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Aliases for TTC28 Gene

Aliases for TTC28 Gene

  • Tetratricopeptide Repeat Domain 28 2 3 5
  • TPR Repeat-Containing Big Gene Cloned At Keio 3 4
  • TPR Repeat Protein 28 3 4
  • TPRBK 3 4
  • TPR-Containing Big Gene Cloned At Keio 3
  • KIAA1043 4

External Ids for TTC28 Gene

Previous GeneCards Identifiers for TTC28 Gene

  • GC22M026704
  • GC22M028374
  • GC22M011338

Summaries for TTC28 Gene

GeneCards Summary for TTC28 Gene

TTC28 (Tetratricopeptide Repeat Domain 28) is a Protein Coding gene. An important paralog of this gene is GPSM1.

UniProtKB/Swiss-Prot for TTC28 Gene

  • During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC28 Gene

Genomics for TTC28 Gene

Regulatory Elements for TTC28 Gene

Promoters for TTC28 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TTC28 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTC28 Gene

Chromosome:
22
Start:
27,978,014 bp from pter
End:
28,679,865 bp from pter
Size:
701,852 bases
Orientation:
Minus strand

Genomic View for TTC28 Gene

Genes around TTC28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC28 Gene

Proteins for TTC28 Gene

  • Protein details for TTC28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AY4-TTC28_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 28
    Protein Accession:
    Q96AY4
    Secondary Accessions:
    • K7ZRV2
    • O95928
    • O95929
    • Q5W189
    • Q9NTE4
    • Q9UG31
    • Q9UGG5
    • Q9UPV8
    • Q9Y3S5

    Protein attributes for TTC28 Gene

    Size:
    2481 amino acids
    Molecular mass:
    270884 Da
    Quaternary structure:
    • Interacts with AURKB.
    SequenceCaution:
    • Sequence=AAH16465.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB62963.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB62964.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for TTC28 Gene

Proteomics data for TTC28 Gene at MOPED

Post-translational modifications for TTC28 Gene

  • Ubiquitination at Lys 713
  • Modification sites at PhosphoSitePlus

Other Protein References for TTC28 Gene

No data available for DME Specific Peptides for TTC28 Gene

Domains & Families for TTC28 Gene

Gene Families for TTC28 Gene

Protein Domains for TTC28 Gene

Suggested Antigen Peptide Sequences for TTC28 Gene

Graphical View of Domain Structure for InterPro Entry

Q96AY4

UniProtKB/Swiss-Prot:

TTC28_HUMAN :
  • Contains 28 TPR repeats.
Similarity:
  • Contains 28 TPR repeats.
genes like me logo Genes that share domains with TTC28: view

Function for TTC28 Gene

Molecular function for TTC28 Gene

UniProtKB/Swiss-Prot Function:
During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody.
genes like me logo Genes that share phenotypes with TTC28: view

Animal Models for TTC28 Gene

MGI Knock Outs for TTC28:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TTC28 Gene

Localization for TTC28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTC28 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Midbody. Note=At interphase, localizes to centrosomes. At prometaphase and metaphase, associated with spindle microtubules and spindle poles. At anaphase, accumulates in the spindle midzone. At telophase, condensed on central spindles. During cytokinesis, condensed on the midbody where it colocalizes with AURKB (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC28 Gene COMPARTMENTS Subcellular localization image for TTC28 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 3
mitochondrion 2
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TTC28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TTC28: view

Pathways & Interactions for TTC28 Gene

SuperPathways for TTC28 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007346 regulation of mitotic cell cycle IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with TTC28: view

No data available for Pathways by source and SIGNOR curated interactions for TTC28 Gene

Drugs & Compounds for TTC28 Gene

No Compound Related Data Available

Transcripts for TTC28 Gene

Unigene Clusters for TTC28 Gene

Tetratricopeptide repeat domain 28:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC28 Gene

No ASD Table

Relevant External Links for TTC28 Gene

GeneLoc Exon Structure for
TTC28
ECgene alternative splicing isoforms for
TTC28

Expression for TTC28 Gene

mRNA expression in normal human tissues for TTC28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TTC28 Gene

