTC30A (NM_152275 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC30A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TTC30A
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC30A
1 GenomeRNAi human phenotype for TTC30A :
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Pathways & Interactionsfor TTC30A gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTC30A 1 Interacting protein for TTC30A (Q86WT1 3 ) via UniProtKB, MINT, STRING, and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0030030 cell projection organization
IEA --
TTC30A for ontologies About GeneDecksing
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Drugs & Compoundsfor TTC30A gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TTC30A Search CenterWatch for drugs/clinical trials and news about TTC30A / TT30A
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Transcriptsfor TTC30A gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TTC30A gene: NM_152275.3 Unigene Cluster for TTC30A:
Tetratricopeptide repeat domain 30A Hs.128384 [show with all ESTs ] Unigene Representative Sequence: NM_152275 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000355689 (uc002ulo.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TTC30A (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TTC30AOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TTC30A (NM_152275 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC30A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TTC30A
Additional cDNA sequence: AK057530.1 AK125104.1 AK292395.1 AL049329.1 BC017695.1 BC042848.1 BC048006.1
3 DOTS entries : DT.40127420 DT.100777529
DT.95145747 24/46 AceView cDNA sequences (see all 46 ):
NM_152275 BF969452 AI948644 BQ015522 AI432662 BM976312 BQ213649 AI381646 AL049329 BQ189398 AK125104 BM684657 AW188998 AU142846 CD359939 CK299531 AA974712 AI857364 AI124807 AK024008 AW663581 BC048006 AK057530 AW274147 GeneLoc Exon Structure
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Expression for TTC30A gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TTC30A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CAGTATTTGT
About this image TTC30A expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Posterior foregut-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See TTC30A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TTC30A SOURCE GeneReport for Unigene cluster: Hs.128384 SABiosciences Custom PCR Arrays for TTC30A Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TTC30ABrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TTC30A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TTC30A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TTC30A In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC30A
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Orthologsfor TTC30A gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for TTC30A gene from 7/21 species (see all 21 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
mouse (Mus musculus)
Mammalia
Ttc30a11 , 5
tetratricopeptide repeat domain 30A11, 5
86.53(n) 1 90.5(a) 1
 
2 (44.80 cM) 5 78802 1 NM_030188.3 1 NP_084464.3 1 75978247 5
chicken (Gallus gallus)
Aves
TTC30A1
tetratricopeptide repeat domain 30A
74.39(n) 76.52(a)
 
429016 XM_426574.3 XP_426574.3
lizard (Anolis carolinensis)
Reptilia
--
--
74(a)
1 → many
GL343411.1(299296-301326)
African clawed frog (Xenopus laevis)
Amphibia
Xl.75502
Xenopus laevis transcribed sequence with weak similarity more
79.87(n)
 
AW645552.1
zebrafish (Danio rerio)
Actinopterygii
flr6
fleer
76(a)
1 → many
3(28982569-29001938)
fruit fly (Drosophila melanogaster)
Insecta
CG51426
--
46(a)
1 → many
2L(13106871-13109468)
worm (Caenorhabditis elegans)
Secernentea
dyf-16
Tetratricopeptide repeat protein 30 homolog
48(a)
1 → many
I(4989556-4994662)
ENSEMBL Gene Tree for TTC30A (if available)TreeFam Gene Tree for TTC30A (if available)
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Paralogsfor TTC30A gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TTC30A gene TTC30B 2 1 SIMAP similar gene for TTC30A using alignment to 1 protein entry: TT30A_HUMAN :TTC30B
TTC30A for paralogs About GeneDecksing
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Genomic Variantsfor TTC30A gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 2 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TTC30A (178479026 - 178483694 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TTC30A: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TTC30A
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Disorders
/ Diseasesfor TTC30A gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TTC30A for disorders About GeneDecksing 1 disease for TTC30A : About MalaCards neuronitis Export disorders for TTC30A gene to outside databases
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Publicationsfor TTC30A gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TTC30A gene integrated from 9 sources : (articles sorted by number of sources associating them with TTC30A) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621) 2 Hillier L.W....Wilson R.K. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548) 1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for TTC30A gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TTC30A gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TTC30A gene
(According to HUGE )
About This Section --
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Specialized Databases showing TTC30A gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TTC30A Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TTC30A gene: Search GeneIP for patents involving TTC30A GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TTC30A gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for TTC30A OriGene shRNA RFP for TTC30A OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TTC30A OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TTC30A OriGene Protein Over-expression Lysate for TTC30A Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TTC30A OriGene 3'-UTR Clone for TTC30A OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TTC30A OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TTC30A Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for TTC30A OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TTC30A OriGene Custom Protein Services for TTC30A OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TTC30A QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TTC30A QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TTC30A QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TTC30A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TTC30A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TTC30A
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TTC30A Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC30A
ThermoFisher Antibodies for TTC30A
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TTC30A
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