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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TTC29 Gene

protein-coding GIFtS: 41
GCID: GC04M147628

tetratricopeptide repeat domain 29

Search for TTC29
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tetratricopeptide Repeat Domain 29¹ ²		TBPP2A²
NYD-SP14¹ ²		Tetratricopeptide Repeat Protein 29²
Testis Development Protein NYD-SP14² ³		Protein TBPP2A³
TPR Repeat Protein 29² ³

External Ids:	HGNC: 29936¹	Entrez Gene: 83894²	Ensembl: ENSG00000137473⁷	UniProtKB: Q8NA56³

Export aliases for TTC29 gene to outside databases

Previous GC identifers: GC04M147847 GC04M143355

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TTC29 gene promoter:
GATA-3 Pbx1a MyoD IRF-1 GATA-2 GATA-1 Evi-1 E47 Nkx6-1 LyF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TTC29 promoter sequence

Search SABiosciences Chromatin IP Primers for TTC29

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC29

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.22 Ensembl cytogenetic band: 4q31.22 HGNC cytogenetic band: 4q31.23

TTC29 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTC29 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M147628: view genomic region (about GC identifiers)

Start:	147,627,790 bp from pter	End:	147,867,034 bp from pter
Size:	239,245 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TTC29_HUMAN, Q8NA56 (See protein sequence)

Recommended Name: Tetratricopeptide repeat protein 29

Size: 475 amino acids; 55082 Da

Sequence caution: Sequence=AAK29064.1; Type=Frameshift; Positions=467;

Secondary accessions: A4GU95 Q9BXB6

Alternative splicing: 2 isoforms: Q8NA56-1 Q8NA56-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TTC29: NX_Q8NA56

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NA56

TTC29 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_114162.2

ENSEMBL proteins:

ENSP00000423505 ENSP00000422648 ENSP00000425778 ENSP00000423646 ENSP00000425665

ENSP00000381861 ENSP00000316740

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TTC29 for domains About GeneDecksing

5 InterPro domains/families:

IPR011990 TPR-like_helical

IPR013105 TPR_2

IPR013026 TPR-contain_dom

IPR024819 TPR_29

IPR019734 TPR_repeat

Graphical View of Domain Structure for InterPro Entry Q8NA56

ProtoNet protein and cluster: Q8NA56

UniProtKB/Swiss-Prot: TTC29_HUMAN, Q8NA56

Similarity: Contains 5 TPR repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Phenotypes:
2 GenomeRNAi human phenotypes for TTC29:

Increased G1 DNA content

Increased cell size

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TTC29

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TTC29

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TTC29
Search CenterWatch for drugs/clinical trials and news about TTC29

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TTC29 gene:

NM_031956.2

Unigene Cluster for TTC29:

Tetratricopeptide repeat domain 29

Hs.378893 [show with all ESTs]

Unigene Representative Sequence: AK225725

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000513335(uc003ikx.4) ENST00000508306(uc010ipc.3) ENST00000504425(uc010ipd.1)

ENST00000504272 ENST00000506019 ENST00000515315 ENST00000502319 ENST00000398886

ENST00000325106(uc003ikw.4)

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Additional cDNA sequence:

AF345910.1 AK093145.1 AK225725.1 AK301807.1 AK314066.1 BC024193.2 EF432564.1

9 DOTS entries:

DT.306467 DT.100718239 DT.100780968 DT.92431208 DT.100780969 DT.100804355 DT.121265345 DT.75121037

DT.92431221

24/30 AceView cDNA sequences (see all 30):

BP369735 CD300189 CD557364 BX423364 BI463320 BP370171 BG719368 CD300577

BP368990 BI827046 BG718887 BG722299 BX419177 BU182395 CD692188 CD558150

BI561048 BI545401 BI826329 BU561208 AA402340 CD690439 BI461897 BI561890

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TTC29 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTACAGATAA

