Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TTC27 Gene

Aliases for TTC27 Gene

  • Tetratricopeptide Repeat Domain 27 2 3 5
  • TPR Repeat Protein 27 4

External Ids for TTC27 Gene

Previous GeneCards Identifiers for TTC27 Gene

  • GC02P032706
  • GC02P032853
  • GC02P032592

Summaries for TTC27 Gene

GeneCards Summary for TTC27 Gene

TTC27 (Tetratricopeptide Repeat Domain 27) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC27 Gene

Genomics for TTC27 Gene

Regulatory Elements for TTC27 Gene

Promoters for TTC27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TTC27 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTC27 Gene

Chromosome:
2
Start:
32,628,020 bp from pter
End:
32,821,051 bp from pter
Size:
193,032 bases
Orientation:
Plus strand

Genomic View for TTC27 Gene

Genes around TTC27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC27 Gene

Proteins for TTC27 Gene

  • Protein details for TTC27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P3X3-TTC27_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 27
    Protein Accession:
    Q6P3X3
    Secondary Accessions:
    • A6NKJ0
    • Q96SS5
    • Q9BVF1
    • Q9NWR4
    • Q9NXG4

    Protein attributes for TTC27 Gene

    Size:
    843 amino acids
    Molecular mass:
    96632 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91048.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91315.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TTC27 Gene

Proteomics data for TTC27 Gene at MOPED

Post-translational modifications for TTC27 Gene

  • Ubiquitination at Lys 803
  • Modification sites at PhosphoSitePlus

Other Protein References for TTC27 Gene

No data available for DME Specific Peptides for TTC27 Gene

Domains & Families for TTC27 Gene

Gene Families for TTC27 Gene

Protein Domains for TTC27 Gene

Suggested Antigen Peptide Sequences for TTC27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P3X3

UniProtKB/Swiss-Prot:

TTC27_HUMAN :
  • Belongs to the TTC27 family.
  • Contains 6 TPR repeats.
Family:
  • Belongs to the TTC27 family.
Similarity:
  • Contains 6 TPR repeats.
genes like me logo Genes that share domains with TTC27: view

Function for TTC27 Gene

genes like me logo Genes that share phenotypes with TTC27: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TTC27 Gene

Localization for TTC27 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC27 Gene COMPARTMENTS Subcellular localization image for TTC27 gene
Compartment Confidence
cytosol 3
mitochondrion 3
nucleus 3
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC27 Gene

Pathways & Interactions for TTC27 Gene

SuperPathways for TTC27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC27 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC27 Gene

Drugs & Compounds for TTC27 Gene

No Compound Related Data Available

Transcripts for TTC27 Gene

Unigene Clusters for TTC27 Gene

Tetratricopeptide repeat domain 27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC27 Gene

No ASD Table

Relevant External Links for TTC27 Gene

GeneLoc Exon Structure for
TTC27
ECgene alternative splicing isoforms for
TTC27

Expression for TTC27 Gene

mRNA expression in normal human tissues for TTC27 Gene

Protein differential expression in normal tissues from HIPED for TTC27 Gene

This gene is overexpressed in Bone (31.6), Peripheral blood mononuclear cells (15.1), and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTC27 Gene



SOURCE GeneReport for Unigene cluster for TTC27 Gene Hs.468125

genes like me logo Genes that share expression patterns with TTC27: view

Protein tissue co-expression partners for TTC27 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTC27 Gene

