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TTC27 Gene

protein-coding   GIFtS: 48
GCID: GC02P032853

Tetratricopeptide Repeat Domain 27

  Search for TTC27
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tetratricopeptide Repeat Domain 271 2
TPR Repeat Protein 272 3
Tetratricopeptide Repeat Protein 272

External Ids:    HGNC: 259861   Entrez Gene: 556222   Ensembl: ENSG000000186997   UniProtKB: Q6P3X33   

Export aliases for TTC27 gene to outside databases

Previous GC identifers: GC02P032706 GC02P032592


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TTC27 Gene:
TTC27 (tetratricopeptide repeat domain 27) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TTC27 gene promoter:
         TBP   Pax-5   Meis-1b   IRF-2   SRY   FAC1   TFIID   SEF-1 (1)   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTC27 promoter sequence
   Search Chromatin IP Primers for TTC27

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTC27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.3   Ensembl cytogenetic band:  2p22.3   HGNC cytogenetic band: 2p22.3

TTC27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTC27 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P032853:  view genomic region     (about GC identifiers)

Start:
32,853,087 bp from pter      End:
33,046,118 bp from pter
Size:
193,032 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TTC27_HUMAN, Q6P3X3 (See protein sequence)
Recommended Name: Tetratricopeptide repeat protein 27  
Size: 843 amino acids; 96632 Da
Sequence caution: Sequence=BAA91048.1; Type=Erroneous initiation; Sequence=BAA91315.1; Type=Erroneous initiation;
Secondary accessions: A6NKJ0 Q96SS5 Q9BVF1 Q9NWR4 Q9NXG4

Explore the universe of human proteins at neXtProt for TTC27: NX_Q6P3X3

Explore proteomics data for TTC27 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys803
  • Modification sites at PhosphoSitePlus

  • See TTC27 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001180438.1  NP_060205.3  

    ENSEMBL proteins: 
     ENSP00000393327   ENSP00000313953   ENSP00000392883   ENSP00000409230   ENSP00000410642  
     ENSP00000398820  

    TTC27 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TTC27

     
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    Cloud-Clone Corp. CLIAs for TTC27
    Search eBioscience for ELISAs for TTC27 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    4 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR001440 TPR_1
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry Q6P3X3

    ProtoNet protein and cluster: Q6P3X3

    UniProtKB/Swiss-Prot: TTC27_HUMAN, Q6P3X3
    Similarity: Belongs to the TTC27 family
    Similarity: Contains 3 HAT repeats
    Similarity: Contains 7 TPR repeats


    Find genes that share domains with TTC27           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TTC27           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TTC27:
     Decreased Wnt reporter activit  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TTC27
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TTC27
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    Predesigned siRNA for gene silencing in human, mouse, rat TTC27

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    Find genes that share ontologies with TTC27           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TTC27
    Interactions:

        Search GeneGlobe Interaction Network for TTC27

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for TTC27 (Q6P3X33 ENSP000003139534) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP5BP065763, ENSP000002620304I2D: score=4 STRING: ENSP00000262030
    PSMC3P179803, ENSP000002988524I2D: score=4 STRING: ENSP00000298852
    ACVR1Q047713, ENSP000002636404I2D: score=3 STRING: ENSP00000263640
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    PTP4A3O753653, ENSP000003322744I2D: score=2 STRING: ENSP00000332274
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with TTC27           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TTC27



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TTC27 gene (2 alternative transcripts): 
    NM_001193509.1  NM_017735.4  

    Unigene Cluster for TTC27:

    Tetratricopeptide repeat domain 27
    Hs.468125  [show with all ESTs]
    Unigene Representative Sequence: NM_017735
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000448773 ENST00000317907(uc002rom.3 uc010ymx.2) ENST00000454690
    ENST00000438654 ENST00000433416 ENST00000428527
    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TTC27
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TTC27 (NM_017735)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TTC27
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC27
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TTC27
      QuantiTect SYBR Green Assays in human, mouse, rat TTC27
      QuantiFast Probe-based Assays in human, mouse, rat TTC27

    Additional mRNA sequence: 

    AK000279.1 AK000665.1 AK027570.1 AK225295.1 AK299196.1 BC001248.1 BC063791.1 

    6 DOTS entries:

    DT.452341  DT.92433731  DT.97770220  DT.91659224  DT.102832169  DT.97845350 

    Selected AceView cDNA sequences (see all 173):

