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Aliases for TTC27 Gene

Aliases for TTC27 Gene

  • Tetratricopeptide Repeat Domain 27 2 3
  • TPR Repeat Protein 27 4

External Ids for TTC27 Gene

Previous GeneCards Identifiers for TTC27 Gene

  • GC02P032706
  • GC02P032853
  • GC02P032592

Summaries for TTC27 Gene

GeneCards Summary for TTC27 Gene

TTC27 (Tetratricopeptide Repeat Domain 27) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC27 Gene

Genomics for TTC27 Gene

Regulatory Elements for TTC27 Gene

Genomic Location for TTC27 Gene

Start:
32,628,020 bp from pter
End:
32,821,051 bp from pter
Size:
193,032 bases
Orientation:
Plus strand

Genomic View for TTC27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTC27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC27 Gene

Proteins for TTC27 Gene

  • Protein details for TTC27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P3X3-TTC27_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 27
    Protein Accession:
    Q6P3X3
    Secondary Accessions:
    • A6NKJ0
    • Q96SS5
    • Q9BVF1
    • Q9NWR4
    • Q9NXG4

    Protein attributes for TTC27 Gene

    Size:
    843 amino acids
    Molecular mass:
    96632 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91048.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91315.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TTC27 Gene

Proteomics data for TTC27 Gene at MOPED

Post-translational modifications for TTC27 Gene

  • Ubiquitination at Lys803
  • Modification sites at PhosphoSitePlus

Other Protein References for TTC27 Gene

No data available for DME Specific Peptides for TTC27 Gene

Domains for TTC27 Gene

Gene Families for TTC27 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for TTC27 Gene

Suggested Antigen Peptide Sequences for TTC27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P3X3

UniProtKB/Swiss-Prot:

TTC27_HUMAN :
  • Q6P3X3
Family:
  • Belongs to the TTC27 family.
Similarity:
  • Contains 6 TPR repeats.
genes like me logo Genes that share domains with TTC27: view

Function for TTC27 Gene

Gene Ontology (GO) - Molecular Function for TTC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TTC27: view

Phenotypes for TTC27 Gene

genes like me logo Genes that share phenotypes with TTC27: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTC27

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TTC27 Gene

Localization for TTC27 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC27 Gene COMPARTMENTS Subcellular localization image for TTC27 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TTC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with TTC27: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TTC27 Gene

Pathways for TTC27 Gene

SuperPathways for TTC27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TTC27: view

No data available for Pathways by source for TTC27 Gene

Transcripts for TTC27 Gene

Unigene Clusters for TTC27 Gene

Tetratricopeptide repeat domain 27:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTC27

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC27 Gene

No ASD Table

Relevant External Links for TTC27 Gene

GeneLoc Exon Structure for
TTC27
ECgene alternative splicing isoforms for
TTC27

Expression for TTC27 Gene

mRNA expression in normal human tissues for TTC27 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTC27 Gene

SOURCE GeneReport for Unigene cluster for TTC27 Gene Hs.468125

genes like me logo Genes that share expressions with TTC27: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTC27 Gene

Orthologs for TTC27 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTC27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC27 35
  • 98.34 (n)
  • 97.98 (a)
TTC27 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TTC27 35
  • 89.96 (n)
  • 89.32 (a)
TTC27 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTC27 35
  • 90.15 (n)
  • 89.68 (a)
TTC27 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc27 35
  • 84.22 (n)
  • 84.58 (a)
Ttc27 16
Ttc27 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTC27 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC27 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttc27 35
  • 84.06 (n)
  • 85.53 (a)
chicken
(Gallus gallus)
Aves TTC27 35
  • 74.31 (n)
  • 73.75 (a)
TTC27 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC27 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24470 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc27 35
  • 67.62 (n)
  • 66.35 (a)
zebrafish
(Danio rerio)
Actinopterygii ttc27 35
  • 59.46 (n)
  • 59.66 (a)
ttc27 36
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006358 35
  • 41.5 (n)
  • 32.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5290 35
  • 43.44 (n)
  • 34.34 (a)
CG5290 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T20B12.1 35
  • 46.97 (n)
  • 36.33 (a)
T20B12.1 36
  • 29 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL177C 35
  • 44.03 (n)
  • 30.09 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMW1 35
  • 41.76 (n)
  • 26.27 (a)
EMW1 36
  • 22 (a)
OneToOne
EMW1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E07239g 35
  • 42.48 (n)
  • 27.86 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09658 35
  • 43.19 (n)
  • 31.53 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC19B12.01 35
  • 46.14 (n)
  • 32.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToOne
Species with no ortholog for TTC27:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC27 Gene

ENSEMBL:
Gene Tree for TTC27 (if available)
TreeFam:
Gene Tree for TTC27 (if available)

Paralogs for TTC27 Gene

No data available for Paralogs for TTC27 Gene

Variants for TTC27 Gene

Sequence variations from dbSNP and Humsavar for TTC27 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs16349 -- 32,820,951(-) AGCAC(-/CTTTTCCAGAATCTG)CTTCC cds-indel
rs220648 -- 32,781,092(-) tccct(C/T)atcaa intron-variant
rs220649 -- 32,781,425(-) aatgg(C/T)ggaca intron-variant
rs220650 -- 32,781,435(-) ttttt(A/T)aaaaa intron-variant
rs220651 -- 32,781,500(-) cttaa(A/G)agaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC27 Gene

Variant ID Type Subtype PubMed ID
esv2422335 CNV Duplication 17116639
esv2751888 CNV Gain 17911159
nsv516173 CNV Gain+Loss 19592680
dgv443n27 CNV Gain 19166990
nsv833692 CNV Loss 17160897
esv2422472 CNV Duplication 17116639
nsv470448 CNV Gain 18288195
nsv456108 CNV Gain 19166990
nsv873782 CNV Loss 21882294
nsv873783 CNV Gain 21882294
nsv873784 CNV Gain 21882294
nsv833703 CNV Loss 17160897
esv2661876 CNV Deletion 23128226
dgv4076n71 CNV Loss 21882294
esv2652244 CNV Deletion 19546169
nsv873787 CNV Gain 21882294

Relevant External Links for TTC27 Gene

HapMap Linkage Disequilibrium report
TTC27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC27 Gene

Disorders for TTC27 Gene

Relevant External Links for TTC27

Genetic Association Database (GAD)
TTC27
Human Genome Epidemiology (HuGE) Navigator
TTC27
genes like me logo Genes that share disorders with TTC27: view

No data available for UniProtKB/Swiss-Prot for TTC27 Gene

Publications for TTC27 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. High-throughput mapping of a dynamic signaling network in mammalian cells. (PMID: 15761153) Barrios-Rodiles M. … Wrana J.L. (Science 2005) 3
  4. Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. (PMID: 17314511) Koch H.B. … Hermeking H. (Cell Cycle 2007) 3
  5. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3

Products for TTC27 Gene

Sources for TTC27 Gene

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