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Aliases for TTC28 Gene

Aliases for TTC28 Gene

  • Tetratricopeptide Repeat Domain 28 2 3 5
  • TPR Repeat-Containing Big Gene Cloned At Keio 3 4
  • TPR Repeat Protein 28 3 4
  • TPRBK 3 4
  • TPR-Containing Big Gene Cloned At Keio 3
  • Tetratricopeptide Repeat Protein 28 3
  • KIAA1043 4

External Ids for TTC28 Gene

Previous GeneCards Identifiers for TTC28 Gene

  • GC22M026704
  • GC22M028374
  • GC22M011338

Summaries for TTC28 Gene

GeneCards Summary for TTC28 Gene

TTC28 (Tetratricopeptide Repeat Domain 28) is a Protein Coding gene. An important paralog of this gene is GPSM2.

UniProtKB/Swiss-Prot for TTC28 Gene

  • During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC28 Gene

Genomics for TTC28 Gene

Regulatory Elements for TTC28 Gene

Enhancers for TTC28 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F028678 1 ENCODE 8.1 -0.2 -204 2.5 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ZNF121 GLIS2 KLF7 FOS KLF13 CHEK2 CCDC117 ENSG00000272858 C22orf31 THOC5 TTC28 PIR35028
GH22F028807 1.8 FANTOM5 Ensembl ENCODE 4.4 -136.4 -136407 18.1 HDGF PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 CCDC117 C22orf31 ZNRF3 ENSG00000272858 XBP1 HSCB TTC28 CHEK2 EMID1 GC22M028836
GH22F028708 1.3 Ensembl ENCODE 5.1 -31.5 -31512 4.9 ARID4B FEZF1 BRCA1 ZNF121 FOS PAF1 MXD4 TSHZ1 PPARG MIER3 CHEK2 ENSG00000272858 TTC28 TTC28-AS1 PIR35028 GC22M028741 GC22M028742
GH22F027863 1.5 FANTOM5 Ensembl ENCODE 4.4 +812.0 812036 9.6 ELF3 INSM2 FEZF1 BRCA1 RAD21 ZNF2 YY1 ZNF366 FOS MIXL1 PITPNB TTC28-AS1 MN1 TTC28 GC22M027880
GH22F028395 1.5 FANTOM5 Ensembl ENCODE 4.3 +283.6 283565 1.4 HDAC1 PKNOX1 TBL1XR1 BMI1 RAD21 RARA YY1 ZNF121 ETV6 CREM TTC28 PITPNB MIR5739 ENSG00000199797
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTC28 on UCSC Golden Path with GeneCards custom track

Promoters for TTC28 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001531977 364 2200 ARNT ARID4B SIN3A DMAP1 ZNF48 ZNF2 ZNF121 GLIS2 KLF7 KLF13

Genomic Location for TTC28 Gene

27,978,014 bp from pter
28,679,865 bp from pter
701,852 bases
Minus strand

Genomic View for TTC28 Gene

Genes around TTC28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC28 Gene

Proteins for TTC28 Gene

  • Protein details for TTC28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tetratricopeptide repeat protein 28
    Protein Accession:
    Secondary Accessions:
    • K7ZRV2
    • O95928
    • O95929
    • Q5W189
    • Q9NTE4
    • Q9UG31
    • Q9UGG5
    • Q9UPV8
    • Q9Y3S5

    Protein attributes for TTC28 Gene

    2481 amino acids
    Molecular mass:
    270884 Da
    Quaternary structure:
    • Interacts with AURKB.
    • Sequence=AAH16465.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB62963.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB62964.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for TTC28 Gene

Post-translational modifications for TTC28 Gene

  • Ubiquitination at Lys 713
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TTC28 Gene

Domains & Families for TTC28 Gene

Gene Families for TTC28 Gene

Protein Domains for TTC28 Gene

Suggested Antigen Peptide Sequences for TTC28 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 28 TPR repeats.
  • Contains 28 TPR repeats.
genes like me logo Genes that share domains with TTC28: view

Function for TTC28 Gene

Molecular function for TTC28 Gene

UniProtKB/Swiss-Prot Function:
During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody.
genes like me logo Genes that share phenotypes with TTC28: view

Animal Models for TTC28 Gene

MGI Knock Outs for TTC28:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TTC28 Gene

Localization for TTC28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTC28 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Midbody. Note=At interphase, localizes to centrosomes. At prometaphase and metaphase, associated with spindle microtubules and spindle poles. At anaphase, accumulates in the spindle midzone. At telophase, condensed on central spindles. During cytokinesis, condensed on the midbody where it colocalizes with AURKB (By similarity). {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC28 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 3
mitochondrion 2
plasma membrane 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TTC28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with TTC28: view

Pathways & Interactions for TTC28 Gene

SuperPathways for TTC28 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007346 regulation of mitotic cell cycle IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with TTC28: view

No data available for Pathways by source and SIGNOR curated interactions for TTC28 Gene

Transcripts for TTC28 Gene

Unigene Clusters for TTC28 Gene

Tetratricopeptide repeat domain 28:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC28 Gene

