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Aliases for TTC27 Gene

Aliases for TTC27 Gene

  • Tetratricopeptide Repeat Domain 27 2 3 5
  • TPR Repeat Protein 27 4

External Ids for TTC27 Gene

Previous GeneCards Identifiers for TTC27 Gene

  • GC02P032706
  • GC02P032853
  • GC02P032592

Summaries for TTC27 Gene

GeneCards Summary for TTC27 Gene

TTC27 (Tetratricopeptide Repeat Domain 27) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC27 Gene

Genomics for TTC27 Gene

Regulatory Elements for TTC27 Gene

Enhancers for TTC27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TTC27 on UCSC Golden Path with GeneCards custom track

Promoters for TTC27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TTC27 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTC27 Gene

Chromosome:
2
Start:
32,628,020 bp from pter
End:
32,821,051 bp from pter
Size:
193,032 bases
Orientation:
Plus strand

Genomic View for TTC27 Gene

Genes around TTC27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC27 Gene

Proteins for TTC27 Gene

  • Protein details for TTC27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P3X3-TTC27_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 27
    Protein Accession:
    Q6P3X3
    Secondary Accessions:
    • A6NKJ0
    • Q96SS5
    • Q9BVF1
    • Q9NWR4
    • Q9NXG4

    Protein attributes for TTC27 Gene

    Size:
    843 amino acids
    Molecular mass:
    96632 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91048.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91315.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TTC27 Gene

Post-translational modifications for TTC27 Gene

  • Ubiquitination at Lys 803
  • Modification sites at PhosphoSitePlus

Other Protein References for TTC27 Gene

No data available for DME Specific Peptides for TTC27 Gene

Domains & Families for TTC27 Gene

Gene Families for TTC27 Gene

Protein Domains for TTC27 Gene

Suggested Antigen Peptide Sequences for TTC27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P3X3

UniProtKB/Swiss-Prot:

TTC27_HUMAN :
  • Belongs to the TTC27 family.
  • Contains 6 TPR repeats.
Family:
  • Belongs to the TTC27 family.
Similarity:
  • Contains 6 TPR repeats.
genes like me logo Genes that share domains with TTC27: view

Function for TTC27 Gene

Gene Ontology (GO) - Molecular Function for TTC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TTC27: view
genes like me logo Genes that share phenotypes with TTC27: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TTC27 Gene

Localization for TTC27 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC27 Gene COMPARTMENTS Subcellular localization image for TTC27 gene
Compartment Confidence
cytosol 3
mitochondrion 3
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TTC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with TTC27: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TTC27 Gene

Pathways & Interactions for TTC27 Gene

SuperPathways for TTC27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TTC27: view

No data available for Pathways by source and SIGNOR curated interactions for TTC27 Gene

Drugs & Compounds for TTC27 Gene

No Compound Related Data Available

Transcripts for TTC27 Gene

Unigene Clusters for TTC27 Gene

Tetratricopeptide repeat domain 27:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC27 Gene

No ASD Table

Relevant External Links for TTC27 Gene

GeneLoc Exon Structure for
TTC27
ECgene alternative splicing isoforms for
TTC27

Expression for TTC27 Gene

mRNA expression in normal human tissues for TTC27 Gene

Protein differential expression in normal tissues from HIPED for TTC27 Gene

This gene is overexpressed in Bone (31.6), Peripheral blood mononuclear cells (15.1), and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTC27 Gene



Protein tissue co-expression partners for TTC27 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TTC27 Gene:

TTC27

SOURCE GeneReport for Unigene cluster for TTC27 Gene:

Hs.468125
genes like me logo Genes that share expression patterns with TTC27: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTC27 Gene

