Aliases for TTC3 Gene
External Ids for TTC3 Gene
Previous GeneCards Identifiers for TTC3 Gene
GeneCards Summary for TTC3 Gene
TTC3 (Tetratricopeptide Repeat Domain 3) is a Protein Coding gene. Diseases associated with TTC3 include Retinitis Pigmentosa 58 and Down Syndrome. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is DZIP3.
UniProtKB/Swiss-Prot for TTC3 Gene
E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of Lys-48-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.