TTC28 Gene
protein-coding GIFtS: 44
GCID: GC22M028374
|
|
tetratricopeptide repeat domain 28
| |
Aliases
for TTC28 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tetratricopeptide Repeat Domain 281 2 | | KIAA10431 3 | | TPR Repeat Protein 282 3 | | TPRBK2 | | Tetratricopeptide Repeat Protein 282 | | TPR-Containing Big Gene Cloned At Keio2 |
Export aliases for TTC28 gene to outside databasesPrevious GC identifers: GC22M026704 GC22M011338 |
Summaries
for TTC28 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TTC28 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TTC28 gene promoter:
HOXA9B HOXA9 SRF AML1a SRF (504 AA) Meis-1b Evi-1 AREB6 FOXC1 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TTC28
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC28 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q12.1 Ensembl cytogenetic band: 22q12.1 HGNC cytogenetic band: 22q12.1TTC28 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M028374: view genomic region
(about GC identifiers)
Start:
|
28,374,002 bp from pter |
End:
|
29,075,853 bp from pter |
Size:
|
701,852 bases |
Orientation:
|
minus strand |
|
Proteins
for TTC28 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TTC28_HUMAN, Q96AY4 (See
protein sequence)Recommended Name: Tetratricopeptide repeat protein 28 Size: 2481 amino acids; 270884 Da
Sequence caution: Sequence=AAH16465.1; Type=Erroneous initiation; Sequence=CAB62963.1; Type=Erroneous gene modelprediction; Sequence=CAB62964.1; Type=Erroneous gene model prediction;
Secondary accessions: O95928 O95929 Q5W189 Q9NTE4 Q9UG31 Q9UGG5 Q9UPV8 Q9Y3S5Explore the universe of human proteins at neXtProt for TTC28: NX_Q96AY4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96AY4
TTC28 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001138890.1
ENSEMBL proteins: ENSP00000381003 ENSP00000410244 ENSP00000388788
Human Recombinant Protein Products for TTC28:
TTC28 Antibody Products:
Assay Products for TTC28: |
Protein
Domains /
Families
for TTC28 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TTC28 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q96AY4ProtoNet protein and cluster: Q96AY4 1 Blocks protein family: IPB011595 TPR-related region
UniProtKB/Swiss-Prot: TTC28_HUMAN, Q96AY4Similarity: Contains 28 TPR repeats |
Function
for TTC28 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 GenomeRNAi human phenotype for TTC28:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC28
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC28 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TTC28 (NM_001145418) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC28 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC28 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC28 |
|
Pathways & Interactions
for TTC28 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTC28
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/7 Interacting proteins for TTC28 (Q96AY43 ENSP000003810034) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
|
Drugs & Compounds
for TTC28 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TTC28
Search CenterWatch for drugs/clinical trials and news about TTC28
|
Transcripts
for TTC28 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TTC28 gene (2 alternative transcripts): NM_015281.1 NM_001145418.1 Unigene Cluster for TTC28: Tetratricopeptide repeat domain 28 Hs.387856 [show with all ESTs]Unigene Representative Sequence: NM_0011454187 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397906(uc003adp.4) ENST00000431039 ENST00000480563 ENST00000469670
ENST00000442232 ENST00000490475 ENST00000468807
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC28
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC28 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TTC28 (NM_001145418) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC28 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC28 |
Additional cDNA sequence: AB028966.3 AB665284.1 AK055553.1 AK092338.1 AL080174.1 AL137328.1 BC016465.1 10 DOTS entries: DT.309770 DT.415144 DT.415145 DT.100022255 DT.99954436 DT.100648656 DT.40241226 DT.86821042 DT.99952911 DT.120662985 24/70 AceView cDNA sequences (see all 70): AW020581 AI005637 AI271769 AW959321 CA397387 BU507114 BE301316 CD557422 AL080174 AA443013 AL137328 BC016465 AW629816 NM_015281 BU902636 AA359630 AB028966 BI826649 CA842002 BI712730 BX458028 BF034701 BI712492 CF143247
GeneLoc Exon Structure
|
Expression
for TTC28 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TTC28 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTTCCCTCA
About this image
See TTC28 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TTC28
SOURCE GeneReport for Unigene cluster: Hs.387856
SABiosciences Custom PCR Arrays for TTC28
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC28
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TTC28 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC28 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC28 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC28 |
Orthologs
for TTC28 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TTC28 gene from 3/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TTC281 |
tetratricopeptide repeat domain 28 |
79.86(n)
89.93(a) |
|
416914 XM_415205.3 XP_415205.3 |
zebrafish
(Danio rerio) |
Actinopterygii |
AL913031.12 |
-- |
73.53(n) |
|
323057 AL913031.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG431631 |
CG43163 |
53.94(n)
51.83(a) |
|
38966 NM_139971.2 NP_648228.2 |
ENSEMBL Gene Tree for TTC28 (if available)
TreeFam Gene Tree for TTC28 (if available) |
Paralogs
for TTC28 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TTC28 gene
- GPSM22 TTC242 GPSM12
TTC28 for paralogs About GeneDecksing
|
Genomic Variants
for TTC28 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TTC28 (28374002 - 28624002 bp, first 250kb of TTC28)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for TTC28
5 CNVs: 73808 91014 59071 32463 31088 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC28 |
|
Disorders
/ Diseases
for TTC28 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TTC28 for disorders About GeneDecksing
OMIM gene information: 615098
OMIM disorders: --
1  disease for TTC28: About MalaCardsobesity
Human Genome Epidemiology (HuGE) Navigator: TTC28 (1 document)
Export disorders for TTC28 gene to outside databases
|
Publications
for TTC28 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TTC28 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with TTC28) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R....Ohara O. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis. (PubMed id 23036704)1 Izumiyama T.... Shimizu N. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A genome-wide association study on obesity and obesit y-related traits. (PubMed id 21552555)1 Wang K....Price R.A. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
|
External Searches for TTC28 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TTC28 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TTC28 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TTC28 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TTC28 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TTC28 gene:
Search GeneIP for patents involving TTC28
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TTC28 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TTC28 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTC28 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC28 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TTC28 | | OriGene 3'-UTR Clone for TTC28 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC28 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC28 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TTC28 | | OriGene Custom Protein Services for TTC28 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TTC28 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC28 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC28 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTC28 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC28 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC28 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TTC28 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | TTC28 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC28 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TTC28 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC28 |
| |  | |
|
|
|