Orthologs for TTC27 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTC27 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TTC27 34
  • 89.96 (n)
  • 89.32 (a)
TTC27 35
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTC27 34
  • 90.15 (n)
  • 89.68 (a)
TTC27 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc27 34
  • 84.22 (n)
  • 84.58 (a)
Ttc27 16
Ttc27 35
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TTC27 34
  • 98.34 (n)
  • 97.98 (a)
TTC27 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttc27 34
  • 84.06 (n)
  • 85.53 (a)
oppossum
(Monodelphis domestica)
Mammalia TTC27 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC27 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC27 34
  • 74.31 (n)
  • 73.75 (a)
TTC27 35
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC27 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc27 34
  • 67.62 (n)
  • 66.35 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24470 34
zebrafish
(Danio rerio)
Actinopterygii ttc27 34
  • 59.46 (n)
  • 59.66 (a)
ttc27 35
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006358 34
  • 41.5 (n)
  • 32.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5290 34
  • 43.44 (n)
  • 34.34 (a)
CG5290 35
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T20B12.1 34
  • 46.97 (n)
  • 36.33 (a)
T20B12.1 35
  • 29 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL177C 34
  • 44.03 (n)
  • 30.09 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E07239g 34
  • 42.48 (n)
  • 27.86 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMW1 34
  • 41.76 (n)
  • 26.27 (a)
EMW1 35
  • 22 (a)
OneToOne
EMW1 37
bread mold
(Neurospora crassa)
Ascomycetes NCU09658 34
  • 43.19 (n)
  • 31.53 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC19B12.01 34
  • 46.14 (n)
  • 32.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToOne
Species where no ortholog for TTC27 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC27 Gene

ENSEMBL:
Gene Tree for TTC27 (if available)
TreeFam:
Gene Tree for TTC27 (if available)

Paralogs for TTC27 Gene

No data available for Paralogs for TTC27 Gene

Variants for TTC27 Gene

Sequence variations from dbSNP and Humsavar for TTC27 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2273660 - 32,736,791(+) TTGTT(A/G)TGAAA intron-variant, reference, missense
rs2273664 - 32,758,413(+) GTACC(A/G/T)CAGTG reference, missense
rs17012268 - 32,777,958(+) TCAGC(A/G)CTGTG intron-variant, reference, missense
rs34188947 - 32,758,332(-) TAGGC(A/G)TTTCT reference, missense
rs1022719 -- 32,777,672(+) TGCAC(G/T)TTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC27 Gene

Variant ID Type Subtype PubMed ID
dgv1109e212 CNV gain 25503493
dgv3749n100 CNV gain 25217958
dgv3750n100 CNV gain 25217958
dgv3751n100 CNV gain 25217958
dgv3752n100 CNV gain 25217958
dgv443n27 CNV gain 19166990
dgv6750n54 CNV gain 21841781
dgv683e214 CNV loss 21293372
esv2422335 CNV duplication 17116639
esv2422472 CNV duplication 17116639
esv2652244 CNV deletion 19546169
esv2661876 CNV deletion 23128226
esv2751888 CNV gain 17911159
esv2763243 CNV gain 21179565
esv3575218 CNV gain 25503493
esv3590249 CNV gain 21293372
esv3590254 CNV gain 21293372
esv3590256 CNV gain 21293372
esv3590257 CNV loss 21293372
esv3590258 CNV loss 21293372
esv3590259 CNV loss 21293372
esv3590263 CNV loss 21293372
esv3590264 CNV gain 21293372
esv3891703 CNV gain 25118596
esv3891714 CNV gain 25118596
nsv1004912 CNV loss 25217958
nsv1005939 CNV gain 25217958
nsv1114065 CNV deletion 24896259
nsv456108 CNV gain 19166990
nsv470448 CNV gain 18288195
nsv516173 CNV gain+loss 19592680
nsv581274 CNV gain 21841781
nsv581281 CNV gain 21841781
nsv581283 CNV loss 21841781
nsv581284 CNV gain 21841781
nsv581285 CNV gain 21841781
nsv581286 CNV loss 21841781
nsv581287 CNV gain 21841781
nsv833692 CNV loss 17160897
nsv833703 CNV loss 17160897

Variation tolerance for TTC27 Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.49; 88.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC27 Gene

Disorders for TTC27 Gene

Relevant External Links for TTC27

Genetic Association Database (GAD)
TTC27
Human Genome Epidemiology (HuGE) Navigator
TTC27
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC27

No disorders were found for TTC27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC27 Gene

Publications for TTC27 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 65
  4. FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development. (PMID: 26124079) Nishiyama M. … Nakayama K.I. (Stem Cells 2015) 3 65
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 65

Products for TTC27 Gene

Sources for TTC27 Gene

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