Orthologs for TTC27 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTC27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC27 36
  • 98 (a)
OneToOne
TTC27 35
  • 98.34 (n)
  • 97.98 (a)
cow
(Bos Taurus)
Mammalia TTC27 36
  • 89 (a)
OneToOne
TTC27 35
  • 89.96 (n)
  • 89.32 (a)
dog
(Canis familiaris)
Mammalia TTC27 35
  • 90.15 (n)
  • 89.68 (a)
TTC27 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc27 16
Ttc27 36
  • 84 (a)
OneToOne
Ttc27 35
  • 84.22 (n)
  • 84.58 (a)
oppossum
(Monodelphis domestica)
Mammalia TTC27 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC27 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttc27 35
  • 84.06 (n)
  • 85.53 (a)
chicken
(Gallus gallus)
Aves TTC27 36
  • 74 (a)
OneToOne
TTC27 35
  • 74.31 (n)
  • 73.75 (a)
lizard
(Anolis carolinensis)
Reptilia TTC27 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24470 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc27 35
  • 67.62 (n)
  • 66.35 (a)
zebrafish
(Danio rerio)
Actinopterygii ttc27 35
  • 59.46 (n)
  • 59.66 (a)
ttc27 36
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006358 35
  • 41.5 (n)
  • 32.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5290 36
  • 27 (a)
OneToOne
CG5290 35
  • 43.44 (n)
  • 34.34 (a)
worm
(Caenorhabditis elegans)
Secernentea T20B12.1 36
  • 29 (a)
OneToOne
T20B12.1 35
  • 46.97 (n)
  • 36.33 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL177C 35
  • 44.03 (n)
  • 30.09 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMW1 36
  • 22 (a)
OneToOne
EMW1 38
EMW1 35
  • 41.76 (n)
  • 26.27 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E07239g 35
  • 42.48 (n)
  • 27.86 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09658 35
  • 43.19 (n)
  • 31.53 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC19B12.01 35
  • 46.14 (n)
  • 32.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToOne
Species with no ortholog for TTC27:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC27 Gene

ENSEMBL:
Gene Tree for TTC27 (if available)
TreeFam:
Gene Tree for TTC27 (if available)

Paralogs for TTC27 Gene

No data available for Paralogs for TTC27 Gene

Variants for TTC27 Gene

Sequence variations from dbSNP and Humsavar for TTC27 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs220650 -- 32,781,435(-) ttttt(A/T)aaaaa intron-variant
rs220651 -- 32,781,500(-) cttaa(A/G)agaac intron-variant
rs220660 -- 32,794,046(-) ttttg(A/G)ttgtt intron-variant
rs220661 -- 32,795,317(+) aatat(A/G)ctaca intron-variant
rs16349 -- 32,820,951(-) AGCAC(-/CTTTTCCAGAATCTG)CTTCC cds-indel

Structural Variations from Database of Genomic Variants (DGV) for TTC27 Gene

Variant ID Type Subtype PubMed ID
esv2422335 CNV Duplication 17116639
esv2751888 CNV Gain 17911159
nsv516173 CNV Gain+Loss 19592680
dgv443n27 CNV Gain 19166990
nsv833692 CNV Loss 17160897
esv2422472 CNV Duplication 17116639
nsv470448 CNV Gain 18288195
nsv456108 CNV Gain 19166990
nsv873782 CNV Loss 21882294
nsv873783 CNV Gain 21882294
nsv873784 CNV Gain 21882294
nsv833703 CNV Loss 17160897
esv2661876 CNV Deletion 23128226
dgv4076n71 CNV Loss 21882294
esv2652244 CNV Deletion 19546169
nsv873787 CNV Gain 21882294

Variation tolerance for TTC27 Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.49; 88.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC27 Gene

HapMap Linkage Disequilibrium report
TTC27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC27 Gene

Disorders for TTC27 Gene

Relevant External Links for TTC27

Genetic Association Database (GAD)
TTC27
Human Genome Epidemiology (HuGE) Navigator
TTC27
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC27

No disorders were found for TTC27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC27 Gene

Publications for TTC27 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PMID: 23402259) Chen R. … Zhang N. (J. Proteome Res. 2013) 3
  5. The functional interactome landscape of the human histone deacetylase family. (PMID: 23752268) Joshi P. … Cristea I.M. (Mol. Syst. Biol. 2013) 3

Products for TTC27 Gene

Sources for TTC27 Gene

Back to Top

Content