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Aliases for TTC29 Gene

Aliases for TTC29 Gene

  • Tetratricopeptide Repeat Domain 29 2 3 5
  • Testis Development Protein NYD-SP14 3 4
  • TPR Repeat Protein 29 3 4
  • Tetratricopeptide Repeat Protein 29 3
  • Testicular Secretory Protein Li 62 3
  • Protein TBPP2A 4
  • NYD-SP14 3
  • TBPP2A 3

External Ids for TTC29 Gene

Previous GeneCards Identifiers for TTC29 Gene

  • GC04M147847
  • GC04M147628
  • GC04M143355

Summaries for TTC29 Gene

GeneCards Summary for TTC29 Gene

TTC29 (Tetratricopeptide Repeat Domain 29) is a Protein Coding gene.

Additional gene information for TTC29 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC29 Gene

Genomics for TTC29 Gene

GeneHancer (GH) Regulatory Elements for TTC29 Gene

Promoters and enhancers for TTC29 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I146945 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 564.1 0.0 -19 1 HDAC1 MXI1 SAP130 SIN3A ZNF335 ZNF316 SCRT2 KLF7 MAFK RFX1 TTC29 GC04M146947 ENSG00000248764 LOC105377473
GH04I146974 Enhancer 0.6 ENCODE 21.9 -29.4 -29368 0.9 TEAD4 TAL1 CEBPB CBFA2T3 ZBTB8A OSR2 PRDM6 GATA3 ZNF610 POLR2A TTC29 POU4F2 GC04M146965 ENSG00000248346 ENSG00000260090 LOC105377473
GH04I146956 Enhancer 0.4 ENCODE 13.7 -11.4 -11372 1.9 JUN EP300 ENSG00000248346 TTC29 ENSG00000248764 GC04M146947 LOC105377473
GH04I147003 Enhancer 0.3 ENCODE 11.8 -58.3 -58336 1.2 POU5F1 ENSG00000260090 TTC29 LOC105377475 GC04M146965
GH04I147198 Enhancer 0.5 Ensembl ENCODE 4.3 -252.8 -252770 1.2 SP1 TTC29 LOC105377476 GC04P147327
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TTC29 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TTC29 gene promoter:

Genomic Locations for TTC29 Gene

Genomic Locations for TTC29 Gene
chr4:146,706,638-146,945,882
(GRCh38/hg38)
Size:
239,245 bases
Orientation:
Minus strand
chr4:147,627,790-147,867,034
(GRCh37/hg19)

Genomic View for TTC29 Gene

Genes around TTC29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC29 Gene

Proteins for TTC29 Gene

  • Protein details for TTC29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NA56-TTC29_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 29
    Protein Accession:
    Q8NA56
    Secondary Accessions:
    • A4GU95
    • Q9BXB6

    Protein attributes for TTC29 Gene

    Size:
    475 amino acids
    Molecular mass:
    55082 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK29064.1; Type=Frameshift; Positions=467; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC29 Gene

Post-translational modifications for TTC29 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TTC29 Gene

Domains & Families for TTC29 Gene

Gene Families for TTC29 Gene

Protein Domains for TTC29 Gene

Suggested Antigen Peptide Sequences for TTC29 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TTC29: view

No data available for UniProtKB/Swiss-Prot for TTC29 Gene

Function for TTC29 Gene

Phenotypes From GWAS Catalog for TTC29 Gene

genes like me logo Genes that share phenotypes with TTC29: view

Animal Model Products

miRNA for TTC29 Gene

miRTarBase miRNAs that target TTC29

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC29 Gene

Localization for TTC29 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC29 gene
Compartment Confidence
mitochondrion 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TTC29 Gene

Pathways & Interactions for TTC29 Gene

SuperPathways for TTC29 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC29 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC29 Gene

Drugs & Compounds for TTC29 Gene

No Compound Related Data Available

Transcripts for TTC29 Gene

Unigene Clusters for TTC29 Gene

Tetratricopeptide repeat domain 29:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC29 Gene

No ASD Table

Relevant External Links for TTC29 Gene

GeneLoc Exon Structure for
TTC29
ECgene alternative splicing isoforms for
TTC29

Expression for TTC29 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTC29 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC29 Gene

This gene is overexpressed in Testis (x42.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TTC29 Gene



Protein tissue co-expression partners for TTC29 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TTC29 Gene:

TTC29

SOURCE GeneReport for Unigene cluster for TTC29 Gene:

Hs.378893
genes like me logo Genes that share expression patterns with TTC29: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC29 Gene

Orthologs for TTC29 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC29 33 34
  • 99.3 (n)
dog
(Canis familiaris)
Mammalia TTC29 33 34
  • 89.19 (n)
cow
(Bos Taurus)
Mammalia TTC29 33 34
  • 87.52 (n)
mouse
(Mus musculus)
Mammalia Ttc29 33 16 34
  • 77.92 (n)
rat
(Rattus norvegicus)
Mammalia Ttc29 33
  • 77.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TTC29 34
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTC29 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC29 33 34
  • 66.52 (n)
lizard
(Anolis carolinensis)
Reptilia TTC29 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc29 33
  • 63.35 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-256m12.5 33
  • 52.72 (n)
TTC29 34
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToMany
-- 34
  • 24 (a)
OneToMany
Species where no ortholog for TTC29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC29 Gene

ENSEMBL:
Gene Tree for TTC29 (if available)
TreeFam:
Gene Tree for TTC29 (if available)

Paralogs for TTC29 Gene

No data available for Paralogs for TTC29 Gene

Variants for TTC29 Gene

Sequence variations from dbSNP and Humsavar for TTC29 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000009070 -- 146,864,235(-) C/T intron_variant
rs1000012200 -- 146,754,096(-) G/T genic_downstream_transcript_variant, intron_variant
rs1000013427 -- 146,905,125(-) A/G intron_variant
rs1000038633 -- 146,864,065(-) T/C intron_variant
rs1000048617 -- 146,868,986(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TTC29 Gene

Variant ID Type Subtype PubMed ID
esv2456671 CNV deletion 19546169
esv2667709 CNV deletion 23128226
esv2677680 CNV deletion 23128226
esv2728498 CNV deletion 23290073
esv3400518 CNV duplication 20981092
esv3564761 CNV deletion 23714750
esv3602584 CNV loss 21293372
esv3602585 CNV loss 21293372
esv3602587 CNV loss 21293372
esv3894049 CNV gain 25118596
nsv1077441 CNV duplication 25765185
nsv1117127 CNV deletion 24896259
nsv461675 CNV gain 19166990
nsv595651 CNV gain 21841781
nsv830107 CNV gain 17160897
nsv956367 CNV deletion 24416366

Variation tolerance for TTC29 Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.87; 96.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTC29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC29 Gene

Disorders for TTC29 Gene

Additional Disease Information for TTC29

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TTC29 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC29 Gene

Publications for TTC29 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Human gingiva transcriptome during wound healing. (PMID: 28005267) Wang Y … Tatakis DN (Journal of clinical periodontology 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TTC29 Gene

Sources for TTC29 Gene

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