About this image

TTC29 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Choroid Plexus

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

See TTC29 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TTC29

SOURCE GeneReport for Unigene cluster: Hs.378893

SABiosciences Custom PCR Arrays for TTC29

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TTC29 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ttc29^{1 , 5}	tetratricopeptide repeat domain 29^{1, 5}	77.92(n)¹ 74.95(a)¹		8 (36.86 cM)⁵ 73301¹ NM_183096.3¹ NP_898919.3¹ 78213297⁵
chicken (Gallus gallus)	Aves	TTC29¹	tetratricopeptide repeat domain 29	66.52(n) 51.78(a)		422468 XM_420433.3 XP_420433.3
lizard (Anolis carolinensis)	Reptilia	TTC29⁶	--	55(a)	1 ↔ 1	5(134384460-134453861)
zebrafish (Danio rerio)	Actinopterygii	LOC799981¹	tetratricopeptide repeat protein 29-like	52.12(n) 39.78(a)		799981 XM_001340238.3 XP_001340274.3

ENSEMBL Gene Tree for TTC29 (if available)
TreeFam Gene Tree for TTC29 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74781141^1,2	C	--	147627727(+)	`CAAGAC/TACATT`	1	--	int¹		0	--	--	--	--
rs6826642^1,2	C,F,H	--	147627803(+)	`ATGTGC/ATATCA`	1	--	int¹		15		NS EA NA CSA WA	1974
rs115407826^1,2	F	--	147627834(+)	`TACTGT/CTACAC`	1	--	int¹		1		NA	120
rs77650106^1,2	F	--	147627888(+)	`GCTTAA/GTTGCT`	1	--	int¹		1		EA	120
rs145414104^1,2		--	147628173(+)	`GAAATA/GCAAAA`	1	--	int¹		0	--	--	--	--
rs190066968^1,2		--	147628210(+)	`TTATTA/GTAACT`	1	--	ut3¹		0	--	--	--	--
rs182696150^1,2		--	147628227(+)	`TATCTC/GTAACA`	1	--	ut3¹		0	--	--	--	--
rs149183387^1,2		--	147628459(+)	`AAATAC/TTTAAC`	1	--	int¹		0	--	--	--	--
rs201641525^1,2		--	147628662(+)	`TTCTGA/CGTTTT`	2	A S	mis¹		0	--	--	--	--
rs142417903^1,2		--	147628670(+)	`TTTGAC/GATACA`	2	S C	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TTC29 (147627790 - 147867034 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TTC29
1 CNV: 98915

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TTC29 for disorders About MalaCards

TTC29 for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: TTC29 (1 document)

Export disorders for TTC29 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TTC29 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TTC29)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)¹ Harrington J.J.... Ducar M. (2001)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)¹ Maruyama K. and Sugano S. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 83894	HGNC: 29936	AceView: NYD-SP14.1	Ensembl:ENSG00000137473	euGenes: HUgn83894
ECgene: TTC29	H-InvDB: TTC29

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TTC29	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TTC29 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TTC29 gene:
Search GeneIP for patents involving TTC29

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TTC29 gene at Home site.

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TTC29 Gene

tetratricopeptide repeat domain 29

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Export list of displayed genes

TTC29 Gene

tetratricopeptide repeat domain 29

Aliasesfor TTC29 gene

Summariesfor TTC29 gene

Genomic Viewsfor TTC29 gene

Proteinsfor TTC29 gene

Protein Domains /Familiesfor TTC29 gene

Functionfor TTC29 gene

Pathways & Interactionsfor TTC29 gene

Drugs & Compoundsfor TTC29 gene

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Expression for TTC29 gene

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Genome Databases showing TTC29 gene

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Specialized Databases showing TTC29 gene

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Aliases
for TTC29 gene

Summaries
for TTC29 gene

Genomic Views
for TTC29 gene

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for TTC29 gene

Protein Domains /
Families
for TTC29 gene

Function
for TTC29 gene

Pathways & Interactions
for TTC29 gene

Drugs & Compounds
for TTC29 gene

Transcripts
for TTC29 gene

Expression
for TTC29 gene

Orthologs
for TTC29 gene

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for TTC29 gene

Genomic Variants
for TTC29 gene

Disorders / Diseases
for TTC29 gene

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for TTC29 gene

Intellectual Property
for TTC29 gene

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for TTC29 gene