No ASD Table

Relevant External Links for TTC28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTC28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTC28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TTC28 Gene

This gene is overexpressed in Testis (14.7), Fetal heart (10.0), Placenta (8.5), Retina (7.2), and Amniocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTC28 Gene

Protein tissue co-expression partners for TTC28 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TTC28 Gene:


SOURCE GeneReport for Unigene cluster for TTC28 Gene:


mRNA Expression by UniProt/SwissProt for TTC28 Gene:

Tissue specificity: Widely expressed in fetal tissues. In adult tissues, expressed in testis and ovary and, at much lower levels, in kidney and pancreas.
genes like me logo Genes that share expression patterns with TTC28: view

Primer Products

No data available for mRNA differential expression in normal tissues for TTC28 Gene

Orthologs for TTC28 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC28 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TTC28 34 35
  • 99.53 (n)
(Canis familiaris)
Mammalia TTC28 34 35
  • 89.89 (n)
(Bos Taurus)
Mammalia TTC28 34 35
  • 89.39 (n)
(Monodelphis domestica)
Mammalia TTC28 35
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia TTC28 35
  • 89 (a)
(Mus musculus)
Mammalia Ttc28 34 16 35
  • 84.88 (n)
(Rattus norvegicus)
Mammalia Ttc28 34
  • 84.13 (n)
(Gallus gallus)
Aves TTC28 34 35
  • 79.9 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc28 34
  • 74.56 (n)
(Danio rerio)
Actinopterygii FP236598.1 35
  • 90 (a)
TTC28 (1 of 2) 35
  • 72 (a)
ttc28 34
  • 71.09 (n)
-- 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002648 34
  • 58.24 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG43163 34 35
  • 54.49 (n)
Species where no ortholog for TTC28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC28 Gene

Gene Tree for TTC28 (if available)
Gene Tree for TTC28 (if available)

Paralogs for TTC28 Gene

Paralogs for TTC28 Gene

genes like me logo Genes that share paralogs with TTC28: view

Variants for TTC28 Gene

Sequence variations from dbSNP and Humsavar for TTC28 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs10084639 -- 28,679,134(+) GCTCT(G/T)TGATG intron-variant
rs10154425 -- 28,097,441(+) CCTCT(A/C)AGGTC intron-variant
rs1016576 -- 28,065,555(+) ACATG(A/T)TTTCT intron-variant
rs1018502 -- 28,591,042(+) acaca(C/T)atata intron-variant
rs1018512 -- 28,606,095(+) ttttt(G/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC28 Gene

Variant ID Type Subtype PubMed ID
dgv758n67 CNV loss 20364138
dgv836e214 CNV loss 21293372
esv22533 CNV gain 19812545
esv2669108 CNV deletion 23128226
esv2671339 CNV deletion 23128226
esv2724118 CNV deletion 23290073
esv3307412 CNV mobile element insertion 20981092
esv3382069 CNV insertion 20981092
esv3385637 CNV insertion 20981092
esv3391897 CNV insertion 20981092
esv3430358 CNV insertion 20981092
esv3568347 CNV loss 25503493
esv3568348 CNV loss 25503493
esv3568349 CNV loss 25503493
esv3575474 CNV gain 25503493
esv3647501 CNV loss 21293372
esv3647505 CNV gain 21293372
esv3647506 CNV loss 21293372
esv3647507 CNV loss 21293372
esv3647508 CNV loss 21293372
esv3647510 CNV loss 21293372
esv3647513 CNV loss 21293372
esv3647515 CNV loss 21293372
esv993498 CNV gain 20482838
nsv1061684 CNV loss 25217958
nsv1064079 CNV gain 25217958
nsv1064624 CNV gain 25217958
nsv1109462 CNV deletion 24896259
nsv1114316 CNV deletion 24896259
nsv1114317 CNV deletion 24896259
nsv1143029 CNV tandem duplication 24896259
nsv3588 CNV insertion 18451855
nsv459867 CNV loss 19166990
nsv472424 CNV novel sequence insertion 20440878
nsv473282 CNV novel sequence insertion 20440878
nsv522306 CNV loss 19592680
nsv525906 CNV loss 19592680
nsv526760 CNV loss 19592680
nsv588879 CNV loss 21841781
nsv588880 CNV loss 21841781
nsv588881 CNV loss 21841781
nsv819641 CNV loss 19587683
nsv829147 CNV loss 20364138
nsv829148 CNV loss 20364138
nsv829152 CNV loss 20364138
nsv953065 CNV duplication 24416366
nsv966097 CNV duplication 23825009
nsv9895 CNV gain+loss 18304495

Variation tolerance for TTC28 Gene

Gene Damage Index Score: 5.52; 71.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC28 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC28 Gene

Disorders for TTC28 Gene

Relevant External Links for TTC28

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TTC28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC28 Gene

Publications for TTC28 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis. (PMID: 23036704) Izumiyama T. … Shimizu N. (Gene 2012) 3 4 64
  3. A genome-wide association study on obesity and obesity-related traits. (PMID: 21552555) Wang K. … Price R.A. (PLoS ONE 2011) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for TTC28 Gene

Sources for TTC28 Gene

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