This gene is overexpressed in Testis (14.7), Fetal heart (10.0), Placenta (8.5), Retina (7.2), and Amniocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTC28 Gene



SOURCE GeneReport for Unigene cluster for TTC28 Gene Hs.387856

mRNA Expression by UniProt/SwissProt for TTC28 Gene

Q96AY4-TTC28_HUMAN
Tissue specificity: Widely expressed in fetal tissues. In adult tissues, expressed in testis and ovary and, at much lower levels, in kidney and pancreas.
genes like me logo Genes that share expression patterns with TTC28: view

Protein tissue co-expression partners for TTC28 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TTC28 Gene

Orthologs for TTC28 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC28 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TTC28 35
  • 89.39 (n)
  • 94.84 (a)
TTC28 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTC28 35
  • 89.89 (n)
  • 94 (a)
TTC28 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc28 35
  • 84.88 (n)
  • 91.14 (a)
Ttc28 16
Ttc28 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TTC28 35
  • 99.53 (n)
  • 99.76 (a)
TTC28 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttc28 35
  • 84.13 (n)
  • 90.7 (a)
oppossum
(Monodelphis domestica)
Mammalia TTC28 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC28 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC28 35
  • 79.9 (n)
  • 90.16 (a)
TTC28 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc28 35
  • 74.56 (n)
  • 84.94 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ttc28 35
  • 71.09 (n)
  • 80.27 (a)
FP236598.1 36
  • 90 (a)
OneToMany
TTC28 (1 of 2) 36
  • 72 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002648 35
  • 58.24 (n)
  • 55.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43163 35
  • 54.49 (n)
  • 52.85 (a)
CG43163 36
  • 43 (a)
OneToOne
Species with no ortholog for TTC28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC28 Gene

ENSEMBL:
Gene Tree for TTC28 (if available)
TreeFam:
Gene Tree for TTC28 (if available)

Paralogs for TTC28 Gene

Paralogs for TTC28 Gene

genes like me logo Genes that share paralogs with TTC28: view

Variants for TTC28 Gene

Sequence variations from dbSNP and Humsavar for TTC28 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs138658 -- 28,004,664(+) GGCTT(A/G)TGGGG intron-variant
rs138659 -- 28,005,768(+) CTGCC(C/G)ACACT intron-variant
rs138660 -- 28,008,018(+) TCTCA(A/C)AGGCC intron-variant
rs138661 -- 28,008,280(+) CTCTC(-/A)TGGCC intron-variant
rs138662 -- 28,008,282(+) CTCAT(-/GGCCG)AGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC28 Gene

Variant ID Type Subtype PubMed ID
nsv522306 CNV Loss 19592680
esv2724118 CNV Deletion 23290073
esv2669108 CNV Deletion 23128226
nsv829147 CNV Loss 20364138
nsv526760 CNV Loss 19592680
esv2671339 CNV Deletion 23128226
esv271686 CNV Insertion 20981092
esv272872 CNV Insertion 20981092
nsv3588 CNV Insertion 18451855
nsv459867 CNV Loss 19166990
nsv9895 CNV Gain+Loss 18304495
esv269768 CNV Insertion 20981092
nsv525906 CNV Loss 19592680
nsv829148 CNV Loss 20364138
nsv819641 CNV Loss 19587683
dgv758n67 CNV Loss 20364138
esv993498 CNV Gain 20482838
nsv829152 CNV Loss 20364138
esv22533 CNV Gain 19812545

Variation tolerance for TTC28 Gene

Gene Damage Index Score: 5.52; 71.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC28 Gene

HapMap Linkage Disequilibrium report
TTC28
Human Gene Mutation Database (HGMD)
TTC28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC28 Gene

Disorders for TTC28 Gene

Relevant External Links for TTC28

Genetic Association Database (GAD)
TTC28
Human Genome Epidemiology (HuGE) Navigator
TTC28
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC28

No disorders were found for TTC28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC28 Gene

Publications for TTC28 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. (PMID: 25086665) Wolpin B.M. … Amundadottir L.T. (Nat. Genet. 2014) 3
  5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3

Products for TTC28 Gene

Sources for TTC28 Gene

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