TTC27 Gene
protein-coding GIFtS: 45
GCID: GC02P032853
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tetratricopeptide repeat domain 27
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Aliases
for TTC27 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tetratricopeptide Repeat Domain 271 2 | | TPR Repeat Protein 272 3 | | FLJ202721 | | Tetratricopeptide Repeat Protein 272 |
Export aliases for TTC27 gene to outside databasesPrevious GC identifers: GC02P032706 GC02P032592 |
Summaries
for TTC27 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TTC27 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TTC27 gene promoter:
TBP Pax-5 Meis-1b IRF-2 SRY FAC1 TFIID SEF-1 (1) Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TTC27
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC27 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p22.3 Ensembl cytogenetic band: 2p22.3 HGNC cytogenetic band: 2p22.3TTC27 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P032853: view genomic region
(about GC identifiers)
Start:
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32,853,087 bp from pter |
End:
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33,046,118 bp from pter |
Size:
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193,032 bases |
Orientation:
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plus strand |
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Proteins
for TTC27 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TTC27_HUMAN, Q6P3X3 (See
protein sequence)Recommended Name: Tetratricopeptide repeat protein 27 Size: 843 amino acids; 96632 Da
Sequence caution: Sequence=BAA91048.1; Type=Erroneous initiation; Sequence=BAA91315.1; Type=Erroneous initiation;
Secondary accessions: A6NKJ0 Q96SS5 Q9BVF1 Q9NWR4 Q9NXG4Explore the universe of human proteins at neXtProt for TTC27: NX_Q6P3X3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P3X3
TTC27 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001180438.1 NP_060205.3
ENSEMBL proteins: ENSP00000393327 ENSP00000313953 ENSP00000392883 ENSP00000409230 ENSP00000410642 ENSP00000398820
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
TTC27 for ontologies About GeneDecksing
TTC27 Antibody Products:
Assay Products for TTC27: |
Protein
Domains /
Families
for TTC27 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TTC27 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6P3X3ProtoNet protein and cluster: Q6P3X3 UniProtKB/Swiss-Prot: TTC27_HUMAN, Q6P3X3Similarity: Belongs to the TTC27 familySimilarity: Contains 3 HAT repeatsSimilarity: Contains 7 TPR repeats |
Function
for TTC27 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC27 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC27 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TTC27 (NM_017735) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC27 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC27 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC27 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
TTC27 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TTC27:
|
Pathways & Interactions
for TTC27 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTC27
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/54 Interacting proteins for TTC27 (Q6P3X33 ENSP000003139534) via UniProtKB, MINT, STRING, and/or I2D (see all 54)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
TTC27 for ontologies About GeneDecksing
|
Drugs & Compounds
for TTC27 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TTC27
Search CenterWatch for drugs/clinical trials and news about TTC27
|
Transcripts
for TTC27 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TTC27 gene (2 alternative transcripts): NM_001193509.1 NM_017735.4 Unigene Cluster for TTC27: Tetratricopeptide repeat domain 27 Hs.468125 [show with all ESTs]Unigene Representative Sequence: NM_0177356 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000448773 ENST00000317907(uc002rom.3 uc010ymx.2) ENST00000454690
ENST00000438654 ENST00000433416 ENST00000428527
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC27 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC27 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TTC27 (NM_017735) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC27 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC27 |
Additional cDNA sequence: AK000279.1 AK000665.1 AK027570.1 AK225295.1 AK299196.1 BC001248.1 BC063791.1 6 DOTS entries: DT.452341 DT.92433731 DT.97770220 DT.91659224 DT.102832169 DT.97845350 24/173 AceView cDNA sequences (see all 173): AA633525 BU543355 BM784203 BM845164 BM792833 BM720851 AA452310 BQ003621 BG288539 AI589083 BE221980 BU618772 CK724868 CA415645 AI078055 BM742838 BM983327 CB145725 BC001248 BQ900208 BE328252 AW150894 BU619527 BM839861
GeneLoc Exon Structure
|
Expression
for TTC27 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TTC27 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGCCATAAA
About this image
See TTC27 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TTC27
SOURCE GeneReport for Unigene cluster: Hs.468125
SABiosciences Custom PCR Arrays for TTC27
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC27
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TTC27 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC27 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC27 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC27 |
Orthologs
for TTC27 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TTC27 gene from 10/31 species (see all 31) About this table
ENSEMBL Gene Tree for TTC27 (if available)
TreeFam Gene Tree for TTC27 (if available) |
Paralogs
for TTC27 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TTC27 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TTC27 (32853087 - 33046118 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for TTC27
5 CNVs: 53694 5202 97805 8367 5203 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC27 |
|
Disorders
/ Diseases
for TTC27 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TTC27 for disorders About GeneDecksing
2  diseases for TTC27: About MalaCardsfanconi's anemia anemia
Human Genome Epidemiology (HuGE) Navigator: TTC27 (1 document)
Export disorders for TTC27 gene to outside databases
|
Publications
for TTC27 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TTC27 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with TTC27) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Multiple loci influencing hippocampal degeneration ide ntified by genome scan. (PubMed id 22745009)1 Melville S.A....Farrer L.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (2009)
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External Searches for TTC27 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TTC27 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TTC27 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TTC27 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TTC27 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TTC27 gene:
Search GeneIP for patents involving TTC27
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TTC27 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TTC27 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTC27 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC27 | | | OriGene Protein Over-expression Lysate for TTC27 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TTC27 | | OriGene 3'-UTR Clone for TTC27 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC27 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC27 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TTC27 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TTC27 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC27 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC27 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTC27 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC27 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC27 |
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 | | | TTC27 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC27 |
|  |  |  | | | | Search ThermoFisher Antibodies for TTC27 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC27 |
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