    BC001248 AA633525 BQ900208 BU543355 BM792833 BM720851 BM784203 BM845164 
    AA452310 AI589083 BQ003621 BE328252 BU619527 CB145725 AW150894 AI078055 
    CK724868 BM983327 CA415645 BU618772 BM742838 BE221980 BG288539 AI911500 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TTC27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCCATAAA
    TTC27 Expression
    About this image

    TTC27 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TTC27 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.468125
        Custom PCR Arrays for TTC27
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC27

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TTC27 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttc271 , 5 tetratricopeptide repeat domain 271, 5 84.22(n)1
    84.58(a)1
      17 (45.64 cM)5
    741961  NM_152817.41  NP_690030.31 
     747177505 
    chicken
    (Gallus gallus)
    Aves TTC271 tetratricopeptide repeat domain 27 74.31(n)
    73.75(a)
      421462  NM_001012567.1  NP_001012585.1 
    lizard
    (Anolis carolinensis)
    Reptilia TTC276
    tetratricopeptide repeat domain 27
    71(a)
    1 ↔ 1
    1(231725767-231817806)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.244702 Xenopus laevis transcribed sequence with weak similarity more 76.44(n)    CB206451.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ttc271 tetratricopeptide repeat domain 27 59.46(n)
    59.66(a)
      317640  NM_173285.2  NP_775392.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG52901 CG5290 43.44(n)
    34.34(a)
      39998  NM_140769.3  NP_649026.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T20B12.11 T20B12.1 46.97(n)
    36.33(a)
      176055  NM_066235.5  NP_498636.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes EMW1(YNL313C)4
    EMW11
    Essential conserved protein with a role in maintaining more4
    EMW11
    41.76(n)1
    26.27(a)1
      14(48022-45308)4
    8554031, 4  NP_014086.11, 4 


    ENSEMBL Gene Tree for TTC27 (if available)
    TreeFam Gene Tree for TTC27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TTC27 (see all 4144)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1864813451,2
    --32590788(+) CAGTAA/GATATT 2 -- us2k10--------
    rs1154054191,2
    C,F--32590830(+) ACATAT/CTTTTA 2 -- us2k11Minor allele frequency- C:0.01NA 120
    rs739227661,2
    C,F--32590856(+) CCCACG/CTACTT 2 -- us2k11Minor allele frequency- C:0.50WA 2
    rs748267461,2
    F--32590982(+) TTACTA/CTGTGG 2 -- us2k11Minor allele frequency- C:0.01WA 118
    rs763192061,2
    C,F--32591051(+) CAGACG/ATTCAT 2 -- us2k14Minor allele frequency- A:0.09NA CSA WA 242
    rs1486559411,2
    --32591128(+) CTGGTA/CAAGTA 2 -- us2k10--------
    rs2019737461,2
    C--32591136(+) GTATC-/ATTTT 
     CTAGAAA
    AATAG
    2 -- us2k10--------
    rs727875181,2
    C,F--32591158(+) TGGGGT/GTTTTT 2 -- us2k14Minor allele frequency- G:0.12NA EA 244
    rs1997153891,2
    C--32591336(+) TTTTT-/AAAAAA 2 -- us2k10--------
    rs1445418871,2
    C--32591433(+) CAAAGG/TGCTGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TTC27 (32853087 - 33046118 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TTC27 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2661876CNV Deletion23128226
    esv2652244CNV Deletion19546169
    esv2422472CNV Duplication17116639
    esv2422335CNV Duplication17116639
    dgv4076n71CNV Loss21882294
    nsv833692CNV Loss17160897
    nsv833703CNV Loss17160897
    nsv873782CNV Loss21882294
    nsv873783CNV Gain21882294
    dgv443n27CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TTC27
    DNA2.0 Custom Variant and Variant Library Synthesis for TTC27

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with TTC27           About GenesLikeMe

    Genetic Association Database (GAD): TTC27
    Human Genome Epidemiology (HuGE) Navigator: TTC27 (1 document)

    Export disorders for TTC27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TTC27 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with TTC27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    4. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    5. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Multiple loci influencing hippocampal degeneration identified by genome scan. (PubMed id 22745009)1 Melville S.A....Farrer L.A. (Ann. Neurol. 2012)
    9. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55622 HGNC: 25986 AceView: FLJ20272 Ensembl:ENSG00000018699 euGenes: HUgn55622
    ECgene: TTC27 H-InvDB: TTC27

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TTC27 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TTC27 gene:
    Search GeneIP for patents involving TTC27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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